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Trial Lecture – time and place
See Trial Lecture.
Adjudication committee
- First opponent: Associate Professor Carsten Daub, Karolinska Institutet, Sweden
- Second opponent: Professor Sushma Nagaraja Grellsheid, University of Bergen
- Third member and chair of the evaluation committee: Professor Yvonne Böttcher, University of Oslo
Chair of the Defence
Professor Lars Eide, University of Oslo
Principal Supervisor
Researcher Diana Domanska, University of Oslo
Summary
Transcriptomics is defined as the study of RNA which in turn can give us insight on the expression of genes, that is the degree of activity exerted by each gene. This activity can in turn translate to the understanding of biological elements such as immune or metabolic activity.
One common challenge in medicine is the proper understanding of disease mechanisms, in other words, the ‘how’ of diseases. Incorrect or incomplete understanding can cause difficulties in both diagnosing, treating, and preventing a disease. Part of the difficulties in understanding diseases is that they are not static, indeed much like how a patient experiences a disease, the disease’s mechanism changes from beginning to end. It is therefore important to account for the aspect of time when researching disease mechanisms.
The work presented in this thesis details the steps, and diseases studied, in the development of a bioinformatic pipeline capable of analyzing and aiding in the interpretation of transcriptomic data collected over any number of time points, effectively creating a time line using transcriptomic data.
Additional information
Contact the research support staff.