Autophagy

The main focus of the Autophagy group led by Anne Simonsen is to elucidate the mechanisms involved in recognition and clearance of cellular components by autophagy and characterize their roles in disease development, specifically tumor biology.

Image may contain: Product, Font, Parallel, Circle, Screenshot.

The role of autophagy in tumorigenesis is highly complex, as autophagy can both protect healthy cells against malignant transformation and promote the growth of malignant cells . Autophagic clearance of dysfunctional mitochondria (mitophagy) or protein aggregates (aggrephagy) can explain the tumor suppressive role of autophagy, but autophagy can also promote tumor cell survival under certain conditions, such as hypoxic stress and chemotherapy. Autophagic clearance of mitochondria may also play an important role in the metabolic shift (from OXPHOS to anaerobic glycolysis) often seen in tumors, referred to as the “Warburg effect”. We aim to understand this conundrum better in order to identify novel autophagy regulators involved in specific pathways.This will enable us to define the disease-autophagy relationship more precisely.

The Autophagy group has recently carried out several screens to identify novel regulators of non-selective and selective autophagy and are currently characterizing their possible function in cancer development. We expect our research to provide novel insight into the role of autophagy in tumorigenesis, with a long-term goal to improve therapeutic treatment for cancer patients

Image may contain: Smile, Shoe, Social group, Event, Team.

The Autophagy group is based at the  Institute of Basic Medical Sciences

 

     

     

    Published June 17, 2022 11:06 AM - Last modified June 20, 2022 4:06 PM

    Contact

    Mailing address
    P.O.Box 1112 Blindern
    0317 Oslo

    Visiting address
    Domus Medica, Gaustad
    Sognsvannsveien 9
    0372 Oslo