We would like to invite you to the upcoming Seminar with CanCell Invited Speaker:
Presenter: Prof. Michael Lazarou (Monash University, Australia)
When: Thursday 3rd September from 14:30-15:30, followed by refreshments
Where: Radium Hospital LU1 auditorium
Neurobiology of mitophagy
Mitochondria are fundamental organelles that generate the energy required for life while also acting as important signalling and metabolic hubs. When mitochondria become damaged or dysfunctional, they can cause human disease including Parkinson’s disease. PINK1 and Parkin are mutated in familial Parkinson’s disease, and together, they function to clear damaged mitochondria through a degradative pathway termed mitophagy. A lot of progress has been made toward understanding the molecular mechanisms of mitophagy using simple cell models that have provided key insights. However, our understanding of the neuronal cell biology of the pathway is much less well understood, and this includes how defective mitophagy might cause neurodegeneration. In this seminar, the mechanisms of mitophagy will be discussed along with a deep exploration into the neuronal cell biology of mitophagy using human stem cell derived neurons.
Everyone is welcome to join for this exciting talk, we look forward to seeing you there!