Rene Holst

• Haukeland-Parker, Stacey Marie; Jervan, Øyvind; Ghanima, Waleed; Spruit, Martijn A.; Holst, Rene & Tavoly, Mazdak [Vis alle 8 forfattere av denne artikkelen] (2024). Physical activity following pulmonary embolism and clinical correlates in selected patients: a cross-sectional study. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 8(2). doi: 10.1016/j.rpth.2024.102366.
• Gleditsch, Jostein; Jervan, Øyvind; Klok, Frederikus A; Holst, Rene; Hopp, Einar & Tavoly, Mazdak [Vis alle 7 forfattere av denne artikkelen] (2023). Does the clot burden as assessed by the Mean Bilateral Proximal Extension of the Clot score reflect mortality and adverse outcome after pulmonary embolism? Acta Radiologica Open. ISSN 2058-4601. 12(6). doi: 10.1177/20584601231187094. Fulltekst i vitenarkiv
• Hjell, Gabriela; Rokicki, Jaroslav; Szabo, Attila; Holst, Rene; Tesli, Natalia & Bell, Christina [Vis alle 19 forfattere av denne artikkelen] (2023). Impulsivity across severe mental disorders: a cross-sectional study of immune markers and psychopharmacotherapy. BMC Psychiatry. ISSN 1471-244X. 23(1). doi: 10.1186/s12888-023-05154-4. Fulltekst i vitenarkiv
• Jervan, Øyvind; Haukeland-Parker, Stacey Marie; Gleditsch, Jostein; Tavoly, Mazdak; Klok, Frederikus A. & Steine, Kjetil [Vis alle 14 forfattere av denne artikkelen] (2023). The Effects of Exercise Training in Patients With Persistent Dyspnea Following Pulmonary Embolism: A Randomized Controlled Trial. Chest. ISSN 0012-3692. 164(4), s. 981–991. doi: 10.1016/j.chest.2023.04.042. Fulltekst i vitenarkiv
• Bang-Kittilsen, Gry; Egeland, Jens; Ueland, Thor; Andersen, Eivind; Bigseth, Therese Torgersen & Holmen, Tom Langerud [Vis alle 9 forfattere av denne artikkelen] (2023). The relationship between the brain-derived neurotrophic factor and neurocognitive response to physical exercise in individuals with schizophrenia. Psychoneuroendocrinology. ISSN 0306-4530. 157. doi: 10.1016/j.psyneuen.2023.106356. Vis sammendrag

  Physical exercise can improve neurocognition in individuals with schizophrenia, presumably by facilitating neuroplasticity. There is, however, large inter-individual variation in response. The brain-derived neurotrophic factor (BDNF) has been proposed to mediate these effects. The current aim was to investigate the sparsely studied relationship between peripheral resting BDNF and neurocognitive response to physical exercise in individuals with schizophrenia. Method The current study reports secondary analyses of data from a randomized controlled trial (RCT), ClinicalTrials.gov number 02205684, recently reported according to the CONSORT guidelines. Eighty-two individuals with schizophrenia (mean age 37 ± 14 years old, 61% men) were randomly allocated to high-intensity interval training (HIIT) or a comparison group performing low-intensity active video gaming (AVG). Both interventions consisted of 2 sessions/week for 12 weeks. In previously published primary RCT analyses, HIIT and AVG showed comparable small to moderate improvements in neurocognition. We now address the inter-individual variability in neurocognitive response. We apply mediation and moderation analyses for repeated measures designs (MEMORE) and mixed effects models. Results Baseline neurocognition was not significantly correlated with baseline levels of mature BDNF (baseline-mBDNF) or the precursor proBDNF. Nonetheless, baseline-mBDNF , but not baseline proBDNF, moderated the effect of exercise on neurocognition ( p = 0.025) and explained 7% of the variance. The neurocognitive improvement increased with increasing baseline-mBDNF values. The moderating effect of baseline-mBDNF remained significant in a more complex model adding the moderating effects of exercise mode, sex, age, duration of illness and baseline VO 2 max on the outcome (neurocognition). Mean baseline-mBDNF significantly decreased from baseline to post-intervention ( p = 0.036), regardless of exercise mode, differing by sex and associated with improved VO 2 max but not with change in neurocognition. A mediating role of mBDNF on the effect of physical exercise on neurocognition was not supported. Values of proBDNF mainly remained stable from baseline to post-intervention. Conclusion We found that baseline-mBDNF moderated the effect of physical exercise on neurocognition in individuals with schizophrenia and explained a small part of the inter-individual variation in neurocognitive response. Mean mBDNF decreased from baseline to post-intervention, regardless of exercise mode. A mediating role of mBDNF on the effect of exercise on neurocognition was not supported. The inter-individual variation in neurocognitive response and the complex role of peripheral BDNF in physical exercise is still to be elucidated.

• Kabeta, Teshome; Holst, Rene; Wondafrash, Beyene; Frigessi, Arnoldo & Gebremariam, Mekdes (2023). Determinants of household dietary diversity in rural Ethiopia: A household panel study. Journal of Agriculture and Food Research. 12. doi: 10.1016/j.jafr.2023.100550. Fulltekst i vitenarkiv
• Garabet, Lamya Samir Noori; Eriksson, Anna Maria; Tjønnfjord, Eirik; Cui, Xueyan; Olsen, Magnus Kringstad & Jacobsen, Hege [Vis alle 18 forfattere av denne artikkelen] (2022). SARS-CoV-2 vaccines are not associated with hypercoagulability in apparently healthy people. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 7(1). doi: 10.1016/j.rpth.2022.100002. Fulltekst i vitenarkiv
• Leblanc, Marissa Erin; Rueegg, Corina Silvia; Bekiroğlu, Nural; Esterhuizen, Tonya M.; Fagerland, Morten Wang & Falk, Ragnhild Sørum [Vis alle 20 forfattere av denne artikkelen] (2022). Statistical advising: Professional development opportunities for the biostatistician. Statistics in Medicine. ISSN 0277-6715. 41(5). doi: 10.1002/sim.9290. Fulltekst i vitenarkiv
• Bang-Kittilsen, Gry; Engh, John; Holst, Rene; Holmen, Tom Langerud; Bigseth, Therese Torgersen & Andersen, Eivind [Vis alle 8 forfattere av denne artikkelen] (2022). High-intensity interval training may reduce depressive symptoms in individuals with schizophrenia, putatively through improved VO 2 max: A randomized controlled trial. Frontiers in Psychiatry. ISSN 1664-0640. 13, s. 1–15. doi: 10.3389/fpsyt.2022.921689. Vis sammendrag

  High-intensity interval training (HIIT) may improve cardiorespiratory fitness (CRF) and mental health. The current observer-blinded RCT investigates the sparsely studied efficiency of HIIT in reducing psychotic and non-psychotic symptoms in schizophrenia and complements previous studies by investigating whether symptom reduction following HIIT is associated with, putatively partly mediated by, increased VO2max. Methods: Participants (outpatients meeting diagnostic criteria for schizophrenia) were randomized to HIIT (n = 43) or a comparison group performing low-intensity active video gaming (AVG) to control for social interaction (n = 39). Both interventions consisted of two supervised sessions/week for 12 weeks and a 4 months follow-up. Effects on overall symptoms and symptom domains [PANSS (0–6 scale), five-factor model] were estimated using mixed-effects models (intention-to-treat, n = 82). Underlying mechanisms were analyzed using moderated mediation analyses (n = 66). We anticipated that HIIT would reduce overall symptoms, particularly depressive symptoms, more than AVG, and symptom reduction would be associated with, putatively mediated through, improved VO2max. Results: Depressive symptoms (baseline score 3.97, 95% CI: 3.41, 4.52), were −1.03 points more reduced in HIIT than AVG at post-intervention (95% CI: −1.71, −0.35, p = 0.003), corresponding to a small to moderate effect size (d = 0.37) and persisting at follow-up. There was a small reduction in overall symptoms, but no significant between-group differences were observed. Change in VO2max correlated negatively with the change in depressive symptoms. Mediation analysis showed a significant effect of change in VO2max on change in depressive symptoms within HIIT. The total effect was moderated by group, and depressive symptoms were more reduced in HIIT. Direct effects, not mediated through VO2max, were non-significant. Indirect effects, mediated through VO2max, were non-significant, but the moderated mediation test indicated a non-significant trend of 0.4 points (95% CI: −1.188, 0.087) and a larger reduction in depressive symptoms through VO2max in HIIT. Conclusion: HIIT reduced depressive symptoms more than AVG, which persisted at follow-up. HIIT may serve as a complementing treatment option targeting these symptoms in individuals with schizophrenia, even before they reach clinical depression. Depressive symptoms are important to prevent, stabilize, and treat due to their negative implications for psychological wellbeing and long-term functional outcome. Reduction in depressive symptoms was associated with improved VO2max, and non-significant trends in the data supported that improved VO2max may be part of the complex mechanisms underlying the anti-depressive effect of HIIT.

• Hjell, Gabriela; Szabo, Attila; Mørch-Johnsen, Lynn Egeland; Holst, Rene; Tesli, Natalia & Bell, Christina [Vis alle 18 forfattere av denne artikkelen] (2022). Interleukin-18 signaling system links to agitation in severe mental disorders. Psychoneuroendocrinology. ISSN 0306-4530. 140:105721, s. 1–8. doi: 10.1016/j.psyneuen.2022.105721. Fulltekst i vitenarkiv Vis sammendrag

  Objective Agitation is a challenging clinical feature in severe mental disorders, but its biological correlates are largely unknown. Inflammasome-related abnormalities have been linked to severe mental disorders and implicated in animal models of agitation. We investigated if levels of circulating inflammasome-related immune markers were associated with agitation in severe mental disorders. Methods Individuals with a psychotic or affective disorder (N = 660) underwent blood sampling and clinical characterization. Plasma levels of interleukin (IL)‐18, IL-18 binding protein (IL-18BP), IL-18 receptor 1 (IL-18R1), IL-18 receptor accessory protein (IL-18RAP), and IL-1 receptor antagonist (IL-1RA) were measured. Agitation levels were estimated with the Positive and Negative Syndrome Scale Excited Component. Multiple linear- and logistic regression were used to investigate the associations between agitation and the immune markers, while controlling for confounders. The influence of psychotic and affective symptoms was assessed in follow-up analyses. Results Agitation was positively associated with IL-18BP (β = 0.13, t = 3.41, p = 0.0007) after controlling for multiple confounders, including BMI, smoking, medication, and substance use. Adjustment for psychotic, manic, and depressive symptoms did not affect the results. There were no significant associations between agitation and the other investigated immune markers (IL-1RA (β = 0.06, t = 1.27, p = 0.20), IL-18 (β = 0.05, t = 1.25, p = 0.21), IL-18R1 (β = 0.04, t = 1.01, p = 0.31), IL-18RAP (odds ratio = 0.96, p = 0.30)). In a subsample (N = 463), we also adjusted for cortisol levels, which yielded unaltered results. Conclusion Our findings add to the accumulating evidence of immune system disturbances in severe mental disorders and suggest the IL-18 system as a part of the biological correlate of agitation independent of affective and psychotic symptoms.

• Gleditsch, Jostein; Jervan, Øyvind; Haukeland-Parker, Stacey Marie; Tavoly, Mazdak; Geier, Oliver & Holst, Rene [Vis alle 10 forfattere av denne artikkelen] (2022). Effects of pulmonary rehabilitation on cardiac magnetic resonance parameters in patients with persistent dyspnea following pulmonary embolism. International journal of cardiology: Heart and Vasculature (IJCHA). ISSN 2352-9067. 40(June). doi: 10.1016/j.ijcha.2022.100995. Fulltekst i vitenarkiv Vis sammendrag

  Background Persistent dyspnea and reduced exercise capacity is common in pulmonary embolism (PE) survivors. Although improved right ventricular function after pulmonary rehabilitation has been demonstrated in chronic thromboembolic pulmonary hypertension, it is still unknown whether a similar effect also occurs in other patients with dyspnea after pulmonary embolism. Purpose The aim of this study was to explore potential effects of a pulmonary rehabilitation program on cardiac structure and function as assessed with cardiac magnetic resonance (CMR). Material and methods Twenty-six PE survivors with persistent dyspnea were included. Right and left ventricular assessment with CMR was performed before and after an eight-week pulmonary rehabilitation program. Results Dyspnea as measured by the Shortness of Breath Questionnaire improved significantly after rehabilitation: 15 (IQR: 7–31) versus 8 (IQR: 3–17). Absolute right ventricular global longitudinal strain by CMR was reduced from 19% to 18% (95% CI of difference: 0–3 percent points), and absolute RV lateral strain from 26% to 24% (95% CI of difference: 1–4 percent points). Right ventricular mass was reduced after rehabilitation from 49 g to 44 g (95% CI of difference: 2–8 g). Conclusion Although there was a substantial improvement in dyspnea after rehabilitation, we found only a minor reduction in absolute right ventricular longitudinal strain and right ventricular mass. No other CMR parameter changed. We therefore suggest that rehabilitation effect of in this patient group was not primarily mediated by cardiac adaptions.

• Lerang, Frode; Holst, Rene; Henriksen, Magne; Wåhlberg, Henrik & Jelsness-Jørgensen, Lars-Petter (2022). Antitumour necrosis factor alpha treatment in Crohn's disease: long-term efficacy, side effects and need for surgery. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 57(8), s. 921–929. doi: 10.1080/00365521.2022.2042592.
• Sækmose, Susanne Gjørup; Holst, Rene; Lottenburger, Tine; Ytting, Henriette; Nielsen, Hans Jørgen & Junker, Peter [Vis alle 8 forfattere av denne artikkelen] (2021). Circadian, Week-to-Week, and Physical Exercise-Induced Variation of Serum Microfibrillar-Associated Protein 4. Biomarker Insights. ISSN 1177-2719. 16. doi: 10.1177/11772719211016359. Fulltekst i vitenarkiv
• Gleditsch, Jostein; Jervan, Øyvind; Tavoly, Mazdak; Geier, Oliver; Holst, Rene & Klok, Frederikus A [Vis alle 8 forfattere av denne artikkelen] (2021). Association between myocardial fibrosis, as assessed with cardiac magnetic resonance T1 mapping, and persistent dyspnea after pulmonary embolism. International journal of cardiology: Heart and Vasculature (IJCHA). ISSN 2352-9067. 38. doi: 10.1016/j.ijcha.2021.100935. Fulltekst i vitenarkiv
• Kristiansen, Anne Lene; Himberg-Sundet, Anne; Bjelland, Mona; Lien, Nanna; Holst, Rene & Andersen, Lene Frost (2021). Exploring intervention components in association with changes in preschool children’s vegetable intake: the BRA-study. BMC Research Notes. ISSN 1756-0500. 14(214), s. 1–6. doi: 10.1186/s13104-021-05629-1. Fulltekst i vitenarkiv
• Birkeland, Eline; Gharagozlian, Sedegheh; Gulseth, Hanne L.; Birkeland, Kåre I.; Hartmann, Bolette & Holst, Jens J. [Vis alle 8 forfattere av denne artikkelen] (2021). Effects of prebiotics on postprandial GLP-1, GLP-2 and glucose regulation in patients with type 2 diabetes: A randomised, double-blind, placebo-controlled crossover trial. Diabetic Medicine. ISSN 0742-3071. 38(10), s. 1–10. doi: 10.1111/dme.14657. Fulltekst i vitenarkiv
• Svendsen, Anders J.; Westergaard, Marie Christine Wulff; Draborg, Anette Holck; Holst, René; Kyvik, Kirsten O. & Jakobsen, Marianne A. [Vis alle 8 forfattere av denne artikkelen] (2021). Altered Antibody Response to Epstein-Barr Virus in Patients With Rheumatoid Arthritis and Healthy Subjects Predisposed to the Disease. A Twin Study. Frontiers in Immunology. ISSN 1664-3224. 12, s. 1–8. doi: 10.3389/fimmu.2021.650713. Fulltekst i vitenarkiv
• Juhl, Claus Bogh; Holst, René; Mundbjerg, Lene Hymøller; Stolberg, Charlotte; Gran, Jon Michael & Thomsen, Gert Frank (2021). Effect of bariatric surgery on employment status -a 7 years controlled nationwide registry study. BMJ Open. ISSN 2044-6055. 11(6). doi: 10.1136/bmjopen-2020-042845. Fulltekst i vitenarkiv
• Jervan, Øyvind; Gleditsch, Jostein; Tavoly, Mazdak; Klok, Frederikus A.; Rashid, Diyar Nori Mohamad & Holst, René [Vis alle 9 forfattere av denne artikkelen] (2021). Pulmonary and cardiac variables associated with persistent dyspnea after pulmonary embolism. Thrombosis Research. ISSN 0049-3848. 201, s. 90–99. doi: 10.1016/j.thromres.2021.02.014. Fulltekst i vitenarkiv
• Hunderi, Jon Olav; Rolfsjord, Leif Bjarte; Carlsen, Karin C. Lødrup; Holst, René; Bakkeheim, Egil & Berents, Teresa Løvold [Vis alle 8 forfattere av denne artikkelen] (2020). Virus, allergic sensitisation and cortisol in infant bronchiolitis and risk of early asthma. European Respiratory Journal Open Research (ERJ Open Research). ISSN 2312-0541. 6(1). doi: 10.1183/23120541.00268-2019. Fulltekst i vitenarkiv Vis sammendrag

  Background: Acute bronchiolitis during infancy and human rhinovirus (HRV) lower respiratory tract infections increases the risk of asthma in atopic children. We aimed to explore whether specific viruses, allergic sensitisation or cortisol levels during acute bronchiolitis in infancy increase the risk of early asthma, using recurrent wheeze as a proxy. Methods: In 294 children with a mean (range) age of 4.2 (0–12) months enrolled during hospitalisation for acute infant bronchiolitis, we analysed virus in nasopharyngeal aspirates, serum specific immunoglobulin E against food and inhalant allergens, and salivary morning cortisol. These factors were assessed by regression analyses, adjusted for age, sex and parental atopy, for risk of recurrent wheeze, defined as a minimum of three parentally reported episodes of wheeze at the 2-year follow-up investigation. Results: At 2 years, children with, compared to without, recurrent wheeze had similar rates of respiratory syncytial virus (RSV) (82.9% versus 81.8%) and HRV (34.9% versus 35.0%) at the acute bronchiolitis, respectively. During infancy, 6.9% of children with and 9.2% of children without recurrent wheeze at 2 years were sensitised to at least one allergen (p=0.5). Neither recurrent wheeze nor incidence rate ratios for the number of wheeze episodes at 2 years were significantly associated with specific viruses, high viral load of RSV or HRV, allergic sensitisation, or morning salivary cortisol level during acute bronchiolitis in infancy. Conclusion: In children hospitalised with acute infant bronchiolitis, specific viruses, viral load, allergic sensitisation and salivary morning cortisol did not increase the risk of early asthma by 2 years of age.

• Frønæs, Synne Grønvold; Jørgensen, Camilla Tøvik; Dahm, Anders Erik A; Wik, Hilde Skuterud; Gleditsch, Jostein & Raouf, Nezar [Vis alle 9 forfattere av denne artikkelen] (2020). Safety of a strategy combining D-dimer testing and whole-leg ultrasonography to rule out deep vein thrombosis. Blood Advances. ISSN 2473-9529. 4(20), s. 5002–5010. doi: 10.1182/BLOODADVANCES.2020002173. Fulltekst i vitenarkiv
• Frønæs, Synne Grønvold; Dahm, Anders Erik Astrup; Skuterud Wik, Hilde; Jørgensen, Camilla Tøvik; Gleditsch, Jostein & Raouf, Nezar [Vis alle 9 forfattere av denne artikkelen] (2020). Safety and feasibility of rivaroxaban in deferred workup of patients with suspected deep vein thrombosis. Blood Advances. ISSN 2473-9529. 4(11), s. 2468–2476. doi: 10.1182/bloodadvances.2020001556. Fulltekst i vitenarkiv
• Hjell, Gabriela; Mørch-Johnsen, Lynn; Holst, René; Tesli, Natalia; Bell, Christina & Lunding, Synve Hoffart [Vis alle 13 forfattere av denne artikkelen] (2020). Disentangling the relationship between cholesterol, aggression, and impulsivity in severe mental disorders. Brain and Behavior. ISSN 2162-3279. 10(9). doi: 10.1002/brb3.1751. Fulltekst i vitenarkiv
• Karlsvik, Tina Margrethe; Borgenvik, Thore Langfeldt; Aadalen, Mirjam; Utne, Kristin Kornelia; Førsund, Eli & Jørgensen, Camilla Tøvik [Vis alle 9 forfattere av denne artikkelen] (2020). Fatigue after initiating rivaroxaban for venous thromboembolism. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 4(4), s. 582–585. doi: 10.1002/rth2.12312. Fulltekst i vitenarkiv
• Kristiansen, Anne Lene; Medin, Anine Christine; Bjelland, Mona; Himberg-Sundet, Anne; Lien, Nanna & Holst, René [Vis alle 7 forfattere av denne artikkelen] (2020). Long-term effects of a cluster randomized controlled kindergarten-based intervention trial on vegetable intake among Norwegian 3-5-year-olds: the BRA-study. BMC Research Notes. ISSN 1756-0500. 13. doi: 10.1186/s13104-020-4892-x. Fulltekst i vitenarkiv Vis sammendrag

  OBJECTIVE: To report on long-term effects of a cluster randomized controlled kindergarten-based intervention trial, which aimed to increase vegetable intake among Norwegian preschool children (3-5 years at baseline). The effects of the intervention at follow-up 1 (immediately post-intervention) have previously been published. This paper presents the effects of the intervention from baseline to follow-up 2 (12 months post-intervention). RESULTS: Parental consents were obtained for 633 out of 1631 eligible children (response rate 38.8%). The effects of the intervention from baseline to follow-up 2 were assessed by mixed-model analyses taking the clustering effect of kindergartens into account. Children's vegetable intake was reported by the parents at baseline (spring 2015), at follow-up 1 (spring 2016) and at follow-up 2 (spring 2017). No significant long-term effects in child vegetable intake were found. A mean difference of - 0.1 times per day (95% CI - 0.5, 0.2) (P = 0.44) was found for the daily frequency of vegetable intake. A mean difference of - 0.2 different kinds of vegetables eaten over a month (95% CI - 1.0, 0.7) (P = 0.70) was found and for daily amount of vegetables a mean difference of - 15.0 g vegetables (95% CI - 38.0, 8.0) (P = 0.19) was found. Trial registration International Standard Randomised Controlled Trials ISRCTN51962956 (http://www.isrctn.com/ISRCTN51962956). Registered 21 June 2016 (retrospectively registered).

• Kristiansen, Anne Lene; Bjelland, Mona; Himberg-Sundet, Anne; Lien, Nanna; Holst, René & Andersen, Lene Frost (2019). Effects of a cluster randomized controlled kindergarten-based intervention trial on vegetable consumption among Norwegian 3–5-year-olds: the BRA-study. BMC Public Health. ISSN 1471-2458. 19(1), s. 1–10. doi: 10.1186/s12889-019-7436-3. Fulltekst i vitenarkiv Vis sammendrag

  Background: Early childhood represents a critical period for the establishment of long-lasting healthy dietary habits. Limited knowledge exists on how to successfully increase vegetable consumption among preschool children. The overall aim of the present study was to improve vegetable intake among preschool children in a kindergarten-based randomized controlled trial. Methods: The target group was preschool children born in 2010 and 2011, attending public or private kindergartens in two counties in Norway. Data about child intake of vegetables were collected by three methods. First, parents filled in a web-based questionnaire of the child’s vegetable intake. Second, among a subsample, trained researchers observed children’s vegetable intake in the kindergarten. Thirdly, a parental web-based 24-h recall assessing the child’s vegetable intake was filled in. For allocation of kindergartens to intervention and control groups, a stratified block randomization was used. Multiple intervention components were implemented from September 2015 to February 2016 and components focused at influencing the four determinants availability, accessibility, encouragement and role modelling. The effect of the intervention from baseline (spring 2015) to follow-up 1 (spring 2016) was assessed by mixed-model analysis taking the clustering effect of kindergartens into account. Results: Parental consent was obtained for 38.8% of the children (633 out of 1631 eligible children). Based on the observational data in the kindergarten setting (n 218 in the control group and n 217 in the intervention group), a tendency to a small positive effect was seen as a mean difference of 13.3 g vegetables/day (95% CI: − 0.2, 26.9) (P = 0.054) was observed. No significant overall effects were found for the total daily vegetable intake or for the parental reported frequency or variety in vegetable intake. Conclusions: Based on the observational data in the kindergarten setting, a tendency to a small positive effect was seen with a mean difference of about 13 g vegetables/day, while no other effects on child vegetable intake were found. Additionally, further research to understand the best strategies to involve parents in dietary interventions studies is warranted.

• Wolderslund, Maiken; Kofoed, Poul-Erik; Holst, René; Waidtløw, Karin & Ammentorp, Jette (2019). Outpatients' recall of information when provided with an audio recording: A mixed-methods study. Patient Education and Counseling. ISSN 0738-3991. doi: 10.1016/j.pec.2019.08.030.
• Holte, Kari; Ersdal, Hege Langli; Eilevstjønn, Joar; Thallinger, Monica; Linde, Jørgen Erland & Klingenberg, Claus [Vis alle 10 forfattere av denne artikkelen] (2019). Predictors for expired CO2 in neonatal bag-mask ventilation at birth: observational study. BMJ Paediatrics Open. ISSN 2399-9772. 3(1). doi: 10.1136/bmjpo-2019-000544. Fulltekst i vitenarkiv
• Garabet, Lamya Samir Noori; Ghanima, Waleed Khalid; Jonassen, Christine Monceyron; Skov, Vibe; Holst, René & Mowinckel, Marie-Christine [Vis alle 12 forfattere av denne artikkelen] (2019). Effect of thrombopoietin receptor agonists on markers of coagulation and P-selectin in patients with immune thrombocytopenia. Platelets. ISSN 0953-7104. 30(2), s. 206–212. doi: 10.1080/09537104.2017.1394451.
• Rutherford, Ole-Christian Walter; Jonasson, Christian; Ghanima, Waleed Khalid; Holst, René & Halvorsen, Sigrun (2018). New score for assessing bleeding risk in patients with atrial fibrillation treated with NOACs. Open heart. ISSN 2053-3624. 5(1). doi: 10.1136/openhrt-2018-000931. Fulltekst i vitenarkiv
• Pedersen, Jens Kristian; Holst, René; Primdahl, Jette; Svendsen, Anders Jørgen & Hørslev-Petersen, Kim (2018). Mortality and its predictors in patients with rheumatoid arthritis: a Danish population-based inception cohort study. Scandinavian Journal of Rheumatology. ISSN 0300-9742. 47(5), s. 371–377. doi: 10.1080/03009742.2017.1420223.
• Pedersen, Malene Roland; Moller, Henrik; Osther, Palle Jorn Sloth; Vedsted, Peter; Holst, Rene & Rafaelsen, Soren Rafael (2017). Comparison of Tissue Stiffness Using Shear Wave Elastography in Men with Normal Testicular Tissue, Testicular Microlithiasis and Testicular Cancer. Ultrasound International Open. ISSN 2199-7152. 3(4), s. E150–E155. doi: 10.1055/s-0043-116660.
• Madsen, Niels & Holst, René (2017). Development and testing of a separator frame in a Norway lobster Nephrops norvegicus fishery. Fisheries Science. ISSN 0919-9268. s. 1–10. doi: 10.1007/s12562-017-1138-5.
• Berggren-Olsen, Mette Marie; Rauff-Mortensen, Andreas; Holst, René; Houlind, Kim Christian & Birke-Sorensen, Hanne (2017). Monitoring of Free Flaps with Combined Tissue Spectrophotometry and Laser Doppler Flowmetry in an Animal Experimental Model. Journal of reconstructive microsurgery. ISSN 0743-684X. 33(8), s. 579–586. doi: 10.1055/s-0037-1603735.
• Indrelid, Stine Anita; Kleiveland, Charlotte Ramstad; Holst, René; Jacobsen, Morten & Lea, Tor Erling (2017). The soil bacterium Methylococcus capsulatus bath interacts with human dendritic cells to modulate immune function. Frontiers in Microbiology. ISSN 1664-302X. 8. doi: 10.3389/fmicb.2017.00320. Fulltekst i vitenarkiv
• Leonardsen, Ann-Chatrin Linqvist; Grøndahl, Vigdis Abrahamsen; Ghanima, Waleed Khalid; Storeheier, Espen; Schönbeck, Anders & Løken, Thor-Asbjørn [Vis alle 10 forfattere av denne artikkelen] (2017). Evaluating patient experiences in decentralised acute care using the Picker Patient Experience Questionnaire; methodological and clinical findings. BMC Health Services Research. ISSN 1472-6963. 17. doi: 10.1186/s12913-017-2614-4. Fulltekst i vitenarkiv
• Jukarainen, Sakari; Holst, René; Dalgård, Christine; Piirila, Paivi; Lundbom, Jesper & Hakkarainen, Antti [Vis alle 12 forfattere av denne artikkelen] (2017). Cardiorespiratory fitness and adiposity as determinants of metabolic health-pooled analysis of two twin cohorts. Journal of Clinical Endocrinology and Metabolism (JCEM). ISSN 0021-972X. 102(5), s. 1520–1528. doi: 10.1210/jc.2016-3435.
• Madsen, Niels; Holst, René; Frandsen, Rikke P. & Hansen, Kurt (2017). Development and test of selective sorting grids used in the Norway lobster (Nephrops norvegicus) fishery. Fisheries Research. ISSN 0165-7836. 185, s. 26–33. doi: 10.1016/j.fishres.2016.10.002.
• Roaldsnes, Christina; Holst, René; Frederiksen, Henrik & Ghanima, Waleed Khalid (2017). Myeloproliferative neoplasms: trends in incidence, prevalence and survival in Norway. European Journal of Haematology. ISSN 0902-4441. 98(1), s. 85–93. doi: 10.1111/ejh.12788.
• Utne, Kristin Kornelia; Tavoly, Mazdak; Skuterud Wik, Hilde; Jelsness-Jørgensen, Lars-Petter; Holst, René & Sandset, Per Morten [Vis alle 7 forfattere av denne artikkelen] (2016). Health-related quality of life after deep vein thrombosis. SpringerPlus. ISSN 2193-1801. 5(1). doi: 10.1186/s40064-016-2949-z.
• Pøhl, Mette; Olsen, Karen Ege; Holst, Rene; Dønnem, Tom; Busund, Lill-Tove & Bremnes, Roy M. [Vis alle 11 forfattere av denne artikkelen] (2016). Keratin 34betaE12/keratin7 expression is a prognostic factor of cancer-specific and overall survival in patients with early stage non-small cell lung cancer. Acta Oncologica. ISSN 0284-186X. 55(2), s. 167–177. doi: 10.3109/0284186X.2015.1049291.
• Kvalsvik, Kurt; Misund, Ole Arve; Engås, Arill; Gamst, Kjell; Holst, Rene & Galbraith, Derek [Vis alle 7 forfattere av denne artikkelen] (2002). Size selection of large catches: using sorting grid in pelagic mackerel trawl. Fisheries Research. ISSN 0165-7836. 59, s. 129–148.

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• Jervan, Øyvind; Haukeland-Parker, Stacey Marie; Gleditsch, Jostein; Tavoly, Mazdak; Klok, Frederikus A. & Steine, Kjetil [Vis alle 14 forfattere av denne artikkelen] (2023). Rehabilitation to improve exercise capacity and quality of life after pulmonary embolism.
• Leoncio Netto, Waldir & Holst, Rene (2022). TruncExpFam: Truncated Exponential Family. Vis sammendrag

  Handles truncated members from the exponential family of probability distributions. Contains functions such as rtruncnorm() and dtruncpois(), which are truncated versions of rnorm() and dpois() from the stats package that also offer richer output containing, for example, the distribution parameters. It also provides functions to retrieve the original distribution parameters from a truncated sample by maximum-likelihood estimation.

• Grøvle, Lars; Hasvik, Eivind Olay; Holst, Rene & Haugen, Anne Julsrud (2022). NSAIDs in sciatica (NIS): study protocol for an investigator-initiated multicentre, randomized placebo-controlled trial of naproxen in patients with sciatica. Trials. ISSN 1745-6215. 23(1). doi: 10.1186/s13063-022-06441-3. Fulltekst i vitenarkiv
• Haukeland-Parker, Stacey Marie; Jervan, Øyvind; Johannessen, Hege Hølmo; Gleditsch, Jostein; Stavem, Knut & Steine, Kjetil [Vis alle 11 forfattere av denne artikkelen] (2021). Pulmonary rehabilitation to improve physical capacity, dyspnea, and quality of life following pulmonary embolism (the PeRehab study): study protocol for a two-center randomized controlled trial. Trials. ISSN 1745-6215. 22, s. 1–9. doi: 10.1186/s13063-020-04940-9. Fulltekst i vitenarkiv

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