Digital Public Defence: Karl-Andreas Dumont

Cand.med. Karl-Andreas Dumont at Institute of Clinical Medicine will be defending the thesis “Quantification of Mitral Annular Dynamics: Validation and Clinical Application of a Novel Autostereoscopic Holographic Display” for the degree of PhD (Philosophiae Doctor).

The public defence will be held as a video conference over Zoom.

The defence will follow regular procedure as far as possible, hence it will be open to the public and the audience can ask ex auditorio questions when invited to do so.

Click here to participate in the public defence

Download Zoom here

Due to copyright reasons, an electronic copy of the thesis must be ordered from the faculty. In order for the faculty to have time to process the order, it must be received by the faculty no later than 2 days prior to the public defence. Orders received later than 2 days before the defence will not be processed. Inquiries regarding the thesis after the public defence must be addressed to the candidate.

Order a digital copy of the thesis here

Digital Trial Lecture – time and place

See Digital Trial Lecture.

Adjudication committee

  • First opponent: Professor Robert J.M Klautz, Leiden University Medical Centre
  • Second opponent: Professor Truls Myrmel, The Arctic University of Norway (UiT)
  • Third member and chair of the evaluation committee: Associate Professor Kristina H Haugaa, University of Oslo

Chair of the Defence

Professor Emeritus Odd Geiran, University of Oslo

Principal Supervisor

Associate Professor Stig Urheim, University of Bergen

Summary

Mitral valve (MV) regurgitation is either primary where the cause of the regurgitation pathology is within the MV tissue or secondary due to pathology affecting the supporting structures of the valve such as ischemic myocardial disease with left ventricular dilatation and malcoaptation of the leaflets. If feasible, MV repair is the optimal treatment. MV lesions may be complex and associated, making preoperative diagnostics difficult. Personalized treatment of complex MV disease depends on the diagnostic capacity of the imaging method. The introduction of 3D echocardiography provided a more effective way of analyzing MV prolapse that can be visualized spatially from a “surgeon’s view”. From the very beginning, mainly qualitative methods were available, until lately, where multi plane reconstructions (MPR) allowed the user to quantify mitral annular dimensions and area. However, great disparity of reported values in the literature, questions the validity of these measures. Especially the saddle shape of the annulus and the commissure width differs a lot. An autostereoscopic holographic display (Setred ®AS) allowed us to navigate and identify the anatomic landmarks of the mitral annulus before quantifying dimensions and area using a dedicated software tool (Samurai®) and the introduction of three-dimensional virtual semitransparent mitral annulus surface (3D VSAS). The method was validated against phantoms (Paper I) and sonomicrometry (Paper II) considered as the gold standard. In Paper III we applied the method in a subset of patients with Barlow’s disease. 3D VSAS showed better agreement with sonomicrometry compared with today available methods. Applying the novel technology, we suggested that mechanisms of regurgitation are determined by annulus dynamics and the mechanical stresses imposed by the left ventricle.  These findings may have implications on patient treatment in the future. 

Additional information

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Published Jan. 11, 2022 1:45 PM - Last modified Jan. 11, 2022 2:19 PM