CanCell seminar with Jesper Olsen: "Defining Critical Switches in Oncogenic EGFR signaling by Quantitative Interaction Proteomics and Phosphoproteomics"
Welcome to the next CanCell seminar scheduled for Thursday 7th of November at 13:00 hrs with Professor Jesper Olsen, Quantitative Proteomics Mass Spec group, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Denmark
Jesper V. Olsen is Deputy Director at Novo Nordisk Foundation Center for Protein Research
"Mass spectrometry (MS)-based proteomics including quantitative interaction proteomics and phosphoproteomics has revolutionized cell signaling in the past decade. We apply this technology to systems-wide analyses of tyrosine phosphorylation (pTyr), which is of great importance in eukaryotic cells due to its crucial role in regulating intracellular signaling networks controlling cell fate decisions such as proliferation, migration, differentiation, cell cycle progression and apoptosis. The receptor tyrosine kinase, EGFR, is often dysregulated in cancer, which makes phosphoproteins involved in the EGFR pathway attractive therapeutic targets. Based on a multidisciplinary approach, which combines in-vivo quantitative phosphoproteomics, interaction proteomics and functional assays, we identified critical cellular switches that control EGF-dependent mechanisms in wildtype and mutated EGF receptor signaling, which specify long-term cellular outcomes and the oncogenic properties of the receptor"