Due to copyright issues, an electronic copy of the thesis must be ordered from the faculty. For the faculty to have time to process the order, the order must be received by the faculty at the latest 2 days before the public defence. Orders received later than 2 days before the defence will not be processed. After the public defence, please address any inquiries regarding the thesis to the candidate.
Order a digital copy of the thesis here
Trial Lecture – time and place
See Trial Lecture.
Adjudication committee
- First opponent: Professor Jesper Petersson, Lund University
- Second opponent: Professor Kathinka Kurz, University of Stavanger
- Third member and chair of the evaluation committee: Professor Øyvind Molberg, University of Oslo
Chair of the Defence
Professor Morten Ingvar Lossius, University of Oslo
Principal Supervisor
Anne Hege Aamodt, Oslo University Hospital
Summary
Endovascular thrombectomy (EVT) is standard care for acute ischemic stroke caused by proximal large vessel occlusion, but many patients seen in clinical practice were underrepresented in the pivotal trials. This thesis examines functional outcome, safety and prognostic determinants after EVT in tandem occlusions, medium vessel occlusions, patients aged 80 years or older, and stroke with large infarct stroke It is based on three observational studies from the OSCAR registry and a secondary analysis of the randomized TENSION trial. EVT could be performed with acceptable safety, and many patients achieved favourable functional outcomes. In patients with large infarcts, functional outcomes after EVT did not differ significantly between women and men. Several factors beyond the occlusion itself were associated with outcome, including the number of thrombectomy passes, baseline tissue condition, premorbid function and patient vulnerability. These findings suggest that individualized assessment of such factors may be important alongside confirming the target occlusion.
Additional information
Contact the research support staff.