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T Cell Activation and Autoimmune Disease

The main focus of our research is regulation of adaptive immunity. We are particularly interested in signaling in activated and experienced T cells, as these cells influence individual susceptibility to autoimmune diseases as well as cancer. 

Image contain pictures of five persons belonging to the group

Screen-shot group meeing on zoom, december 2020

About the group

T cells play a crucial role in our defense against infection and cancer, but these cells are also a two-edged sword. Sometimes they start to react against the body they are supposed to defend, leading to autoimmune disease.

How T cells recognize and react to foreign antigens is therefore a key to understand how T cell mediated diseases develop and how they may be prevented or treated.

The research group therefore focuses primarily on elucidating molecular mechanisms for control of T cell activation, and in particular the role of adaptor molecules in this process.

Tags: Immunology, adaptive immunity, T cells
Published Feb. 24, 2011 7:36 PM - Last modified Jan. 19, 2021 1:59 PM


Dept. of Molecular Medicine
Domus Medica, room 2501
Sognsvannsveien 9
0372 Oslo


Group leader