Human cytomegalovirus (CMV) is a widely spread β-herpesvirus infecting the majority of the population.
CMV can cause severe disease in immunosuppressed patients, sometimes with fatal outcome. In addition, the virus is the most common cause of intrauterine infection and may result in brain damage of the fetus.
We investigate the impact of DNA-damage and DNA-repair on viral replication as well as epigenetic regulation of latency and reactivation. In addition, we have an interest in virus-mediated apoptosis and autophagy regulation as well as specific T-cell immunity in CMV-seropositive transplant patients.
Our current projects are:
- Role of DNA-damage and DNA-repair in CMV replication
- The interplay of viral and cellular factors on CMV DNA transcription and DNA replication
- Studies of epigenetic regulation of CMV latency and reactivation
- CMV-specific T-cell immunity in renal transplant patient
- CMV drug resistance testing of subpopulations by Next Generation Sequencing
- The significance of CMV specific T-cell immunity in kidney transplant patients