Gunn-Helen Øiseth Moen

• Linares-Pineda, Teresa M.; Fragoso Bargas, Nicolas; Picón, María José; Molina-Vega, Maria; Jenum, Anne Karen & Sletner, Line [Show all 14 contributors for this article] (2024). DNA methylation risk score for type 2 diabetes is associated with gestational diabetes. Cardiovascular Diabetology. ISSN 1475-2840. 23(1). doi: 10.1186/s12933-024-02151-z.
• Opsahl, J. O.; Fragoso-Bargas, N.; Lee, Y.; Carlsen, E. Ø.; Lekanova, N. & Qvigstad, E. [Show all 13 contributors for this article] (2024). Epigenome-wide association study of DNA methylation in maternal blood leukocytes with BMI in pregnancy and gestational weight gain. International Journal of Obesity. ISSN 0307-0565. p. 1–10. doi: 10.1038/s41366-024-01458-x. Full text in Research Archive
• D'Urso, Shannon; Moen, Gunn-Helen Øiseth; Hwang, Liang-Dar; Hannigan, Laurie John; Corfield, Elizabeth Claire & Ask, Helga [Show all 12 contributors for this article] (2023). Intrauterine Growth and Offspring Neurodevelopmental Traits A Mendelian Randomization Analysis of the Norwegian Mother, Father and Child Cohort Study (MoBa). JAMA psychiatry. ISSN 2168-6238. 81(2), p. 144–156. doi: 10.1001/jamapsychiatry.2023.3872. Full text in Research Archive
• Beaumont, Robin N.; Flatley, Christopher; Vaudel, Marc; Wu, Xiaoping; Chen, Jing & Moen, Gunn-Helen Øiseth [Show all 88 contributors for this article] (2023). Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth. Nature Genetics. ISSN 1061-4036. 55, p. 1807–1819. doi: 10.1038/s41588-023-01520-w. Full text in Research Archive
• Solé-Navais, Pol; Flatley, Christopher; Steinthorsdottir, Valgerdur; Vaudel, Marc; Juodakis, Julius & Chen, Jing [Show all 85 contributors for this article] (2023). Genetic effects on the timing of parturition and links to fetal birth weight. Nature Genetics. ISSN 1061-4036. 55, p. 559–567. doi: 10.1038/s41588-023-01343-9. Full text in Research Archive
• Fragoso-Bargas, Nicolas; Page, Christian Magnus; Joubert, Bonnie R.; London, Stephanie J.; Lee-Ødegård, Sindre & Opsahl, Julia Onsrud [Show all 13 contributors for this article] (2023). Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes. Epigenomics. ISSN 1750-1911. 15(1), p. 39–52. doi: 10.2217/epi-2022-0427. Full text in Research Archive
• Brito Nunes, Caroline; Huang, Peiyuan; Wang, Geng; Lundberg, Mischa; D'Urso, Shannon & Wootton, Robyn E [Show all 12 contributors for this article] (2023). Mendelian randomization study of maternal coffee consumption and its influence on birthweight, stillbirth, miscarriage, gestational age and pre-term birth. International Journal of Epidemiology. ISSN 0300-5771. 52(1), p. 165–177. doi: 10.1093/ije/dyac121. Full text in Research Archive
• Fragoso-Bargas, Nicolas; Elliott, Hannah R.; Lee-Ødegård, Sindre; Opsahl, Julia Onsrud; Sletner, Line & Jenum, Anne Karen [Show all 12 contributors for this article] (2022). Cross-Ancestry DNA Methylation Marks of Insulin Resistance in Pregnancy: An Integrative Epigenome-Wide Association Study. Diabetes. ISSN 0012-1797. 72(3), p. 415–426. doi: 10.2337/db22-0504.
• Sommer, Christine; Vangberg, Kjersti G; Moen, Gunn-Helen Øiseth; Evans, David M.; Lee-Ødegård, Sindre & Høgestøl, Ingvild Kristine [Show all 11 contributors for this article] (2022). Insulin and Body Mass Index Decrease Serum Soluble Leptin Receptor Levels in Humans. Journal of Clinical Endocrinology and Metabolism (JCEM). ISSN 0021-972X. 108(5), p. 1110–1119. doi: 10.1210/clinem/dgac699. Full text in Research Archive
• D’Urso, Shannon; Arumugam, Pooja; Weider, Therese; Hwang, Liang-Dar; Bond, Tom A. & Kemp, John P. [Show all 10 contributors for this article] (2022). Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk. BMC Medicine. ISSN 1741-7015. 20:419, p. 1–17. doi: 10.1186/s12916-022-02585-w. Full text in Research Archive
• Moen, Gunn-Helen Øiseth; Nivard, Michel; Bhatta, Laxmi; Warrington, Nicole Maree; Willer, Cristen & Åsvold, Bjørn Olav [Show all 8 contributors for this article] (2022). Using Genomic Structural Equation Modeling to Partition the Genetic Covariance Between Birthweight and Cardiometabolic Risk Factors into Maternal and Offspring Components in the Norwegian HUNT Study. Behavior Genetics. ISSN 0001-8244. 53, p. 40–52. doi: 10.1007/s10519-022-10116-9. Full text in Research Archive
• Pervjakova, Natalia; Moen, Gunn-Helen Øiseth; Borges, Maria-Carolina; Ferreira, Teresa; Cook, James P. & Allard, Catherine [Show all 73 contributors for this article] (2022). Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes. Human Molecular Genetics. ISSN 0964-6906. 31(19), p. 3377–3391. doi: 10.1093/hmg/ddac050. Full text in Research Archive
• Hwang, Liang-Dar; Moen, Gunn-Helen Øiseth & Evans, David M. (2022). Using adopted individuals to partition indirect maternal genetic effects into prenatal and postnatal effects on offspring phenotypes. eLIFE. ISSN 2050-084X. 11. doi: 10.7554/elife.73671. Full text in Research Archive
• Fragoso-Bargas, Nicolas; Opsahl, Julia Onsrud; Kiryushchenko, Nadezhda; Böttcher, Yvonne; Lee-Ødegård, Sindre & Qvigstad, Elisabeth [Show all 15 contributors for this article] (2021). Cohort profile: Epigenetics in Pregnancy (EPIPREG) – Population-based sample of European and South Asian pregnant women with epigenome-wide DNA methylation (850k) in peripheral blood leukocytes. PLOS ONE. ISSN 1932-6203. 16(8), p. 1–15. doi: 10.1371/journal.pone.0256158. Full text in Research Archive
• Wang, Geng; Bhatta, Laxmi; Moen, Gunn-Helen; Hwang, Liang-Dar; Kemp, John P. & Bond, Tom A. [Show all 10 contributors for this article] (2021). Investigating a Potential Causal Relationship Between Maternal Blood Pressure During Pregnancy and Future Offspring Cardiometabolic Health. Hypertension. ISSN 0194-911X. 79(1), p. 170–177. doi: 10.1161/HYPERTENSIONAHA.121.17701. Full text in Research Archive Show summary

  Gastric cancer is still an important disease causing many deaths worldwide, although there has been a marked reduction in prevalence during the last few decades. The decline in gastric cancer prevalence is due to a reduction in Helicobacter pylori infection which has occurred for at least 50 years. The most probable mechanism for the carcinogenic effect of H. pylori is hypergastrinemia since H. pylori infected individuals do not have increased risk of gastric cancer before the development of oxyntic atrophy. When atrophy has developed, the carcinogenic process continues independent of H. pylori. Autoimmune gastritis also induces oxyntic atrophy leading to marked hypergastrinemia and development of ECL cell neoplasia as well as adenocarcinoma. Similarly, long-term treatment with efficient inhibitors of acid secretion like the proton pump inhibitors (PPIs) predisposes to ECL cell neoplasia of a different degree of malignancy. Contrasting the colon where most cancers develop from polyps, most polyps in the stomach have a low malignant potential. Nevertheless, gastric polyps may also give rise to cancer and have some risk factors and mechanisms in common with gastric cancer. In this overview the most common gastric polyps, i.e., hyperplastic polyps, adenomatous polyps and fundic gland polyps will be discussed with respect to etiology and particularly use of PPIs and relation to gastric carcinogenesis.

• Moen, Gunn-Helen; Beaumont, Robin N.; Grarup, Niels; Sommer, Christine; Shields, Beverley M. & Lawlor, Debbie A. [Show all 9 contributors for this article] (2021). Investigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight. International Journal of Epidemiology. ISSN 0300-5771. 50(1), p. 179–189. doi: 10.1093/ije/dyaa256. Full text in Research Archive
• Opsahl, Julia; Moen, Gunn-Helen Øiseth; Qvigstad, Elisabeth; Böttcher, Yvonne; Birkeland, Kåre Inge & Sommer, Christine (2020). Epigenetic signatures associated with maternal body mass index or gestational weight gain: a systematic review. Journal of Developmental Origins of Health and Disease. ISSN 2040-1744. doi: 10.1017/S2040174420000811.
• D'Urso, Shannon; Wang, Geng; Hwang, Liang-Dar; Moen, Gunn-Helen; Warrington, Nicole Maree & Evans, David M. (2020). A cautionary note on using Mendelian randomization to examine the Barker hypothesis and Developmental Origins of Health and Disease (DOHaD). Journal of Developmental Origins of Health and Disease. ISSN 2040-1744. p. 1–6. doi: 10.1017/S2040174420001105. Full text in Research Archive
• Lee, Yunsung; Jacobsen, Kristine Løkås; Denault, William Robert Paul; Nustad, Haakon Egdetveit; Page, Christian & Lyle, Robert [Show all 19 contributors for this article] (2020). Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array. BMC Genomics. ISSN 1471-2164. 21(1). doi: 10.1186/s12864-020-07168-8. Full text in Research Archive
• Hwang, Liang-Dar; Tubbs, Justin D.; Luong, Justin; Lundberg, Mischa; Moen, Gunn-Helen & Wang, Geng [Show all 10 contributors for this article] (2020). Estimating indirect parental genetic effects on offspring phenotypes using virtual parental genotypes derived from sibling and half sibling pairs. PLoS Genetics. ISSN 1553-7390. 16(10), p. 1–29. doi: 10.1371/journal.pgen.1009154. Full text in Research Archive
• Moen, Gunn-Helen; Brumpton, Ben Michael; Willer, Cristen J.; Åsvold, Bjørn Olav; Birkeland, Kåre I. & Wang, Geng [Show all 13 contributors for this article] (2020). Mendelian randomization study of maternal influences on birthweight and future cardiometabolic risk in the HUNT cohort. Nature Communications. ISSN 2041-1723. 11:5404, p. 1–12. doi: 10.1038/s41467-020-19257-z. Full text in Research Archive
• Opsahl, Julia Onsrud; Moen, Gunn-Helen; Qvigstad, Elisabeth; Böttcher, Yvonne; Birkeland, Kåre I. & Sommer, Christine (2020). Epigenetic signatures associated with maternal body mass index or gestational weight gain: A systematic review. Journal of Developmental Origins of Health and Disease. ISSN 2040-1744. p. 1–11. doi: 10.1017/S2040174420000811. Full text in Research Archive
• Evans, David M.; Moen, Gunn-Helen; Hwang, Liang-Dar; Lawlor, Debbie A. & Warrington, Nicole Maree (2019). Elucidating the role of maternal environmental exposures on offspring health and disease using two-sample Mendelian randomization. International Journal of Epidemiology. ISSN 0300-5771. 48(3), p. 861–875. doi: 10.1093/ije/dyz019. Full text in Research Archive
• Arora, G. P.; Åkerlund, M.; Bruns, C; Moen, Gunn-Helen; Wasenius, N. S. & Sommer, Christine [Show all 17 contributors for this article] (2019). Phenotypic and genotypic differences between Indian and Scandinavian women with gestational diabetes mellitus. Journal of Internal Medicine. ISSN 0954-6820. doi: 10.1111/joim.12903.
• Moen, Gunn-Helen; Hemani, Gibran; Warrington, Nicole Maree & Evans, David M. (2019). Calculating power to detect maternal and offspring genetic effects in genetic association studies. Behavior Genetics. ISSN 0001-8244. 49(3), p. 327–339. doi: 10.1007/s10519-018-9944-9. Full text in Research Archive
• Moen, Gunn-Helen Øiseth; LeBlanc, Marissa; Sommer, Christine; Prasad, Rashmi B.; Lekva, Tove & Normann, Kjersti Ringvoll [Show all 11 contributors for this article] (2018). Genetic determinants of glucose levels in pregnancy: Genetic risk scores analysis and GWAS in the Norwegian STORK cohort. European Journal of Endocrinology (EJE). ISSN 0804-4643. 179(6), p. 363–372. doi: 10.1530/EJE-18-0478.
• Moen, Gunn-Helen Øiseth; Qvigstad, Elisabeth; Birkeland, Kåre I.; Evans, David & Sommer, Christine (2018). Are serum concentrations of vitamin B-12 causally related to cardiometabolic risk factors and disease? A Mendelian randomization study . American Journal of Clinical Nutrition. ISSN 0002-9165. 108(2), p. 398–404. doi: 10.1093/ajcn/nqy101.
• Moen, Gunn-Helen Øiseth; Sommer, Christine; Prasad, Rashmi B.; Sletner, Line; Groop, Leif & Qvigstad, Elisabeth [Show all 7 contributors for this article] (2017). Epigenetic modifications and gestational diabetes: A Systematic review of published literature. European Journal of Endocrinology (EJE). ISSN 0804-4643. 176(5), p. R247–R267. doi: 10.1530/EJE-16-1017.
• Moen, Gunn-Helen Øiseth; Moen, Aurora Lie; Schistad, Ellina Iordanova & Gjerstad, Johannes (2017). Local up-regulation of interferon-γ (IFN-γ) following disc herniation is involved in the inflammatory response underlying acute lumbar radicular pain. Cytokine. ISSN 1043-4666. 97, p. 181–186. doi: 10.1016/j.cyto.2017.06.005. Show summary

  Lumbar radicular pain after disc herniation may be associated with release of pro-inflammatory cytokines from nucleus pulposus (NP) tissue. In the present study we examined the role of interferon-γ (IFN-γ) and cluster of differentiation 68 (CD68) in the acute phase of this process. First, in an animal model mimicking the clinical situation after disc herniation, the role of IFN-γ close to the dorsal nerve roots was studied. Next, in patients with lumbar radicular pain due to disc herniation, we examined how two single nucleotide polymorphisms (SNPs; rs2069705 and rs2069718) are important for the IFN-γ expression influenced the pain behavior. The animal data demonstrated a significant increase in the nociceptive activity at the spinal level after local application of NP and IFN-γ onto the dorsal nerve roots. A positive correlation between IFN-γ and CD68 in the NP tissue was also demonstrated. In the patients, a significant increase in Oswestry Disability Index (ODI) score was observed in carriers of the IFN-γ SNPs; rs2069705 A and rs2069718 G alleles. The present data suggest that IFN-γ close to the dorsal nerve roots may contribute to the pathogenesis, the nociceptive activity and the pain behavior following lumbar disc herniation.

• Lunde, Lars-Kristian; Koch, Markus; Veiersted, Kaj Bo; Moen, Gunn-Helen Øiseth; Wærsted, Morten & Knardahl, Stein (2016). Heavy physical work: Cardiovascular load in male construction workers. International Journal of Environmental Research and Public Health (IJERPH). ISSN 1661-7827. 13(4). doi: 10.3390/ijerph13040356. Full text in Research Archive Show summary

  This study aimed to elucidate cardiovascular loads (CVL) in construction workers during work and leisure by relative heart rate (RHR) over several days. Furthermore, we sought to evaluate the level of CVL in relation to individual factors, work ability, musculoskeletal pain and subjective general health. From a group of 255 construction workers responding to the baseline questionnaire, the CVL during work and leisure time was determined by recording RHR in 42 workers over 3–4 days. Almost 60% of the workday was spent below 20% RHR. The mean RHR during work for all participants was 16% RHR, with large differences between professions. On average, the 42 workers spent 14% of the workday at a RHR above 33%, and four subjects (10%) had a mean RHR above 33% during work. Eight (19%) of the participants had a mean length of their workday exceeding calculated maximal acceptable work time. Seven persons (17%) experienced on average one or more episode(s) of 5 min or more continuously above 33% RHR. The cardiovascular load at work was significantly associated with age and V˙O2max, but not with work ability, musculoskeletal pain or subjective general health.

View all works in Cristin

• Fragoso Bargas, Nicolas; Linares-Pineda, Teresa; Molina-Vega, María; Picón, María José; Jenum, Anne Karen & Sletner, Line [Show all 14 contributors for this article] (2023). Methylation risk score for gestational diabetes on DNA methylation patterns associated with type 2 diabetes.
• Solé-Navais, Pol; Flatley, Christopher; Steinthorsdottir, Valgerdur; Vaudel, Marc; Juodakis, Julius & Chen, Jing [Show all 85 contributors for this article] (2023). Author Correction: Genetic effects on the timing of parturition and links to fetal birth weight (Nature Genetics, (2023), 55, 4, (559-567), 10.1038/s41588-023-01343-9). Nature Genetics. ISSN 1061-4036. doi: 10.1038/s41588-023-01412-z.
• Fragoso-Bargas, Nicolas; Lee-Ødegård, Sindre; Moen, Gunn-Helen Øiseth; Oppsahl, JO; Sletner, Line & Jenum, Anne Karen [Show all 12 contributors for this article] (2022). Epigenome-Wide Association Study of objectively measured physical activity in pregnancy.
• Fragoso-Bargas, Nicolas; Lee-Ødegård, Sindre; Moen, Gunn-Helen Øiseth; oppsahl, JO; Sletner, Line & Jenum, Anne Karen [Show all 13 contributors for this article] (2022). Epigenome-Wide Association Study of objectively measured moderate physical activity in pregnan. Show summary

  Epigenome-Wide Association Study of objectively measured moderate physical activity in pregnancy Nicolas Fragoso-Bargas1,2, Sindre Lee-Ødegård2, Gunn-Helen Moen2,3,4,5, Julia O. Opsahl2, Line Sletner2,6, Anne Karen Jenum2, Paul Franks7, Rashmi B. Prasad8, Leif C. Groop8, Elisabeth Qvigstad1,2, Kåre I. Birkeland2, Kåre R. Richardsen9, Christine Sommer1 1Oslo University Hospital, Oslo, Norway, 2University of Oslo, Oslo, Norway, 3The University of Queensland Diamantina Institute, Brisbane, Australia, 4Norwegian University of Science and Technology, Trondheim, Norway, 5University of Bristol, UK, 6Akershus University Hospital, Oslo, Norway, 7Lund University Genetic and Molecular Epidemiology, Malmö, Sweden, 8Lund University Diabetes Centre, Malmö, Sweden,9Oslo Metropolitan University, Oslo, Norway. Physical activity (PA) is recommended during pregnancy to reduce the risk of excessive weight gain and gestational diabetes mellitus, and to improve general health. DNA methylation (DNAm) has been proposed as a potential molecular mechanism through which physical activity (PA) mediates the effects on the transcriptome. Here we performed an epigenome-wide association study (EWAS) of objectively measured moderate physical activity in pregnancy, which has not been performed previously. In EPIPREG (a sub-sample of the population-based STORK Groruddalen study) we quantified DNAm at gestational week 28 (±2 SD) with Illumina’s Infinium Methylation EPIC BeadChip. With SenseWear™ Pro3 Armband, we measured hours per day of moderate PA (3.0 to 6.0 metabolic equivalent for task (MET)) and steps/day. DNAm outliers that were 4 times the interquartile range below or above the 25TH and 75TH percentiles respectively were removed, before the beta values were transformed to M-values. Of the 472 that passed the EWAS quality control, 239 European (EUR) and 109 South Asian women (SA) had two valid days of recorded PA (19.2h per day), and were non-outliers (±4 SD) in their respective ethnic group. We used two approaches to test the association between M-values and moderate PA (hours/day): 1) A trans-ethnic approach using mixed linear models adjusted for blood cell proportions, age, smoking, number of steps, number of valid days (between 2 to 8), and ethnicity as a random intercept, and 2) through separate analyses in EUR and SA using linear modelling adjusted with the before mentioned covariates. We accepted a false discovery rate of 10%. In the trans-ethnic analysis, only cg08148261 located in the promoter area of LDHB was significantly associated with moderate PA. In Europeans, eight sites were significant: cg19031974 (BSN-AS2), cg19053287 (MCF2L) cg14930390 (MUTED), cg18517050 (CIAPIN1) and cg26191378 (TMUB1), located near promoter areas, cg27160968 (ESRRA) and cg15879426 (c17orf101) located in exon boundaries, and cg10421808 which is unannotated. In South Asians, only cg05999993 in the promoter area of AOAH was associated with moderate PA. Most of the sites showed decreased DNAm at increased moderate PA (hours/day), while in cg10421808, cg14930390 and cg15879426 the opposite was observed. In conclusion, we found several significant associations between DNAm and moderate PA. Several CpGs were located near gene promoter areas, which could imply altered transcription of the respective genes. These findings suggest that PA may exert changes in DNAm with important transcriptional implications during pregnancy.

View all works in Cristin