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Trial Lecture – time and place
See Trial Lecture.
Adjudication committee
- First opponent: Adjunct Professor Stela Vujosevic, San Guiseppe Hospital, Italy
- Second opponent: Associate Professor Ragnhild Wivestad Jansson, University of Bergen
- Third member and chair of the evaluation committee: Associate Professor Sinan Ahmed Dheyauldeen Dheyauldeen, University of Oslo
Chair of the Defence
Professor Emeritus Torleiv Ole Rognum, University of Oslo
Principal Supervisor
Professor II Tor Paaske Utheim, University of Oslo
Summary
This thesis explores fundus autofluorescence (AF) imaging, a novel non-invasive technique, in the evaluation and monitoring of patients with rhegmatogenous retinal detachment or intraocular tumors near the optic nerve.
While surgical intervention for retinal detachment can restore vision, significant knowledge gaps remain regarding the pathophysiology of reattachment and visual recovery. Our research shows that ultra-widefield AF offers crucial insights into retinal reattachment, oxidative stress, and healing in both the macula and peripheral retina. This technique may serve as a prognostic biomarker for postoperative visual recovery and the onset of proliferative vitreoretinopathy.
Distinguishing pigmented lesions abutting the optic nerve is challenging due to size, location and biopsy risks. We found that AF enables non-invasive differentiation from malignant tumors, enhancing diagnostic accuracy.
In summary, this novel imaging technique offers objective documentation of postoperative retinal changes, improves surgical decision-making and aids in diagnosing intraocular tumors, significantly impacting patients’ vision and life expectancy.
Additional information
Contact the research support staff.