Ivar Prydz Gladhaug

• Li, Yuchuan; Amrutkar, Manoj; Finstadsveen, Anette V.; Dalen, Knut Tomas; Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2023). Fatty acids abrogate the growth-suppressive effects induced by inhibition of cholesterol flux in pancreatic cancer cells. Cancer Cell International. ISSN 1475-2867. 23. doi: 10.1186/s12935-023-03138-8. Full text in Research Archive
• Amrutkar, Manoj; Berg, Kjersti; Balto, Aina; Skilbrei, Miguel Garcia; Finstadsveen, Anette Vefferstad & Aasrum, Monica [Show all 8 contributors for this article] (2023). Pancreatic stellate cell-induced gemcitabine resistance in pancreatic cancer is associated with LDHA- and MCT4-mediated enhanced glycolysis. Cancer Cell International. ISSN 1475-2867. 23, p. 1–17. doi: 10.1186/s12935-023-02852-7. Full text in Research Archive
• Amrutkar, Manoj; Verbeke, Caroline Sophie; Vefferstad, Anette; Dorg, Linda Trobe; Labori, Knut Jørgen & Gladhaug, Ivar Prydz (2022). Neoadjuvant chemotherapy is associated with an altered metabolic profile and increased cancer stemness in patients with pancreatic ductal adenocarcinoma. Molecular Oncology. ISSN 1574-7891. 17(1), p. 59–81. doi: 10.1002/1878-0261.13344. Full text in Research Archive Show summary

  he modest clinical benefits of neoadjuvant chemotherapy (NAT) in pancreatic ductal adenocarcinoma (PDAC) are associated with a lack of robust data on treatment-induced changes in the tumor. To this end, comparative proteomic profiling of tumor tissue samples from treatment-naïve (TN, n = 20) and NAT-treated (n = 22) PDACs was performed. Differentially expressed proteins were identified and correlation with overall survival (OS) was performed. Tumors were also examined for histopathological changes and expression of cancer stem cell (CSC) markers. Serum from 33 matched patients was analyzed for metabolic markers. Cytotoxicity, proliferation, and expression of CSC markers were assessed in chemoresistant Panc-1 and Mia PaCa-2 cells. Of the 2265 proteins identified, 227 and 144 proteins showed significantly altered expression and differential phosphorylation, respectively, in NAT compared with TN samples. The majority of these were metabolism-related proteins, and 14 of these correlated moderately with OS. NAT-treated tumors and chemoresistant cancer cells showed increased expression of CSC markers. Serum ALDH1A1 was higher in NAT compared with TN. Differentially phosphorylated proteins were mainly involved in cytoskeleton organization, cell locomotion, motility, and migration, and 17 of these showed a strong positive correlation with OS. This study provides evidence of the effects of NAT on PDAC metabolism at both the tumor and the systemic levels. NAT-treated tumors showed significantly lower expression of metabolic proteins, and patients who underwent NAT showed reduced serum lactate and high-density lipoprotein-cholesterol. Lastly, cancer cells that survived cytotoxic treatment expressed higher CSC markers, both in vivo and in vitro.

• Santha, Petra; Lenggenhager, Daniela; Vefferstad, Anette; Dorg, Linda Trobe; Tøndel, Kristin & Amrutkar, Manoj [Show all 8 contributors for this article] (2021). Morphological heterogeneity in pancreatic cancer reflects structural and functional divergence. Cancers. ISSN 2072-6694. 13(4). doi: 10.3390/cancers13040895. Full text in Research Archive Show summary

  Pancreatic cancer has a poor prognosis, which is largely due to resistance to treatment. Tumor heterogeneity is a known cause for treatment failure and has been studied at the molecular level. Morphological heterogeneity is common but has not been investigated, despite the fact that pathology examination is an integral part of clinical diagnostics. This study assessed whether morphological heterogeneity reflects structural and functional diversity in key cancer biological processes. Using archival tissues from resected pancreatic cancer, we selected four common and distinct morphological phenotypes and demonstrated that these differed significantly for a panel of 26 structural and functional features of the cancer-cell and stromal compartments. The strong link between these features and morphological phenotypes allowed prediction of the latter based on the results for the panel of features. The findings of this study indicate that morphological heterogeneity reflects biological diversity and that its assessment may potentially provide clinically relevant information.

• Amrutkar, Manoj & Gladhaug, Ivar Prydz (2021). Stellate cells aid growth‐permissive metabolic reprogramming and promote gemcitabine chemoresistance in pancreatic cancer. Cancers. ISSN 2072-6694. 13:601(4), p. 1–21. doi: 10.3390/cancers13040601. Full text in Research Archive
• Amrutkar, Manoj; Vethe, Nils Tore; Verbeke, Caroline Sophie; Aasrum, Monica; Vefferstad, Anette & Santha, Petra [Show all 7 contributors for this article] (2020). Differential gemcitabine sensitivity in primary human pancreatic cancer cells and paired stellate cells is driven by heterogenous drug uptake and processing. Cancers. ISSN 2072-6694. 12:3628(12), p. 1–18. doi: 10.3390/cancers12123628. Full text in Research Archive
• Engebretsen, Eivind & Gladhaug, Ivar Prydz (2020). Er det plass til et sykepleievitenskapelig fagmiljø på et medisinsk fakultet? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(9), p. 1–3. doi: 10.4045/tidsskr.20.0311.
• Amrutkar, Manoj; Larsen, Emma Kristine; Aasrum, Monica; Finstadsveen , Anette Vefferstad; Andresen, Per Arne & Verbeke, Caroline Sophie [Show all 7 contributors for this article] (2020). Establishment and Characterization of Paired Primary Cultures of Human Pancreatic Cancer Cells and Stellate Cells Derived from the Same Tumor. Cells. ISSN 2073-4409. 9:227(1), p. 1–18. doi: 10.3390/cells9010227. Full text in Research Archive
• Lenggenhager, Daniela; Amrutkar, Manoj; Santha, Petra; Aasrum, Monica; Löhr, Johannes-Matthias & Gladhaug, Ivar Prydz [Show all 7 contributors for this article] (2019). Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions With Pancreatic Cancer Cells. Cells. ISSN 2073-4409. 8:E23(1), p. 1–18. doi: 10.3390/cells8010023. Full text in Research Archive
• Amrutkar, Manoj; Aasrum, Monica; Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2019). Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells. BMC Cancer. ISSN 1471-2407. 19(596). doi: 10.1186/s12885-019-5803-1. Full text in Research Archive
• Kleive, Dyre; Labori, Knut Jørgen; Line, Pål Dag; Gladhaug, Ivar Prydz & Verbeke, Caroline Sophie (2019). Pancreatoduodenectomy with venous resection for ductal adenocarcinoma rarely achieves complete (R0) resection. HPB. ISSN 1365-182X. 22(1), p. 50–57. doi: 10.1016/j.hpb.2019.05.005. Full text in Research Archive
• Lothe, Inger Marie Bowitz; Kleive, Dyre; Pomianowska, Ewa; Småstuen, Milada Cvancarova; Kure, Elin Wenche Hegland & Dueland, Svein [Show all 8 contributors for this article] (2019). Clinical relevance of pancreatobiliary and intestinal subtypes of ampullary and duodenal adenocarcinoma: Pattern of recurrence, chemotherapy, and survival after pancreatoduodenectomy. Pancreatology (Print). ISSN 1424-3903. 19(2), p. 316–324. doi: 10.1016/j.pan.2019.01.019. Full text in Research Archive
• Kleive, Dyre; Sahakyan, Mushegh; Søreide, Kjetil; Brudvik, Kristoffer Watten; Line, Pål Dag & Gladhaug, Ivar Prydz [Show all 7 contributors for this article] (2018). Risk for hemorrhage after pancreatoduodenectomy with venous resection. Langenbeck's Archives of Surgery. ISSN 1435-2443. p. 1–9. doi: 10.1007/s00423-018-1721-y.
• Tjomsland, Vegard; Aasrum, Monica; Christoffersen, Thoralf & Gladhaug, Ivar Prydz (2017). Functional heterogeneity in tumor-derived human pancreatic stellate cells: Differential expression of HGF and implications for mitogenic signaling and migration in pancreatic cancer cells. OncoTarget. ISSN 1949-2553. 8(42), p. 71672–71684. doi: 10.18632/oncotarget.17800.
• Kleive, Dyre; Berstad, Audun Elnæs; Sahakyan, Mushegh; Verbeke, Caroline Sophie; Naper, Christian & Haugvik, Sven-Petter [Show all 9 contributors for this article] (2017). Portal vein reconstruction using primary anastomosis or venous interposition allograft in pancreatic surgery. Journal of Vascular Surgery: Venous and Lymphatic Disorders (JVS-VL). ISSN 2213-333X. 6(1), p. 66–74. doi: 10.1016/j.jvsv.2017.09.003.
• Amrutkar, Manoj & Gladhaug, Ivar Prydz (2017). Pancreatic cancer chemoresistance to gemcitabine. Cancers. ISSN 2072-6694. 9(11:157), p. 1–23. doi: 10.3390/cancers9110157.
• Kleive, Dyre; Sahakyan, Mushegh; Berstad, Audun Elnæs; Verbeke, Caroline Sophie; Gladhaug, Ivar Prydz & Edwin, Bjørn [Show all 9 contributors for this article] (2017). Trends in indications, complications and outcomes for venous resection during pancreatoduodenectomy. British Journal of Surgery. ISSN 0007-1323. 104(11), p. 1558–1567. doi: 10.1002/bjs.10603.
• Haugvik, Sven-Petter; Basim, Ibrahim; Hedenström, Per; Valente, Roberto; Hayes, Alastair J. & Siuka, Darko [Show all 8 contributors for this article] (2017). Smoking, alcohol and family history of cancer as risk factors for small intestinal neuroendocrine tumors: a systematic review and meta-analysis. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 52(8), p. 797–802. doi: 10.1080/00365521.2017.1310290.
• Tjomsland, Vegard; Pomianowska, Ewa; Aasrum, Monica; Sandnes, Dagny Lise; Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2016). Profile of MMP and TIMP expression in human pancreatic stellate cells: regulation by IL-1? and TGF? and implications for migration of pancreatic cancer cells. Neoplasia. ISSN 1522-8002. 18(7), p. 447–456. doi: 10.1016/j.neo.2016.06.003.
• Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2016). Dissection of Pancreatic Resection Specimens. Surgical Pathology Clinics. ISSN 1875-9181. 9(4), p. 523–538. doi: 10.1016/j.path.2016.05.001.
• Kleive, Dyre; Berstad, Audun Elnæs; Verbeke, Caroline Sophie; Haugvik, Sven-Petter; Gladhaug, Ivar Prydz & Line, Pål Dag [Show all 7 contributors for this article] (2016). Cold-stored cadaveric venous allograft for superior mesenteric/portal vein reconstruction during pancreatic surgery. HPB. ISSN 1365-182X. 18(7), p. 615–622. doi: 10.1016/j.hpb.2016.05.010. Show summary

  Background SMV/PV resection has become common practice in pancreatic surgery. The aim of this study was to evaluate the technical feasibility and surgical outcome of using cold-stored cadaveric venous allografts (AG) for superior mesenteric vein (SMV) and portal vein (PV) reconstruction during pancreatectomy. Methods Patients who underwent pancreatic resection with concomitant vascular resection and reconstruction with AG between January 2006 and December 2014 were identified from our institutional prospective database. Medical records and pre- and postoperative CT-images were reviewed. Results Forty-five patients underwent SMV/PV reconstruction with AG interposition (n = 37) or AG patch (n = 8). The median operative time and blood loss were 488 min (IQR: 450–551) and 900 ml (IQR: 600-2000), respectively. Major morbidity (Clavien ≥ III) occurred in 16 patients. Four patients were reoperated (thrombosis n = 2, graft kinking/low flow n = 2) and in-hospital mortality occurred in two patients. On last available CT scan, 3 patients had thrombosis, all of whom also had local recurrence. Estimated cumulative patency rate (reduction in SMV/PV luminal diameter <70% and no thrombosis) at 12 months was 52%. Conclusion Cold-stored cadaveric venous AG for SMV/PV reconstruction during pancreatic surgery is safe and associated with acceptable long-term patency.

• Johannessen, Lene Elisabeth; Panagopoulos, Ioannis; Haugvik, Sven-Petter; Gladhaug, Ivar Prydz; Heim, Sverre & Micci, Francesca (2016). Upregulation of INS-IGF2 read-through expression and identification of a novel INS-IGF2 splice variant in insulinomas. Oncology Reports. ISSN 1021-335X. 36(5), p. 2653–2662. doi: 10.3892/or.2016.5132.
• Tjomsland, Vegard; Sandnes, Dagny Lise; Pomianowska, Ewa; Cizmovic, Smiljana Torbica; Aasrum, Monica & Brusevold, Ingvild Johnsen [Show all 8 contributors for this article] (2016). The TGFβ-SMAD3 pathway inhibits IL-1α induced interactions between human pancreatic stellate cells and pancreatic carcinoma cells and restricts cancer cell migration. Journal of Experimental & Clinical Cancer Research. ISSN 1756-9966. 35:122, p. 1–12. doi: 10.1186/s13046-016-0400-5.
• Haugvik, Sven-Petter; Vodak, Daniel; Haugom, Lisbeth; Hovig, Johannes Eivind; Gladhaug, Ivar Prydz & Heim, Sverre [Show all 7 contributors for this article] (2016). Transcriptomic Profiling of Tumor Aggressiveness in Sporadic Nonfunctioning Pancreatic Neuroendocrine Neoplasms. Pancreas. ISSN 0885-3177. 45(8), p. 1196–1203. doi: 10.1097/MPA.0000000000000610.
• Haugvik, Sven-Petter; Kaemmerer, Daniel; Gaujoux, Sebastien; Labori, Knut Jørgen; Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2016). Pathology and Surgical Treatment of High-Grade Pancreatic Neuroendocrine Carcinoma: an Evolving Landscape. Current Oncology Reports. ISSN 1523-3790. 18(5). doi: 10.1007/s11912-016-0518-9.
• Labori, Knut Jørgen; Matthew H, Katz; Tzeng, Ching; Bjørnbeth, Bjørn Atle; Småstuen, Milada Cvancarova & Edwin, Bjørn [Show all 11 contributors for this article] (2016). Impact of early disease progression and surgical complications on adjuvant chemotherapy completion rates and survival in patients undergoing the surgery first approach for resectable pancreatic ductal adenocarcinoma - A population-based cohort study. Acta Oncologica. ISSN 0284-186X. 55(3), p. 265–277. doi: 10.3109/0284186X.2015.1068445.
• Haugvik, Sven-Petter; Janson, Eva Tiensuu; Osterlund, Pia; Langer, Seppo W; Falk, Ragnhild Sørum & Labori, Knut Jørgen [Show all 10 contributors for this article] (2016). Surgical Treatment as a Principle for Patients with High-Grade Pancreatic Neuroendocrine Carcinoma: A Nordic Multicenter Comparative Study. Annals of Surgical Oncology. ISSN 1068-9265. 23(5), p. 1721–1728. doi: 10.1245/s10434-015-5013-2.
• Otterdal, Kari; Haukeland, John Willy; Yndestad, Arne; Dahl, Tuva Børresdatter; Holm, Sverre & Segers, Filip [Show all 11 contributors for this article] (2015). Increased serum levels of LIGHT/TNFSF14 in nonalcoholic fatty liver disease: Possible role in hepatic inflammation. Clinical and Translational Gastroenterology. ISSN 2155-384X. 6:e95. doi: 10.1038/ctg.2015.23. Full text in Research Archive
• Haugvik, Sven-Petter; Hedenström, Per; Korsæth, Emilie; Valente, Roberto; Hayes, Alastair & Siuka, Darko [Show all 10 contributors for this article] (2015). Diabetes, smoking, alcohol use, and family history of cancer as risk factors for pancreatic neuroendocrine tumors: A systematic review and meta-analysis. Neuroendocrinology. ISSN 0028-3835. 101(2), p. 133–142. doi: 10.1159/000375164.
• Haugvik, Sven-Petter; Gorunova, Ludmila; Haugom, Lisbeth; Eibak, Anne Mette E.; Gladhaug, Ivar Prydz & Heim, Sverre [Show all 7 contributors for this article] (2014). Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms. Oncology Reports. ISSN 1021-335X. p. 906–912. doi: 10.3892/or.2014.3328.
• Vedeld, Hege Marie; Andresen, Kim; Eilertsen, Ina Andrassy; Nesbakken, Arild; Seruca, Raquel & Gladhaug, Ivar Prydz [Show all 10 contributors for this article] (2014). The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers. International Journal of Cancer. ISSN 0020-7136. 136(4), p. 844–853. doi: 10.1002/ijc.29039.
• Pomianowska, Ewa; Sandnes, Dagny Lise; Grzyb, Krzysztof; Schjølberg, Aasa Rambæk; Aasrum, Monica & Tveteraas, Ingun Heiene [Show all 9 contributors for this article] (2014). Inhibitory effects of prostaglandin E&lt;sub&gt;2&lt;/sub&gt; on collagen synthesis and cell proliferation in human stellate cells from pancreatic head adenocarcinoma. BMC Cancer. ISSN 1471-2407. 14(1). doi: 10.1186/1471-2407-14-413.
• Pomianowska, Ewa; Schjølberg, Aasa Rambæk; Clausen, Ole Petter Fraas & Gladhaug, Ivar Prydz (2014). COX-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis. BMC Cancer. ISSN 1471-2407. 14458. doi: 10.1186/1471-2407-14-458.
• Del Chiaro, Marco; Verbeke, Caroline Sophie; Salvia, Roberto; Klöppel, Gunter; Werner, Jens & McKay, Colin [Show all 39 contributors for this article] (2013). European experts consensus statement on cystic tumours of the pancreas. Digestive and Liver Disease. ISSN 1590-8658. 45(9), p. 703–711. doi: 10.1016/j.dld.2013.01.010.
• Hagness, Morten; Foss, Aksel; Line, Pål Dag; Scholz, Tim; Jørgensen, Pål Foyn & Fosby, Bjarte [Show all 13 contributors for this article] (2013). Liver Transplantation for Nonresectable Liver Metastases From Colorectal Cancer. Annals of Surgery. ISSN 0003-4932. 257(5), p. 800–806. doi: 10.1097/SLA.0b013e3182823957.
• Haugvik, Sven-Petter; Labori, Knut Jørgen; Waage, Anne; Line, Pål Dag; Mathisen, Øystein & Gladhaug, Ivar Prydz (2013). Pancreatic Surgery with Vascular Reconstruction in Patients with Locally Advanced Pancreatic Neuroendocrine Tumors. Journal of Gastrointestinal Surgery. ISSN 1091-255X. 17(7), p. 1224–1232. doi: 10.1007/s11605-013-2221-6.
• Haugvik, Sven-Petter; Marangos, Irina Pavlik; Røsok, Bård Ingvald; Pomianowska, Ewa; Gladhaug, Ivar Prydz & Mathisen, Øystein [Show all 7 contributors for this article] (2013). Long-Term Outcome of Laparoscopic Surgery for Pancreatic Neuroendocrine Tumors. World Journal of Surgery. ISSN 0364-2313. 37(3), p. 582–590. doi: 10.1007/s00268-012-1893-5.
• Pomianowska, Ewa; Westgaard, Arne; Mathisen, Øystein; Clausen, Ole Petter Fraas & Gladhaug, Ivar Prydz (2013). Prognostic Relevance of Number and Ratio of Metastatic Lymph Nodes in Resected Pancreatic, Ampullary, and Distal Bile Duct Carcinomas. Annals of Surgical Oncology. ISSN 1068-9265. 20(1), p. 233–241. doi: 10.1245/s10434-012-2592-z.
• Westgaard, Arne; Pomianowska, Ewa; Clausen, Ole Petter Fraas & Gladhaug, Ivar Prydz (2013). Intestinal-type and Pancreatobiliary-type Adenocarcinomas: How Does Ampullary Carcinoma Differ from Other Periampullary Malignancies? Annals of Surgical Oncology. ISSN 1068-9265. 20(2), p. 430–439. doi: 10.1245/s10434-012-2603-0.
• Pomianowska, Ewa; Grzyb, Krzysztof; Westgaard, Arne; Clausen, Ole Petter Fraas & Gladhaug, Ivar Prydz (2012). Reclassification of tumour origin in resected periampullary adenocarcinomas reveals underestimation of distal bile duct cancer. European Journal of Surgical Oncology. ISSN 0748-7983. 38(11), p. 1043–1050. doi: 10.1016/j.ejso.2012.07.113.
• Marangos, Irina Pavlik; Buanes, Trond; Røsok, Bård Ingvald; Kazaryan, Airazat M.; Rosseland, Arne Retvedt & Grzyb, Krzysztof [Show all 10 contributors for this article] (2012). Laparoscopic resection of exocrine carcinoma in central and distal pancreas results in a high rate of radical resections and long postoperative survival. Surgery. ISSN 0039-6060. 151(5), p. 717–723. doi: 10.1016/j.surg.2011.12.016.
• Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2012). Resection margin involvement and tumour origin in pancreatic head cancer. British Journal of Surgery. ISSN 0007-1323. 99(8), p. 1036–1049. doi: 10.1002/bjs.8734.
• Haukeland, John Willy; Dahl, Tuva Børresdatter; Yndestad, Arne; Gladhaug, Ivar Prydz; Løberg, Else Marit & Haaland, Therese Kristina [Show all 13 contributors for this article] (2012). Fetuin A in nonalcoholic fatty liver disease: in vivo and in vitro studies. European Journal of Endocrinology (EJE). ISSN 0804-4643. 166(3), p. 503–510. doi: 10.1530/EJE-11-0864.
• Haugvik, Sven-Petter; Labori, Knut Jørgen; Edwin, Bjørn; Mathisen, Øystein & Gladhaug, Ivar Prydz (2012). Surgical Treatment of Sporadic Pancreatic Neuroendocrine Tumors: A State of the Art Review. Scientific World Journal. ISSN 1537-744X. Article ID 357475, p. 9–sider. doi: 10.1100/2012/357475.
• Verbeke, Caroline Sophie; Knapp, Johannes & Gladhaug, Ivar Prydz (2011). Tumour growth is more dispersed in pancreatic head cancers than in rectal cancer: implications for resection margin assessment. Histopathology. ISSN 0309-0167. 59(6), p. 1111–1121. doi: 10.1111/j.1365-2559.2011.04056.x.
• Westgaard, Arne; Clausen, Ole Petter Fraas & Gladhaug, Ivar Prydz (2011). Survival estimates after pancreatoduodenectomy skewed by non-standardized histopathology reports. APMIS - Journal of Pathologiy, Microbiology and Immunology. ISSN 0903-4641. 119(10), p. 689–700. doi: 10.1111/j.1600-0463.2011.02783.x.
• Weden, Synne L. S.; Klemp, Marianne ; Gladhaug, Ivar Prydz; Møller, Mona; Eriksen, Jon Amund & Gaudernack, Gustav [Show all 7 contributors for this article] (2011). Long-term follow-up of patients with resected pancreatic cancer following vaccination against mutant K-ras. International Journal of Cancer. ISSN 0020-7136. 128(5), p. 1120–1128. doi: 10.1002/ijc.25449.
• Dahl, Tuva Børresdatter; Haukeland, John Willy; Yndestad, Arne; Ranheim, Trine; Gladhaug, Ivar Prydz & Damås, Jan Kristian [Show all 16 contributors for this article] (2010). Intracellular Nicotinamide Phosphoribosyltransferase Protects against Hepatocyte Apoptosis and Is Down-Regulated in Nonalcoholic Fatty Liver Disease. Journal of Clinical Endocrinology and Metabolism (JCEM). ISSN 0021-972X. 95(6), p. 3039–3047. doi: 10.1210/jc.2009-2148.
• Pomianowska, Ewa; Gladhaug, Ivar Prydz; Grzyb, Krzysztof; Røsok, Bård Ingvald; Edwin, Bjørn & Bergestuen, Deidi Ann [Show all 7 contributors for this article] (2010). Survival following resection of pancreatic endocrine tumors: importance of R-status and the WHO and TNM classification systems. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 45(7-8), p. 971–979. doi: 10.3109/00365521003782363.
• Gladhaug, Ivar Prydz; Westgaard, Arne; Schjølberg, Aasa Rambæk; Auensen, Espen; Pomianowska, Ewa & Clausen, Ole Petter Fraas (2010). Spindle proteins in resected pancreatic head adenocarcinomas: BubR1 is an independent prognostic factor in pancreatobiliary-type tumours. Histopathology. ISSN 0309-0167. 56(3), p. 345–355. doi: 10.1111/j.1365-2559.2010.03489.x.
• Westgaard, Arne; Schjølberg, Aasa Rambæk; Cvancarova, Milada; Eide, Tor Jacob; Clausen, Ole Petter Fraas & Gladhaug, Ivar Prydz (2009). Differentiation markers in pancreatic head adenocarcinomas: MUC1 and MUC4 expression indicates poor prognosis in pancreatobiliary differentiated tumours. Histopathology. ISSN 0309-0167. 54(3), p. 337–347. doi: 10.1111/j.1365-2559.2009.03227.x.
• Westgaard, Arne; Larønningen, Siri; Mellem, Christine; Eide, Tor Jacob; Clausen, Ole Petter Fraas & Møller, Bjørn [Show all 7 contributors for this article] (2009). Are survival predictions reliable? Hospital volume versus standardisation of histopathologic reporting for accuracy of survival estimates after pancreatoduodenectomy for adenocarcinoma. European Journal of Cancer. ISSN 0959-8049. 45(16), p. 2850–2859. doi: 10.1016/j.ejca.2009.03.019.
• Westgaard, Arne; Tafjord, S; Farstad, IN; Cvancarova, M; Eide, TJ & Mathisen, O [Show all 8 contributors for this article] (2008). Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma. BMC Cancer. ISSN 1471-2407. 8. doi: 10.1186/1471-2407-8-170.
• Westgaard, Arne; Tafjord, S; Farstad, IN; Cvancarova, M; Eide, TJ & Mathisen, O [Show all 8 contributors for this article] (2008). Resectable adenocarcinomas in the pancreatic head: the retroperitoneal resection margin is an independent prognostic factor. BMC Cancer. ISSN 1471-2407. 8. doi: 10.1186/1471-2407-8-5.
• Frich, Lars; Brabrand, Knut; Aaløkken, Trond Mogens; Edwin, Bjørn & Gladhaug, Ivar Prydz (2008). Radiofrekvensablasjon av kolorektale levermetastaser. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 128(1), p. 57–60.
• Frich, L; Halvorsen, PS; Skulstad, H; Damas, JK & Gladhaug, Ivar Prydz (2007). Microbubbles in the pulmonary artery generated during experimental hepatic radiofrequency increased ablation is correlated with pulmonary arterial pressure. Journal of Vascular and Interventional Radiology. ISSN 1051-0443. 18. doi: 10.1016/j.jvir.2006.12.010.
• Frich, L; Hagen, G; Brabrand, K; Edwin, B; Mathisen, O & Aalokken, TM [Show all 7 contributors for this article] (2007). Local tumor progression after Radiofrequency ablation of colorectal liver metastases: Evaluation of ablative margin and three-dimensional volumetric analysis. Journal of Vascular and Interventional Radiology. ISSN 1051-0443. 18, p. 1134–1140. doi: 10.1016/j.jvir.2007.06.007.
• Frich, Lars Inge; Hol, Per Kristian; Roy, Sumit; Mala, Tom; Edwin, Bjørn & Clausen, Ole Petter F. [Show all 7 contributors for this article] (2006). Experimental hepatic radiofrequency ablation using wet electrodes: electrode-to-vessel distance is a significant predictor for delayed portal vein thrombosis. European Radiology. ISSN 0938-7994. 16, p. 1990–1999.
• Frich, L; Mala, T & Gladhaug, Ivar Prydz (2006). Hepatic radiofrequency ablation using perfusion electrodes in a pig model: Effect of the Pringle manoeuvre. European Journal of Surgical Oncology. ISSN 0748-7983. 32, p. 527–532.
• Frich, Lars Inge; Bjørnland, Kristin; Pettersen, Solveig; Clausen, Ole Petter Fraas & Gladhaug, Ivar Prydz (2006). Increased Activity of Matrix Metalloproteinase 2 and 9 After Hepatic Radiofrequency Ablation. Journal of Surgical Research. ISSN 0022-4804. p. 297–304.
• Mala, Tom; Edwin, Bjørn; Rosseland, Arne Retvedt; Gladhaug, Ivar Prydz; Fosse, Erik & Mathisen, Øystein (2005). Laparoscopic liver resection: experience of 53 procedures at a single center. Journal of Hepato-Biliary-Pancreatic Surgery. ISSN 0944-1166. 12(4), p. 298–303.
• Frich, Lars; Edwin, Bjørn; Brabrand, Knut; Rosseland, Arne Retvedt; Mala, Tom & Mathisen, Øystein [Show all 7 contributors for this article] (2005). Gastric perforation after percutaneous radiofrequency ablation of a colorectal liver metastasis in a patient with adhesions in the peritoneal cavity. American Journal of Roentgenology. ISSN 0361-803X. 184, p. 120–122.
• Mala, Tom; Aurdal, Lars; Frich, Lars Inge; Samset, Eigil; Hol, Per Kristian & Edwin, Bjørn [Show all 7 contributors for this article] (2004). Liver tumor cryoablation: a commentary on the need of improved procedural monitoring. Technology in Cancer Research & Treatment (TCRT). ISSN 1533-0346. 3(1), p. 85–91.
• Stensvold, E; Aass, Nina Kathrine; Gladhaug, Ivar Prydz; Stenwig, Anna Elisabeth; Clausen, Ole Petter Fraas & Fosså, Sophie Dorothea (2004). Erroneous diagnosis of pancreatic cancer after radiotherapy of testicular cancer. European Journal of Surgical Oncology. ISSN 0748-7983. 30(3), p. 352–355. doi: 10.1016/j.ejso.2003.09.003.
• Frich, Lars Inge; Bjørnerud, Atle; Fossheim, Sigrid Lise; Tillung, Terje & Gladhaug, Ivar Prydz (2004). Experimental application of thermosensitive paramagnetic liposomes for monitoring magnetic resonance imaging guided thermal ablation. Magnetic Resonance in Medicine. ISSN 0740-3194. 52(6), p. 1302–1309. doi: 10.1002/mrm.20289.
• Edwin, Bjørn; Mala, Tom; Mathisen, Øystein; Gladhaug, Ivar Prydz; Buanes, Trond & Lunde, O.C. [Show all 9 contributors for this article] (2004). Laparoscopic resection of the pancreas: a feasibility study of the short-term outcome. Surgical Endoscopy. ISSN 0930-2794. 18(3), p. 407–411.
• Mala, Tom; Edwin, Bjørn; Mathisen, Øystein; Tillung, Terje; Fosse, Erik & Bergan, Anstein Bjørnar [Show all 8 contributors for this article] (2004). Cryoablation of colorectal liver metastases: Minimally invasive tumour control. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 39, p. 571–578.
• Samset, Eigil; Mala, Tom; Ellingsen, Reinold; Gladhaug, Ivar Prydz; Søreide, O & Fosse, Erik (2001). Temperature measurement in soft tissue using a distributed fibre Bragg-grating sensor system. MITAT. Minimally invasive therapy & allied technologies. ISSN 1364-5706. 10(2), p. 83–93. doi: 10.1080/13645700152601379.

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• Rosvold, Elin Olaug & Gladhaug, Ivar Prydz (2022). Opptaksprøve på medisinstudiet? Khrono.no. ISSN 1894-8995.
• Berg, Jens Petter & Gladhaug, Ivar Prydz (2020). Disputasen er en del av doktorgradsproven. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(9), p. 1–3. doi: 10.4045/tidsskr.20.0328.
• Gladhaug, Ivar Prydz & Engebretsen, Eivind (2020). Unyansert oppgjør med fortiden. Morgenbladet. ISSN 0805-3847.
• Engebretsen, Eivind & Gladhaug, Ivar Prydz (2020). Er det plass til et sykepleievitenskapelig fagmiljø på et medisinsk fakultet? Tidsskrift for Den norske legeforening. ISSN 0029-2001.
• Berg, Jens Petter & Gladhaug, Ivar Prydz (2019). Viktig at prøveforelesningens hensikt blir oppfylt. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 139(16), p. 1534–1534. doi: 10.4045/tidsskr.19.0646.
• Labori, Knut Jørgen; Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2015). Information needs among patients and a surveillance strategy after surgery for pancreatic and periampullary cancer. HPB Surgery. ISSN 0894-8569. 17(7). doi: 10.1111/hpb.12411.
• Haugvik, Sven-Petter; Gaujoux, Sebastien; Røsok, Bård Ingvald; Gladhaug, Ivar Prydz; Dousset, Bertrand & Edwin, Bjørn (2014). Laparoscopic versus open pancreas resection for neuroendocrine tumours: Need for evaluation of oncological outcomes. HPB Surgery. ISSN 0894-8569. 16(9). doi: 10.1111/hpb.12254.
• Hagness, Morten; Foss, Aksel; Line, Pål Dag; Scholz, Tim; Jørgensen, Pål Foyn & Fosby, Bjarte [Show all 13 contributors for this article] (2012). Liver Transplantation for Non-Resectable Liver Metastases from Colorectal Cancer. Liver transplantation. ISSN 1527-6465. 18, p. S140–S140.
• Haugvik, Sven-Petter; Marangos, Irina Pavlik; Røsok, Bård Ingvald; Mathisen, Øystein; Pomianowska, Ewa & Gladhaug, Ivar Prydz [Show all 7 contributors for this article] (2012). Laparoscopic Surgery of Pancreatic Neuroendocrine Tumors: Results From a Tertiary Care Institution. Neuroendocrinology. ISSN 0028-3835. 96, p. 34–35.
• Haukeland, John Willy; Zbigniew, Konopski; AASHEIM, ERLEND T.; Johansen, Odd Erik; Løberg, Else Marit & Haaland, T. [Show all 12 contributors for this article] (2010). ELEVATED LEVELS OF FETUIN A IN NONALCOHOLIC FATTY LIVER DISEASE. Journal of Hepatology. ISSN 0168-8278. 52, p. S143–S144.
• Gladhaug, Ivar Prydz; Westgaard, Arne; Schjolberg, AR; Burum-Auensen, E; Pomianowska, Ewa & Clausen, Ole Petter Fraas (2009). Spindle proteins in resected pancreatic head adenocarcinomas: BUB1B is an independent prognostic factor in pancreatobiliary-differentiated tumours. APMIS - Journal of Pathologiy, Microbiology and Immunology. ISSN 0903-4641. 117(3), p. 237–238.
• Westgaard, Arne; Laronningen, S; Clausen, Ole Petter Fraas; Mellem, C; Eide, Tor Jacob & Mathisen, O [Show all 8 contributors for this article] (2009). Standardized histopathologic reporting after pancreatoduodenectomy for adenocarcinoma is necessary to determine tumour origin, nodal and margin status, and assures prognostic validity. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 44, p. 36–36.
• Westgaard, Arne; Laronningen, S; Mellem, C; Eide, Tor Jacob; Clausen, Ole Petter Fraas & Moller, B [Show all 7 contributors for this article] (2009). Standardized histopathologic reporting improves survival estimates: A population-based nationwide study of pancreatic head resections for adenocarcinoma from the Norwegian Cancer Registry. APMIS - Journal of Pathologiy, Microbiology and Immunology. ISSN 0903-4641. 117(3), p. 235–236.
• Westgaard, Arne; Schjolberg, A; Cvancarova, M; Eide, Tor Jacob; Clausen, Ole Petter Fraas & Gladhaug, Ivar Prydz (2008). Histological and immunohistochemical classification and prognosis of resected periampullary adenocarcinomas. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 43, p. 33–34.
• Westgaard, Arne; Tafjord, Svetlana; Farstad, Inger Nina; Cvancarova, Milada; Eide, Tor Jacob & Mathisen, Øystein [Show all 8 contributors for this article] (2007). Histologisk type er en uavhengig prognostisk faktor etter pankreatikoduodenektomi for periampullært adenokarsinom.
• Westgaard, Arne; Tafjord, Svetlana; Farstad, Inger Nina; Eide, Tor Jacob; Mathisen, Øystein & Clausen, Ole Petter Fraas [Show all 7 contributors for this article] (2006). Whipple-operasjon for adenokarsinom, Rikshospitalet 1998-2004: Retroperitoneale reseksjonsflate og histologisk type.
• Westgaard, Arne; Tafjord, Svetlana; Farstad, Inger Nina; Cvancarova, Milada; Eide, Tor Jacob & Mathisen, Øystein [Show all 8 contributors for this article] (2006). Histologisk type er en uavhengig prognostisk faktor etter pankreatikoduodenektomi for adenokarsinom i pancreashodet. Show summary

  BAKGRUNN: Adenokarsinomer i pancreashodet operert ved pankreatikoduodenektomi a.m. Whipple kan utgå fra duktalt pancreasvev, ampulla Vateri, intrapankreatiske del av ductus choledochus eller duodenalt epitel. Utgangspunktet har betydning for prognosen, men kan være vanskelig å fastslå nøyaktig. Svulster utgått fra ampullen deles inn etter differensieringsretning i intestinal eller pankreatobiliær histologisk type, men vi har tidligere vist at også svulster i pancreashodet med annet utgangspunkt enn ampullen kan klassifiseres på denne måten. Vi har nå sett nærmere på om histologisk type er en uavhengig prognostisk faktor for svulster i pancreashodet, vurdert etter en systematisk protokoll for beskjæring og histopatologisk vurdering av whippleresektater. PASIENTER OG METODE: Fra 1998 har Avdeling for patologi ved Rikshospitalet hatt en standardisert, systematisk protokoll for histopatologisk undersøkelse av whippleresektater. I perioden 1998–2004 ble det på Kirurgisk avdeling utført 114 makroskopisk tumorfrie whipplereseksjoner for primært adenokarsinom, hvorav 41 svulster utgikk fra ampulla Vateri. Vi har klassifisert alle disse 114 svulstene som enten intestinale eller pankreatobiliære. Vi har deretter gjort overlevelsesanalyse etter Kaplan-Meier-metoden, samt univariat og multippel Cox-analyse, for å estimere betydningen av histologisk type og øvrige histopatologiske faktorer for overlevelse. RESULTATER: For alle whipplereseksjoner sett under ett (n=114) fordelte histologisk type seg på 67 pankreatobiliære og 47 intestinale, med henholdsvis 16,4 % og 52,8 % femårs aktuarisk overlevelse (p<0,001). Ampullesvulstene (n=41) bestod av 13 pankreatobiliære og 28 intestinale, med henholdsvis 23,1 % og 60,5 % femårs aktuarisk overlevelse (p=0,013). Multippel analyse viste at følgende faktorer har uavhengig betydning for overlevelse ved adenokarsinom i pancreashodet (n=114): lymfeknutestatus (p=0,002), karinfiltrasjon (p=0,033), diameter (p=0,015), samt histologisk type (p<0,001). For undergruppen ampullære svulster (n=41) kommer histologisk type (p=0,009), lymfeknutestatus (p<0,001) og tumordiameter (p=0,004) ut som uavhengige faktorer for overlevelse, mens karinfiltrasjon ikke lenger oppnår statistisk signifikans. KONKLUSJON: Adenokarsinomer i pancreashodet kan uavhengig av anatomisk utgangspunkt inndeles i ”intestinal” og ”pankreatobiliær” type. Histologisk type er en uavhengig prognostisk faktor etter whippleoperasjon for adenokarsinom i caput pancreatis.

• Tafjord, Svetlana; Westgaard, Arne; Farstad, Inger Nina; Eide, Tor Jacob; Mathisen, Øystein & Clausen, Ole Petter Fraas [Show all 7 contributors for this article] (2006). Retroperitoneale reseksjonsrand er en uavhengig prognostisk faktor ved pankreatikoduodenektomi for periampullært adenokarsinom. Show summary

  BAKGRUNN Pasienter antatt kurativt operert for adenokarsinom i pancreashodet får ofte residiv. En årsak til dette kan være ikke-erkjent tumorinfiltrasjon i retroperitoneale reseksjonsflate. Vi har benyttet en protokoll med særlig henblikk på snittuttak fra denne reseksjonsflaten og undersøkt histopatologiske faktorers betydning for overlevelse etter pankreatikoduodenektomi a.m. Whipple. PASIENTER OG METODE Fra 1998 er alle whipplereseksjoner utført på Kirurgisk avdeling Rikshospitalet blitt undersøkt på Avdeling for patologi Rikshospitalet etter en standardisert systematisk protokoll for snittuttak og mikroskopisk undersøkelse, spesielt med henblikk på retroperitoneale reseksjonsflate. Vi har revurdert hele vårt materiale i perioden 1998–2004 (n=161) og registrert histopatologiske data for pasienter som er makroskopisk tumorfritt operert (R0/R1) for primære duktale adenokarsinomer i pancreashodet (n=114). Dette inkluderer svulster utgått fra pancreas (n=40), ampulla Vateri (n=41), intrapankreatiske del av ductus choledochus (n=17) og peri-ampullære duodenum (n=16). RESULTATER Førti av 114 (35 %) reseksjoner hadde mikroskopisk infiltrasjon i en eller flere av reseksjonsrendene (R1-reseksjoner), hvorav 32 (32/40) hadde infiltrasjon i retroperitoneale reseksjonsrand. Både univariat og multifaktor analyse viste at tumorinfiltrasjon i bakre reseksjonsrand hadde signifikant betydning for overlevelse etter Whipples operasjon for periampullære adenokarsinomer. KONKLUSJON Systematisk undersøkelse av Whippleresektatet med særlig henblikk på retroperitoneale reseksjonsflate er essensielt for å identifisere kurative reseksjoner og for å oppnå pålitelige histopatologiske prognostiske data ved pankreatikoduodenektomi for periampullært adenokarsinom. Tumorinfiltrasjon i bakre reseksjonsrand er uavhengig prognostisk faktor etter Whipples operasjon for periampullære adenokarsinomer.

• Westgaard, Arne; Tafjord, Svetlana; Farstad, Inger Nina; Eide, Tor Jacob; Mathisen, Øystein & Clausen, Ole Petter Fraas [Show all 7 contributors for this article] (2006). Retroperitoneale reseksjonsrand er en uavhengig prognostisk faktor ved pankreatikoduodenektomi for periampullært adenokarsinom. Show summary

  BAKGRUNN Pasienter antatt kurativt operert for adenokarsinom i pancreashodet får ofte residiv. En årsak til dette kan være ikke-erkjent tumorinfiltrasjon i retroperitoneale reseksjonsflate. Vi har benyttet en standardisert, systematisk protokoll med særlig henblikk på snittuttak fra denne reseksjonsflaten og undersøkt histopatologiske faktorers betydning for overlevelse etter pankreatikoduodenektomi a.m. Whipple. PASIENTER OG METODE Fra 1998 er alle whipplereseksjoner utført på Kirurgisk avdeling Rikshospitalet blitt undersøkt på Avdeling for patologi Rikshospitalet etter en standardisert systematisk protokoll for snittuttak og mikroskopisk undersøkelse, spesielt med henblikk på retroperitoneale reseksjonsflate. Vi har revurdert alle histologiske snitt fra perioden 1998–2004 (n=161) og registrert histopatologiske data for pasienter som er makroskopisk tumorfritt operert (R0/R1) for primære duktale adenokarsinomer i pancreashodet (n=114). Dette inkluderer svulster utgått fra pancreas (n=40), ampulla Vateri (n=41), intrapankreatiske del av ductus choledochus (n=17) og peri-vateriske duodenum (n=16). RESULTATER Førti av 114 (35 %) reseksjoner hadde mikroskopisk infiltrasjon i en eller flere av reseksjonsrendene (R1-reseksjoner), hvorav 32 (32/40) hadde infiltrasjon i retroperitoneale reseksjonsrand. I univariat analyse hadde følgende histopatologiske faktorer prognostisk betydning: tumors utgangspunkt, differensieringsgrad, størrelse, infiltrasjon i retroperitoneale reseksjonsrand, vaskulær infiltrasjon og perinevral infiltrasjon, samt regional lymfeknutemetastasering (p<0,01 for hver faktor). Multippel analyse viste at følgende faktorer har uavhengig betydning for overlevelse: lymfeknutestatus (p=0,025), perinevral infiltrasjon (p=0,012), samt retroperitoneale reseksjonsflate (p=0,016). Grensesignifikante faktorer var differensieringsgrad (p=0,059) og tumordiameter (p=0,068). KONKLUSJON Systematisk undersøkelse av whippleresektatet med særlig henblikk på retroperitoneale reseksjonsflate er essensielt for å identifisere kurative reseksjoner og for å oppnå pålitelige histopatologiske prognostiske data ved pankreatikoduodenektomi for periampullært adenokarsinom. Lymfeknutestatus, perinevral infiltrasjon og reseksjonsstatus for retroperitoneale rand er uavhengige prognostiske faktorer.

• Westgaard, Arne; Tafjord, Svetlana; Farstad, Inger Nina; Eide, Tor Jacob; Mathisen, Øystein & Clausen, Ole Petter Fraas [Show all 7 contributors for this article] (2006). Histologisk type er en uavhengig prognostisk faktor ved pankreatikoduodenektomi for periampullært adenokarsinom. Show summary

  BAKGRUNN: Adenokarsinomer i pancreashodet operert ved pankreatikoduodenektomi a.m. Whipple kan utgå fra duktalt pancreasvev, ampulla Vateri, intrapankreatiske del av ductus choledochus eller duodenalt epitel. Utgangspunktet har betydning for prognosen, men kan være vanskelig å fastslå nøyaktig. Svulster utgått fra ampullen deles inn etter differensieringsretning i intestinal eller pankreatobiliær histologisk type, men vi har tidligere vist at også svulster i pancreashodet med annet utgangspunkt enn ampullen kan klassifiseres på denne måten. Vi har nå sett nærmere på om histologisk type er en uavhengig prognostisk faktor for svulster i pancreashodet, vurdert etter en systematisk protokoll for beskjæring og histopatologisk vurdering av whippleresektater. PASIENTER OG METODE: Fra 1998 har Avdeling for patologi ved Rikshospitalet hatt en standardisert, systematisk protokoll for histopatologisk undersøkelse av whippleresektater. I perioden 1998–2004 ble det på Kirurgisk avdeling utført 114 makroskopisk tumorfrie whipplereseksjoner for primært adenokarsinom, hvorav 41 svulster utgikk fra ampulla Vateri. Vi har klassifisert alle disse 114 svulstene som enten intestinale eller pankreatobiliære. Vi har deretter gjort overlevelsesanalyse etter Kaplan-Meier-metoden, samt univariat og multippel Cox-analyse, for å estimere betydningen av histologisk type og øvrige histopatologiske faktorer for overlevelse. RESULTATER: For alle whipplereseksjoner sett under ett (n=114) fordelte histologisk type seg på 67 pankreatobiliære og 47 intestinale, med henholdsvis 16,4 % og 52,8 % femårs aktuarisk overlevelse (p<0,001). Ampullesvulstene (n=41) bestod av 13 pankreatobiliære og 28 intestinale, med henholdsvis 23,1 % og 60,5 % femårs aktuarisk overlevelse (p=0,013). Multippel analyse viste at følgende faktorer har uavhengig betydning for overlevelse ved adenokarsinom i pancreashodet (n=114): lymfeknutestatus (p=0,002), karinfiltrasjon (p=0,033), diameter (p=0,015), samt histologisk type (p<0,001). For undergruppen ampullære svulster (n=41) kommer histologisk type (p=0,009), lymfeknutestatus (p<0,001) og tumordiameter (p=0,004) ut som uavhengige faktorer for overlevelse, mens karinfiltrasjon ikke lenger oppnår statistisk signifikans. KONKLUSJON: Adenokarsinomer i pancreashodet kan uavhengig av anatomisk utgangspunkt inndeles i ”intestinal” og ”pankreatobiliær” type. Histologisk type er en uavhengig prognostisk faktor etter whippleoperasjon for adenokarsinom i caput pancreatis.

• Øyen, Ole; Eskild, Winnie; Attramadal, Håvard; Gladhaug, Ivar Prydz; Knutsen, G. & Richards, JoAnne S. [Show all 8 contributors for this article] (1986). Hormonal regulation of mRNA for the regulatory subunit (R-II51) of type II cAMP-dependent protein kinase in rat Sertoli cells.
• Øyen, Ole; Eskild, Winnie; Attramadal, Håvard; Gladhaug, Ivar Prydz; Levy, Finn Olav & Knutsen, G. [Show all 9 contributors for this article] (1986). Cyclic AMP increases the mRNA levels for the regulatory subunit (R-II51) of type II cAMP-dependent protein kinase in rat Sertoli cells.
• Søreide, Jon Arne; Grønbech, Jon Erik; Lassen, Kristoffer; Dueland, Svein; Smaaland, Rune & Gladhaug, Ivar Prydz [Show all 12 contributors for this article] (2014). Nasjonalt handlingsprogram med retningslinjer for diagnostikk, behandling og oppfølging av pasienter med pancreaskreft. Helsedirektoratet. ISSN 978-82-8081-296-4.
• Westgaard, Arne & Gladhaug, Ivar Prydz (2010). Standardised histopathologic evaluation after pancreatoduodenectomy for adenocarcinoma – Resection margins, tumour origin, and survival. Unipub forlag.
• Frich, Lars Inge & Gladhaug, Ivar Prydz (2007). Radiofrequency ablation of liver tumors : an experimental and clinical study. Unipub forlag. ISSN 978-82-8072-693-3.

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