Public defence: Karoline Holsen Kyte

Cand.med. Karoline Holsen Kyte at the Institute of Clinical Medicine will be defending the thesis “Vascular function, bone health and breathing reserve in Norwegian female elite runners” for the degree of PhD (Philosophiae Doctor).

Bildet kan inneholde: person, smil, hår, hode, erme.

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Due to copyright issues, an electronic copy of the thesis must be ordered from the faculty. For the faculty to have time to process the order, the order must be received by the faculty at the latest 2 days before the public defence. Orders received later than 2 days before the defence will not be processed. After the public defence, please address any inquiries regarding the thesis to the candidate.

Order a digital copy of the thesis here

Trial Lecture – time and place

See Trial Lecture.

Adjudication committee

  • First opponent: Professor Maria Hopman, Radboud University, the Netherlands
  • Second opponent: Associate Professor Inger-Lise Aamot Aksetøy, Norwegian University of Science and Technology (NTNU), Norway
  • Third member and chair of the evaluation committee: Professor II Erik Sveberg Dietrichs, University of Oslo

Chair of the Defence

Professor Kåre-Olav Stensløkken, University of Oslo

Principal Supervisor

Professor II Jonny Hisdal, University of Oslo

Summary

Endurance training is generally beneficial for cardiovascular, skeletal and metabolic health. However, high training volumes at the elite level may increase the risk of low energy availability and relative energy deficiency in sport (REDs), with potential consequences for health and performance.

In the thesis Vascular function, bone health and breathing reserve in Norwegian female elite runners, Karoline Holsen Kyte and colleagues examined vascular health, bone health, lung function and breathing reserve in Norwegian female elite runners compared with age-matched inactive women.

Vascular function and structure were well preserved in the runners and were comparable to those of the inactive controls.

The runners had higher bone mineral density in the proximal femur and total body, whereas no difference was found in the lumbar spine. This suggests that the skeletal benefits of long-distance running are site-specific. Three runners had low bone mineral density in the lumbar spine. All were at risk of REDs and had a history of amenorrhea. Among the runners, proximal femur bone mineral density was positively associated with estradiol and negatively associated with symptoms of low energy availability.

The runners also had substantially lower breathing reserve at maximal exercise than the inactive women, despite similar lung function. This is the first study to investigate breathing reserve in female elite runners. The findings suggest that the respiratory system may represent a more important limitation to performance in female endurance athletes than previously recognized.

Overall, the findings underline the importance of preventing and detecting low energy availability and menstrual disturbances. Further research is needed to clarify the role of the respiratory system in the performance of female endurance athletes.

Additional information

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Published Nov. 5, 2026 6:46 AM - Last modified Nov. 5, 2026 9:11 AM