Digital Public Defence: Elisa Napoli

Msc Elisa Napoli at Institute of Clinical Medicine will be defending the thesis “Quantification methods of 224Ra and 212Pb activity applied to characterize therapeutic radiopharmaceuticals” for the degree of PhD (Philosophiae Doctor).

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Photo: OSCARS Studio&Galleri, Lillestrøm.

The public defence will be held as a video conference over Zoom.

The defence will follow regular procedure as far as possible, hence it will be open to the public and the audience can ask ex auditorio questions when invited to do so.

Click here to participate in the public defence

Download Zoom here

Due to copyright reasons, an electronic copy of the thesis must be ordered from the faculty. In order for the faculty to have time to process the order, it must be received by the faculty no later than 2 days prior to the public defence. Orders received later than 2 days before the defence will not be processed. Inquiries regarding the thesis after the public defence must be addressed to the candidate.

Digital Trial Lecture – time and place

See Digital Trial Lecture.

Adjudication committee

  • First opponent: Professor Begoña Quintana Arnés, University of Salamanca
  • Second opponent: Research Professor Yuni Dewaraja, University of Michigan
  • Third member and chair of the evaluation committee: Associate Professor Taran Paulsen Hellebust, University of Oslo

Chair of the Defence

Professor II Kjersti Flatmark, Faculty of Medicine, University of Oslo

Principal Supervisor

Professor Øyvind S. Bruland, Faculty of Medicine, University of Oslo


A carrier compound of CaCO3 microparticles radiolabeled with the α-emitting Ra-224 nuclide is a promising treatment of metastatic cancers in body cavities. To secure a safe and internationally consistent dosing to patients, radioactivity standards are developed and established by national metrology institutes.

This thesis presents the work of primary and secondary standardization of radium-224, performed at the National Institute of Standards and Technology (NIST) in the USA. The standardization of radium-224 was based on liquid scintillation (LS) counting, triple-to-double coincidence ratio (TDCR), CIEMAT-NIST efficiency tracing and the live-timed anticoincidence counting (LTAC) techniques.

It is also presented in the thesis the use of calibrated counters to study properties of multi-step decaying radium-224 labeled microparticles, and the fate of radioactive progenies, including radon-220 and lead-212.

It was found that the re-adsorption of lead-212 onto the microparticles can contribute the retention of activity in the targeted area, while the diffusion of radon-220 up to a few hundred micrometers can extend the effective range of the alpha particles causing a beneficial “dose-smoothening effect”.

Additional information

Contact the research support staff.



Published Nov. 26, 2021 10:51 AM - Last modified Dec. 14, 2021 9:13 AM