We investigate the mechanisms involved in the development and progression of sarcomas.

Our group has several research projects:


  • FGFRThe role of fibroblast growth factor receptor (FGFR) signalling in rhabdomyosarcoma, liposarcoma and osteosarcoma.  
  • Cell migrationWe study cell migration to understand when a localized tumor develops into a metastatic one. 
  • ELECTTRA - Efficient Low-energy Electron Cancer Therapy with Terbium-161  – targeted radiotherapy of cancers overexpressing FGFRs (Wesche). 
  • Liquid biopsiesEstablish new modalities for sensitive non-invasive monitoring of sarcoma patients by use of “liquid biopsies” (Meza-Zepeda). 
  • GIST - Characterize intra-tumoral heterogeneity in relation to resistance in GIST, and reveal the molecular determinants linked to imatinib resistance at a single cell level (Meza-Zepeda). Identification of prognostic biomarkers for long term responders in GIST, (Meza-Zepeda). 
  • NoSarCNorwegian Sarcoma Consortium (NoSarC) genomic characterization (~300 normal/tumour pairs) of patient material and establishment of patient-derived sarcoma cell lines and xenograft models (Myklebost, Boye and Meza-Zepeda).


Published Apr. 8, 2022 9:48 AM - Last modified Apr. 8, 2022 11:28 AM