Program
Day 1
Wednesday September 7th
12.00 Registration + Green Lunch
Poster setup + Exhibition
12.55 –13.00 Opening words
13.00 –15.15 Instructing chromatin (session 1A)
Chair: Rein Aasland, Department of Biosciences, University of Oslo, Norway
13.00 – 14.00 Keynote Yang Shi, Ludwig Cancer Research, University of Oxford, UK
Dynamic regulation of histone methylation
14.00 – 14.30 Anita Göndör, Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden and Department of Clinical Molecular Biology, University of Oslo
WNT signaling-dependent gating of MYC requires CTCF binding to a distal oncogenic super-enhancer
14.30 – 15.00 Pierre Chymkowitch, Department of Biosciences, University of Oslo, Norway
Mitotic chromosome condensation resets chromatin to safeguard transcriptional homeostasis during interphase
15.00 – 15.15 Short talk: Helga Landsverk, Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
The RNA polymerase II phosphatase WDR82/PNUTS-PP1 prevents transcription-replication conflicts
15.15 – 15.45 Coffee/Tea, Cake & Exhibition
15.45 – 17.15 Single cell multi-omics (session 1B)
Chair: Arne Klungland, Department of Biosciences, University of Oslo, Norway
15.45 – 16.15 Pernette Verschure, Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands
Dynamic epigenetic regulation and transcription bursting in single cells
16.15 – 16.45 John Arne Dahl, Dept. of Microbiology, Laboratory Medicine, Oslo University Hospital, Norway
Method development to gain insight in the epigenomes and epitranscriptomes of oocytes and embryos
16.45 – 17.00 Short talk: Liangru Fei, Centre for Molecular Medicine, Faculty of Medicine, University of Oslo and University of Helsinki, Finland
Global epigenome and transcriptome remodeling during direct reprogramming of human fibroblasts to pancreatic exocrine cells
17.00 – 17.15 Sponsor talk: Feri Shahin, Singleron
FocuSCOPE: A multi-omics solution to simultaneously analyze genetic variants and transcriptomes in single cells
17.15-19.00 Poster session with snacks in Glasshall
Free Evening/Speakers dinner
Day 2
Thursday September 8th
09.00 – 11:00 Nuclear organisation (session 2A)
Chair: Ragnhild Eskeland, Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Norway
09.00 – 10.00 Keynote Lecture: Kerstin Bystricky, Toulouse Centre de Biologie Integrative, University of Toulouse, France.
Chromatin dynamics during transcription activation
10.00 – 10.30 Jonas Paulsen, Department of Biosciences, University of Oslo, Norway
Loops and loopholes in 3D genome modeling
10.30 – 10.45 Short talk: Frank Fackelmayer, Laboratory of Epigenetics and Chromosome Biology Biomedical Research Institute, Foundation of Research and Technology Hellas (BRI-FORTH), University Campus, Greece
Scaffold Attachment Factor A (SAF-A) is an essential component of the nuclear scaffold in live human cells and controls chromatin compaction
10.45 – 11.00 Short talk: Vipin Kumar, Centre for Molecular Medicine, Faculty of Medicine, University of Oslo, Norway
BootHiCC: Integrating Hi-C and transcriptomics to detect transcriptional hubs
11:00 – 11.30 Coffee/Tea/Fruit & Exhibition
11:30 – 12:45 Nuclear organisation II (session 2B)
Chair: Kerstin Bystricky, Toulouse Centre de Biologie Integrative, University of Toulouse, France.
11.30 – 12.00 Argyris Papantonis, Göttingen Graduate Center for Neurosciences, Biophysics, and Molecular Biosciences, Georg August University, Germany
RNA PolII is essential for 3D chromatin folding and antagonises loop extrusion
12.00 – 12.15 Short talk: Julia Madsen-Østerbye, Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Norway
Dynamics of lamina-associated domains during adipogenic induction
12.15 – 12.30 Short talk: Winnok H. de Vos, Laboratory of Cell Biology and Histology and Antwerp Centre for Advanced Microscopy, University of Antwerp, Belgium
Lamin B1 curtails early human papillomavirus infection by safeguarding nuclear compartmentalization and autophagic capacity
12.30 – 12.45 Short talk: Roza Berhanu Lemma, Centre for Molecular Medicine Norway, Faculty of Medicine, and Department of Biosciences, University of Oslo, Norway
MYB regulates the SUMO-protease SENP1 and its novel interaction partner UXT –implications for modulating the SUMO landscape and the profile of MYB target genes
12.45 – 13.30 Lunch & Exhibition
13.30 – 15.00 Chromatin and DNA repair (session 3A)
Chair: Odd Stokke Gabrielsen, Department of Biosciences, University of Oslo, Norway
13.30 – 14.00 Hilde Nilsen, Institute of Clinical Medicine, Department of Clinical Molecular Biology, University of Oslo, and Dept. of Microbiology, Laboratory Medicine, Oslo University Hospital Norway
SMUG1 at the crossroads of DNA repair and RNA processing
14.00 – 14.30 Barbara van Loon, Department of Cancer Research and Molecular Medicine, Norwegian University for Science and Technology, Norway
Non-canonical functions of AAG DNA glycosylase in gene expression and associated impacts on behavior
14.30 – 14.45 Short talk: Torkild Visnes, Department of Biotechnology and Nanomedicine, SINTEF Industry, Trondheim, Norway
Small molecule inhibitors to modulate DNA repair-mediated gene regulation
14.45 – 15.00 Sponsor talk: Bärbel Lorenz, Lumicks
Decipher the mechanisms of protein complexes regulating DNA damage response and chromatin organization with single-molecule resolution in real-time
15.00 - 15:30 Coffee/Tea Cake & Exhibition
15:30 - 16:30 DNA/RNA modifications and epitranscriptomics (session 3B)
Chair: Pål Falnes, Department of Biosciences, University of Oslo, Norway
Arne Klungland, Department of Biosciences, University of Oslo, Norway
15.30 – 16.00 Dynamic epitranscriptomic marks; critical regulators of meiosis and function in genome stability
16.00 – 16.15 Short talk: Adam Fillipczyk, Division of Laboratory Medicine, Laboratory for Stem Cell Dynamics, Oslo University Hospital, Norway
N6-methyladenosine (m6A) depletion regulates pluripotency exit by activating signaling pathways in embryonic stem cells
16.15 – 16.30 COST PRoteCure Dissemination talk: İkbal Agah İNCE, Acıbadem University, School of Medicine, Department of Medical Microbiology, Turkey and INRA, UR892, Molecular Virology and Immunology, France
Targeted Methylation Analysis of human mitochondria
16.30-17.30 Epigenetics and hormones (session 3C)
Chair: Deo Pandey, Dept. of Microbiology, Oslo University Hospital, Oslo University Hospital, Oslo, Norway
16.30 –17.00 Marija Kundakovic, Fordham University, New York, USA
Sex-specific multi-level 3D genome dynamics in the mouse brain
17.00 –17.15 Short talk: Mads Bengtsen, Department of Biosciences, University of Oslo, Norway
Testosterone affects and alters the epigenome in muscles
17.30-19:00 Poster session in Glasshall
19.00 Tapas Dinner with a View
Day 3
Friday September 9th
09.00 - 10.30 Epigenetics in specialised chromatin (session 4A)
Chair: Nikolina Sekulic, Centre for Molecular Medicine Norway, Faculty of Medicine, University of Oslo, Norway
09.00 – 09.30 Andrea Musacchio, Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Germany
Epigenetics of centromere specification: down to mechanisms
09.30 – 10.00 Ferenc Mueller, Institute of Cancer and Genomic Sciences, University of Birmingham, UK
Epigenomic organisation and vertebrate conservation of cis-regulatory landscape during zebrafish development
10.00 – 10.15 Short talk: Erna Magnusdottir, Department of Anatomy and Department of Biomedical Sciences, University of Iceland, Iceland
Transcriptional effects of Rhox proteins in mouse embryonic stem cell
10.15 – 10.30 Short talk: Natalia M. Galigniana, Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Norway
Telomeres express their lncRNAs TERRA and recruit FKBP51 in response to increased ROS during the epithelial-to-mesenchymal transition
10.30 - 11.00 Coffee/Tea, Fruit & Exhibition
11.00 - 13.00 Epigenetics and cancer (session 4B)
Chair: Thomas Fleischer, Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Norway
11.00 – 11.30 Biswajyoti Sahu, Centre for Molecular Medicine, UiO, Norway
Sequence determinants of human gene regulatory elements and the role of transcription factors in cell fate control and cancer
11.30 – 11.45 Short talk: Deo Pandey, Dept. of Microbiology, Oslo University Hospital, Oslo University Hospital, Oslo, Norway
CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival
11.45 – 12.00 Short talk: Aurelie Bellanger, Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway
Deciphering genome organization dynamics in a breast cancer progression model
Chair: Ragnhild Eskeland, Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Norway
12.00 - 13.00 Dentist Olaf Aase and wife memorial lecture: Kristian Helin, The Institute of Cancer Research, London, UK
Epigenetics and its role in transcriptional control, cell fate and cancer
13.00 Closing Remarks
13.00 -14.00 Lunch & Departure