Eduardo Moreno: Cell competition and cancer

Welcome to the next CanCell seminar scheduled for Friday 26th of April at 14:00 hrs.

Invited Speaker: Eduardo Moreno, Principle Investigator of The Cell Fitness Group at Champalimaud Research Foundation, Portugal

Title: Cell competition and cancer

Introducing 'young shot' talk: 

Viola Lobert, Tumor-Host Biology Group, CanCell, UiO and Molecular Cell Biology, ICR, OUS

Title: TBA

Title: Cell competition and cancer

 

Eduardo Moreno, Champalimaud Centre for the Unknown (Lisbon, Portugal)

 

During my talk I will discuss recent results regarding the role of cell competition and cancer. First, I will describe recent progress regarding our studies of cell competition mediated by fitness comparison using dedicated molecules called fitness fingerprints. Cell-fitness comparison is used in Drosophila for detection and elimination of viable but impaired cells, to delay aging and prevent developmental malformations (Merino et al., Cell, 2015; Coelho et al., Cell Rep., 2018). But those benefits come at a cost for the organism, which is to allow tumors to benefit from fitness-based selection (Levayer et al., Nature, 2015). Both in Drosophila and humans, cancer tissue shows increased Win expression and proliferate in presence of Lose-expressing stroma, this allows cancer to gain competitive growth. Flower inhibition reduces tumor growth, metastasis and provides chemo-sensitization. Our results illustrate how ancient mechanisms of cell recognition and selection are not only active in Drosophila, but also in humans, and impact oncogenic growth.

Secondly, I will discuss a different type of oncogene induced competition called mechanical supercompetition (Levayer et al., Curr. Bio., 2015; Moreno et al., Curr. Bio., 2019). Mechanical supercompetition occurs in tissues with limited space where a clone of fast growing cells induces compression in the surrounding tissue. Compressive forces trigger caspase activation and cell death. In particular, we find that the activation of the oncogene Ras in clones can downregulate ERK and activate apoptosis in the neighboring cells through their compaction, which eventually contributes to Ras clone expansion. The mechanical modulation of EGFR/ERK during growth-mediated competition for space contributes to tumor progression and tissue destruction.

 

Published Mar. 25, 2019 11:44 AM - Last modified Apr. 5, 2019 8:04 AM