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Nevroimmunologi ved depresjon, alkoholmisbrukslidelse og immunologi (DARCY)

Det er en stor grad av samsykelighet mellom depresjon og alkoholmisbrukslisdelse. Målet med studien er å undersøke om immunologiske forandringer kan forklare noe av denne samsykeligheten.

Om prosjektet

Denne undersøkelsen omfatter flere prosjekter om samsykeligheten og immunologiske parametres betydning.

Prosjektet startet i 2009 og vil pågå i første omgang til 2017. De viktigste samarbeidene institusjoner er Nasjonal kompetansetjeneste ROP, Sykehuset Innlandet, NTNU, Modum Bad og immunologisk avdeling ved Rikshospitalet, OUS.

Detaljert informasjon om prosjektet finnes på denne siden (engelsk).

Publikasjoner fra prosjektet

  • Neupane SP, Neuroimmune factors related to depression in alcohol-use disorders: A cross-sectional study of Nepalese patients undergoing treatment for alcohol-use disorders (2015). PhD dissertation (University of Oslo). ISBN 978-82-8333-037-3
  • Martinez P, Neupane SP, Perlestenbakken B, Toutoungi C & Bramness JG. (2015) The association between alcohol use and depressive symptoms across socioeconomic status among 40- and 45-year-old Norwegian adults. BMC Public Health. Nov 19;15(1):1146. doi: 10.1186/s12889-015-2479-6
  • Neupane SP, Lien L, Ueland T, Mollnes TE, Aukrust P, Bramness JG (2015) Serum brain-derived neurotrophic factor levels in relation to comorbid depression and cytokine levels in Nepalese men with alcohol-use disorders. Alcohol. doi:10.1016/j.alcohol.2015.01.012
  • Neupane SP, Lien L, Martinez P, Hestad K, Bramness JG (2015) The relationship of alcohol-use disorders and depressive symptoms to tryptophan metabolism: cross-sectional data from a Nepalese alcohol treatment sample Alcoholism: Clinical and Experimental Research 3:514–521. doi:10.1111/acer.12651
  • Neupane SP, Bramness JG (2014) Who seeks treatment for alcohol problems? Demography and alcohol-use characteristics of patients in taboo and non-taboo drinking groups attending professional alcohol services in Nepal. Asian J Psychiatr 12:82-87.
  • Neupane SP, Lien L, Martinez P, Aukrust P, Ueland T, Mollnes TE, Hestad K, Bramness JG (2014) High Frequency and Intensity of Drinking may Attenuate Increased Inflammatory Cytokine Levels of Major Depression in Alcohol-use Disorders. CNS Neuroscience & Therapeutics 20:898-904.
  • Neupane, SP & Bramness, JG (2013). Prevalence and correlates of major depression among Nepalese patients in treatment for alcohol-use disorders. Drug and Alcohol Review.  32(2), 170- 177. doi: 10.1111/j.1465-3362.2012.00487.x
  • Neupane, SP; Lien, L; Hilberg, T & Bramness, JG (2013). Vitamin D deficiency in alcohol-use disorders and its relationship to comorbid major depression: A cross-sectional study of inpatients in Nepal. Drug And Alcohol Dependence.  133(2), 480- 485. doi:10.1016/j.drugalcdep.2013.07.006
  • Neupane, SP (2011). Prevalence and correlates of major depression and anxiety disorders among patients with alcohol-use disorders in Nepal. MPhil Dissertation. University of Oslo, http://urn.nb.no/URN:NBN:no-29755.

Konferansebidrag

  • Toft HP. (Sept 2016). Associations between immune status and depression with and without alcohol use. Innlandskonferensen, Hamar, Norway
  • Bramness JG. (Sept 2016). Cytokine level changes following acute ethanol intoxication in healthy men: a cross-over study. World Congress on Alcohol and Alcoholism (ISBRA/ESBRA). Berlin, Germany.
  • Neupane SP. (June 2016). Cytokine level changes following acute ethanol intoxication in healthy men: a cross-over study. Psychoneuroimmunological Research Society’s 21st annual meeting, Brighton, UK.
  • Martinez P. (Mar 2016). Cytokine levels, depression and psychological distress among people with substance use disorders. Behavior, Biology, and Chemistry Conference. San Antonio, TX, USA.
  • Neupane SP. (June 2014). Alteration of circulatory cytokine levels in alcohol-use disorder patients with or without comorbid major depression. College on Problems of Drug Dependence annual conference. San Juan, Puerto Rico.
  • Neupane SP. (Sept 2011) Depression and anxiety among Nepalese patients with alcohol use disorders. International Society of Addiction Medicine annual conference (ISAM), Oslo, Norway.

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Publisert 27. jan. 2012 14:26 - Sist endret 18. aug. 2017 12:05

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