Selected publications 2021-2008

  • Borowicz P, Sundvold V, Chan H, Abrahamsen G, Kjelstrup K, Nyman TA, Spurkland A: Tyr192 regulates lymphocyte-specific tyrosine kinase activity in T cells. J. Immunol. 207:1128-1137, doi: 10.4049/jimmunol.2001105, 2021.

  • Borowicz P, Chan H, Hauge ASpurkland A. Adaptor proteins: Flexible and dynamic modulators of immune cell signalling. (review) Scand J Immunol.  Nov;92(5):e12951. doi: 10.1111/sji.12951, 2020.

  • Borowicz P, Chan H, Medina D, Gumpelmair D, Kjelstrup H, Spurkland A: A simple and efficient workflow for generation of knock-in mutations in Jurkat T cells using CRISPR/Cas9. Scand. J. Immunol. 91 (4), e12862, 2020.

  • Andersen TCB, Kristiansen PE, Huszenicza Z, Johansson MU, Gopalakrishnan RP, Boyken S, Sundvold-Gjerstad V, Granum S, Sørli M, Backe PH, Fulton DB, Karlsson BG, Andreotti AH, Spurkland A: The SH3 domains of Itk and Lck compete for adjacent sites on T cell-specific adapter protein. J Biol Chem. 294 (42), 15480-15494, 2019.
  • Abrahamsen G, Sundvold-Gjerstad V, Mekonnen MH, Bogen B, Spurkland A: T cell specific adapter protein regulates polarity towards the immunological synapse in experienced CD4+ T cells. Sci Rep. 2018 Sep 6;8(1):13319
  • Hem CD, Ekornhol M, Granum S, Sundvold-Gjerstad V, Spurkland A: CD6 and Linker of Activated T cells are potential interaction partners for T cell Specific Adaptor protein. Scand. J. Immunol. 85:104-112. doi: 10.1111/sji.12513, 2017.
  • Gordon EJ, Fukuhara D, Weström S, Padhan N, Sjöström EO, van Meeteren L, He L, Orsenigo F, Dejana E4, Bentley K, Spurkland A, Claesson-Welsh L:The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation. Sci. Signal. Jul 19;9(437):ra72, 2016.
  • Hem CD, Sundvold-Gjerstad V, Granum S, Koll L, Abrahamsen G, Buday L, Spurkland A: T cell specific protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells. Cell Commun. Signal. 13:31, 2015
  • Granum S, Sundvold-Gjerstad V, Abrahamsen G, Berge T, Koll L, Sørlie M, Spurkland A. Itk and the adapter TSAd co-operate to promote phosphorylation dependent altered specificity of Lck. Science Signaling, 7:p. ra118, 2014.
  • International Multiple Sclerosis Genetics Consortium (IMSGC) with Spurkland A as one of the co-authors: Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet. 45:1353-60, 2013
  • Berge T, Grønningsæter IHB, Lorvik KB, Granum S, Sundvold-Gjerstad V, Corthay A, Bogen B, Spurkland A: SH2D2A Modulates T Cell Mediated Protection to a B Cell Derived Tumor in Transgenic Mice. PloSOne, 7(10):e48239, 2012.
  • Syn Z, Li X, Massena S, Kutschera S, Padhan N, Gualandi L, Sundvold-Gjerstad V, Gustafsson K, Choi WW, Zang G, Quach M, Jansson L, Phillipson M, Abid MR, Spurkland A, Claesson-Welsh L: VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd. J. Ex. Med., 209(7):1363-77, 2012
  • International Multiple Sclerosis Genetics Consortium; Wellcome Trust Case Control Consortium 2, (with Spurkland A as one of the co-authors): Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature. 476:214-9, 2011.
  • Kolltveit KM, Schreurs O, Østrem J, Søland TM, Khuu C, Berge T, Messelt E, Hayashi K, Granum S, Spurkland A and Schenck K: The adapter protein TSAd is necessary for the normal structure of oral epithelium. Eur. J. Oral. Sci. 118: 159–167, 2010.
  • Berge T, Sundvold-Gjerstad V, Andersen TCB, Holte GB, Granum S, Claesson-Welsh L, Andreotti A, Inngjerdingen M, Spurkland A. T cell specific adapter protein (TSAd) interacts with Inducible Tec kinase (Itk) to promote CXCL12 induced T cell migration. PLoS One.5:e9761. 2010
  • Granum S, Andersen TCB, Sørlie M, Jørgensen M, Koll L, Berge T, Lea T, Fleckenstein B, Spurkland A, Sundvold-Gjerstad V. Modulation of Lck function through multi-site docking to T cell specific adapter protein. J. Biol. Chem,283:21909-19, 2008.
  • Kolltveit KM, Granum S, Aasheim HC, Kristiansen M, Sundvold-Gjerstad V, Dai KZ, Molberg O, Schjetne KW, Bogen B, Shapiro VS, Johansen FE, Schenck K, Spurkland A: Expression of  SH2D2A in T cells is regulated both at the transcriptional and translational level. Mol. Immunol. 5:2380-90, 2008.
Published Apr. 14, 2011 4:19 PM - Last modified Jan. 15, 2022 2:42 PM