Nuclear lamina in cancer

Levels of A-type nuclear lamins often vary between tumors and within tumors, but their roles in cancer development are unclear. We study the role of lamin A/C, as a genome organizer, in breast cancer progression through EMT.

Ongoing research

A-type lamins and transcription factor dynamics in a breast cancer model of EMT
Relationship between the nuclear lamina, 3D genome organization and breast cancer progression

Recent findings

Re-wiring of transcription factor networks by lamin A/C in a breast cancer EMT model (Bellanger, in prep)
Loss of 3D genome organization at multiple levels in a model of breast cancer progression (Rossini 2026 Genome Res)
A polymer model of chromatin to infer chromatin behavior at the nuclear lamina (Brunet 2021 Nucleus)
Chrom3D: a platform for 3D genome modeling from Hi-C and LAD data (Paulsen 2017 Genome Biol; Paulsen 2018 Nature Protoc)
Chrom3D on github: https://github.com/Chrom3D/Chrom3D

Participants

Aurelie Nathalie Pascale Bellanger University of Oslo Project leader
Elizabeth Otti Surgucheva University of Oslo
Mohamed Abdelhalim University of Oslo

Norwegian version of this page

Published Mar. 2, 2026 10:52 PM - Last modified Apr. 24, 2026 11:14 AM

Nuclear lamina in cancer

Ongoing research

Recent findings

Participants

Involved research groups