Kjetil Steine

• Solberg, Magnar Gangås; Enger, Steve; Berge, Trygve; Rønningen, Peter Selmer; Aagaard, Erika Nerdrum & Pervez, Mohammad Osman [Vis alle 12 forfattere av denne artikkelen] (2024). Left atrial function in middle-aged men and women with and without paroxysmal atrial fibrillation: Data from the Akershus Cardiac Examination (ACE) 1950 study. Echocardiography. ISSN 0742-2822. 41(6). doi: 10.1111/echo.15852.
• Mecinaj, Albulena; Gulati, Geeta; Ree, Anne Hansen; Gravdehaug, Berit; Røsjø, Helge Rørvik & Steine, Kjetil [Vis alle 10 forfattere av denne artikkelen] (2024). Impact of the ESC Cardio-Oncology Guidelines Biomarker Criteria on Incidence of Cancer Therapy–Related Cardiac Dysfunction. JACC: CardioOncology. ISSN 2666-0873. 6(1), s. 83–95. doi: 10.1016/j.jaccao.2023.10.008.
• Jervan, Øyvind; Haukeland-Parker, Stacey Marie; Gleditsch, Jostein; Tavoly, Mazdak; Klok, Frederikus A. & Steine, Kjetil [Vis alle 14 forfattere av denne artikkelen] (2023). The Effects of Exercise Training in Patients With Persistent Dyspnea Following Pulmonary Embolism: A Randomized Controlled Trial. Chest. ISSN 0012-3692. 164(4), s. 981–991. doi: 10.1016/j.chest.2023.04.042. Fulltekst i vitenarkiv
• Jervan, Øyvind; Dhayyat, Adam; Gleditsch, Jostein; Haukeland-Parker, Stacey Marie; Tavoly, Mazdak & Klok, Frederikus A. [Vis alle 10 forfattere av denne artikkelen] (2023). Demographic, clinical, and echocardiographic factors associated with residual perfusion defects beyond six months after pulmonary embolism. Thrombosis Research. ISSN 0049-3848. 229, s. 7–14. doi: 10.1016/j.thromres.2023.06.004. Fulltekst i vitenarkiv
• Saberniak, Jørg; Strøm, Loreta Skrebelyte; Orstad, Eivind Bjørkan; Mykland Hilde, Janne; Solberg, Magnar Gangås & Rønning, Ole Morten [Vis alle 8 forfattere av denne artikkelen] (2023). Left atrial appendage strain predicts subclinical atrial fibrillation in embolic strokes of undetermined source. European Heart Journal Open (EHJ Open). 3(3). doi: 10.1093/ehjopen/oead039. Fulltekst i vitenarkiv
• Aagaard, Erika Nerdrum; Lyngbakken, Magnus Nakrem; Kvisvik, Brede Alexander Havneraas; Berge, Trygve; Pervez, Mohammad Osman & Ariansen, Inger Kristine Holtermann [Vis alle 10 forfattere av denne artikkelen] (2022). Associations between cardiovascular risk factors, biomarkers, and left ventricular mechanical dispersion: insights from the ACE 1950 Study . European Heart Journal Open (EHJ Open). 2(2), s. 1–10. doi: 10.1093/ehjopen/oeac006. Fulltekst i vitenarkiv
• Strøm, Loreta Skrebelyte; Rønning, Ole Morten; Dahl, Fredrik Andreas; Steine, Kjetil & Kjekshus, Harald (2022). Prediction of occult atrial fibrillation in patients after cryptogenic stroke and transient ischaemic attack: PROACTIA. Europace. ISSN 1099-5129. 24(12), s. 1881–1888. doi: 10.1093/europace/euac092. Fulltekst i vitenarkiv Vis sammendrag

  Aims Studies with implantable cardiac monitors (ICMs) show that one-third of patients with cryptogenic stroke/transient ischaemic attack (TIA) have episodes of subclinical atrial fibrillation (SCAF) and benefit switching from antiplatelet- to anticoagulant therapy. However, ICMs are costly and resource demanding. We aimed to build a score based on participant’s baseline characteristics that could assess individual risk of SCAF. Methods and results In a prospective study, 236 eligible patients with a final diagnosis of cryptogenic stroke/TIA had an ICM implantated during the index hospitalization. Pre-specified evaluated variables were: CHA2DS2-VASc, P-wave duration, P-wave morphology, premature atrial beats (PAC)/24 h, supraventricular tachycardia/24 h, left atrial end-systolic volume index (LAVI), Troponin-T, NT-proBNP, and D-dimer. SCAF was detected in 84 patients (36%). All pre-specified variables were significantly associated with SCAF detection in univariate analysis. P-wave duration, followed by PAC/24 h, NT-proBNP, and LAVI, had the largest ratio of SCAF prevalence between its upper and lower quartiles (3.3, vs. 3.2, vs. 3.1 vs. 2.8, respectively). However, in a multivariate analysis, only PAC/24t, P-wave duration, P-wave morphology, and LAVIs remained significant predictors and were included in the PROACTIA score. Subclinical atrial fibrillation prevalence was 75% in the highest vs. 10% in the lowest quartile of the PROACTIA score with a 10-fold higher number of patients with an atrial fibrillation burden >6 h in the highest vs. the lowest quartile. Conclusion The PROACTIA score can identify patients with cryptogenic stroke/TIA at risk of subsequent SCAF detection. The large difference in SCAF prevalence between groups may provide a basis for future tailored therapy. Clinical trial registration Clinical Trial Registration: ClinicalTrials.gov; NCT02725944.

• Lyngbakken, Magnus Nakrem; Rønningen, Peter Selmer; Solberg, Magnar Gangås; Berge, Trygve; Brynildsen, Jon & Aagaard, Erika Nerdrum [Vis alle 11 forfattere av denne artikkelen] (2022). Prediction of incident atrial fibrillation with cardiac biomarkers and left atrial volumes. Heart. ISSN 1355-6037. doi: 10.1136/heartjnl-2022-321608. Fulltekst i vitenarkiv
• Lyngbakken, Magnus Nakrem; Kvisvik, Brede Alexander Havneraas; Berge, Trygve; Pervez, Mohammad Osman; Aagaard, Erika Nerdrum & Ariansen, Inger Kristine Holtermann [Vis alle 10 forfattere av denne artikkelen] (2022). Serial blood pressure measurements, left ventricular remodelling and cardiovascular outcomes. European Journal of Clinical Investigation. ISSN 0014-2972. 53(1). doi: 10.1111/eci.13876. Fulltekst i vitenarkiv Vis sammendrag

  Background Hypertension is a risk factor for the development of cardiovascular disease. Whether serial blood pressure (BP) measurements are more closely associated with subclinical left ventricular (LV) remodelling and better predict risk of cardiovascular events over individual BP measurements are not known. Methods We assessed systolic BP, diastolic BP and pulse pressure at several time points during adulthood in 1333 women and 1211 men participating in the Akershus Cardiac Examination 1950 Study. We defined serial BP measurements as the sum of averaged BPs from adjacent consecutive visits indexed to total exposure time between measurements. We assessed the associations between serial and individual BP measurements and (1) LV structure, function and volumes and (2) incident myocardial infarction, ischemic stroke, heart failure and cardiovascular death. Results All indices of higher serial BP measurements were associated with increased indexed LV mass, and the associations were stronger than those of individual BP measurements. Serial diastolic BP pressure was strongly and inversely associated with LV systolic function, while higher serial systolic BP was primarily associated with higher LV volumes. Both serial systolic (incidence rate ratio [IRR] 1.10, 95% CI 1.03 to 1.17) and diastolic BPs (IRR 1.14, 95% CI 1.02 to 1.27) were associated with increased incidence of clinical events. Conclusion In healthy community dwellers without established cardiovascular disease, different serial BP indices associate strongly with LV remodelling and cardiovascular outcomes. Whether the use of serial BP indices for guiding treatment is superior to individual measurements should be explored in additional prospective studies.

• Fyksen, Tea Sætereng; Vanberg, Paul; Gjesdal, Knut Tjøl; von Lueder, Thomas Gero; Bjørnerheim, Reidar & Steine, Kjetil [Vis alle 8 forfattere av denne artikkelen] (2022). Cardiovascular phenotype of long-term anabolic-androgenic steroid abusers compared with strength-trained athletes. Scandinavian Journal of Medicine & Science in Sports. ISSN 0905-7188. 32(8), s. 1170–1181. doi: 10.1111/sms.14172. Fulltekst i vitenarkiv
• Rønningen, Peter Selmer; Berge, Trygve; Solberg, Magnar Gangås; Enger, Steve; Pervez, Mohammad Osman & Orstad, Eivind Bjørkan [Vis alle 13 forfattere av denne artikkelen] (2022). Impact of Blood Pressure in the Early 40s on Left Atrial Volumes in the Mid-60s: Data From the ACE 1950 Study. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 11(11). doi: 10.1161/JAHA.121.023738. Fulltekst i vitenarkiv
• Cooper, Trond Johan; Cleland, John G.F.; Guazzi, Marco; Pellicori, Pierpaolo; Ben Gal, Tuvia & Amir, Offer [Vis alle 11 forfattere av denne artikkelen] (2022). Effects of sildenafil on symptoms and exercise capacity for heart failure with reduced ejection fraction and pulmonary hypertension (the SilHF study): a randomized placebo-controlled multicentre trial. European Journal of Heart Failure. ISSN 1388-9842. 24(7), s. 1239–1248. doi: 10.1002/ejhf.2527.
• Myhre, Peder Langeland; Lyngbakken, Magnus Nakrem; Berge, Trygve; Røysland, Ragnhild; Aagaard, Erika Nerdrum & Pervez, Mohammad Osman [Vis alle 13 forfattere av denne artikkelen] (2021). Diagnostic Thresholds for Pre-Diabetes Mellitus and Diabetes Mellitus and Subclinical Cardiac Disease in the General Population: Data From the ACE 1950 Study. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 10(11). doi: 10.1161/JAHA.120.020447. Fulltekst i vitenarkiv
• Heck, Siri Lagethon; Mecinaj, Albulena; Ree, Anne Hansen; Hoffmann, Pavel; Schulz-Menger, Jeanette & Fagerland, Morten [Vis alle 12 forfattere av denne artikkelen] (2021). Prevention of cardiac dysfunction during adjuvant breast cancer therapy (PRADA): Extended follow-up of a 2×2 factorial, randomized, placebo-controlled, double-blind clinical trial of candesartan and metoprolol. Circulation. ISSN 0009-7322. 143(25), s. 2431–2440. doi: 10.1161/CIRCULATIONAHA.121.054698. Fulltekst i vitenarkiv
• Jervan, Øyvind; Gleditsch, Jostein; Tavoly, Mazdak; Klok, Frederikus A.; Rashid, Diyar Nori Mohamad & Holst, René [Vis alle 9 forfattere av denne artikkelen] (2021). Pulmonary and cardiac variables associated with persistent dyspnea after pulmonary embolism. Thrombosis Research. ISSN 0049-3848. 201, s. 90–99. doi: 10.1016/j.thromres.2021.02.014. Fulltekst i vitenarkiv
• Lyngbakken, Magnus; Kvisvik, Brede Alexander; Aagaard, Erika Nerdrum; Berge, Trygve; Pervez, Mohammad Osman & Brynildsen, Jon [Vis alle 10 forfattere av denne artikkelen] (2020). B-Type Natriuretic Peptide Is Associated with Indices of Left Ventricular Dysfunction in Healtahy Subjects from the General Population: The Akershus Cardiac Examination 1950 Study. Clinical Chemistry. ISSN 0009-9147. doi: 10.1093/clinchem/hvaa257. Fulltekst i vitenarkiv
• Lyngbakken, Magnus; Aagaard, Erika Nerdrum; Kvisvik, Brede Alexander; Berge, Trygve; Pervez, Mohammad Osman & Brynildsen, Jon [Vis alle 10 forfattere av denne artikkelen] (2020). Cardiac troponin I and T are associated with left ventricular function and structure: Data from the Akershus Cardiac Examination 1950 Study. Clinical Chemistry. ISSN 0009-9147. 66(4), s. 567–578. doi: 10.1093/clinchem/hvaa023. Fulltekst i vitenarkiv
• Hilde, Janne Mykland; Hisdal, Jonny; Skjørten, Ingunn; Hansteen, Viggo; Melsom, Morten Nissen & Grøtta, Ole Jørgen [Vis alle 11 forfattere av denne artikkelen] (2020). Left ventricular dysfunction in COPD without pulmonary hypertension. PLOS ONE. ISSN 1932-6203. 15(7), s. 1–15. doi: 10.1371/journal.pone.0235075. Fulltekst i vitenarkiv
• Rønningen, Peter Selmer; Berge, Trygve; Solberg, Magnar Gangås; Enger, Steve; Nygård, Ståle & Pervez, Mohammad Osman [Vis alle 12 forfattere av denne artikkelen] (2020). Sex differences and higher upper normal limits for left atrial end-systolic volume in individuals in their mid-60s: data from the ACE 1950 Study. European Heart Journal-Cardiovascular Imaging. ISSN 2047-2404. 21(5), s. 501–507. doi: 10.1093/ehjci/jeaa004.
• Aagaard, Erika Nerdrum; Kvisvik, Brede Alexander; Pervez, Mohammad Omar; Lyngbakken, Magnus; Berge, Trygve & Enger, Steve [Vis alle 12 forfattere av denne artikkelen] (2019). Left ventricular mechanical dispersion in a general population: Data from the Akershus Cardiac Examination 1950 study. European Heart Journal-Cardiovascular Imaging. ISSN 2047-2404. 21. doi: 10.1093/ehjci/jez210.
• Skjørten, Ingunn; Mykland Hilde, Janne; Melsom, Morten Nissen; Hisdal, Jonny; Hansteen, Viggo & Steine, Kjetil [Vis alle 7 forfattere av denne artikkelen] (2018). Exercise capacity in COPD patients with exercise-induced pulmonary hypertension. The International Journal of Chronic Obstructive Pulmonary Disease. ISSN 1176-9106. 13, s. 3599–3610. doi: 10.2147/COPD.S161175. Fulltekst i vitenarkiv
• Berge, Trygve; Lyngbakken, Magnus; Ihle-Hansen, Håkon; Brynildsen, Jon; Pervez, Mohammad Osman & Aagaard, Erika Nerdrum [Vis alle 14 forfattere av denne artikkelen] (2018). Prevalence of atrial fibrillation and cardiovascular risk factors in a 63-65 years old general population cohort: The Akershus Cardiac Examination (ACE) 1950 Study. BMJ Open. ISSN 2044-6055. 8:e021704(7), s. 1–9. doi: 10.1136/bmjopen-2018-021704. Fulltekst i vitenarkiv
• von Lueder, Thomas Gero; Hodt, Anders; Gjerdalen, Gard Filip & Steine, Kjetil (2018). Left ventricular biomechanics in professional football players. Scandinavian Journal of Medicine & Science in Sports. ISSN 0905-7188. 28(1), s. 187–195. doi: 10.1111/sms.12893.
• Skjørten, Ingunn; Mykland Hilde, Janne; Melsom, Morten Nissen; Hisdal, Jonny; Hansteen, Viggo & Steine, Kjetil [Vis alle 7 forfattere av denne artikkelen] (2018). Cardiopulmonary exercise test and PaO2 in evaluation of pulmonary hypertension in COPD. The International Journal of Chronic Obstructive Pulmonary Disease. ISSN 1176-9106. 2018:13, s. 91–100. doi: 10.2147/COPD.S150034.
• Heck, Siri Lagethon; Gulati, Geeta; HOFFMANN, PAVEL; von Knobelsdorff-Brenkenhoff, Florian; Storås, Tryggve & Ree, Anne Hansen [Vis alle 12 forfattere av denne artikkelen] (2018). Effect of candesartan and metoprolol on myocardial tissue composition during anthracycline treatment: The PRADA trial. European Heart Journal-Cardiovascular Imaging. ISSN 2047-2404. 19(5), s. 544–552. doi: 10.1093/ehjci/jex159. Fulltekst i vitenarkiv Vis sammendrag

  Aims: Anthracycline treatment may cause myocyte loss and expansion of the myocardial extracellular volume (ECV) fraction by oedema and fibrosis. We tested the hypotheses that adjuvant treatment for early breast cancer with the anthracycline epirubicin is dose dependently associated with increased ECV fraction and total ECV, as well as reduced total myocardial cellular volume, and that these changes could be prevented by concomitant angiotensin or beta-adrenergic blockade. Methods and results: PRevention of cArdiac Dysfunction during Adjuvant breast cancer therapy (PRADA) was a 2 × 2 factorial, placebo-controlled, double-blinded trial of candesartan and metoprolol. Sixty-nine women had valid ECV measurements. ECV fraction, total ECV, and total cellular volume were measured by cardiovascular magnetic resonance before and at the completion of anthracycline therapy. ECV fraction increased from 27.5 ± 2.7% to 28.6 ± 2.9% (P = 0.002). A cumulative doxorubicin equivalent dose of 268 mg/m2 was associated with greater increase in ECV fraction than doses <268 mg/m2 (mean change 3.4% [95% confidence interval (CI) 1.2, 5.5] vs. 0.7% [95% CI 0.0, 1.5], P = 0.006), as well as greater increase in total ECV (1.9 mL [95% CI 0.4, 3.5] vs. 0.1 mL [95% CI -0.6, 0.8], P = 0.04). In patients receiving candesartan, total cellular volume decreased (-3.5 mL [95% CI - 4.7, -2.2], P < 0.001) while in patients not receiving candesartan, it remained unchanged (P = 0.45; between group difference P = 0.003). Conclusions: Anthracycline therapy is associated with dose-dependent increase in ECV fraction and total ECV. Concomitant treatment with candesartan reduces left ventricular total cellular volume.

• Mecinaj, Albulena; Reier-Nilsen, Frode; Le, Tri Minh & Steine, Kjetil (2017). Long-term peritoneal port-catheter in a patient with cardiac ascites. BMJ Case Reports. ISSN 1757-790X. 2017. doi: 10.1136/bcr-2017-219258.
• Gulati, Geeta; Heck, Siri Lagethon; Røsjø, Helge; Ree, Anne Hansen; HOFFMANN, PAVEL & Hagve, Tor-Arne [Vis alle 11 forfattere av denne artikkelen] (2017). Neurohormonal blockade and circulating cardiovascular biomarkers during anthracycline therapy in breast cancer patients: Results from the PRADA (Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy) study. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 6(11). doi: 10.1161/JAHA.117.006513. Fulltekst i vitenarkiv
• Larssen, Marte Strømsnes; Steine, Kjetil; Mykland Hilde, Janne; Skjørten, Ingunn; Hodnesdal, Christian & Liestøl, Knut [Vis alle 7 forfattere av denne artikkelen] (2017). Mechanisms of ECG signs in chronic obstructive pulmonary disease. Open heart. ISSN 2053-3624. 4(1). doi: 10.1136/openhrt-2016-000552. Fulltekst i vitenarkiv
• Gulati, Geeta; Heck, Siri Lagethon; Ree, Anne Hansen; HOFFMANN, PAVEL; Schulz-Menger, Jeanette & Fagerland, Morten [Vis alle 15 forfattere av denne artikkelen] (2016). Prevention of cardiac dysfunction during adjuvant breast cancer therapy (PRADA): a 2 x 2 factorial, randomized, placebo-controlled, double-blind clinical trial of candesartan and metoprolol. European Heart Journal. ISSN 0195-668X. 37(21), s. 1671–1680. doi: 10.1093/eurheartj/ehw022.
• Mykland Hilde, Janne; Skjørten, Ingunn; Hansteen, Viggo; Melsom, Morten Nissen; Atar, Dan & Hisdal, Jonny [Vis alle 8 forfattere av denne artikkelen] (2016). Assessment of right ventricular afterload in COPD. COPD: Journal of Chronic Obstructive Pulmonary Disease. ISSN 1541-2555. 13(2), s. 176–185. doi: 10.3109/15412555.2015.1057275.
• Gjerdalen, Gard Filip; Hisdal, Jonny; Solberg, Erik Ekker; Andersen, Thor Einar; Radunovic, Zoran & Steine, Kjetil (2015). Atrial size and function in athletes. International Journal of Sports Medicine (IJSM). ISSN 0172-4622. 36(14), s. 1170–1176. doi: 10.1055/s-0035-1555780. Vis sammendrag

  We wanted to explore whether change in LA (left atrium) size would influence LA function, or increase regurgitation in the atrioventricular valves. 595 male elite football players and 47 non-athletic controls were included. End-systolic LA volume and RA area and end-diastolic LV volume and RV area were measured by 2-dimensional (2D) echocardiography Pulsed and colour Doppler were used to estimate tricuspid and mitral regurgitations. 2D longitudinal strain of the 50 football players with the largest LA volumes were compared with the 50 players with the smallest LA volumes. The LA volumes in some athletes with large atria were more than tripled, compared to athletes with small atria. 2D strain however, could not reveal any impairment of LA function in the players with the largest atria, compared to those with the smallest LA. Tricuspid valve regurgitation was found in 343 (58%) of the athletes, compared to 17 (36%) of the controls (p<0.01), while mitral regurgitation was found in 116 (20%) football players and 7 (15%) controls (NS). Furthermore, the RA area was significantly larger in athletes with tricuspid regurgitation compared to athletes without. The present study demonstrated a huge variation in atrial size between the athletes. This variation, however, had no impact on LA function. Tricuspid regurgitation was significantly more prevalent among the athletes, than among the controls.

• Radunovic, Zoran & Steine, Kjetil (2015). Prevalence of Cardiovascular Disease and Cardiac Symptoms: Left and Right Ventricular Function in Adults With Osteogenesis Imperfecta. Canadian Journal of Cardiology. ISSN 0828-282X. 31(11), s. 1386–1392. doi: 10.1016/j.cjca.2015.04.016.
• Berge, Trygve; Vigen, Thea; Pervez, Mohammad Omar; Ihle-Hansen, Håkon; Lyngbakken, Magnus Nakrem & Omland, Torbjørn [Vis alle 10 forfattere av denne artikkelen] (2015). Heart and brain interactions - the Akershus Cardiac Examination (ACE) 1950 study design. Scandinavian Cardiovascular Journal. ISSN 1401-7431. 49(6), s. 308–315. doi: 10.3109/14017431.2015.1086813.
• Hodt, Anders; Hisdal, Jonny; Stugaard, Marie; Stranden, Einar; Atar, Dan & Steine, Kjetil (2015). Increased LV apical untwist during preload reduction in healthy humans. An echocardiographic speckle tracking study during lower body negative pressure (LBNP) . Physiological Reports. ISSN 2051-817X. 3(3). doi: 10.14814/phy2.12330. Fulltekst i vitenarkiv Vis sammendrag

  Background: We sought to investigate the effect of reduced preload on LV untwist and early diastolic filling in healthy individuals. Methods: Twelve healthy men, 22 (22,23) years of age, were examined at rest and during applied lower body negative pressure (LBNP) of -20 mmHg and -40 mmHg, respectively. Regional untwist and untwist rate during IVRT were calculated at LV basal, papillary, sub-papillary and apical short axis levels by two dimensional speckle tracking echocardiography. LV early diastolic filling was assessed by transmitral E-wave (E) peak velocity by pulsed Doppler and flow propagation velocity (Vp) by color M-mode Doppler and early diastolic pulsed Doppler tissue velocities (E`) from septal and lateral mitral annulus. Results: From rest to LBNP -40 mmHg the LV untwist and untwist rate at sub-papillary level increased from 2.3 (1.4,3.5) to 4.5 (3.1,7.6) degrees and from -36 (-51,-25) to -69 (-127,-42) /s (p<0.001, p=0.003), respectively, while apical untwist and untwist rate increased from 3.9 (2.3,4.3) to 7.6 (6.4,10.5) degrees and from -51 (-69,-40) to -118 (-170,-84) /s (p<0.001, p<0.001), respectively. Since untwist and untwist rate at the basal level were unchanged, this created markedly larger base to apical untwist and untwist rate gradients from rest to LBNP -40 mmHg. E, Vp and E` were reduced by 34, 32 and 39 %, respectively. Conclusions: LV untwist and untwist rate during IVRT were increased at apical levels, which might be a physiological mechanism to minimize the impairment in LV early diastolic filling during preload reduction.

• Berge, Hilde Moseby; Gjesdal, Knut; Andersen, Thor Einar; Solberg, Erik Ekker & Steine, Kjetil (2015). Prevalence of abnormal ECGs in male soccer players decreases with the Seattle criteria, but is still high. Scandinavian Journal of Medicine & Science in Sports. ISSN 0905-7188. 25(4), s. 501–508. doi: 10.1111/sms.12274. Vis sammendrag

  Electrocardiogram (ECG) and echocardiography are mandatory in preparticipation cardiac screening in soccer players. Abnormal ECG findings usually require follow-up investigations. The main aim of this study was to compare the prevalence of abnormal ECG findings in male professional soccer players according to European Society of Cardiology's (ESC) recommendations and the Seattle criteria, and to assess the need for echocardiography. ECGs from 587 of 595 (99%) players were recorded with ClickECG, and measurements were derived with visually adjusted on-screen calipers on the computer-based averaged PQRST complex. Echocardiographic recordings were performed with Vivid 7/i and categorized according to reference values for athlete's heart. After the initial screening, 32 (5.5%) players were recommended for follow-up. The prevalence of abnormal ECGs was 29.3% vs 11.2% according to the ESC's recommendations and the Seattle criteria, respectively. None of the players with abnormal ECGs only according to the ESC's recommendations had abnormal echocardiograms. Echocardiography alone detected one player with abnormalities (athlete's heart). The Seattle criteria reduced the number of athletes with abnormal ECGs considerably compared with the ESC recommendations. Based on echocardiographic evaluations, this increased the specificity of the Seattle criteria, without increasing the number of false-negative ECGs. The need for mandatory echocardiography in soccer players seems limited.

• Sveen, Kari Anne; Nerdrum, Tone; Hanssen, Kristian Folkvord; Brekke, Magne; Torjesen, Peter A & Strauch, Christopher M [Vis alle 10 forfattere av denne artikkelen] (2014). Impaired left ventricular function and myocardial blood flow reserve in patients with long-term type 1 diabetes and no significant coronary artery disease: Associations with protein glycation. Diabetes & vascular disease research. ISSN 1479-1641. 11(2), s. 84–91. doi: 10.1177/1479164113518805.
• Gjerdalen, Gard Filip; Hisdal, Jonny; Solberg, Erik Ekker; Andersen, Thor Einar; Radunovic, Zoran & Steine, Kjetil (2014). The Scandinavian athlete's heart; echocardiographic characteristics of male professional football players. Scandinavian Journal of Medicine & Science in Sports. ISSN 0905-7188. 24(5), s. e372–e380. doi: 10.1111/sms.12178. Vis sammendrag

  This investigation explores the cardiac four-chamber remodeling response to training in male players in Norwegian professional football league, and ethnicity as determinants in the development of athlete’s heart. Standard 2D echocardiographic examination and analysis of all four cavities were performed in 504 football players of Caucasian origin, 49 of African origin, and 47 matched Caucasian controls (<3 h training /week). All results were indexed to body surface area (BSA). Most athletes exhibited BSA-indexed values within normal ranges. Left ventricle (LV) mass was equally enlarged in both groups of athletes, but LV relative wall thickness and right ventricular (RV) relative wall thickness were increased in Africans compared with Caucasian athletes (0.37 ± 0.06 vs 0.33 ± 0.06 and 0.25 ± 0.06 vs 0.22 ± 0.04, respectively). Both LV and RV were smaller in Africans than in Caucasian athletes (67.8 ± 12.0 ml/m2 vs 73.6 ± 13.2 ml/m2 and 12.8 ± 2.1 vs 13.7 ± 2.4 cm2/m2, respectively, both P < 0.05), while left and right atria increased similarly. This first large-scale echocardiographic survey of elite football players in a Scandinavian league suggests use of BSA-indexed upper normal limits for both LV and RV in athletes. African athletes had significantly more concentric remodeled LV and RV than the Caucasian athletes.

• Berge, Hilde Moseby; Steine, Kjetil; Andersen, Thor Einar; Solberg, Erik Ekker & Gjesdal, Knut (2014). Visual or computer-based measurements: important for interpretation of athletes’ ECG. British Journal of Sports Medicine. ISSN 0306-3674. 48(9), s. 761–767. doi: 10.1136/bjsports-2014-093412. Vis sammendrag

  Background: ECG is recommended for preparticipation health examination in athletes. Owing to a lack of consensus on how to read and interpret athletes’ ECGs, different criteria for abnormality are used. Aims: To compare the prevalence of abnormal ECGs and test the correlation between visual and computerbased measurements. Methods: In a preparticipation cardiac screening examination of 595 male professional soccer players aged 18–38 years, ECGs were categorised according to the European Society of Cardiology’s (ESC) recommendations and the Seattle criteria, respectively. Visual measurements were conducted with callipers onscreen on the averaged PQRST complex in each lead, calculated by the trimmed mean. Computer-based measurements were derived from the medium beat. Heart rhythm and conduction were scored visually by a cardiologist. Categorical variables were compared by κ statistics (K) and continuous variables by intraclass correlation. Results: ECGs of good quality were available from 579 players. According to the ESC’s recommendations and Seattle criteria, respectively, ECGs were categorised as abnormal in 171 (29.5%) vs 64 (11.1%) players after visual assessment, and in 293 (50.6%; K=0.395) vs 127 (21.9%; K=0.564) after computer-based measurements. Intraclass correlation was very good for measurements of R and S wave amplitudes and moderate to very good for intervals. K was very good for pathological Q wave amplitudes and moderate for T wave inversions. Conclusions: Abnormal ECGs were more than twice as common after computer-based than after visual measurements. Such a difference will markedly influence the number of athletes who need further examinations. Reference values may need adjustments dependent on measurement methods.

• Petersson, Richard; Berge, Hilde Moseby; Gjerdalen, Gard Filip; Carlson, Jonas; Holmqvist, Fredrik & Steine, Kjetil [Vis alle 7 forfattere av denne artikkelen] (2014). P-Wave Morphology Is Unaffected by Atrial Size: A Study in Healthy Athletes. Annals of Noninvasive Electrocardiology. ISSN 1082-720X. 19(4), s. 366–373. doi: 10.1111/anec.12132. Vis sammendrag

  Background: Orthogonal P-wave morphology has previously been described in different populations, but its relation to atrial size has not been studied in detail. In this study, we investigated whether atrial size affects P-wave morphology in athletes, who are known to have different degrees of atrial enlargement. Methods: A total of 504 healthy, male, professional soccer players were included (median age 25 years). All underwent echocardiographic and 12-lead electrocardiographic (ECG) recordings. The ECG was transformed into orthogonal leads, using the inverse Dower transform. The association between echocardiographic parameters and standard P-wave measures (i.e., orthogonal morphology, left atrial abnormality assessed as negative P-wave terminal force [PTF] in lead V1 > 0.04 mm × s, and duration) was analyzed. Results: The vast majority had either type 1 P-wave morphology (75%) (positive leads X and Y and negative lead Z) or type 2 P-wave morphology (22%) (positive leads X and Y and biphasic lead Z [negative/positive]). Left atrial enlargement (≥29 mL/m2) was found in 79% on echocardiography. There was no significant difference in left atrial end-systolic volume, left or right atrial diameters, or right atrial area between individuals with different P-wave morphologies. ECG signs of left atrial abnormality were found in eight subjects, who did not have significantly larger left atrial dimensions than the rest. Conclusions: We demonstrated that P-wave morphology does not depend on the size of the atria in young, healthy athletes, and that PTF is not a reliable marker of left atrial enlargement in the current population.

• Hilde, Janne Mykland; skjørten, i; Hansteen, Viggo; Melsom, Morten Nissen; Hisdal, J & Hummerfelt, S [Vis alle 7 forfattere av denne artikkelen] (2013). Haemodynamic response to exercise in patients With copd. European Respiratory Journal. ISSN 0903-1936. 41, s. 1031–1041. doi: 10.1183/09031936.00085612.
• Hilde, Janne Mykland; skjørten, i; Grøtta, Ole Jørgen; Hansteen, Viggo; Melsom, Morten Nissen & Hisdal, J [Vis alle 8 forfattere av denne artikkelen] (2013). Right ventricular dysfunction and remodelling in chronic obstructive pulmonary disease without pulmonary hypertension. Journal of the American College of Cardiology. ISSN 0735-1097. 17. doi: 10.1016/j.jacc.2013.04.091.
• Skjørten, Ingunn; Hilde, Janne Mykland; Melsom, Morten Nissen; Hansteen, Viggo; Steine, Kjetil & Hummerfelt, S (2013). pulmonary artery pressure and Pa=2 in chronic obstructive pulmonary disease. Respiratory Medicine. ISSN 0954-6111. 107, s. 1271–1279. doi: 10.1016/j.rmed.2013.03.021.
• Gulati, Geeta; Heck, Siri Lagethon; Ree, Anne Hansen; Gravdehaug, Berit; Røsjø, Helge & Steine, Kjetil [Vis alle 10 forfattere av denne artikkelen] (2013). Cardioprotective treatment during adjuvant cancer therapy. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 133(17), s. 1832–1836. doi: 10.4045/tidsskr.12.1514.
• Mykland Hilde, Janne; Skjørten, Ingunn; Grøtta, Ole Jørgen; Hansteen, Viggo; Melsom, Morten Nissen & Hisdal, Jonny [Vis alle 8 forfattere av denne artikkelen] (2013). Right ventricular dysfunction and remodeling in chronic obstructive pulmonary disease without pulmonary hypertension. Journal of the American College of Cardiology. ISSN 0735-1097. 62(12), s. 1103–1111. doi: 10.1016/j.jacc.2013.04.091.
• Skjørten, Ingunn; Mykland Hilde, Janne; Melsom, Morten Nissen; Hansteen, Viggo; Steine, Kjetil & Hummerfeldt, Sjur (2013). Pulmonary artery pressure and PaO2 in chronic obstructive pulmonary disease. Respiratory Medicine. ISSN 0954-6111. 107(8), s. 1271–1279. doi: 10.1016/j.rmed.2013.03.021.
• Mykland Hilde, Janne; Skjørten, Ingunn; Hansteen, Viggo; Melsom, Morten Nissen; Hisdal, Jonny & Hummerfeldt, Sjur [Vis alle 7 forfattere av denne artikkelen] (2013). Haemodynamic responses to exercise in patients with CORD. European Respiratory Journal. ISSN 0903-1936. 41(5), s. 1031–1041. doi: 10.1183/09031936.00085612.
• Berge, Hilde Moseby; Andersen, Thor Einar; Solberg, Erik Ekker & Steine, Kjetil (2013). High ambulatory blood pressure in male professional football players. British Journal of Sports Medicine. ISSN 0306-3674. 47(8), s. 521–525. doi: 10.1136/bjsports-2013-092354. Vis sammendrag

  Background: No data exist on ambulatory blood pressure (ABP) in athletes. Objectives: To identify ABP and examine recommended follow-up of high office blood pressure (OBP) in male professional football players and secondary study indicators of sympathetic activity. Methods: Players with high OBP (cases) from a previous screening of 594 players (n=28) were matched for age and ethnicity with players with optimal OBP (controls). High ABP was defined as a mean of ≥135/85 mm Hg during daytime and ≥120/75 mm Hg during night-time. The players replied to questions regarding follow-up of high OBP. High night-time ABP and lack of nocturnal dip (≤10% decline in average BP) were taken as indicators of increased sympathetic activity. Results: 26 cases and 26 controls, mean age 28±4 years, were included. 15 (58%) of the cases had sustained hypertension and 11 (42%) white coat hypertension. Among the controls, 17 (65%) had normotension and 9 (35%) masked hypertension. ABP during night-time was high in 23 (88%) of the cases and in 16 (64%) of the controls, and nocturnal dip was absent in 9 (35%) and 11 (42%), respectively. 10 (38%) of the cases had no follow-up of high OBP. Conclusions: More than one-third of the players with optimal OBP had masked hypertension during daytime and more than half of all players had high ABP during night-time, which are novel findings in athletes. Together with the reduced nocturnal dip, this might indicate increased sympathetic activity. Follow-up of high OBP after preparticipation screening is random and should be organised.

• Berge, Hilde Moseby; Gjerdalen, Gard Filip; Andersen, Thor Einar; Solberg, Erik Ekker & Steine, Kjetil (2013). Blood pressure in professional male football players in Norway. Journal of Hypertension. ISSN 0263-6352. 31(4), s. 672–679. doi: 10.1097/HJH.0b013e32835eb5fe.
• Radunovic, Zoran; Wekre, Lena Lande & Steine, Kjetil (2012). Right Ventricular and Pulmonary Arterial Dimensions in Adults With Osteogenesis Imperfecta. American Journal of Cardiology. ISSN 0002-9149. 109(12), s. 1807–1813. doi: 10.1016/j.amjcard.2012.01.402.
• Hodt, Anders; Stugaard, Marie; Hisdal, Jonny; Stranden, Einar; Atar, Dan & Steine, Kjetil (2012). Regional LV deformation in healthy individuals during isovolumetric contraction and ejection phases assessed by 2D speckle tracking echocardiography. Clinical Physiology and Functional Imaging. ISSN 1475-0961. 32(5), s. 372–379. doi: 10.1111/j.1475-097X.2012.01139.x.
• Heck, Siri Lagethon; Gulati, Geeta; Ree, Anne Hansen; Schulz-Menger, Jeanette; Gravdehaug, Berit & Røsjø, Helge [Vis alle 11 forfattere av denne artikkelen] (2012). Rationale and Design of the Prevention of Cardiac Dysfunction during an Adjuvant Breast Cancer Therapy (PRADA) Trial. Cardiology. ISSN 0008-6312. 123(4), s. 240–247. doi: 10.1159/000343622.
• Hodt, Anders; Hisdal, Jonny; Stugaard, Marie; Stranden, Einar; Atar, Dan & Steine, Kjetil (2011). Reduced preload elicits increased LV twist in healthy humans. Clinical Physiology and Functional Imaging. ISSN 1475-0961. 31(5), s. 382–389. doi: 10.1111/j.1475-097X.2011.01029.x.
• Radunovic, Zoran; Wekre, Lena Lande; Diep, Lien My & Steine, Kjetil (2011). Cardiovascular abnormalities in adults with osteogenesis imperfecta. American Heart Journal. ISSN 0002-8703. 161(3), s. 523–529. doi: 10.1016/j.ahj.2010.11.006.

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• Jervan, Øyvind; Haukeland-Parker, Stacey Marie; Gleditsch, Jostein; Tavoly, Mazdak; Klok, Frederikus A. & Steine, Kjetil [Vis alle 14 forfattere av denne artikkelen] (2023). Rehabilitation to improve exercise capacity and quality of life after pulmonary embolism.
• Andel, Peter Michael; Aukrust, Pål; Gleditsch, Jostein; Gude, Einar; Haugeberg, Glenn & Høie, Sverre [Vis alle 9 forfattere av denne artikkelen] (2023). Residiverende perikarditt. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 143(8), s. 708–711. doi: 10.4045/tidsskr.22.0580. Fulltekst i vitenarkiv
• Haukeland-Parker, Stacey Marie; Jervan, Øyvind; Johannessen, Hege Hølmo; Gleditsch, Jostein; Stavem, Knut & Steine, Kjetil [Vis alle 11 forfattere av denne artikkelen] (2021). Pulmonary rehabilitation to improve physical capacity, dyspnea, and quality of life following pulmonary embolism (the PeRehab study): study protocol for a two-center randomized controlled trial. Trials. ISSN 1745-6215. 22, s. 1–9. doi: 10.1186/s13063-020-04940-9. Fulltekst i vitenarkiv
• Heck, Siri Lagethon; Gulati, Geeta; HOFFMANN, PAVEL; von Knobelsdorff-Brenkenhoff, Florian; Storås, Tryggve & Ree, Anne Hansen [Vis alle 11 forfattere av denne artikkelen] (2016). Effects of Candesartan and Metoprolol on Myocardial Mass, Edema, and Fibrosis During Anthracycline Treatment in Early Breast Cancer: APRADA-CMR substudy.
• Gulati, Geeta; Heck, Siri Lagethon; Geisler, Jürgen; Gravdehaug, Berit; Ree, Anne Hansen & HOFFMANN, PAVEL [Vis alle 9 forfattere av denne artikkelen] (2016). Atrio-ventricular plane excursion is impaired after ten weeks of anthracycline treatment in breast cancer patients; Data from the PRADA-study.
• Gulati, Geeta; Heck, Siri Lagethon; Geisler, Jürgen; Gravdehaug, Berit; HOFFMANN, PAVEL & Steine, Kjetil [Vis alle 9 forfattere av denne artikkelen] (2016). Troponin I and Cardiac Function During Breast Cancer Therapy in Human Epidermal Growth Factor Receptor 2 Positive and Negative Patients: Results from the PRADA Study.
• Gulati, Geeta; Heck, Siri Lagethon; Geisler, Jürgen; Fagerland, Morten; HOFFMANN, PAVEL & Gravdehaug, Berit [Vis alle 10 forfattere av denne artikkelen] (2016). Effect of candesartan and metoprolol on subclinical myocardial injury during anthracycline therapy: data from the prevention of cardiac dysfunction during adjuvant breast cancer therapy (PRADA) study.
• Gulati, Geeta; Heck, Siri Lagethon; HOFFMANN, PAVEL; Ree, Anne Hansen; Schulz-Menger, Jeanette & von Knobelsdorff-Brenkenhoff, Florian [Vis alle 12 forfattere av denne artikkelen] (2016). Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy (PRADA): Primary Results of a Randomized, 2 x 2 Factorial, Placebo-Controlled, Double-Blind Clinical Trial. Circulation. ISSN 0009-7322.
• Gulati, Geeta; Heck, Siri Lagethon; Ree, Anne Hansen; Bratland, Åse; Steine, Kjetil & Schulz-Menger, Jeanette [Vis alle 11 forfattere av denne artikkelen] (2015). Abstract CT321: Prevention of cardiac dysfunction during adjuvant breast cancer therapy: the PRADA study. Cancer Research. ISSN 0008-5472.
• Berge, Hilde Moseby; Steine, Kjetil; Andersen, Thor Einar; Solberg, Erik Ekker & Gjesdal, Knut (2014). Measurement method is important for interpretation of athletes’ ECG.
• Berge, Hilde Moseby; Steine, Kjetil; Andersen, Thor Einar; Solberg, Erik Ekker & Gjesdal, Knut (2014). Measurement method is important for interpetation of athletes' ECG. British Journal of Sports Medicine. ISSN 0306-3674. 48(7), s. 567–568.
• Hilde, J.M.; Hisdal, Jonny; Melsom, Morten Nissen; Hansteen, Viggo; Seljeflot, Ingebjørg & Arnesen, Harald [Vis alle 7 forfattere av denne artikkelen] (2013). Reduced systemic arterial compliance and subclinical LV systolic dysfunction in COPD. European Heart Journal. ISSN 0195-668X. 34, s. 296–296.
• Gjerdalen, Gard Filip; Slagsvold, Carl Erik; Steine, Kjetil; Morken, Brit & Hisdal, Jonny (2013). STYRING AV TRENINGSINTENSITET HOS PASIENTER MED MARFAN SYNDROM, KASUSPRESENTASJON.
• Gjerdalen, Gard Filip; Hisdal, Jonny; Solberg, Erik Ekker; Andersen, Thor Einar; Radunovic, Zoran & Steine, Kjetil (2013). Increased LV filling pressure in elite football players with large left atrial volumes.
• Gjerdalen, Gard Filip; Hisdal, Jonny; Solberg, Erik Ekker; Andersen, Thor Einar; Radunovic, Zoran & Steine, Kjetil (2013). Enlarged atria in athletes lead to higher prevalence of valvular regurgitation but no change in function.
• Berge, Hilde Moseby; Gjesdal, K; Andersen, Thor Einar; Solberg, Erik Ekker & Steine, Kjetil (2013). Flere unormale EKG-forandringer hos fotballspillere i Norge enn hos idrettsutøvere i andre land. Norsk idrettsmedisin. ISSN 0806-9328. s. 20–20.
• Berge, Hilde Moseby; Gjesdal, Knut; Andersen, Thor Einar; Solberg, Erik Ekker & Steine, Kjetil (2013). ECG measurement method (visually or by software) has a significant impact on number of pathological findings in athletes.
• Berge, Hilde Moseby; Gjesdal, Knut; Andersen, Thor Einar; Solberg, Erik Ekker & Steine, Kjetil (2013). The new Seattle criteria reduce the prevalence of abnormal ECG findings in professional football players.
• Berge, Hilde Moseby; Gjesdal, Knut; Andersen, Thor Einar; Solberg, Erik Ekker & Steine, Kjetil (2013). Høy forekomst av unormale ekg-forandringer ved hjertescreening av profesjonelle fotballspillere i Norge.
• Berge, Hilde Moseby; Gjesdal, Knut; Andersen, Thor Einar; Solberg, Erik Ekker & Steine, Kjetil (2013). Flere unormale ekg-forandringer hos fotballspillere i Norge enn hos idrettsutøvere i andre land.
• Berge, Hilde Moseby; Andersen, Thor Einar; Solberg, Erik Ekker & Steine, Kjetil (2012). High prevalence of masked hypertension in Norwegian male professional football players. Journal of Hypertension. ISSN 0263-6352. 30, s. e371–e371.
• Berge, Hilde Moseby; Gjerdalen, Gard Filip; Andersen, Thor Einar; Solberg, Erik Ekker & Steine, Kjetil (2012). Elevated blood pressure in young athletes is associated with increased left ventricle mass and reduced arterial compliance. Journal of Hypertension. ISSN 0263-6352. 30, s. e171–e172.
• Berge, Hilde Moseby; Gjerdalen, Gard Filip; Andersen, Thor Einar; Solberg, Erik Ekker & Steine, Kjetil (2012). Elevated blood pressure in young athletes is associated with increased left ventricle mass and reduced arterial compliance.
• Berge, Hilde Moseby; Andersen, Thor Einar; Solberg, Erik Ekker & Steine, Kjetil (2012). High prevalence of masked hypertension in Norwegian male professional football players.
• Berge, Hilde Moseby; Andersen, Thor Einar; Solberg, Erik Ekker & Steine, Kjetil (2012). High prevalence of masked hypertension in male Norwegian elite football players. Hjerteforum. ISSN 0802-1465. 25(3).
• Gjerdalen, Gard Filip; Hisdal, Jonny; Solberg, Erik Ekker; Andersen, Thor Einar; Radunovic, Zoran & Steine, Kjetil (2011). Idrettsutøvere har ikke bedre systolisk og diastolisk funksjonfor venstre ventrikkel enn utrente konroller målt med standard ekkokardiografi og vevsdoppler.
• Hodt, Anders; Stugaard, Marie; Hisdal, Jonny; Stranden, Einar; Atar, Dan & Steine, Kjetil (2011). Redusert preload bidrar til økt apikal rotasjon i venstre ventrikkel hos friske individer.
• Radunovic, Zoran; Lande Wekre, Lena & Steine, Kjetil (2011). Increased right ventricle dimensions in adults with osteogenesis imperfecta.
• Radunovic, Zoran; Lande Wekre, Lena; Diep, Lien My & Steine, Kjetil (2010). Left ventricle dimensions in adults with osteogenesis imperfecta in Norway, Substudy of the Norwegean Survey on Adults with OI.
• Radunovic, Zoran; Lande Wekre, Lena & Steine, Kjetil (2010). Left ventricle dimensions in adults with osteogenesis imperfecta in Norway.
• Berge, Hilde Moseby; Gjerdalen, Gard Filip; Andersen, T.; Solberg, Erik Ekker & Steine, Kjetil (2010). PREVALENCE OF HYPERTENSION IN ELITE FOOTBALL PLAYERS. Journal of Hypertension. ISSN 0263-6352. 28, s. E250–E251.
• Berge, Hilde Moseby; Gjerdalen, GF; Andersen, Thor Einar; Solberg, Erik Ekker & Steine, Kjetil (2010). Elevated blood pressure in Norwegian elite football players is associated with increased sympathetic activity and left ventricle mass.
• Berge, Hilde Moseby; Gjerdalen, GF; Andersen, Thor Einar; Solberg, Erik Ekker & Steine, Kjetil (2010). Har elitefotballspillere høyt blodtrykk og stort hjerte?
• Andersen, Thor Einar; Steine, Kjetil; Solberg, Erik Ekker & Gjerdalen, Gard (2010). Har elitefotballspillere høyt blodtrykk og stort hjerte? Høyt blodtrykk hos elitefotballspillere er assosisert med økt sympatisk aktivitet og venstre ventrikkelmasse, Konferanserapport fra Primærmedisinsk uke. Vis sammendrag

  Bakgrunn Det Europeiske Fotballforbundet har bestemt at alle mannlige toppfotballspillere må hjertescreenes. Formål Som en del av hjertescreeningen av norske fotballspillere i 2008 ønsket vi å undersøke prevalensen av høyt blodtrykk (BT), og se om det hadde sammenheng med hjertefrekvens (HR), pulstrykk (PP), økt venstre ventrikkel (VV) masse eller VV diastolisk dysfunksjon. Metode Alle fotballspillere i Tippe- og Adeccoligaen ble screenet.594 spillere ble inkludert. Blodtrykket ble målt ? 1 time etter fysisk aktivitet og kategorisert i samsvar med European Society of Hypertensions retningslinjer. Høyt BT er definert ? 140/90 mmHg. VV masse og diastolisk funksjon ble målt med henholdsvis to-dimensjonal- og pulset Doppler ekkokardiografi. Spillerne oppga høyde og vekt. Resultater Gjennomsnittlig alder for spillerne var 25 år (variasjonsbredde 18-38), gjennomsnittlig BMI 23,7 kg/m² (20-29) og gjennomsnittlig BT 122/69 mmHg. Høyt BT ble målt hos 39 spillere (6,7%), inkludert to med grad 2 (>160 mmHg) systolisk hypertensjon og forstørret VV. Det var en signifikant lineær sammenheng mellom gjennomsnittlig arterietrykk (MAP) og HR, PP og indeksert VV masse med regresjonskoeffisient h.h.v. 0,195, 0,180 og 0,256 (alle; p<0,01). Konklusjon Omtrent en fjerdedel av toppfotballspillerne hadde enten hypertensjon (6,7%) eller høyt normalt BT (18%). Høyt blodtrykk var assosiert med økt hjertefrekvens og pulstrykk, noe som indikerer økt sympatisk aktivitet. Økende BT viste en signifikant sammenheng med økende indeksert VV masse, noe som indikerer en tidlig start på organskade. Når vi vet at et tilfeldig målt høyt blodtrykk i ung alder kan forutsi hypertensjon senere i livet, så støtter våre data BT-screening av atleter.

• Andersen, Thor Einar; Steine, Kjetil; Solberg, Erik Ekker & Gjerdalen, Gard (2010). Har elitefotballspillere høyt blodtrykk og stort hjerte? Høyt blodtrykk hos elitefotballspillere er assosisert med økt sympatisk aktivitet og venstre ventrikkelmasse. Vis sammendrag

  Bakgrunn Det Europeiske Fotballforbundet har bestemt at alle mannlige toppfotballspillere må hjertescreenes. Formål Som en del av hjertescreeningen av norske fotballspillere i 2008 ønsket vi å undersøke prevalensen av høyt blodtrykk (BT), og se om det hadde sammenheng med hjertefrekvens (HR), pulstrykk (PP), økt venstre ventrikkel (VV) masse eller VV diastolisk dysfunksjon. Metode Alle fotballspillere i Tippe- og Adeccoligaen ble screenet.594 spillere ble inkludert. Blodtrykket ble målt ? 1 time etter fysisk aktivitet og kategorisert i samsvar med European Society of Hypertensions retningslinjer. Høyt BT er definert ? 140/90 mmHg. VV masse og diastolisk funksjon ble målt med henholdsvis to-dimensjonal- og pulset Doppler ekkokardiografi. Spillerne oppga høyde og vekt. Resultater Gjennomsnittlig alder for spillerne var 25 år (variasjonsbredde 18-38), gjennomsnittlig BMI 23,7 kg/m² (20-29) og gjennomsnittlig BT 122/69 mmHg. Høyt BT ble målt hos 39 spillere (6,7%), inkludert to med grad 2 (>160 mmHg) systolisk hypertensjon og forstørret VV. Det var en signifikant lineær sammenheng mellom gjennomsnittlig arterietrykk (MAP) og HR, PP og indeksert VV masse med regresjonskoeffisient h.h.v. 0,195, 0,180 og 0,256 (alle; p<0,01). Konklusjon Omtrent en fjerdedel av toppfotballspillerne hadde enten hypertensjon (6,7%) eller høyt normalt BT (18%). Høyt blodtrykk var assosiert med økt hjertefrekvens og pulstrykk, noe som indikerer økt sympatisk aktivitet. Økende BT viste en signifikant sammenheng med økende indeksert VV masse, noe som indikerer en tidlig start på organskade. Når vi vet at et tilfeldig målt høyt blodtrykk i ung alder kan forutsi hypertensjon senere i livet, så støtter våre data BT-screening av atleter.

• Berge, Hilde Moseby; Gjerdalen, GF; Andersen, Thor Einar; Solberg, Erik Ekker & Steine, Kjetil (2010). Høyt blodtrykk hos norske toppfotballspillere er assosiert med økt sympatisk aktivitet og venstre ventrikkel masse. Norsk idrettsmedisin. ISSN 0806-9328. s. 32–33.
• Berge, Hilde Moseby; Gjerdalen, GF; Andersen, Thor Einar; Solberg, Erik Ekker & Steine, Kjetil (2010). Høyt blodtrykk hos norske toppfotballspillere er assosiert med økt sympatisk aktivitet og venstre ventrikkel masse.
• Gjerdalen, Gard Filip; Hisdal, Jonny; Solberg, Erik Ekker; Andersen, Thor Einar; Radunovic, Zoran & Stranden, Einar [Vis alle 7 forfattere av denne artikkelen] (2010). Økt volumbelastning hos idrettsutøvere gir økt reservoar funksjon for høyre og venstre atrium.
• Gjerdalen, Gard Filip; Hisdal, Jonny; Solberg, Erik Ekker; Andersen, Thor Einar; Radunovic, Zoran & Steine, Kjetil (2010). The athletes heart: different training responses in African and Caucasian male elite football players. European Heart Journal. ISSN 0195-668X. 31, s. 317–318.
• Gjerdalen, Gard Filip; Hisdal, Jonny; Solberg, Erik Ekker; Andersen, Thor; Radunovic, Zoran & Steine, Kjetil (2010). Enhanced RV systolic function but no difference in pulmonary artery pressure in athletes. European Heart Journal. ISSN 0195-668X. 31, s. 454–455.
• von Lueder, Thomas Gero; Hodt, Anders; Gjerdalen, Gard Filip; Andersen, Thor Einar; Solberg, Erik Ekker & Steine, Kjetil (2010). Lower left ventricular peak systolic twist rate, but enhanced and earlier peak diastolic untwist rate in elite football players. European Heart Journal. ISSN 0195-668X. 31, s. 1062–1062.
• Gjerdalen, GF; Hisdal, J; Solberg, Erik Ekker; Andersen, Thor Einar; Radunovic, Z & Stranden, E [Vis alle 7 forfattere av denne artikkelen] (2009). Økt volumbelastning hos idrettsutøvere gir økt reservoar funksjon for høyre og venstre atrium. Norsk idrettsmedisin. ISSN 0806-9328.
• Gjerdalen, GF; Solberg, Erik Ekker; Andersen, Thor Einar; Radunovic, Z; Stranden, E & Hisdal, J [Vis alle 7 forfattere av denne artikkelen] (2009). Økt venstre atrium volum hos norske forballspillere på toppnivå. Norsk idrettsmedisin. ISSN 0806-9328.
• Gjerdalen, GF; Hisdal, J; Solberg, Erik Ekker; Andersen, Thor Einar; Radunovic, Z & Stranden, E [Vis alle 7 forfattere av denne artikkelen] (2009). Økt volumbelastning hos idrettsutøvere gir økt reservoar funksjon for høyre og venstre atrium.
• Gjerdalen, GF; Solberg, Erik Ekker; Andersen, Thor Einar; Radunovic, Z; Stranden, E & Hisdal, J [Vis alle 7 forfattere av denne artikkelen] (2009). Økt venstre atrium volum hos norske forballspillere på toppnivå.
• Mykland Hilde, Janne & Steine, Kjetil (2014). Pulmonary hypertension and ventricular function in chronic obstructive pulmonary disease. A cross-sectional echocardiographic and invasive hemodynamic study of stable patients with smoke-induced COPD. Akademika forlag.
• Berge, Hilde Moseby; Andersen, Thor Einar & Steine, Kjetil (2014). The Norwegian athlete’s heart. Cardiac screening of 595 professional soccer players. Universitetet i Oslo. ISSN 978-82-8264-857-8.

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