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Stem cells and mechanisms

The group’s current research aims are to perform molecular genetic analysis to increase the knowledge and expertise in psychiatric genetics and genomics and to identify cellular and  molecular phenotypes underlying psychiatric disease using stem cells models.

Photo: Adriano Winterton, NORMENT

About the group

We carry out projects to identify molecular-genetic risk factors for disease vulnerability. Then we test their functional significance in stem cell models. Our research group is also responsible for the management and operation of the biobank and stem cell facilities at NORMENT.

Projects

  • Human induced pluripotent stem cell (hiPSC) technologies in psychiatric molecular genetics
  • Identification of the hidden heritability of severe mental disorders
  • Identifying the polygenic basis of the human brain and neurodevelopmental disorders 
  • Prediction of longitudinal outcome and brain phenotype by polygenic scores
  • Identification of genetic loci associated with neurocognitive and MR phenotypes and implications for disease mechanisms in severe mental disorders
  • Biobanking, database, sample preparations, quality control 

Collaboration

  • Karolinska institutet, Stockholm, Sweden
  • Psychiatric Center Sct. Hans, Denmark, through Scandinavian Collaboration on Psychiatric Etiology (SCOPE).
  • International consortia: Psychiatric Genetics Consortium (PGC), COGENT, ENIGMA, European IPSC Consortium for Neuropsychiatric Disorders (EURICND), Maximising Impact of Research in Neurodevelopmental Disorders (MINDDS).
Published Nov. 13, 2018 9:17 AM - Last modified Mar. 27, 2019 2:26 PM