Our long-term goal is to understand the molecular principles behind the 3-dimensional organization of the eukaryotic genome in the context of chromatin, and how 3-D genome folding contributes to the differentiation capacity of stem cells from adipose tissue. 

Our projects include:

  1. identifying transitions in epigenetic states, chromosome-chromosome interactions and chromosome-nuclear envelope contacts during lineage-directed differentiation
  2. modeling these interactions in 3 and 4 dimensions
  3. identifying functional determinants of chromatin assembly 
Published Mar. 9, 2011 4:26 PM - Last modified Apr. 7, 2017 3:25 PM