Bjarne Bogen

Image of Bjarne Bogen
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Phone +47-23073015
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Visiting address Sognsvannsveien 20 Rikshospitalet 0372 OSLO
Postal address Postboks 4950 Nydalen 0424 OSLO

Academic interests

Bjarne Bogen has an interest in  immunology of T and B lymphocytes,  autoimmune diseases, immunosurveillance of cancer, and development of more powerful vaccines. Below is a short overview of studies in which many co-workers contributed substantially over the years (see original research reports).

1. Idiotype-driven T-B collaboration, autoimmune diseases and development of B cell cancers. Idiotopes(Id) are antigenic determinants localized to immunoglobulin (Ig) Variable (V) regions.   Bogen described that B cells process their Ig receptor  (BCR) and that fragments of the variable (V) regions are presented on Major Histocompatibility Complex (MHC) class II molecules to Id-specific CD4+ T cells. This results in Id-driven T-B collaboration. In subsequent work, he showed that chronic Id-driven T-B collaboration could result in autoimmune diseases and development of B lymphomas (PNAS-89, EMBO-J-89, Cell-91, EMBO-J-93, EJI-99, JI -04, JI -05, JEM-07, Am J Pathol-09).

2. Immunosurveilance of cancer mediated by CD4+ T cells. Bogen showed that Id-specific TCR-transgenic mice resist challenges with Id+ B lymphoma cells and multiple myeloma cells. He showed that Ig secreted by the tumor cells were taken up by dendritic cells and macrophages infiltrating the tumor. These latter cells processed the monoclonal Ig and presented Id-peptides on their MHC II molecules to Id-specific CD4+ T cells that entered the tumor after first beeing stimulated in the draining lymph node. The tumor-infiltrating CD4+ T cells were of a Th1 type and secreted IFNg that activated macrophages to become cytotoxic to the cancer cells (PNAS-94, PNAS -00, Blood -01, Blood -03, Immunity -05, Cancer Res -09, Nat. Commun. -11)

3. Novel vaccine molecules: Troybodies and Vaccibodies. In Troybodies, T cell epitopes are inserted into loops between beta-strands in Ig constant domains. Next, such modified Ig is equipped with V-regions that target antigen presenting cells (APC). This results in enhanced T cell epitope presentation on MHC molecules of the APC,  and increasedT cell responses (Nat Biotech-89, PNAS-2001, JI -02, JI-03, EJI-05 etc.). In Vaccibodies, large antigens with intact B cell determinants are inserted into  Ig-based homodimers. The Vaccibodies are targeted to APC either by use of natural ligands or scFv specific for APC. Vaccibodies increase both antibody and T cells responses.  They may be administered as DNA vaccines. Currently, vaccibodies are developed for a number of differents diseases such as influenza, HIV, tubeculosis and certain cancers.(Mol Ther -06, JI -07, Blood -07, Vaccine -10, Eur J Hematol -11).

Courses taught

  • Bjarne Bogen is responsible for the teaching programme in immunology at The Medical Faculty
  • He mainly teaches basic immunology in the 3. semester
  • He has, together with Ludvig Munthe, written a textbook in immunology (Immunologi, Universitetsforlaget, 2000, 2nd edition 2007)

Background

1977 - MD, University of Oslo

1977-78 Intern (surgery, internal medicine, general practice) at Sandnassjøen Hospital and Lurøy/Træna.

1979-1984 PhD student ans assistent professor, University of Tromsø

1984: PhD University of Tromsø

1985 and parts of 86 and 87: Member and visitor, Basel Institute for Immunology

1986 - present: Associate professor and professor (1993), the Medical Faculty, University of Oslo

1991: Specialist in Immunology and transfusion Medicine (the Norwegian Medical Association).

1995 - present: Senior consultant, Oso University Hospital -Rikshospitalet

1989 - 2004: Adjunct professor, Norwegian college of Veterinary Medicine

1996-97: Sabbatical at Stanford University

2004-2005: Sabbatical at Dana Farber Cancer Institute/Harvard University

Awards

  •  Innovation Prize , University of Oslo/The Oslo Research Park
  • The Medinnova Prize
  • The Tano-Aschehoug Prize
  • Senior Research Award, U.S. Multiple Myeloma Research Foundation

Collaboration

Bjarne Bogen has over the years collaborated with numerous investigators and labs as should be clear from the list of publications. His research group is presently member of the CoE Centre for Immune Immune Regulation sponsered by the Research Council of Norway.

Tags: multiple myeloma, B cell lymphomas, Nordic, T cells, USA, China, B cells, autoimmunity, India, Immunology, Japan, Life sciences, Global South, vaccine molecules

Publications

            Weiss S, Bogen B (1989) B lymphoma cells process and present their endogenous immunoglobulin to MHC-restricted T cells. Proc Natl Acad Sci USA 86:282-287

                      

            Bogen B, Lambris JD (1989) Minimum length of an idiotypic peptide and a model for its binding to a major histocompatibility complex class II molecule. EMBO Journal 8:1947-1952

 

            Weiss S, Bogen B (1991) MHC class II-restricted presentation of intracellular antigen. Cell 64:767-776

                                                          

            Bogen B, Dembic Z, and Weiss S (1993) Clonal  deletion of specific thymocytes by an immunoglobulin idiotype.EMBO Journal 12:357-363

          

            Lauritzsen G.F, Weiss S, Dembic Z, and Bogen B (1994) Naive idiotype-specific CD4+ T cells and immunosurveillance of B cell tumors.Proc Natl Acad Sci USA 91:5700-5704

                                              

            Lunde, E., Munthe, L.A., Vabø, A. Sandlie, I, Bogen, B (1999). Antibodies engineered with anti IgD-specificity efficiently deliver integrated T cell epitopes for antigen presentation by B cells.  Nature Biotechnology, 17:670-75

 

            Djerbi, M., Screpanti, V., Anca,IC, Bogen, B., Biberfeld, P. and Grandien, A (1999). The inhibitor of death receptor signaling FLIP defines a new class of tumor progression factors. J.Exp.Med.  190: 1025-1031

 

            Dembic,Z, Schenk, K., , Bogen, B (2000). Dendritic cells purified from myeloma are primed with tumor-specific antigen (idiotype) and activate CD4+ T cells. Proc.Natl. Acad. Sci (U.S.A). 97:2697-2702.

 

            Dembic, Z., Røttingen, J-A, Dellacasagrande, J. Schenk, K., Bogen, B.(2001)Phagocytic dendritic cells from myelomas activate tumor-specific T cells at a single cell level. Blood, 97:2808-2814

 

            Rasmussen, IB, Lunde, E., Michaelsen. TE. Bogen, B. Sandlie, I (2001). A new principle for delivery of T cell epitopes to antigen presenting cells applied to peptides from influenza virus, ovalbumin and hen egg lysozyme: Implications for peptide  

            vaccination. Proc.Natl. Acad. Sci (U.S.A). 98: 10296-10301                  

          

            Lunde E., Western K.H., Rasmussen I B., Sandlie I, Bogen B (2002). Efficient delivery of T-cell epitopes to APC by use of MHC class II-specific antibodies. J. Immunol. 168:2154-2162

 

            Lundin KU, Hofgaard PO, Omholt H, Munthe, LA, Corthay A, Bogen B (2003). Therapeutic effect of idiotype-specific CD4+ T cells against B-cell lymphoma in the absence of anti-idiotypic antibodies. Blood 102:605-612, 2003

 

           Schjetne, K.W., Thompson K.M., Fleckenstein B., Aarvak T., Flo T.H., Iversen J.G:, Espevik T., Bogen B (2003). Cutting edge: Link between innate and adaptive immunity: Toll like receptor 2 (TLR 2) captures antigen for MHC class II presentation to CD4+ T cells.  

           J.  Immunol. 171: 32–36, 2003.

 

           Munthe, L A., Os, A., Zangani, M, Bogen, B. MHC-Restricted Ig V Region-Driven T-B Lymphocyte Collaboration: B Cell Receptor Ligation Facilitates Switch to IgG Production.

 

           J .Immunol 2004 Jun 15;172(12):7476-84.

 

           Corthay A, Skovseth DK, Lundin KU, Rosjo E, Omholt H, Hofgaard PO, Haraldsen G, Bogen B. Primary Antitumor Immune Response Mediated by CD4(+) T Cells. Immunity. 2005 Mar;22(3):371-83.

 

          Munthe, LA, Corthay, A, Os, A, Zangani, M, Bogen, B:systemic autoimmune disease caused by autoreactive B cells that receive chronic help from Ig v-region-specific T cells. J. Immunol 2005, 15. 175, 2391-400

 

           FredriksenAB, Sandlie I,  Bogen B. DNA vaccines increase immunogenicity of idiotypic tumor antigen by targeting novel fusion proteins to antigen presenting cells. Mol Ther. 2006 Apr;13(4):776-85.

        

                      Husebye, H, Halaas, O, Stenmark, H, Tunheim, G, Sandanger, O, Bogen, B, Brech, A, Latz, E, Espevik, T. Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. EMBO-J 2006 Feb 22;25(4):683-92.

         

           Schjetne, KW, Fredriksen, AB, Bogen, B .Delivery of antigen to CD40 induces protective immune responses against tumors. J Immunol. 2007 , 178: 4169-76.

 

          Zangani MM, Frøyland M., Qui, GY, Meza-Zepeda, LA, Kutok, JL, Thompson, KM, Munthe LA, Bogen, B. Lymphomas can develop from B cells chronically helped by idiotype-specific T cells. J.Exp.Med. 2007, 204:1189-91.

 

         Fredriksen, AB, Bogen B. Chemokine-idiotype fusion DNA vaccines are potentiated by bivalency and xenogeneic sequences. Blood. 2007, 110(6):1797-805

       

         Flobakk, M, Rasmussen, I, Lunde, E, Frigstad, T, Berntzen, G, Michaelsen, TE, Bogen, B, Sandlie, I.Processing of an Antigenic Sequence from IgG Constant Domains for Presentation by MHC Class II.  J Immunol. 2008 Nov 15;181(10):7062-72

 

        Zangani, M; Carlsen, H; Kielland, A; Os, A; Hauglin, H, Blomhoff, R; Munthe, LA,Bogen, B. Tracking early autoimmune disease by bioluminescent imaging of NF-kB activation reveals pathology in multiple organ systems. Am. J. Pathol. 2009, 174: 1358- 1367.

 

        Corthay, A, Lundin, K, Lorvik KB,Hofgaard, PO, Bogen, B. Secretion of tumor-specific antigen by myeloma cells enhances cancer immunosurveillance by CD4+ T cells. Cancer Research, 2009 Jul 15;69(14):5901-7.

 

      Jacobsen JT, Lunde E, Sundvold-Gjerstad V, Munthe LA, Bogen B. The celllular mechanism by which complementary Id(+) and anti-Id antibodies communicate: T cells integrated into idiotypic regulation ..Immunol Cell Biol.88: 515-22, 2010.

     

       Holmøy, T, vartdal, V, Hestvik, AL, Munthe, LA, Bogen, B. the idiotypic connection: linking infection and multiple sclerosis. Trends Immunol 2010, 31: 56-62

 

        Ruffini PA, Grødeland G, Fredriksen, Bogen, B: Human chemokine MIP1aincreases efficiency of targeted DNA fusion vaccines. Vaccine 2010 Dec 16;29(2):191-9.

 

        Haabeth OAW, Lorvik KB, Hammarström C, Donaldson IM, Haraldsen G, Bogen B, Corthay A. Inflammation driven by tumor-specific Th1 cells protects against B-cell cancer. Nat Commun. 2011 Mar;2:240.

  • Anderson, Ane Marie; Baranowska-Hustad, Marta Natalia; Braathen, Ranveig; Grødeland, Gunnveig & Bogen, Bjarne (2018). Simultaneous targeting of multiple hemagglutinins to APCs for induction of broad immunity against influenza. Journal of Immunology.  ISSN 0022-1767.  200(6), s 2057- 2066 . doi: 10.4049/jimmunol.1701088
  • Braathen, Ranveig; Spång, Heidi Cecilie Larsen; Lindeberg, Mona Mari; Fossum, Even; Grødeland, Gunnveig & Bogen, Bjarne (2018). The Magnitude and IgG Subclass of Antibodies Elicited by Targeted DNA Vaccine Are Influenced by Specificity for APC Surface Molecules. ImmunoHorizons.  ISSN 2573-7732.  2(1), s 38- 53 . doi: https://goi.org/10.4049/immunohorizons.1700038 Show summary
  • Fauskanger, Marte; Haabeth, Ole Audun; Skjeldal, Frode Miltzow; Bogen, Bjarne & Tveita, Anders (2018). Tumor killing by CD4+ T cells is mediated via induction of inducible nitric oxide synthase-dependent macrophage cytotoxicity. Frontiers in Immunology.  ISSN 1664-3224.  9:1684, s 1- 13 . doi: 10.3389/fimmu.2018.01684
  • Andersen, Tor Kristian; Zhou, Fan; Cox, Rebecca Jane; Bogen, Bjarne & Grødeland, Gunnveig (2017). A DNA vaccine that targets hemagglutinin to antigen-presenting cells protects mice against H7 influenza. Journal of Virology.  ISSN 0022-538X.  91:e01340-17(23), s 1- 13 . doi: 10.1128/JVI.01340-17 Full text in Research Archive.
  • Deloizy, Charlotte; Fossum, Even; Barnier-Quer, Christophe; Urien, Céline; Chrun, Tiphany; Duval, Audrey; Codjovi, Maelle; Bouguyon, Edwige; Maisonnasse, Pauline; Hervé, Pierre-Louis; Barc, Céline; Boulesteix, Olivier; Pezant, Jérémy; Chevalier, Christophe; Collin, Nicolas; Dalod, Marc; Bogen, Bjarne; Bertho, Nicolas & Schwartz-Cornil, Isabelle (2017). The anti-influenza M2e antibody response is promoted by XCR1 targeting in pig skin. Scientific Reports.  ISSN 2045-2322.  7:7639, s 1- 12 . doi: 10.1038/s41598-017-07372-9
  • Gudjonsson, Arnar; Lysén, Anna Karin Christina; Balan, Sreekumar; Gjerstad, Vibeke Sundvold; Arnold-Schrauf, Catharina; Richter, Lisa Maria; Bækkevold, Espen Sønderaal; Dalod, Marc; Bogen, Bjarne & Fossum, Even (2017). Targeting influenza virus hemagglutinin to Xcr1+ dendritic cells in the absence of receptor-mediated endocytosis enhances protective antibody responses. Journal of Immunology.  ISSN 0022-1767.  198(7), s 2785- 2795 . doi: 10.4049/jimmunol.1601881
  • Høglund, Rune Alexander; Lossius, Peter Andreas Vold; Johansen, Jorunn; Homan, Jane; Saltyte Benth, Jurate; Robins, Harlan; Bogen, Bjarne; Bremel, Robert D & Holmøy, Trygve (2017). In silico prediction analysis of idiotope-driven T-B cell collaboration in multiple sclerosis. Frontiers in Immunology.  ISSN 1664-3224.  8 . doi: 10.3389/fimmu.2017.01255 Full text in Research Archive.
  • Lilly, Cameron L; Villa, Nancy Y; de Matos, Ana Lemos; Ali, Haider M; Dhillon, Jess-Karan S; Hofland, Tom; Rahman, Masmudur M; Chan, Winnie; Bogen, Bjarne; Cogle, Christopher & McFadden, Grant (2017). Ex Vivo Oncolytic Virotherapy with Myxoma Virus Arms Multiple Allogeneic Bone Marrow Transplant Leukocytes to Enhance Graft versus Tumor. Molecular Therapy - Oncolytics.  ISSN 2372-7705.  4, s 31- 40 . doi: 10.1016/j.omto.2016.12.002
  • Park, Bo Mi; Kim, Eun Jin; Nam, Hye Yeon; Zhang, Dongdong; Bae, Chu Hyun; Kang, Myeongmo; Kim, Heeyoun; Lee, Weontae; Bogen, Bjarne & Lim, Sung-Kil (2017). Cyclized oligopeptide targeting LRP5/6-DKK1 interaction reduces the growth of tumor burden in a multiple myeloma mouse model. Yonsei medical journal.  ISSN 0513-5796.  58(3), s 505- 513 . doi: 10.3349/ymj.2017.58.3.505
  • Wang, Dong; Fløisand, Yngvar; Myklebust, Camilla Victoria; Bürgler, Simone; Ribes, Anna Maria Parente; Hofgaard, Peter Olaf; Bogen, Bjarne; Tasken, Kjetil; Tjønnfjord, Geir Erland; Schjesvold, Fredrik Hellem; Dalgaard, Jakob; Tveita, Anders & Munthe, Ludvig Andre (2017). Autologous bone marrow Th cells can support multiple myeloma cell proliferation in vitro and in xenografted mice. Leukemia.  ISSN 0887-6924.  31(10), s 2114- 2121 . doi: 10.1038/leu.2017.69
  • Andersen, Aram Nikolai; Landsverk, Ole J. B.; Simonsen, Anne; Bogen, Bjarne; Corthay, Alexandre & Øynebråten, Inger (2016). Coupling of HIV-1 antigen to the selective autophagy receptor SQSTM1/p62 promotes T-cell-mediated immunity. Frontiers in Immunology.  ISSN 1664-3224.  7 . doi: 10.3389/fimmu.2016.00167 Full text in Research Archive.
  • Ardouin, Laurence; Luche, Hervé; Chelbi, Rabie; Carpentier, Sabrina; Shawket, Alaa; Montanana Sanchis, Frédéric; Santa Maria, Camille; Grenot, Pierre; Alexandre, Yannick; Gregoire, Claude; Fries, Anissa; Vu Manh, Thien-Phong; Tamoutounour, Samira; Crozat, Karine; Tomasello, Elena; Jorquera, Audrey; Fossum, Even; Bogen, Bjarne; Azukizawa, Hiroaki; Bajenoff, Marc; Henri, Sandrine; Dalod, Marc & Malissen, Bernard (2016). Broad and largely concordant molecular changes characterize tolerogenic and immunogenic dendritic cell maturation in thymus and periphery. Immunity.  ISSN 1074-7613.  45(2), s 305- 318 . doi: 10.1016/j.immuni.2016.07.019
  • Bartee, Eric; Bartee, Mee Y.; Bogen, Bjarne & Yu, Xue-Zhong (2016). Systemic therapy with oncolytic myxoma virus cures established residual multiple myeloma in mice. Molecular Therapy - Oncolytics.  ISSN 2372-7705.  3:201632 . doi: 10.1038/mto.2016.32
  • Deloizy, Charlotte; Bouguyon, Edwige; Fossum, Even; Sebo, Peter; Osička, Radim; Bole, Angelique; Pierres, Michel; Biacchesi, Stephane; Dalod, Marc; Bogen, Bjarne; Bertho, Nicolas & Schwartz-Cornil, Isabelle (2016). Expanding the tools for identifying mononuclear phagocyte subsets in swine: Reagents to porcine CD11c and XCR1. Developmental and Comparative Immunology.  ISSN 0145-305X.  65, s 31- 40 . doi: 10.1016/j.dci.2016.06.015
  • Grødeland, Gunnveig; Fredriksen, Agnete; Løset, Geir Åge; Vikse, Elisabeth Lea; Fugger, Lars & Bogen, Bjarne (2016). Antigen targeting to human HLA Class II molecules increases efficacy of DNA vaccination. Journal of Immunology.  ISSN 0022-1767.  197(9), s 3575- 3585 . doi: 10.4049/jimmunol.1600893
  • Guilliams, Martin; Dutertre, Charles-Antoine; Scott, Charlotte L.; McGovern, Naomi; Sichien, Dorine; Chakarov, Svetoslav; Van Gassen, Sofie; Chen, Jinmiao; Poidinger, Michael; De Prijck, Sofie; Tavernier, Simon J.; Low, Ivy; Irac, Sergio Erdal; Mattar, Citra Nurfarah; Sumatoh, Hermi Rizal; Low, Gillian Hui Ling; Chung, Tam John Kit; Chan, Dedrick Kok Hong; Tan, Ker Kan; Hon, Tony Lim Kiat; Fossum, Even; Bogen, Bjarne; Choolani, Mahesh; Chan, Jerry Kok Yen; Larbi, Anis; Luche, Hervé; Henri, Sandrine; Saeys, Yvan; Newell, Evan William; Lambrecht, Bart N.; Malissen, Bernard & Ginhoux, Florent (2016). Unsupervised high-dimensional analysis aligns dendritic cells across tissues and species. Immunity.  ISSN 1074-7613.  45(3), s 669- 684 . doi: 10.1016/j.immuni.2016.08.015
  • Haabeth, Ole Audun; Lorvik, Kristina Berg; Yagita, Hideo; Bogen, Bjarne & Corthay, Alexandre (2016). Interleukin-1 is required for cancer eradication mediated by tumor-specific Th1 cells. Oncoimmunology.  ISSN 2162-402X.  5(1) . doi: 10.1080/2162402X.2015.1039763
  • Kulkarni, Upasana; Karsten, Christian M.; Kohler, Thomas; Hammerschmidt, Sven; Bommert, Kurt; Tiburzy, Benjamin; Meng, Lingzhang; Thieme, Lara; Recke, Andreas; Ludwig, Ralf J.; Pollok, Karolin; Kalies, Kathrin; Bogen, Bjarne; Boettcher, Martin; Kamradt, Thomas; Hauser, Anja E.; Langer, Christian; Huber-Lang, Markus; Finkelman, Fred D.; Köhl, Jörg; Wong, David M. & Manz, Rudolf Armin (2016). IL-10 mediates plasmacytosis-associated immunodeficiency by inhibiting complement-mediated neutrophil migration. Journal of Allergy and Clinical Immunology.  ISSN 0091-6749.  137(5), s 1487- 1497e6 . doi: 10.1016/j.jaci.2015.10.018
  • Lambert, Laura; Kinnear, Ekaterina; McDonald, Jacqueline U.; Grødeland, Gunnveig; Bogen, Bjarne; Stubsrud, Elisabeth; Lindeberg, Mona Mari; Fredriksen, Agnete & Tregoning, John S. (2016). DNA vaccines encoding antigen targeted to MHC class II induce influenza-specific CD8+ T cell responses, enabling faster resolution of influenza disease. Frontiers in Immunology.  ISSN 1664-3224.  7:321 . doi: 10.3389/fimmu.2016.00321
  • Lorvik, Kristina Berg; Hammarström, Clara Louise; Fauskanger, Marte; Haabeth, Ole Audun; Zangani, Michael M; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2016). Adoptive transfer of tumor-specific Th2 cells eradicates tumors by triggering an in situ inflammatory immune response. Cancer Research.  ISSN 0008-5472.  76(23), s 6864- 6876 . doi: 10.1158/0008-5472.CAN-16-1219
  • Tveita, Anders; Fauskanger, Marte; Bogen, Bjarne & Haabeth, Ole Audun (2016). Tumor-specific CD4<sup>+</sup> T cells eradicate myeloma cells genetically deficient in MHC class II display. OncoTarget.  ISSN 1949-2553.  7(41), s 67175- 67182 . doi: 10.18632/oncotarget.11946
  • Zhou, Peng; Chionh, Yok Teng; Irac, Sergio Erdal; Ahn, Matae; Jia Ng, Justin Han; Fossum, Even; Bogen, Bjarne; Ginhoux, Florent; Irving, Aaron T; Dutertre, Charles-Antoine & Wang, Lin-Fa (2016). Unlocking bat immunology: Establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages. Scientific Reports.  ISSN 2045-2322.  6 . doi: 10.1038/srep38597
  • Aas-Hanssen, Kristin; Thompson, Keith M; Bogen, Bjarne & Munthe, Ludvig Andre (2015). Systemic lupus erythematosus: Molecular mimicry between anti-dsDNA CDR3 idiotype, microbial and self peptides-as antigens for Th cells. Frontiers in Immunology.  ISSN 1664-3224.  6:00382 . doi: 10.3389/fimmu.2015.00382 Full text in Research Archive.
  • Baranowska, Marta Natalia; Hauge, Anna G; Hoornaert, Chloe; Bogen, Bjarne & Grødeland, Gunnveig (2015). Targeting of nucleoprotein to chemokine receptors by DNA vaccination results in increased CD8(+)-mediated cross protection against influenza.. Vaccine.  ISSN 0264-410X.  33(49), s 6988- 6996 . doi: 10.1016/j.vaccine.2015.08.094 Show summary
  • Bürgler, Simone; Vives, Aleix Gimeno; Ribes, Anna Maria Parente; Wang, Dong; Os, Audun; Devereux, Stephen; Jebsen, Peter Wilhelm; Bogen, Bjarne; Tjønnfjord, Geir Erland & Munthe, Ludvig Andre (2015). Chronic lymphocytic leukemia cells express CD38 in response to Th1 cell-derived IFN-γ by a T-bet-dependent mechanism. Journal of Immunology.  ISSN 0022-1767.  194(2), s 827- 835 . doi: 10.4049/jimmunol.1401350
  • Fossum, Even; Grødeland, Gunnveig; Terhorst, Dorothea; Tveita, Anders; Vikse, Elisabeth Lea; Mjaaland, Siri; Henri, Sandrine; Malissen, Bernard & Bogen, Bjarne (2015). Vaccine molecules targeting Xcr1 on cross-presenting DCs induce protective CD8+ T-cell responses against influenza virus. European Journal of Immunology.  ISSN 0014-2980.  45(2), s 624- 635 . doi: 10.1002/eji.201445080
  • Grødeland, Gunnveig & Bogen, Bjarne (2015). Efficient vaccine against pandemic influenza: Combining DNA vaccination and targeted delivery to MHC class II molecules. Expert Review of Vaccines.  ISSN 1476-0584.  14(6), s 805- 814 . doi: 10.1586/14760584.2015.1029919
  • Grødeland, Gunnveig; Fossum, Even & Bogen, Bjarne (2015). Polarizing T and B cell responses by APC-targeted subunit vaccines. Frontiers in Immunology.  ISSN 1664-3224.  6 . doi: 10.3389/fimmu.2015.00367
  • Kikuchi, Jiro; Koyama, Daisuke; Wada, Taeko; Izumi, Tohru; Hofgaard, Peter Olaf; Bogen, Bjarne & Furukawa, Yusuke (2015). Phosphorylation-mediated EZH2 inactivation promotes drug resistance in multiple myeloma. Journal of Clinical Investigation.  ISSN 0021-9738.  125(12), s 4375- 4390 . doi: 10.1172/JCI80325
  • Matthes, Thomas W.; Manfroi, B.; Zeller, Andreas; Dunand-Sauthier, Isabelle; Bogen, Bjarne & Huard, Bertrand (2015). Autocrine amplification of immature myeloid cells by IL-6 in multiple myeloma-infiltrated bone marrow. Leukemia.  ISSN 0887-6924.  29(9), s 1882- 1890 . doi: 10.1038/leu.2015.145
  • Terhorst, Dorothea; Fossum, Even; Baranska, Anna; Tamoutounour, Samira; Malosse, Camille; Garbani, Mattia; Braun, Reinhard; Lechat, Elmira; Crameri, Reto; Bogen, Bjarne; Henri, Sandrine & Malissen, Bernard (2015). Laser-Assisted Intradermal Delivery of Adjuvant-Free Vaccines Targeting XCR1+ Dendritic Cells Induces Potent Antitumoral Responses. Journal of Immunology.  ISSN 0022-1767.  194(12), s 5895- 5902 . doi: 10.4049/jimmunol.1500564
  • Tveita, Anders; Schjesvold, Fredrik Hellem; Haabeth, Ole Audun; Fauskanger, Marte Hotvedt & Bogen, Bjarne (2015). Tumors escape CD4+ T-cell-mediated immunosurveillance by impairing the ability of infiltrating macrophages to indirectly present tumor antigens. Cancer Research.  ISSN 0008-5472.  75(16), s 3268- 3278 . doi: 10.1158/0008-5472.CAN-14-3640 Show summary
  • Aas-Hanssen, Kristin; Funderud, Ane; Thompson, Keith M; Bogen, Bjarne & Munthe, Ludvig Andre (2014). Idiotype-specific Th cells support oligoclonal expansion of Anti-dsDNA B cells in mice with lupus. Journal of Immunology.  ISSN 0022-1767.  193(6), s 2691- 2698 . doi: 10.4049/jimmunol.1400640
  • Balan, Sreekumar; Ollion, Vincent; Colletti, Nicholas; Chelbi, Rabie; Montanana-Sanchis, Frederic; Liu, Hong; Manh, Thien-Phong Vu; Sanchez, Cindy; Savoret, Juliette; Perrot, Ivan; Doffin, Anne-Claire; Fossum, Even; Bechlian, Didier; Chabannon, Christian; Bogen, Bjarne; Asselin-Paturel, Carine; Shaw, Michael; Soos, Timothy; Caux, Christophe; Valladeau-Guilemond, Jenny & Dalod, Marc (2014). Human XCR1<sup>+</sup> dendritic cells derived in vitro from CD34 <sup>+</sup> progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells. Journal of Immunology.  ISSN 0022-1767.  193(4), s 1622- 1635 . doi: 10.4049/jimmunol.1401243
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  • Bjerkan, Louise; Braathen, Ranveig; Gudjonsson, Arnar; Grødeland, Gunnveig; Visweswaran, Ganesh Ram & Bogen, Bjarne (2018). An APC-targeted PfRH5 containing DNA vaccine induce protective immune responses against Plasmodium falciparum.
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  • Braathen, Ranveig; Fredriksen, Agnete; Spång, Heidi Cecilie Larsen; Lindeberg, Mona Mari; Fossum, Even & Bogen, Bjarne (2011). Targeting DNA Vaccines against Influenza, can the Immune Response be Orchestered?. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 382- 383
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  • Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarstrom, C; Donaldson, Ian Matthew; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2011). A cancer-protective role of inflammation. Cytokine.  ISSN 1043-4666.  56(1), s 101- 101 . doi: 10.1016/j.cyto.2011.07.392
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  • Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarström, Clara; Donaldson, Ian Matthew; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2011). Inflammation Driven by Tumor-Specific Th1 Cells Protects against B-Cell Cancer. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 384- 384
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Published Apr. 13, 2011 2:53 PM - Last modified June 2, 2016 1:36 PM