Norwegian version of this page

Synaptic physiology

My group studies how neurons in the mammalian brain communicate with each other at synapses. We use advanced electrophysiological, imaging and computer modeling techniques to analyze synaptic signaling mechanisms in presynaptic axons and postsynaptic dendrites.

Confocal imaging and patch clamp recordings.

About the group

Our group aims to unravel mechanisms of synaptic computation in the mammalian brain and translate the scientific results to the clinic to combat diseases of the nervous system. We use a combination of cutting edge electrophysiological, optical and computational tools to study synaptic computation in dendrites and axons of cortical neurons.

 

Projects

Functional analysis of cortical interneuron axons. Inhibitory interneurons play a key role in several higher microcircuit functions, such as feedforward and feedback inhibition, high-frequency network oscillations, and temporal encoding of information in the brain. Many of these functions are critically dependent on the rapid and temporally precise release of GABA from inhibitory axon terminals. We study synaptic computation mechanisms in these interneuron axon terminals that are highly specialized in fast signaling.

Dendritic computation in the medial entorhinal cortex. Combining electrophysiological recording, 2-photon glutamate uncaging, and molecular manipulation of dendritic ion channels, we aim to understand how grid cells in the medial entorhinal cortex process synaptic input during spatial navigation.

 

 

Published Mar. 12, 2018 3:58 PM - Last modified Dec. 12, 2019 1:12 PM

Contact

 

Dept. of Molecular Medicine
Domus Medica
Gaustad
Sognsvannsveien 9
0372 Oslo

 

Group leader

Hua Hu