Yun Zhou

Avdelingsingeniør - Seksjon for anatomi
Bilde av Yun Zhou
English version of this page
Telefon +47 22851243
Rom 1291
Brukernavn
Besøksadresse Sognsvannsveien 9 Domus Medica 0372 Oslo
Postadresse Postboks 1105 Blindern 0317 Oslo

Utdanning

2012: PhD Molecular Neuroscience, Medical Faculty, UiO

2008: Msc Cell biology, Physiology and neuroscience, Faculty of Mathematics and Natural Science; University of Oslo

2005: Bsc Biology, HuaZhong Agricultural University, China

Researcher unique identifier

ORCID: 0000‐0002‐5682‐0169

ResearcherID: I-1840-2017

https://publons.com/researcher/2107139/yun-zhou/metrics/

Google scholar citations 

Emneord: Hjernen og nervesystemet, Molekylær ernæring

Publikasjoner

  • Verbruggen, Lise; Ates, Gamze; Lara, Olaya; De Munck, Jolien; Villers, Agnès & De Pauw, Laura [Vis alle 23 forfattere av denne artikkelen] (2022). Lifespan extension with preservation of hippocampal function in aged system x<inf>c</inf><sup>−</sup>-deficient male mice. Molecular Psychiatry. ISSN 1359-4184. doi: 10.1038/s41380-022-01470-5.
  • Farina, Maxwell G; Sandhu, Mani Ratnesh S; Parent, Maxime; Sanganahalli, Basavaraju G; Derbin, Matthew & Dhaher, Roni [Vis alle 12 forfattere av denne artikkelen] (2021). Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity. Epilepsia. ISSN 0013-9580. 62, s. 2858–2870. doi: 10.1111/epi.17072.
  • Danbolt, Niels Christian; López-Corcuera, Beatriz & Zhou, Yun (2021). Reconstitution of GABA, Glycine and Glutamate Transporters. Neurochemical Research. ISSN 0364-3190. 47, s. 85–110. doi: 10.1007/s11064-021-03331-z. Fulltekst i vitenarkiv
  • Zhou, Yun; Eid, Tore; Hassel, Bjørnar & Danbolt, Niels Christian (2020). Novel aspects of glutamine synthetase in ammonia homeostasis: Glutamine synthetase and ammonia. Neurochemistry International. ISSN 0197-0186. 140, s. 1–18. doi: 10.1016/j.neuint.2020.104809. Fulltekst i vitenarkiv
  • Hu, Qiu Xiang; Klatt, Gesa; Gudmundsrud, Ruben; Ottestad-Hansen, Sigrid; Verbruggen, Lisa & Massie, Ann [Vis alle 8 forfattere av denne artikkelen] (2020). Semi-quantitative distribution of excitatory amino acid (glutamate) transporters 1-3 (EAAT1-3) and the cystine-glutamate exchanger (xCT) in the adult murine spinal cord. Neurochemistry International. ISSN 0197-0186. 140. doi: 10.1016/j.neuint.2020.104811. Fulltekst i vitenarkiv
  • Albertini, Giulia; Deneyer, L.; Hansen, Sigrid Ottestad; Zhou, Yun; Ates, G & Walrave, L [Vis alle 13 forfattere av denne artikkelen] (2018). Genetic deletion of xCT attenuates peripheral and central inflammation and mitigates LPS-induced sickness and depressive-like behavior in mice. Glia. ISSN 0894-1491. 66(9), s. 1845–1861. doi: 10.1002/glia.23343.
  • Zhou, Yun; Dhaher, Roni; Parent, Maxime; Hu, Qiu Xiang; Hassel, Bjørnar & Yee, Siu-Pok [Vis alle 9 forfattere av denne artikkelen] (2018). Selective deletion of glutamine synthetase in the mouse cerebral cortex induces glial dysfunction and vascular impairment that precede epilepsy and neurodegeneration. Neurochemistry International. ISSN 0197-0186. s. 1–12. doi: 10.1016/j.neuint.2018.07.009. Fulltekst i vitenarkiv
  • Zhou, Yun; Hassel, Bjørnar; Eid, Tore & Danbolt, Niels Christian (2018). Axon-terminals expressing EAAT2 (GLT-1; Slc1a2) are common in the forebrain and not limited to the hippocampus. Neurochemistry International. ISSN 0197-0186. 123, s. 101–113. doi: 10.1016/j.neuint.2018.03.006. Fulltekst i vitenarkiv
  • Hansen, Sigrid Ottestad; Hu, Qiu Xiang; Follin-Arbelet, Virginie; Bentea, Eduard; Sato, Hideyo & Massie, Ann [Vis alle 8 forfattere av denne artikkelen] (2018). The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain. Glia. ISSN 0894-1491. 66(5), s. 951–970. doi: 10.1002/glia.23294. Fulltekst i vitenarkiv
  • Hu, Qiu Xiang; Hansen, Sigrid Ottestad; Holmseth, Silvia; Hassel, Bjørnar; Danbolt, Niels Christian & Zhou, Yun (2018). Expression of glutamate transporters in mouse liver, kidney, and intestine. Journal of Histochemistry and Cytochemistry. ISSN 0022-1554. 66(3), s. 189–202. doi: 10.1369/0022155417749828. Fulltekst i vitenarkiv
  • Eid, Tore; Gruenbaum, SE; Dhaher, R; Lee, T W; Zhou, Yun & Danbolt, Niels Christian (2016). The Glutamate-Glutamine Cycle in Epilepsy. Advances in neurobiology. ISSN 2190-5215. 13, s. 351–400. doi: 10.1007/978-3-319-45096-4_14.
  • Danbolt, Niels Christian; Zhou, Yun; Furness, David N & Holmseth, Silvia (2016). Strategies for immunohistochemical protein localization using antibodies: What did we learn from neurotransmitter transporters in glial cells and neurons. Glia. ISSN 0894-1491. 64(12), s. 2045–2064. doi: 10.1002/glia.23027. Fulltekst i vitenarkiv
  • Danbolt, Niels Christian; Furness, David N & Zhou, Yun (2016). Neuronal vs glial glutamate uptake: Resolving the conundrum. Neurochemistry International. ISSN 0197-0186. 98, s. 29–45. doi: 10.1016/j.neuint.2016.05.009. Fulltekst i vitenarkiv
  • Zhou, Yun; Kempson, S.A. & Danbolt, Niels Christian (2015). Betaine uptake with a focus on the betaine/GABA transporter. Food and Nutritional Components in Focus. ISSN 2045-1695. 2015-January(7), s. 76–89. doi: 10.1039/9781782628446-00076.
  • Petr, Geraldine T; Sun, Yan; Frederick, Natalie M; Zhou, Yun; Dhamne, Sameer C & Hameed, Mustafa Q [Vis alle 15 forfattere av denne artikkelen] (2015). Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes. Journal of Neuroscience. ISSN 0270-6474. 35(13), s. 5187–5201. doi: 10.1523/JNEUROSCI.4255-14.2015.
  • Zhou, Yun; Wang, Xiaoyu; Tzingounis, Anastasios V; Danbolt, Niels Christian & Larsson, H Peter (2014). EAAT2 (GLT-1; slc1a2) glutamate transporters reconstituted in liposomes argues against heteroexchange being substantially faster than net uptake. Journal of Neuroscience. ISSN 0270-6474. 34(40), s. 13472–13485. doi: 10.1523/JNEUROSCI.2282-14.2014.
  • Zhou, Yun; Waanders, LF; Holmseth, Silvia; Guo, C; Berger, Urs V & Li, Yuchuan [Vis alle 9 forfattere av denne artikkelen] (2014). Proteome analysis and conditional deletion of the EAAT2 glutamate transporter provide evidence against a role of EAAT2 in pancreatic insulin secretion in mice. Journal of Biological Chemistry. ISSN 0021-9258. 289(3), s. 1329–1344. doi: 10.1074/jbc.M113.529065.
  • Zhou, Yun & Danbolt, Niels Christian (2014). Glutamate as a neurotransmitter in the healthy brain. Journal of Neural Transmission. ISSN 0300-9564. 121(8), s. 799–817. doi: 10.1007/s00702-014-1180-8. Fulltekst i vitenarkiv
  • Bjørnsen, Lars Petter; Hadera, Mussie Ghezu; Zhou, Yun; Danbolt, Niels Christian & Sonnewald, Ursula (2014). The GLT-1 (EAAT2; Slc1a2) glutamate transporter is essential for glutamate homeostasis in the neocortex of the mouse. Journal of Neurochemistry. ISSN 0022-3042. 128(5), s. 641–649. doi: 10.1111/jnc.12509.
  • Zhou, Yun; Waanders, Leonie; Holmseth, Silvia; Guo, Caiying; Berger, Urs V & Li, Yuchuan [Vis alle 9 forfattere av denne artikkelen] (2013). Proteome analysis and conditional deletion of the EAAT2 glutamate transporter provide evidence against a role of EAAT2 in pancreatic insulin secretion in mice. Journal of Biological Chemistry. ISSN 0021-9258. doi: 10.1074/jbc.M113.529065.
  • Zhou, Yun & Danbolt, Niels Christian (2013). GABA and Glutamate Transporters in Brain. Frontiers in Endocrinology. ISSN 1664-2392. 4. doi: 10.3389/fendo.2013.00165.
  • Zhou, Yun; Holmseth, Silvia; Guo, C; Hassel, Bjørnar; Höfner, G & Huitfeldt, Henrik [Vis alle 7 forfattere av denne artikkelen] (2012). Deletion of the γ-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents. Journal of Biological Chemistry. ISSN 0021-9258. 287(42), s. 35733–35746. doi: 10.1074/jbc.M112.368175.
  • Li, Yuchuan; Zhou, Yun & Danbolt, Niels Christian (2012). The Rates of Postmortem Proteolysis of Glutamate Transporters Differ Dramatically between Cells and between Transporter Subtypes. Journal of Histochemistry and Cytochemistry. ISSN 0022-1554. 60(11), s. 811–821. doi: 10.1369/0022155412458589.
  • Holmseth, Silvia; Dehnes, Yvette; Huang, YHH; Follin-Arbelet, Virginie; Verket, Nina Julie & Mylonakou, Maria-Niki [Vis alle 12 forfattere av denne artikkelen] (2012). The Density of EAAC1 (EAAT3) Glutamate Transporters Expressed by Neurons in the Mammalian CNS. Journal of Neuroscience. ISSN 0270-6474. 32(17), s. 6000–6013. doi: 10.1523/JNEUROSCI.5347-11.2012.
  • Zhou, Yun; Holmseth, Silvia; Hua, Rui; Lehre, Anne- Catherine W G; Olofsson, Anna Maria & Poblete-Naredo, Irais [Vis alle 8 forfattere av denne artikkelen] (2012). The betaine-GABA transporter (BGT1, slc6a12) is predominantly expressed in the liver and at lower levels in the kidneys and at the brain surface. American Journal of Physiology - Renal, fluid and electrolyte physiology. ISSN 0363-6127. 302(3), s. F316–F328. doi: 10.1152/ajprenal.00464.2011.
  • Holmseth, Silvia; Zhou, Yun; Follin-Arbelet, Virginie; Lehre, Knut Petter Dæhlin; Bergles, Dwight E. & Danbolt, Niels Christian (2012). Specificity Controls for Immunocytochemistry: The Antigen Preadsorption Test Can Lead to Inaccurate Assessment of Antibody Specificity. Journal of Histochemistry and Cytochemistry. ISSN 0022-1554. 60(3), s. 174–187. doi: 10.1369/0022155411434828.
  • Lehre, Anne- Catherine W G; Rowley, Nicole; Zhou, Yun; Holmseth, Silvia; Guo, Chungang & Holen, Torgeir [Vis alle 16 forfattere av denne artikkelen] (2011). Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice. Epilepsy Research. ISSN 0920-1211. 95(1-2), s. 70–81. doi: 10.1016/j.eplepsyres.2011.02.014.
  • Furness, DN; Dehnes, Yvette; Akhtar, Aisha Qureshi; Rossi, DJ; Hamann, M & Grutle, Nina J. [Vis alle 14 forfattere av denne artikkelen] (2008). A QUANTITATIVE ASSESSMENT OF GLUTAMATE UPTAKE INTO HIPPOCAMPAL SYNAPTIC TERMINALS AND ASTROCYTES: NEW INSIGHTS INTO A NEURONAL ROLE FOR EXCITATORY AMINO ACID TRANSPORTER 2 (EAAT2). Neuroscience. ISSN 0306-4522. 157(1), s. 80–94. doi: 10.1016/j.neuroscience.2008.08.043.

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  • Klatt, Gesa Mirjam; Danbolt, Niels Christian & Zhou, Yun (2021). Congential Glutamine Synthetase Deficiency: What lessons can we learn?
  • Zhou, Yun & Danbolt, Niels Christian (2021). Make the unseen see.
  • Klatt, Gesa Mirjam; Hu, Qiu Xiang; Gudmundsrud, Ruben; Ottestad-Hansen, Sigrid; Verbruggen, Lisa & Massie, Ann [Vis alle 8 forfattere av denne artikkelen] (2020). Semi-quantitative distribution of excitatory amino acid (glutamate) transporters 1-3 (EAAT1-3) and the cystine-glutamate exchanger (xCT) in the adult murine spinal cord.
  • Zhou, Yun (2020). GABA uptake-functional roles of non-GAT1 transporters.
  • Zhou, Yun & Danbolt, Niels Christian (2019). Glutamate Transporters with Dual Personality.
  • Hu, Qiu Xiang; Zhou, Yun & Danbolt, Niels Christian (2019). The concentration of GABA transporter proteins GAT1 and GAT3 in young adult mouse brain relative to those of glutamate transporter proteins.
  • Hu, Qiu Xiang; Klatt, Gesa; Ottestad-Hansen, Sigrid; Gudmundsrud, Ruben; Massie, Ann & Danbolt, Niels Christian [Vis alle 7 forfattere av denne artikkelen] (2019). Differential Distribution of Glutamate Transporters EAAT1-3 and xCT in murine spinal cord: a semi-quantitative study.
  • Danbolt, Niels Christian & Zhou, Yun (2019). The Functional Importance of Neuronal vs Glial Glutamate Uptake.
  • Zhou, Yun (2018). Glutamate uptake in nerve terminals.
  • Zhou, Yun (2018). Neuronal vs glial glutamate uptake: Resolving the conundrum.
  • Gudmundsrud, Ruben; Ottestad-Hansen, Sigrid; Hu, Qiu Xiang; Danbolt, Niels Christian & Zhou, Yun (2018). The role of glutamate/cystine exchanger (slc7a11) in amyotrophic lateral sclerosis.
  • Danbolt, Niels Christian; Ottestad-Hansen, Sigrid; Hu, Qiu Xiang; Follin-Arbelet, Virginie; Bentea, Eduard & Sato, Hideyo [Vis alle 8 forfattere av denne artikkelen] (2018). The cysteine-glutamate exchanger (xCT, slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain.
  • Zhou, Yun; Hassel, Bjørnar; Eid, Tore & Danbolt, Niels Christian (2018). Axon-terminals expressing EAAT2 (GLT-1; slc1a2) are common in the forebrain and not limited to the hippocampus.
  • Ottestad-Hansen, Sigrid; Hu, Qiu Xiang; Follin-Arbelet, Virginie; Sato, Hideyo; Bentea, Eduard & Massie, Ann [Vis alle 8 forfattere av denne artikkelen] (2017). The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain.
  • Danbolt, Niels Christian; Zhou, Yun; Dhaher, Roni; Parent, Maxime; Yee, Siu-Pok & Hyder, Fahmeed [Vis alle 8 forfattere av denne artikkelen] (2017). Loss of glutamine synthetase initiates a sequence of neuropathological events that culminate in epilepsy and neurodegeneration.
  • Hu, Qiu Xiang; Danbolt, Niels Christian; Eid, Tore & Zhou, Yun (2017). Phenotypic differences between brain- and liver-specific glutamine synthetase knockout mice.
  • Ottestad-Hansen, Sigrid; Zhou, Yun; Follin-Arbelet, Virginie; Sato, Hideyo; Massie, Ann & Danbolt, Niels Christian (2016). The localization of glutamate-cystine exchanger xCT (slc7a11) in mouse brain.
  • Hu, Qiu Xiang; Ottestad-Hansen, Sigrid; Kavanaugh, M.; Danbolt, Niels Christian & Zhou, Yun (2016). Vizualization of the EAAT3 glutamate transporter EAAC1 in mouse kidney and intestine.
  • Wang, Helen; Dhaher, Roni; Farina, M.; Zhou, Yun; Yee, Siu-Pok & Danbolt, Niels Christian [Vis alle 7 forfattere av denne artikkelen] (2015). Brain site specific suppression of glutamine synthetase in mice using an adenoassociated virus knockout approach .
  • Wang, Helen; Dhaher, Roni; Farina, M.; Zhou, Yun; Yee, Siu-Pok & Danbolt, Niels Christian [Vis alle 7 forfattere av denne artikkelen] (2015). Brain site specific suppression of glutamine synthetase in mice using an adenoassociated virus knockout approach.
  • Danbolt, Niels Christian; Zhou, Yun; Xu, Ji & Khakh, Baljit (2015). Generation and characterization of BAC transgenic GABA transporter 2 (GAT2; slc6a13) tdTomato reporter mice .
  • Zhou, Yun; Corbin, Karen; Xiang, Yi-Kong; Eskild, Winnie; Zeisel, Steven H. & Danbolt, Niels Christian (2015). The betaine-GABA transporter (BGT1; slc6a12) is not involved in the inactivation of transmitter GABA, but plays a role in preserving the choline levels in the liver.
  • Danbolt, Niels Christian; Zhou, Yun; Xu, Ji & Khakh, Baljit (2015). Generation and characterization of BAC transgenic GABA transporter 2 (GAT2; slc6a13) tdTomato reporter mice .
  • Zhou, Yun; Corbin, Karen; Xiang, Yi-Kong; Eskild, Winnie; Zeisel, Steven H. & Danbolt, Niels Christian (2015). The betaine-GABA transporter (BGT1; slc6a12) may play its main roles in the liver rather than in the brain .
  • Zhou, Yun; Danbolt, Niels Christian & Kempson, S.A. (2014). The Betaine-GABA transporter. I Preedy, Victor R. (Red.), Betaine - Chemistry, Analysis, Function and Effects. Royal Society of Chemistry. ISSN 9781849738866.
  • Kempson, SA; Zhou, Yun & Danbolt, Niels Christian (2014). The betaine/GABA transporter and betaine: Roles in brain, kidney, and liver. Frontiers in Physiology. ISSN 1664-042X. 5 APR. doi: 10.3389/fphys.2014.00159.
  • Hadera, Mussie Ghezu; Bjørnsen, Lars Petter; Zhou, Yun; Sonnewald, Ursula & Danbolt, Niels Christian (2013). Impairment of glial-neuronal interaction in GLT-1 knockout mice: an NMR spectroscopy study. Journal of Neurochemistry. ISSN 0022-3042. 125, s. 109–109.
  • Hadera, Mussie Ghezu; Bjørnsen, Lars Petter; Zhou, Yun; Sonnewald, Ursula & Danbolt, Niels Christian (2013). Impairment of glial-neuronal interaction in GLT-1 knockout mice: an NMR spectroscopy study.
  • Zhou, Yun; Holmseth, Silvia; Holen, Torgeir & Danbolt, Niels Christian (2011). EVIDENCE AGAINST A ROLE OF THE BETAINE-GABA TRANSPORTER (BGT1, SLC6A12) IN THE CONTROL OF GABA RECEPTOR ACTIVATION. Glia. ISSN 0894-1491. 59, s. S69–S70.
  • Danbolt, Niels Christian; Holmseth, Silvia; Dehnes, Yvette; Huang, Y.; Follin-Arbelet, Virginie & Grutle, N [Vis alle 11 forfattere av denne artikkelen] (2011). QUANTIFICATION AND LOCALIZATION OF THE EAAC1 GLUTAMATE TRANSPORTER IN BRAIN. Glia. ISSN 0894-1491. 59, s. S66–S66.

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Publisert 13. apr. 2011 10:42 - Sist endret 10. mai 2021 12:31

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