Genetic test may predict risk of developing Alzheimer's disease
Researchers at NORMENT have contributed to a study of genetic prediction of Alzheimer's disease, which was recently published in PLOS Medicine.
Ole A. Andreassen
The researchers participated in a large international consortium where they analyzed the genes from more than 70.000 patients with Alzheimer's disease and healthy elderly individuals. By combining different types of genetic data they developed a novel tool to predict the age-specific risk for developing Alzheimer's disease.
The research is based on a long standing collaboration between NORMENT and the Center for Translational Imaging and Precision Medicine at the University of California San Diego (UCSD). The researchers are now working to improve the method for mental illness applications.
Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, Karch CM, Bonham LW, Yokoyama JS, Rosen HJ, Miller BL, Dillon WP, Wilson DM, Hess CP, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Hardy J, Goate AM, Hyman BT, Schellenberg GD, McEvoy LK, Andreassen OA, Dale AM. Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score, PLoS Medicine, 2017, Mar 21;14(3):e1002258. doi: 10.1371/journal.pmed.1002258.