Nuclear Architecture in Adipose and Cancer Stem Cells
We are interested in understanding chromatin features that pattern 3D genome architecture during adipogenesis and breast cancer tumorigenesis.
The Collas lab 2021 (standing, from left): Anita Løvstad Sørensen, Sarah Hazell Pickering, Natalia Galigniana, Mohamed Abdelhalim, Philippe Collas, Thomas Germier, Sumithra Maud Taraldsen, Nolwenn Briand, Aurélie Nathalie Pascale Bellanger, (sitting, from left): Kristin Vekterud, Thomas Sæther, Julia-Kristina Madsen-Østerbye.
Cell fate decisions are programmed by multiple layers of regulation of gene expression involving chromatin modifications and a dynamic organization of the genome in the 3-dimensional cell nucleus space.
CollasLab is interested in understanding chromatin features that pattern 3D genome architecture during adipogenesis and breast cancer tumorigenesis.
To this end, we combine cell biological, biochemical, imaging, genomics and computational approaches.
- The 3-dimensional conformation of the genome
- Nuclear lamins and lipodystrophic laminopathies
- Nutritional regulation of transcription