Program outline:
• Opening by Harald Stenmark (CanCell Director)
• Young Shot speaker Simona Migliano (Department of Molecular Cell Biology, Institute for Cancer Research) Rings of Power:Targeting oncogenic ecDNA
• Invited speaker Isidro Cortés-Ciriano (EMBL-EBI, UK) Single-molecule cancer genome analysis at a national scale
• Meet the speakers with light refreshments
Isidro Cortés-Ciriano leads the Cancer Genomics group at the EMBL-EBI and is Associate Faculty at the Sanger Institute. His laboratory focuses on the development of computational methods for early cancer detection and to study the mechanisms underpinning cancer evolution using whole-genome sequencing. Recent work by his group includes the discovery of novel mechanisms of cancer development, such as Loss-Translocation-Amplification chromothripsis in osteosarcoma, and the development of novel methods for the analysis of single cell and long-read sequencing data, such as SComatic and SAVANA. A major goal of his group is to harness novel technologies applicable in clinical settings to improve early cancer detection and treatment selection, which he is pursuing thanks to the support of a CRUK Career Establishment Award. For instance, his laboratory is leading the application of long-read sequencing technologies for tumour profiling and liquid biopsy analysis through various national studies, such as the CRUK-funded initiatives, such as the Stratified Medicine Paediatrics (SMPEDS) programme and the Cancer Grand Challenges team SAMBAI. Before joining EMBL-EBI, Isidro trained as a postdoctoral fellow at Harvard Medical School in the laboratory of Prof. Peter Park, and received his PhD from the Pasteur Institute in 2015 after obtaining MSc degrees in biology and biochemistry from the University of Navarra.
Group website: https://www.ebi.ac.uk/research/cortes-ciriano