The research group engages in clinical, molecular genetic (tumor, blood and faeces) and animal experimental studies on colorectal cancer, rectal polyps and pseudomyxoma.
The colorectal surgery group engages in both clinical and molecular-translational research. The main aims for the translational projects are detection and validation of new diagnostic, prognostic, predictive and monitoring molecular biomarkers, and to make them feasible in the routine clinical setting across laboratories. This effort focuses on achieving a more personalized treatment of patients.
The group studies:
- Primary tumor
- Liver metastases
- Peritoneal metastases
- Exfoliated cells in the peritoneal
- Tumor cells in the circulation and bone marrow
- Response to radiotherapy
Innovation as a tool towards advanced treatment possibilities, is an important part of the group's effort and several patents have been registered by the group during the past years.
The colorectal surgery research group covers a broad range of topics and consists of four sub-teams:
- Genetic and epigenetic errors in the development of colorectal cancer as a basis for new diagnostics and treatment
Team leader of clinical part: Professor Arild Nesbakken
Team leader of molecular genetics: Professor Ragnhild A. Lothe
- Cancer of the peritoneal surface and Locally advanced rectal cancer
Team leader: Professor Kjersti Flatmark
- Peritoneal carcinomatosis of colorectal cancer origin and the treatment of locally advanced rectal cancer
Team leader: Dr. Stein-Gunnar Larsen
- The metastasis process in colorectal cancer
Team leader: Dr. Gro Wiedswang