Marius Trøseid

Professor II - Research Institute for Internal Medicine

Norwegian version of this page

Email marius.troseid@medisin.uio.no

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Visiting address Sognsvannsveien 20 OUS Rikshospitalet 0372 Oslo

Postal address Postboks 4950 Nydalen OUS, Rikshospitalet 0424 Oslo

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About

Adjunct Professor Marius Trøseid is also a senior consultant in infectious diseases and clinical immunology at Oslo University Hospital and leading a national research network on clinical microbiota science (Microbiota).

They have developed an in house sequencing-based microbiota-profiling pipeline including bioinformatics and applied it in multiple conditions and study designs, including RCTs in chronic infections and inflammatory diseases.

Trøseid has been involved in several RCTs as PI or co-PI, including interventions with statins, probiotics, antibiotics and life style interventions.

Ongoing projects

CoMicS (Copenhagen-Oslo HIV Comorbidity and Microbiota Study) - The largest microbiota study in HIV-infected individuals to date
SCRATCH consortium (Microbiota-based SCReening of Anal Cancer in HIV-infected individuals) - EU funded
GutHeart trial (RCT of gut microbiota intervention in heart failure) - First-in-man multi center

Clinical and scientific focus

More recently, the clinical and scientific focus has shifted to also include COVID-19, as part of the Nordic branch of the WHO solidarity trial, as coordinator of the national reference group on COVID-19 treatment in Norway and as co-applicant for the Horizon 2020 consortium EU-RESPONSE (European Research and Preparedness Network for Pandemics and Emerging Infectious Diseases).

Trøseid is now chief investigator of the novel pan-European adaptive platform trial for COVID and emerging pandemics, EU SolidAct, set up to run phase II and phase III trials in around 15 European countries.

Tags: gut microbiota, immunology, inflammation, HIV, Covid-19, RCT

Raju, Sajan; Molinaro, Antonio; Awoyemi, Ayodeji Olawale; Jørgensen, Silje Fjellgård; Braadland, Peder Rustøen & Nendl, Andraz [Show all 19 contributors for this article] (2024). Microbial-derived imidazole propionate links the heart failure-associated microbiome alterations to disease severity. Genome Medicine. ISSN 1756-994X. 16(1). doi: 10.1186/s13073-024-01296-6.
De Bortoli, Alessandro; Nordøy, Ingvild; Connelly, James Patrick; Viermyr, Hans-Kittil; Bjerkreim, Randi Haukaas & Broch, Kaspar [Show all 15 contributors for this article] (2024). Diagnostics, treatment and outcomes of cardiac sarcoidosis in a Norwegian cohort. International Journal of Cardiology. ISSN 0167-5273. 400. doi: 10.1016/j.ijcard.2024.131809.
Patrick-Brown, Dawn Judith; Trøseid, Marius & Olsen, Inge Christoffer (2024). Experiences and challenges with the new European Clinical Trials Regulation. Trials. ISSN 1745-6215. 25(1). doi: 10.1186/s13063-023-07869-x.
Knudsen, Andreas D; Eskelund, Christian Winther; Benfield, Thomas; Yanan, Zhao; Gelpi, Marco & Køber, Lars [Show all 13 contributors for this article] (2023). Clonal hematopoiesis of indeterminate potential in persons with HIV. AIDS (London). ISSN 0269-9370. 38(4), p. 487–495. doi: 10.1097/QAD.0000000000003788.
Ueland, Thor; Michelsen, Annika Elisabet; Tveita, Anders; Kåsine, Trine; Dahl, Tuva Børresdatter & Finbråten, Ane-Kristine [Show all 16 contributors for this article] (2023). Coagulopathy and adverse outcomes in hospitalized patients with COVID-19: results from the NOR-Solidarity trial. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 8(1). doi: 10.1016/j.rpth.2023.102289. Full text in Research Archive
Thudium, Rebekka F; Arentoft, Nicoline S; Hoel, Hedda; Afzal, Shoaib; Von Stemann, Jakob H & Forman, Julie L [Show all 15 contributors for this article] (2023). Elevated Levels of Interleukin-1β and Interleukin-10 Are Associated with Faster Lung Function Decline in People with Well-Treated Human Immunodeficiency Virus. Journal of Infectious Diseases. ISSN 0022-1899. 228(8), p. 1080–1088. doi: 10.1093/infdis/jiad233.
Murphy, Sarah Louise Mikalsen; Halvorsen, Bente; Holter, Jan Cato; Huse, Camilla; Tveita, Anders & Trøseid, Marius [Show all 24 contributors for this article] (2023). Circulating markers of extracellular matrix remodelling in severe COVID-19 patients. Journal of Internal Medicine. ISSN 0954-6820. 294(6), p. 784–797. doi: 10.1111/joim.13725. Full text in Research Archive
Knudsen, Andreas D; Fuchs, Andreas; Benfield, Thomas; Gerstoft, Jan; Køber, Lars & Trøseid, Marius [Show all 8 contributors for this article] (2023). Coronary Artery Disease in Persons with Human Immunodeficiency Virus Without Detectable Viral Replication. Open Forum Infectious Diseases. ISSN 2328-8957. 10(7). doi: 10.1093/ofid/ofad298. Full text in Research Archive
Braadland, Peder Rustøen; Bergquist, Annika; Kummen, Martin; Bossen, Lars; Engesæter, Lise Katrine & Reims, Henrik Mikael [Show all 21 contributors for this article] (2023). Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation. Journal of Hepatology. ISSN 0168-8278. 79(4), p. 955–966. doi: 10.1016/j.jhep.2023.05.038. Full text in Research Archive
Serrano-Villar, Sergio; Tincati, Camilla; Raju, Sajan; Sáenz, Johan S.; Moreno, Elena & Bargiela, Rafael [Show all 19 contributors for this article] (2023). Microbiome-derived cobalamin and succinyl-CoA as biomarkers for improved screening of anal cancer. Nature Medicine. ISSN 1078-8956. 29(7), p. 1738–1749. doi: 10.1038/s41591-023-02407-3.
Ueland, Thor; Waagsbø, Bjørn; Berge, Rolf Kristian; Trøseid, Marius; Aukrust, Pål & Damås, Jan Kristian (2023). Fatty Acids Composition and HIV Infection: Altered Levels of n-6 Polyunsaturated Fatty Acids Are Associated with Disease Progression. Viruses. ISSN 1999-4915. 15(7). doi: 10.3390/v15071613. Full text in Research Archive
Nendl, Andraz; Raju, Sajan; Broch, Kaspar; Mayerhofer, Christiane Caroline; Holm, Kristian & Halvorsen, Bente [Show all 12 contributors for this article] (2023). Intestinal fatty acid binding protein is associated with cardiac function and gut dysbiosis in chronic heart failure. Frontiers in Cardiovascular Medicine. ISSN 2297-055X. 10. doi: 10.3389/fcvm.2023.1160030. Full text in Research Archive
Mikaeloff, Flora; Gelpi, Marco; Benfeitas, Rui; Knudsen, Andreas D.; Vestad, Beate & Høgh, Julie [Show all 14 contributors for this article] (2023). Network-based multi-omics integration reveals metabolic at-risk profile within treated HIV-infection. eLIFE. ISSN 2050-084X. 12. doi: 10.7554/eLife.82785. Full text in Research Archive
Trøseid, Marius; Holter, Jan Cato; Holm, Kristian; Vestad, Beate; Sazonova, Taisiia & Granerud, Beathe Kiland [Show all 17 contributors for this article] (2023). Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19. Critical Care. ISSN 1364-8535. 27(1). doi: 10.1186/s13054-023-04356-2. Full text in Research Archive
Terzić, Vida; Levoyer, Léa; Figarella, Mélanie; Bigagli, Elisabetta; Mercier, Noémie & De Gastines, Lucie [Show all 27 contributors for this article] (2023). Implementation of a centralized pharmacovigilance system in academic pan-European clinical trials: Experience from EU-Response and conect4children consortia. British Journal of Clinical Pharmacology. ISSN 0306-5251. 89(4), p. 1318–1328. doi: 10.1111/bcp.15669. Full text in Research Archive
Trøseid, Marius; Arribas, José R.; Assoumou, Lambert; Holten, Aleksander Rygh; Poissy, Julien & Terzić, Vida [Show all 56 contributors for this article] (2023). Efficacy and safety of baricitinib in hospitalized adults with severe or critical COVID‑19 (Bari‑SolidAct): a randomised, double‑blind, placebo‑controlled phase 3 trial. Critical Care. ISSN 1364-8535. 27, p. 1–15. doi: 10.1186/s13054-022-04205-8. Full text in Research Archive
Pan, Hongchao; Peto, Richard; Karim, Quarraisha Abdool; Alejandria, Marissa M.; Henao-Restrepo, Ana-Maria & Hernández-García, César [Show all 51 contributors for this article] (2022). Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses. The Lancet. ISSN 0140-6736. 399(10339), p. 1941–1953. doi: 10.1016/S0140-6736(22)00519-0. Full text in Research Archive Show summary
Background The Solidarity trial among COVID-19 inpatients has previously reported interim mortality analyses for four repurposed antiviral drugs. Lopinavir, hydroxychloroquine, and interferon (IFN)-β1a were discontinued for futility but randomisation to remdesivir continued. Here, we report the final results of Solidarity and meta-analyses of mortality in all relevant trials to date. Methods Solidarity enrolled consenting adults (aged ≥18 years) recently hospitalised with, in the view of their doctor, definite COVID-19 and no contraindication to any of the study drugs, regardless of any other patient characteristics. Participants were randomly allocated, in equal proportions between the locally available options, to receive whichever of the four study drugs (lopinavir, hydroxychloroquine, IFN-β1a, or remdesivir) were locally available at that time or no study drug (controls). All patients also received the local standard of care. No placebos were given. The protocol-specified primary endpoint was in-hospital mortality, subdivided by disease severity. Secondary endpoints were progression to ventilation if not already ventilated, and time-to-discharge from hospital. Final log-rank and Kaplan-Meier analyses are presented for remdesivir, and are appended for all four study drugs. Meta-analyses give weighted averages of the mortality findings in this and all other randomised trials of these drugs among hospital inpatients. Solidarity is registered with ISRCTN, ISRCTN83971151, and ClinicalTrials.gov, NCT04315948. Findings Between March 22, 2020, and Jan 29, 2021, 14 304 potentially eligible patients were recruited from 454 hospitals in 35 countries in all six WHO regions. After the exclusion of 83 (0·6%) patients with a refuted COVID-19 diagnosis or encrypted consent not entered into the database, Solidarity enrolled 14 221 patients, including 8275 randomly allocated (1:1) either to remdesivir (ten daily infusions, unless discharged earlier) or to its control (allocated no study drug although remdesivir was locally available). Compliance was high in both groups. Overall, 602 (14·5%) of 4146 patients assigned to remdesivir died versus 643 (15·6%) of 4129 assigned to control (mortality rate ratio [RR] 0·91 [95% CI 0·82–1·02], p=0·12). Of those already ventilated, 151 (42·1%) of 359 assigned to remdesivir died versus 134 (38·6%) of 347 assigned to control (RR 1·13 [0·89–1·42], p=0·32). Of those not ventilated but on oxygen, 14·6% assigned to remdesivir died versus 16·3% assigned to control (RR 0·87 [0·76–0·99], p=0·03). Of 1730 not on oxygen initially, 2·9% assigned to remdesivir died versus 3·8% assigned to control (RR 0·76 [0·46–1·28], p=0·30). Combining all those not ventilated initially, 11·9% assigned to remdesivir died versus 13·5% assigned to control (RR 0·86 [0·76–0·98], p=0·02) and 14·1% versus 15·7% progressed to ventilation (RR 0·88 [0·77–1·00], p=0·04). The non-prespecified composite outcome of death or progression to ventilation occurred in 19·6% assigned to remdesivir versus 22·5% assigned to control (RR 0·84 [0·75–0·93], p=0·001). Allocation to daily remdesivir infusions (vs open-label control) delayed discharge by about 1 day during the 10-day treatment period. A meta-analysis of mortality in all randomised trials of remdesivir versus no remdesivir yielded similar findings. Interpretation Remdesivir has no significant effect on patients with COVID-19 who are already being ventilated. Among other hospitalised patients, it has a small effect against death or progression to ventilation (or both).
Stø, Kristine; Valeur, Jørgen; Ueland, Thor; Malmstrøm, Gunn Helen; Bjerkeli, Vigdis & Trøseid, Marius [Show all 12 contributors for this article] (2022). Fecal level of butyric acid, a microbiome-derived metabolite, is increased in patients with severe carotid atherosclerosis. Scientific Reports. ISSN 2045-2322. 12(1), p. 1–9. doi: 10.1038/s41598-022-26759-x. Full text in Research Archive
Aune, Susanne Kristine; Bonnevie-Svendsen, Martin; Nyborg, Christoffer; Trøseid, Marius; Seljeflot, Ingebjørg & Hisdal, Jonny [Show all 7 contributors for this article] (2022). Gut Leakage and Cardiac Biomarkers after Prolonged Strenuous Exercise. Medicine & Science in Sports & Exercise. ISSN 0195-9131. 54(9), p. 1476–1482. doi: 10.1249/MSS.0000000000002948.
Suarez-Zdunek, Moises Alberto; Høgh, Julie; Kirkegaard-Klitbo, Ditte Marie; Jensen, Anne Marie R.; Rupert, Adam & Trøseid, Marius [Show all 9 contributors for this article] (2022). High incidence of subclinical peripheral artery disease in people with HIV. AIDS (London). ISSN 0269-9370. 36(10), p. 1355–1362. doi: 10.1097/QAD.0000000000003252.
Gelpi, M; Vestad, Beate; Raju, Sajan; Hansen, Simen Hyll; Høgh, J & Midttun, Øivind [Show all 13 contributors for this article] (2022). Association of the Kynurenine Pathway of Tryptophan Metabolism with Human Immunodeficiency Virus-Related Gut Microbiota Alterations and Visceral Adipose Tissue Accumulation. Journal of Infectious Diseases. ISSN 0022-1899. 225(11), p. 1948–1954. doi: 10.1093/infdis/jiac018.
Larsen, Christopher Storm; Hande, Liv Nesse; Kummen, Martin; Thunhaug, Hilde; Vestad, Beate & Hansen, Simen Hyll [Show all 10 contributors for this article] (2022). Reduced gut microbial diversity in familial hypercholesterolemia with no effect of omega-3 polyunsaturated fatty acids intervention–a pilot trial. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 82(5), p. 363–370. doi: 10.1080/00365513.2022.2102540. Full text in Research Archive
Knudsen, Andreas D.; Bouazzi, Randa; Afzal, Shoaib; Gelpi, Marco; Benfield, Thomas & Høgh, Julie [Show all 10 contributors for this article] (2022). Monocyte count and soluble markers of monocyte activation in people living with HIV and uninfected controls. BMC Infectious Diseases. ISSN 1471-2334. 22(1). doi: 10.1186/s12879-022-07450-y.
Tveita, Anders Aune; Murphy, Sarah Louise Mikalsen; Holter, Jan Cato; Kildal, Anders Benjamin; Michelsen, Annika Elisabet & Lerum, Tøri Vigeland [Show all 28 contributors for this article] (2022). High Circulating Levels of the Homeostatic Chemokines CCL19 and CCL21 Predict Mortality and Disease Severity in COVID-19. Journal of Infectious Diseases. ISSN 0022-1899. 226(12), p. 2150–2160. doi: 10.1093/infdis/jiac313. Full text in Research Archive
Trøseid, Marius; Dahl, Tuva Børresdatter; Holter, Jan Cato; Kildal, Anders Benjamin; Murphy, Sarah Louise Mikalsen & Yang, Kuan [Show all 28 contributors for this article] (2022). Persistent T-cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID-19: Results from two Norwegian cohort studies. Journal of Internal Medicine. ISSN 0954-6820. 292(5), p. 816–828. doi: 10.1111/joim.13549. Full text in Research Archive
Meyer-Myklestad, Malin Holm; Medhus, Asle Wilhelm; Stiksrud, Birgitte; Lorvik, Kristina Berg; Seljeflot, Ingebjørg & Hansen, Simen Hyll [Show all 13 contributors for this article] (2022). Probiotics to HIV-infected immunological nonresponders: Altered mucosal immunity and microbial diversity restricted to ileum. Journal of Acquired Immune Deficiency Syndromes. ISSN 1525-4135. 89(1), p. 77–86. doi: 10.1097/QAI.0000000000002817.
Vestad, Beate; Ueland, Thor; Lerum, Tøri Vigeland; Dahl, Tuva Børresdatter; Holm, Kristian & Barratt-Due, Andreas [Show all 37 contributors for this article] (2022). Respiratory dysfunction three months after severe COVID-19 is associated with gut microbiota alterations. Journal of Internal Medicine. ISSN 0954-6820. 291(6), p. 801–812. doi: 10.1111/joim.13458. Full text in Research Archive Show summary
Background: Although coronavirus disease 2019 (COVID-19) is primarily a respiratory infection, mounting evidence suggests that the gastrointestinal (GI) tract is involved in the disease, with gut barrier dysfunction and gut microbiota alterations being related to disease severity. Whether these alterations persist and are related to long-term respiratory dysfunction remains unknown. Methods: Plasma was collected during hospital admission and after three months from the NOR-Solidarity trial (n = 181) and analysed for markers of gut barrier dysfunction and inflammation. At the three-month follow-up, pulmonary function was assessed by measuring the diffusing capacity of the lungs for carbon monoxide (DLCO ). Rectal swabs for gut microbiota analyses were collected (n = 97) and analysed by sequencing the 16S rRNA gene. Results: Gut microbiota diversity was reduced in COVID-19 patients with respiratory dysfunction, defined as DLCO below the lower limit of normal three months after hospitalisation. These patients also had an altered global gut microbiota composition, with reduced relative abundance of 20 bacterial taxa and increased abundance of five taxa, including Veillonella, potentially linked to fibrosis. During hospitalisation, increased plasma levels of lipopolysaccharide-binding protein (LBP) were strongly associated with respiratory failure, defined as pO2 /fiO2 -(P/F ratio)
Thudium, Rebekka F.; Knudsen, Andreas; Von Stemann, Jakob Hjorth; Hove-Skovsgaard, Malene; Hoel, Hedda Benedicte & Mocroft, Amanda [Show all 14 contributors for this article] (2021). Independent Association of Interleukin 6 With Low Dynamic Lung Function and Airflow Limitation in Well-Treated People With Human Immunodeficiency Virus. Journal of Infectious Diseases. ISSN 0022-1899. 223(10), p. 1690–1698. doi: 10.1093/infdis/jiaa600.
Thudium, Rebekka F.; Ringheim, Hedda; Ronit, Andreas; Hoel, Hedda; Benfield, Thomas & Mocroft, Amanda [Show all 12 contributors for this article] (2021). Independent Associations of Tumor Necrosis Factor-Alpha and Interleukin-1 Beta With Radiographic Emphysema in People Living With HIV. Frontiers in Immunology. ISSN 1664-3224. 12. doi: 10.3389/fimmu.2021.668113.
Kåsine, Trine; Riise, Anne Margarita Dyrhol; Barratt-Due, Andreas; Kildal, Anders Benjamin; Olsen, Inge Christoffer & Nezvalova-Henriksen, Katerina [Show all 39 contributors for this article] (2021). Neutrophil count predicts outcome in hospitalized COVID-19 patients. Results from the NOR-Solidarity trial. Journal of Internal Medicine. ISSN 0954-6820. 291(2), p. 241–243. doi: 10.1111/joim.13377. Show summary
Despite numerous studies on SARS-CoV-2-induced inflammation, we still lack markers for rapid disease progression with admission to intensive care unit (ICU) or respiratory failure(RF). Few studies have evaluated the prognostic value of routine diagnostic repertoire available at most hospitals. The NOR-Solidarity trial is an independent add-on study to the WHO Solidarity trial, evaluating hydroxychloroquine (HCQ)and remdesivir compared to standard of care in hospitalized COVID-19 patients [1]. We explored whether standard biomarkers in peripheral blood could give information on ICU admission and RFin hospitalized COVID-19 patients.
Diallo, Alpha; Trøseid, Marius; Simensen, Victoria C; Boston, Anaïs; Demotes, Jacques & Olsen, Inge Christoffer [Show all 28 contributors for this article] (2021). Accelerating clinical trial implementation in the context of the COVID-19 pandemic: challenges, lessons learned and recommendations from DisCoVeRy and the EU-SolidAct EU response group. Clinical Microbiology and Infection (CMI). ISSN 1198-743X. 28(1), p. 1–6. doi: 10.1016/j.cmi.2021.10.011.
Ianevski, Aleksandr; Yao, Rouan; Zusinaite, Eva; Lello, Laura Sandra; Wang, Sainan & Jo, Eunji [Show all 28 contributors for this article] (2021). Synergistic interferon-alpha-based combinations for treatment of sars-cov-2 and other viral infections. Viruses. ISSN 1999-4915. 13:2489(12), p. 1–18. doi: 10.3390/v13122489. Full text in Research Archive Show summary
Background: There is an urgent need for new antivirals with powerful therapeutic potential and tolerable side effects. Methods: Here, we tested the antiviral properties of interferons (IFNs), alone and with other drugs in vitro. Results: While IFNs alone were insufficient to completely abolish replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), IFNα, in combination with remdesivir, EIDD-2801, camostat, cycloheximide, or convalescent serum, proved to be more effective. Transcriptome and metabolomic analyses revealed that the IFNα–remdesivir combination suppressed SARS-CoV-2-mediated changes in Calu-3 cells and lung organoids, although it altered the homeostasis of uninfected cells and organoids. We also demonstrated that IFNα combinations with sofosbuvir, telaprevir, NITD008, ribavirin, pimodivir, or lamivudine were effective against HCV, HEV, FLuAV, or HIV at lower concentrations, compared to monotherapies. Conclusions: Altogether, our results indicated that IFNα can be combined with drugs that affect viral RNA transcription, protein synthesis, and processing to make synergistic combinations that can be attractive targets for further pre-clinical and clinical development against emerging and re-emerging viral infections.
Lerum, Tøri Vigeland; Maltzahn, Niklas; Aukrust, Pål; Trøseid, Marius; Nezvalova-Henriksen, Katerina & Kåsine, Trine [Show all 27 contributors for this article] (2021). Persistent pulmonary pathology after COVID-19 is associated with high viral load, weak antibody response, and high levels of matrix metalloproteinase-9. Scientific Reports. ISSN 2045-2322. 11, p. 1–12. doi: 10.1038/s41598-021-02547-x. Full text in Research Archive Show summary
The association between pulmonary sequelae and markers of disease severity, as well as pro-fibrotic mediators, were studied in 108 patients 3 months after hospital admission for COVID-19. The COPD assessment test (CAT-score), spirometry, diffusion capacity of the lungs (DLCO), and chest-CT were performed at 23 Norwegian hospitals included in the NOR-SOLIDARITY trial, an open-labelled, randomised clinical trial, investigating the efficacy of remdesivir and hydroxychloroquine (HCQ). Thirty-eight percent had a CAT-score ≥ 10. DLCO was below the lower limit of normal in 29.6%. Ground-glass opacities were present in 39.8% on chest-CT, parenchymal bands were found in 41.7%. At admission, low pO2/FiO2 ratio, ICU treatment, high viral load, and low antibody levels, were predictors of a poorer pulmonary outcome after 3 months. High levels of matrix metalloproteinase (MMP)-9 during hospitalisation and at 3 months were associated with persistent CT-findings. Except for a negative effect of remdesivir on CAT-score, we found no effect of remdesivir or HCQ on long-term pulmonary outcomes. Three months after hospital admission for COVID-19, a high prevalence of respiratory symptoms, reduced DLCO, and persistent CT-findings was observed. Low pO2/FiO2 ratio, ICU-admission, high viral load, low antibody levels, and high levels of MMP-9 were associated with a worse pulmonary outcome.
Vestad, Beate; Nyman, Tuula A.; Hove-Skovsgaard, Malene; Stensland, Maria; Hoel, Hedda Benedicte & Siebke, Anne-Marie [Show all 13 contributors for this article] (2021). Plasma extracellular vesicles in people living with HIV and type 2 diabetes are related to microbial translocation and cardiovascular risk. Scientific Reports. ISSN 2045-2322. 11(1). doi: 10.1038/s41598-021-01334-y. Full text in Research Archive
Drivsholm, Ninna; Knudsen, Andreas; Faurholt-Jepsen, Maria; Midttun, Øivind; Trøseid, Marius & Kirkegaard-Klitbo, Ditte M. [Show all 9 contributors for this article] (2021). Alterations in the Kynurenine Pathway of Tryptophan Metabolism Are Associated With Depression in People Living With HIV. Journal of Acquired Immune Deficiency Syndromes. ISSN 1525-4135. 87(2), p. e177–e181. doi: 10.1097/QAI.0000000000002664.
Aune, Susanne Kristine; Cwikiel, Joanna; Flaa, Arnljot; Arnesen, Harald; Solheim, Svein & Awoyemi, Ayodeji Olawale [Show all 9 contributors for this article] (2021). Gut leakage markers in response to strenuous exercise in patients with suspected coronary artery disease. Cells. ISSN 2073-4409. 10(9). doi: 10.3390/cells10092193. Full text in Research Archive
Hustad, Nina Berger; Degerud, Hanna M; Hjelmerud, Ingrid; Fraz, Mai Sasaki Aanensen; Nordøy, Ingvild & Trøseid, Marius [Show all 9 contributors for this article] (2021). Real-World Experiences With Facilitated Subcutaneous Immunoglobulin Substitution in Patients With Hypogammaglobulinemia, Using a Three-Step Ramp-Up Schedule. Frontiers in Immunology. ISSN 1664-3224. 12, p. 1–7. doi: 10.3389/fimmu.2021.670547. Full text in Research Archive
Awoyemi, Ayodeji Olawale; Mayerhofer, Christiane Caroline; Felix, Alex S.; Hov, Johannes Espolin Roksund; Moscavitch, Samuel D. & Lappegård, Knut Tore [Show all 23 contributors for this article] (2021). Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial. EBioMedicine. ISSN 2352-3964. 70. doi: 10.1016/j.ebiom.2021.103511. Full text in Research Archive
Barratt-Due, Andreas; Olsen, Inge Christoffer; Nezvalova-Henriksen, Katerina; Kåsine, Trine; Lund-Johansen, Fridtjof & Hoel, Hedda Benedicte [Show all 43 contributors for this article] (2021). Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 : A Randomized Trial. Annals of Internal Medicine. ISSN 0003-4819. 174(9), p. 1261–1269. doi: 10.7326/M21-0653. Full text in Research Archive Show summary
Background: New treatment modalities are urgently needed for patients with COVID-19. The World Health Organization (WHO) Solidarity trial showed no effect of remdesivir or hydroxychloroquine (HCQ) on mortality, but the antiviral effects of these drugs are not known. Objective: To evaluate the effects of remdesivir and HCQ on all-cause, in-hospital mortality; the degree of respiratory failure and inflammation; and viral clearance in the oropharynx. Design: NOR-Solidarity is an independent, add-on, randomized controlled trial to the WHO Solidarity trial that included biobanking and 3 months of clinical follow-up (ClinicalTrials.gov: NCT04321616). Setting: 23 hospitals in Norway. Patients: Eligible patients were adults hospitalized with confirmed SARS-CoV-2 infection. Intervention: Between 28 March and 4 October 2020, a total of 185 patients were randomly assigned and 181 were included in the full analysis set. Patients received remdesivir (n = 42), HCQ (n = 52), or standard of care (SoC) (n = 87). Measurements: In addition to the primary end point of WHO Solidarity, study-specific outcomes were viral clearance in oropharyngeal specimens, the degree of respiratory failure, and inflammatory variables. Results: No significant differences were seen between treatment groups in mortality during hospitalization. There was a marked decrease in SARS-CoV-2 load in the oropharynx during the first week overall, with similar decreases and 10-day viral loads among the remdesivir, HCQ, and SoC groups. Remdesivir and HCQ did not affect the degree of respiratory failure or inflammatory variables in plasma or serum. The lack of antiviral effect was not associated with symptom duration, level of viral load, degree of inflammation, or presence of antibodies against SARS-CoV-2 at hospital admittance. Limitation: The trial had no placebo group. Conclusion: Neither remdesivir nor HCQ affected viral clearance in hospitalized patients with COVID-19.
Aune, Susanne Kristine; Byrkjeland, Rune; Solheim, Svein; Arnesen, Harald; Trøseid, Marius & Awoyemi, Ayodeji Olawale [Show all 8 contributors for this article] (2021). Gut related inflammation and cardiorespiratory fitness in patients with CAD and type 2 diabetes: a sub-study of a randomized controlled trial on exercise training. Diabetology and Metabolic Syndrome. ISSN 1758-5996. 13(1), p. 1–9. doi: 10.1186/s13098-021-00655-2. Full text in Research Archive
Skaarud, Kristin Aneta Joan; Hov, Johannes Espolin Roksund; Hansen, Simen Hyll; Kummen, Martin; Valeur, Jørgen & Seljeflot, Ingebjørg [Show all 12 contributors for this article] (2021). Mortality and microbial diversity after allogenic hematopoietic stem cell transplantation: secondary analysis of a randomized nutritional intervention trial. Scientific Reports. ISSN 2045-2322. doi: 10.1038/s41598-021-90976-z. Full text in Research Archive
Dhillon, Amandeep Kaur; Rupp, Christian; Bergquist, Annika; Voitl, Robert; Folseraas, Trine & Trøseid, Marius [Show all 12 contributors for this article] (2021). Associations of neopterin and kynurenine–tryptophan ratio with survival in primary sclerosing cholangitis. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 56(4), p. 443–452. doi: 10.1080/00365521.2021.1880627. Full text in Research Archive
Meyer-Myklestad, Malin Holm; Medhus, Asle Wilhelm; Lorvik, Kristina Berg; Seljeflot, Ingebjørg; Hansen, Simen Hyll & Holm, Kristian [Show all 13 contributors for this article] (2020). HIV-infected immunological non-responders have colon-restricted gut mucosal immune dysfunction. Journal of Infectious Diseases. ISSN 0022-1899. doi: 10.1093/infdis/jiaa714. Full text in Research Archive
Kummen, Martin; Thingholm, Louise B.; Rühlemann, Malte C.; Holm, Kristian; Hansen, Simen Hyll & Moitinho-Silva, Lucas [Show all 22 contributors for this article] (2020). Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis. Gastroenterology. ISSN 0016-5085. doi: 10.1053/j.gastro.2020.12.058. Full text in Research Archive
Mayerhofer, Christiane Caroline; Kummen, Martin; Holm, Kristian; Broch, Kaspar; Awoyemi, Ayodeji Olawale & Vestad, Beate [Show all 17 contributors for this article] (2020). Low fibre intake is associated with gut microbiota alterations in chronic heart failure. ESC Heart Failure. ISSN 2055-5822. 7(2), p. 456–466. doi: 10.1002/ehf2.12596. Full text in Research Archive
Nordøy, Ingvild; Fraz, Mai Sasaki Aanensen; Trøseid, Marius; Fevang, Børre & Aukrust, Pål (2020). Høyt serum-ferritin ikke kun uttrykk for leversvikt. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(8). doi: 10.4045/tidsskr.20.0376.
Hove-Skovsgaard, Malene; Abildgaard, Julie; Gelpi, Marco; Gaardbo, Julie C.; Kolte, Lilian & Ullum, Henrik [Show all 9 contributors for this article] (2020). No evidence of a synergistic effect of HIV infection and diabetes mellitus type 2 on fat distribution, plasma adiponectin or inflammatory markers. BMC Infectious Diseases. ISSN 1471-2334. 20(1). doi: 10.1186/s12879-020-05594-3. Full text in Research Archive
Gelpi, Marco; Vestad, Beate; Hansen, Simen Hyll; Holm, Kristian; Drivsholm, Ninna & Götz, Alexandra [Show all 17 contributors for this article] (2020). Impact of human immunodeficiency virus-related gut microbiota alterations on metabolic comorbid conditions. Clinical Infectious Diseases. ISSN 1058-4838. 71(8), p. e359–e367. doi: 10.1093/cid/ciz1235. Full text in Research Archive
Macpherson, Magnhild Eide; Hov, Johannes Espolin Roksund; Ueland, Thor; Dahl, Tuva Børresdatter; Kummen, Martin & Otterdal, Kari [Show all 14 contributors for this article] (2020). Gut microbiota-dependent trimethylamine N-oxide associates with inflammation in common variable immunodeficiency. Frontiers in Immunology. ISSN 1664-3224. 11. doi: 10.3389/fimmu.2020.574500. Full text in Research Archive
Hoel, Hedda Benedicte; Heggelund, Lars; Reikvam, Dag Henrik; Stiksrud, Birgitte; Ueland, Thor & Michelsen, Annika [Show all 15 contributors for this article] (2020). Elevated markers of gut leakage and inflammasome activation in COVID-19 patients with cardiac involvement. Journal of Internal Medicine. ISSN 0954-6820. doi: 10.1111/joim.13178. Full text in Research Archive
Gelpi, Marco; Ueland, Per Magne; Trøseid, Marius; Mocroft, Amanda; Lebech, Anne-Mette & Ullum, Henrik [Show all 9 contributors for this article] (2020). Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus. Journal of Infectious Diseases. ISSN 0022-1899. 221(3), p. 419–427. doi: 10.1093/infdis/jiz465.
Hoel, Hedda Benedicte; Ueland, Thor; Knudsen, Andreas; Kjær, Andreas; Michelsen, Annika & Sagen, Ellen Lund [Show all 12 contributors for this article] (2020). Soluble Markers of Interleukin 1 Activation as Predictors of First-Time Myocardial Infarction in HIV-Infected Individuals. Journal of Infectious Diseases. ISSN 0022-1899. 221(4), p. 506–509. doi: 10.1093/infdis/jiz253.
Hoel, Hedda Benedicte; Ueland, Thor; Hove-Skovsgaard, Malene; Hartling, Hans Jakob; Gelpi, Marco & Benfield, Thomas [Show all 11 contributors for this article] (2020). Soluble T-Cell Immunoglobulin Mucin Domain-3 Is Associated With Hepatitis C Virus Coinfection and Low-Grade Inflammation During Chronic Human Immunodeficiency Virus Infection. Open Forum Infectious Diseases. ISSN 2328-8957. 29(7). doi: 10.1093/ofid/ofaa033. Full text in Research Archive
Kummen, Martin; Solberg, Ole Geir; Larsen, Christopher Storm; Holm, Kristian; Ragnarsson, Asgrimur & Trøseid, Marius [Show all 18 contributors for this article] (2020). Rosuvastatin alters the genetic composition of the human gut microbiome. Scientific Reports. ISSN 2045-2322. 10:5397, p. 1–9. doi: 10.1038/s41598-020-62261-y. Full text in Research Archive
Fretheim, Håvard Halland; Chung, Brian K.; Didriksen, Henriette; Bækkevold, Espen Sønderaal; Midtvedt, Øyvind & Brunborg, Cathrine [Show all 18 contributors for this article] (2020). Fecal Microbiota Transplantation in Systemic Sclerosis: A Double-Blind, Placebo-Controlled Randomized Pilot Trial. PLOS ONE. ISSN 1932-6203. 15:e0232739(5), p. 1–14. doi: 10.1371/journal.pone.0232739. Full text in Research Archive
Trøseid, Marius; Andersen, Geir Øystein; Broch, Kaspar & Hov, Johannes Espolin Roksund (2020). The gut microbiome in coronary artery disease and heart failure: Current knowledge and future directions. EBioMedicine. ISSN 2352-3964. 52:102649, p. 1–10. doi: 10.1016/j.ebiom.2020.102649. Full text in Research Archive
Reikvam, Dag Henrik; Meyer-Myklestad, Malin Holm; Trøseid, Marius & Stiksrud, Birgitte (2020). Probiotics to manage inflammation in HIV infection. Current Opinion in Infectious Diseases. ISSN 0951-7375. 33(1), p. 34–43. doi: 10.1097/QCO.0000000000000612.
Trøseid, Marius; Mayerhofer, Christiane Caroline; Broch, Kaspar; Arora, Satish; Svardal, Asbjørn M. & Hov, Johannes Espolin Roksund [Show all 14 contributors for this article] (2019). The carnitine-butyrobetaine-TMAO pathway after cardiac transplant: Impact on cardiac allograft vasculopathy and acute rejection. The Journal of Heart and Lung Transplantation. ISSN 1053-2498. 38(10), p. 1097–1103. doi: 10.1016/j.healun.2019.06.003. Full text in Research Archive
Stiksrud, Birgitte; Aass, Hans Christian Dalsbotten; Lorvik, Kristina Berg; Ueland, Thor; Trøseid, Marius & Dyrhol-Riise, Anne Ma (2019). Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4+ recovery. AIDS (London). ISSN 0269-9370. 33(7), p. 1117–1129. doi: 10.1097/QAD.0000000000002173. Full text in Research Archive
Awoyemi, Ayodeji Olawale; Trøseid, Marius; Arnesen, Harald; Solheim, Svein & Seljeflot, Ingebjørg (2019). Effects of dietary intervention and n-3 PUFA supplementation on markers of gut-related inflammation and their association with cardiovascular events in a high-risk population. Atherosclerosis. ISSN 0021-9150. 286, p. 53–59. doi: 10.1016/j.atherosclerosis.2019.05.004.
Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin & Rashidi, Azita [Show all 18 contributors for this article] (2019). Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency. Scientific Reports. ISSN 2045-2322. 9:167, p. 1–10. doi: 10.1038/s41598-018-35367-7. Full text in Research Archive
Dhillon, Amandeep Kaur; Kummen, Martin; Trøseid, Marius; Åkra, Sissel; Liaskou, Evaggelia & Moum, Bjørn [Show all 10 contributors for this article] (2019). Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis. Liver international (Print). ISSN 1478-3223. 39(2), p. 371–381. doi: 10.1111/liv.13979. Full text in Research Archive
Trøseid, Marius; Nordøy, Ingvild; Fevang, Børre & Aukrust, Pål (2018). Anbud på hivlegemidler er ikke faglig begrunnet. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(20), p. 1–3. doi: 10.4045/tidsskr.18.0808.
Arnbjerg, Caroline J; Vestad, Beate; Hov, Johannes Espolin Roksund; Pedersen, Karin K; Jespersen, Sofie & Johannesen, Helle H [Show all 15 contributors for this article] (2018). Effect of Lactobacillus rhamnosus GG Supplementation on Intestinal Inflammation Assessed by PET/MRI Scans and Gut Microbiota Composition in HIV-Infected Individuals. Journal of Acquired Immune Deficiency Syndromes. ISSN 1525-4135. 78(4), p. 450–457. doi: 10.1097/QAI.0000000000001693.
Larsen, Christopher Storm; Stiksrud, Birgitte; Eriksen, Carsten; Eriksen, C.; Nowak, Piotr & Nowak, P. [Show all 14 contributors for this article] (2018). Microbial translocation revisited: targeting the endotoxic potential of gut microbes in HIV-infected individuals. AIDS (London). ISSN 0269-9370. 33(4), p. 645–653. doi: 10.1097/QAD.0000000000002087. Full text in Research Archive
Missailidis, Catharina; Neogi, Ujjwal; Stenvinkel, Peter; Trøseid, Marius; Nowak, Piotr & Bergman, Peter (2018). The microbial metabolite trimethylamine-N-oxide in association with inflammation and microbial dysregulation in three HIV cohorts at various disease stages. AIDS (London). ISSN 0269-9370. 32(12), p. 1589–1598. doi: 10.1097/QAD.0000000000001813. Full text in Research Archive
Awoyemi, Ayodeji Olawale; Trøseid, Marius; Arnesen, Harald; Solheim, Svein & Seljeflot, Ingebjørg (2018). Markers of metabolic endotoxemia as related to metabolic syndrome in an elderly male population at high cardiovascular risk: A cross-sectional study. Diabetology and Metabolic Syndrome. ISSN 1758-5996. 10(1). doi: 10.1186/s13098-018-0360-3. Full text in Research Archive
Mayerhofer, Christiane Caroline; Awoyemi, Ayodeji Olawale; Moscavitch, Samuel D.; Lappegård, Knut Tore; Hov, Johannes Espolin Roksund & Aukrust, Pål [Show all 13 contributors for this article] (2018). Design of the GutHeart-targeting gut microbiota to treat heart failure-trial: a Phase II, randomized clinical trial. ESC Heart Failure. ISSN 2055-5822. 5, p. 978–985. doi: 10.1002/ehf2.12332. Full text in Research Archive
Hoel, Hedda Benedicte; Hove-Skovsgaard, Malene; Hov, Johannes Espolin Roksund; Gaardbo, Julie Christine; Holm, Kristian & Kummen, Martin [Show all 17 contributors for this article] (2018). Impact of HIV and type 2 diabetes on gut microbiota diversity, tryptophan catabolism and endothelial dysfunction. Scientific Reports. ISSN 2045-2322. 8. doi: 10.1038/s41598-018-25168-3. Full text in Research Archive
Hovland, Anders; Nestvold, Torunn Kristin; Bohov, Pavol; Trøseid, Marius; Aukrust, Pål & Berge, Rolf Kristian [Show all 9 contributors for this article] (2017). Bariatric surgery reduces fasting total fatty acids and increases n-3 polyunsaturated fatty acids in morbidly obese individuals. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 77(8), p. 628–633. doi: 10.1080/00365513.2017.1393691. Full text in Research Archive
Mayerhofer, Christiane Caroline; Ueland, Thor; Broch, Kaspar; Vincent, Royce P.; Cross, Gemma F. & Dahl, Christen Peder [Show all 10 contributors for this article] (2017). Increased secondary/primary bile acid ratio in chronic heart failure. Journal of Cardiac Failure. ISSN 1071-9164. 23(9), p. 666–671. doi: 10.1016/j.cardfail.2017.06.007. Full text in Research Archive
Haissman, Judith M.; Haugaard, Anna K.; Ostrowski, Sisse R.; Berge, Rolf Kristian; Hov, Johannes Espolin Roksund & Trøseid, Marius [Show all 7 contributors for this article] (2017). Microbiota-dependent metabolite and cardiovascular disease marker trimethylamine-N-oxide (TMAO) is associated with monocyte activation but not platelet function in untreated HIV infection. BMC Infectious Diseases. ISSN 1471-2334. 17:445, p. 1–8. doi: 10.1186/s12879-017-2547-x.
Hove-Skovsgaard, Malene; Gaardbo, Julie Christine; Kolte, Lilian; Winding, Kamilla; Seljeflot, Ingebjørg & Svardal, Asbjørn M. [Show all 11 contributors for this article] (2017). HIV-infected persons with type 2 diabetes show evidence of endothelial dysfunction and increased inflammation. BMC Infectious Diseases. ISSN 1471-2334. 17:234, p. 1–8. doi: 10.1186/s12879-017-2334-8. Full text in Research Archive
Gelpi, Marco; Hartling, Hans Jakob; Ueland, Per Magne; Ullum, Henrik; Trøseid, Marius & Nielsen, Susanne D. (2017). Tryptophan catabolism and immune activation in primary and chronic HIV infection. BMC Infectious Diseases. ISSN 1471-2334. 17:349, p. 1–8. doi: 10.1186/s12879-017-2456-z.
Prebensen, Christian; Trøseid, Marius; Ueland, Thor; Dahm, Anders Erik A; Sandset, Per Morten & Aaberge, Ingeborg Sundsvalen [Show all 10 contributors for this article] (2017). Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial. PLOS ONE. ISSN 1932-6203. 12(5). doi: 10.1371/journal.pone.0176527. Full text in Research Archive

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Trøseid, Marius (2017). Book of Abstracts: 4rd National Microbiota Conference. Universitetet i Oslo. ISBN 000-00-000-0000-0. 200 p.

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Hites, Maya; Lapique, Eva Larranaga; Massonnaud, Clément R.; Belhadi, Drifa; Jamard, Simon & Goehringer, François [Show all 86 contributors for this article] (2024). Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): A phase 3, randomized, double-blind, placebo-controlled trial. Journal of Infection. ISSN 0163-4453. 88(3). doi: 10.1016/j.jinf.2024.106120.
Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin & Rashidi, Azita [Show all 18 contributors for this article] (2024). Retraction to: Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency (Scientific Reports, (2019), 9, 1, (167), 10.1038/s41598-018-35367-7). Scientific Reports. ISSN 2045-2322. 14(1). doi: 10.1038/s41598-024-54117-6.
Serrano-Villar, Sergio; Tincati, Camilla; Raju, Sajan; Sáenz, Johan S.; Moreno, Elena & Bargiela, Rafael [Show all 19 contributors for this article] (2023). Author Correction: Microbiome-derived cobalamin and succinyl-CoA as biomarkers for improved screening of anal cancer (Nature Medicine, (2023), 29, 7, (1738-1749), 10.1038/s41591-023-02407-3). Nature Medicine. ISSN 1078-8956. doi: 10.1038/s41591-023-02529-8.
Juul, Frederik Emil; Hov, Johannes Espolin Roksund; Trøseid, Marius; Johnsen, Peter Holger & Valeur, Jørgen (2023). Tarmflora og tarmsykdom – en edruelig formaning. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 143(10), p. 849–850. doi: 10.4045/tidsskr.23.0121.
Moreno, Elena; Trøseid, Marius; Vujkovic-Cvijin, Ivan; Marchetti, Giulia; Martín-Pedraza, Laura & Serrano-Villar, Sergio (2023). Editorial: Targeting the microbiota to attenuate chronic inflammation. Frontiers in Immunology. ISSN 1664-3224. 14. doi: 10.3389/fimmu.2023.1202222.
Ueland, Thor; Äikäs, Lauri A.O.; Dahl, Tuva Børresdatter; Gregersen, Ida; Olsen, Maria Belland & Michelsen, Annika Elisabet [Show all 20 contributors for this article] (2023). Low-density lipoprotein particles carrying proinflammatory proteins with altered aggregation pattern detected in COVID-19 patients 3 months after hospitalization. Journal of Infection. ISSN 0163-4453. 86(5), p. 489–492. doi: 10.1016/j.jinf.2023.02.024.
Awoyemi, Ayodeji Olawale; Hov, Johannes Espolin Roksund & Trøseid, Marius (2022). Phenylacetylglutamine From the Gut Microbiota: A Future Therapeutic Target in Heart Failure? Circulation: Heart Failure. ISSN 1941-3289. doi: 10.1161/CIRCHEARTFAILURE.122.010222.
Gregersen, Ida; Ueland, Thor; Holter, Jan Cato; Olsen, Maria Belland; Michelsen, Annika Elisabet & Murphy, Sarah L [Show all 22 contributors for this article] (2022). CXCL16 associates with adverse outcome and cardiac involvement in hospitalized patients with Covid-19. Journal of Infection. ISSN 0163-4453. 85(6), p. 735–738. doi: 10.1016/j.jinf.2022.09.029.
Murphy, Sarah Louise Mikalsen; Halvorsen, Bente; Barratt-Due, Andreas; Dyrhol-Riise, Anne Ma; Aukrust, Pål & Trøseid, Marius [Show all 7 contributors for this article] (2022). Remdesivir modifies interferon response in hospitalized COVID-19 patients. Journal of Infection. ISSN 0163-4453. 85(5), p. 573–607. doi: 10.1016/j.jinf.2022.07.021.
Hentzien, Maxime; Owen, Andrew; Strub-Wourgaft, Nathalie; Pérez-Casas, Carmen; Trøseid, Marius & Calmy, Alexandra (2022). Rethinking treatment paradigms for the deployment of SARS-CoV-2 antiviral drugs on the shifting landscape of new variants. Frontiers in Microbiology. ISSN 1664-302X. 13. doi: 10.3389/fmicb.2022.998287.
Trøseid, Marius; Diallo, Alpha; Hites, Maya; Røttingen, John-Arne & Yazdanpanah, Yazdan (2022). Accelerating clinical trial implementation in the context of the COVID-19 pandemic: author's response. Clinical Microbiology and Infection (CMI). ISSN 1198-743X. 28(5), p. 743–744. doi: 10.1016/j.cmi.2021.12.014.
Trøseid, Marius; Hites, Maya; Barratt-Due, Andreas; Ader, Florence & Yazdanpanah, Yazdan (2021). Assessing the evidence on remdesivir. The Lancet Infectious Diseases. ISSN 1473-3099. 21(12), p. 1630–1631. doi: 10.1016/S1473-3099(21)00695-2.
Tangen, Jorun; Aukrust, Pål; Barrat-Due, A; Trøseid, Marius; Olsen, Inge Christoffer & Nezvalova-Henriksen, Katerina [Show all 15 contributors for this article] (2021). Cardiac function is normal in most patients recovered from COVID-19 .
Stø, Kristine; Valeur, Jørgen; Ueland, Thor; Malmstrøm, Gunn Helen; Bjerkeli, Vigdis & Kazmi, Syed Sajid Hussain [Show all 10 contributors for this article] (2021). Increased fecal levels of the SCFA butyrate may indicate poor absorption due to disrupted gut barrier in patients with carotid stenosis.
Trøseid, Marius (2020). Når covid-19 møter afrikansk helsevesen. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 104(7), p. 1–2. doi: 10.4045/tidsskr.20.0283.
Trøseid, Marius; Lutro, Olav & Ormaasen, Vidar (2020). Utprovende behandling for covid-19 bor forega i randomiserte studier. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(7), p. 1–3. doi: 10.4045/TIDSSKR.20.0282.
Meyer-Myklestad, Malin Holm; Kummen, Martin; Stiksrud, Birgitte; Holm, Kristian; Dyrhol-Riise, Anne Ma & Kvale, Dag [Show all 11 contributors for this article] (2019). ALTERED GUT IMMUNITY IN IMMUNOLOGICAL NONRESPONDERS PARTLY RESTORED BY PROBIOTICS.
Trøseid, Marius (2019). Benmargstransplantasjon - en kur mot hiv? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 139(7). doi: 10.4045/tidsskr.19.0199.
Mayerhofer, Christiane Caroline; Awoyemi, Ayodeji Olawale; Hov, Johannes Espolin Roksund; Trøseid, Marius & Broch, Kaspar (2019). Reply: Potential risk associated with direct modulation of the gut flora in patients with heart failure. ESC Heart Failure. ISSN 2055-5822. 6(3), p. 557–558. doi: 10.1002/ehf2.12437.
Nilsen, Lisbeth; Hov, Johannes Espolin Roksund; Trøseid, Marius; Valeur, Jørgen & Midtvedt, Tore (2018). Forsker på om tarmbakteriene kan forutsi sykdom. [Newspaper]. Dagens Medisin.
Kummen, Martin; Mayerhofer, Christiane Caroline; Vestad, Beate; Broch, Kaspar; Awoyemi, Ayodeji Olawale & Storm-Larsen, Christopher [Show all 10 contributors for this article] (2018). Gut Microbiota Signature in Heart Failure Defined From Profiling of 2 Independent Cohorts. Journal of the American College of Cardiology. ISSN 0735-1097. 71(10), p. 1184–1186. doi: 10.1016/j.jacc.2017.12.057.
Bernhoft, Aksel; Midtvedt, Tore; Eggesbø, Merete Åse; Aas, Anne-Marie; Berstad, Arnold & Harstad, Odd Magne [Show all 15 contributors for this article] (2017). Tarmens viktige mikrober - hvordan mater vi dem, og hva gjør de med oss? Årbok 2016 Det Norske Videnskaps-Akademi. Novus Forlag. ISSN 978-82-7099-888-3. p. 438–453.
Trøseid, Marius (2017). Gutmicrobiota and acute coronary syndromes: Ready for use in the emergency room? European Heart Journal. ISSN 0195-668X. 38(11), p. 825–827. doi: 10.1093/eurheartj/ehx005.
Kielland, Ingrid Røise; Stenvik, Bår; Øien, Torbjørn; Eggesbø, Merete Åse; Valeur, Jørgen & Birkeland, Stein-Erik [Show all 16 contributors for this article] (2017). Bakteriebomben. [Newspaper]. D2 - Dagens Næringsliv.

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Published Apr. 4, 2016 9:21 AM - Last modified May 25, 2023 2:37 PM

Research groups

Infectious Immunology