Mathis Korseberg Stokke

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Visiting address Kirkeveien 166 Bygg 7 0450 Oslo
Postal address Postboks 4956 Nydalen OUS HF Ullevål sykehus 0424 Oslo

Mathis Korseberg Stokke is Full Professor at UiO and Consultant Cardiologist at the Arrhythmia Unit, Department of Cardiology, Oslo University Hospital Rikshospitalet. He leads a research group at the Institute for Experimental Medical Research that work to unravel fundamental principles of cardiac electrophysiology, in order to provide a better understanding and management of clinical conditions caused by abnormal electrical activity in the heart. The group use observations from patients as the outset for our laboratory experiments, and test key findings in large animal models and clinical situations. The group members have different academic backgrounds and specific know-how, from nanotechnology and molecular biology to clinical training in cardiology. The group also collaborates closely with clinicians and researchers at Oslo University Hospital, and with international collaborators in the US, Germany and UK. Stokke is also Deputy Director of NORHEART – The Norwegian PhD School of Heart Research, and teaches at several courses at the Medical Faculty.

Publications

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  • Stokke, Mathis K.; Castrini, Anna I.; Aneq, Meriam Åström; Jensen, Henrik K.; Madsen, Trine & Hansen, Jim [Show all 12 contributors for this article] (2021). Reply to: TFC ECG in arrhythmogenic cardiomyopathy: Inadequate mixture of criteria? International Journal of Cardiology. ISSN 0167-5273. 323. doi: 10.1016/j.ijcard.2020.08.050.
  • Haugaa, Kristina & Stokke, Mathis Korseberg (2019). Cardiac electrical and mechanical alterations - united in the long QT syndrome. International Journal of Cardiology. ISSN 0167-5273. 274, p. 190–191. doi: 10.1016/j.ijcard.2018.09.048. Full text in Research Archive
  • Danielsen, Tore Kristian; Manotheepan, Ravinea; Sadredini, Mani; Leren, I.S.; Edwards, Andrew & Vincent, K. [Show all 11 contributors for this article] (2016). Mechanisms underlying the frequency-dependence of triggered arrhythmias in catecholaminergic polymorphic ventricular tachycardia type 1.
  • Manotheepan, Ravinea; Danielsen, Tore Kristian; Saberniak, Jorg; Sadredini, Mani; Anderson, Mark e. & Carlson, Cathrine Rein [Show all 11 contributors for this article] (2016). Exercise training as anti-arrhythmic therapy in cathecholaminergic polymorphic ventricular tachycardia type 1.
  • Sadredini, Mani; Manotheepan, Ravinea; Danielsen, Tore Kristian; Lehnart, Stefan; Sjaastad, Ivar & Stokke, Mathis Korseberg (2016). Epac2 inhibition reduces arrhythmogenic Ca2+ wave frequently in cardiomyocytes from mice With catecholaminergic polymorphic ventricular tachcardia type 1.
  • Sadredini, Mani Nikoo; Danielsen, Tore Kristian; Aronsen, Jan Magnus; Manotheepan, Ravinea; Hougen, Karina & Sjaastad, Ivar [Show all 7 contributors for this article] (2015). Beta-adrenoceptor stimulation reveals Ca2+ overload paradox in left ventricular cardiomyocytes from post-infarction rats with and without heart failure.
  • Danielsen, Tore Kristian; Manotheepan, Ravinea; Sadredini, Mani Nikoo; Gaur, Namit; Leren, IS & Edwards, Andrew [Show all 11 contributors for this article] (2015). Mechanisms for the frequency-dependence of triggered activity in catecholaminergic polymorphic ventricular tachycardia type 1.
  • Manotheepan, Ravinea; Danielsen, Tore Kristian; Sadredini, Mani Nikoo; Anderson, Mark e.; Carlson, Cathrine Rein & Lehnart, Stefan [Show all 8 contributors for this article] (2015). Exercise training reduced CaMKII-dependent arrhythmogenic Ca2+ release and prevents ventricular tachycardia in CPVT 1.
  • Sadredini, Mani Nikoo; Danielsen, Tore Kristian; Aronsen, Jan Magnus; Manotheepan, Ravinea; Hougen, Karina & Sjaastad, Ivar [Show all 7 contributors for this article] (2015). Beta-adrenoreceptor stimulation reveals Ca2+ overload paradox in left ventricular cardiomyocytes from post-infarction rats with and without heart failure.
  • Kolstad, Terje R Selnes; Stokke, Mathis Korseberg; Stang, Espen; Brorson, Sverre Henning; Louch, William Edward & Sejersted, Ole M (2015). Serca located in the junctional SR shapes calcium release in cardiac myocytes. Biophysical Journal. ISSN 0006-3495. 108, p. 503a–503a.
  • Manotheepan, Ravinea; Danielsen, Tore Kristian; Sadredini, Mani Nikoo; Lehnart, Stefan; Sjaastad, Ivar & Stokke, Mathis Korseberg (2014). Exercise training reduces CaMKII-dependent phosphorylation of the cardiac ryanodine receptor and arrhythmogenic SR Ca2+ leak in mice with mutant cardiac ryanodine receptor 2.
  • Manotheepan, Ravinea; Danielsen, Tore Kristian; Sadredini, Mani Nikoo; Anderson, Mark E.; Lehnart, Stephan & Sjaastad, Ivar [Show all 7 contributors for this article] (2014). Exercise training reduces CaMKII-dependent phosphorylation of RyR2 and arrhythmogenic SR Ca2+ release in mince with CPVT.
  • Kolstad, Terje R Selnes; Stokke, Mathis Korseberg; Stang, Espen; Brorson, Sverre Henning; Louch, William Edward & Sejersted, Ole M (2014). SERCA localized near the dyad regulates calcium release in cardiac myocytes.
  • Kolstad, Terje R Selnes; Stokke, Mathis Korseberg; Stang, Espen; Brorson, Sverre Henning; Louch, William Edward & Sejersted, Ole M (2014). SERCA localized near the dyad regulates calcium release in cardiac myoctyes.
  • Kolstad, Terje R Selnes; Stokke, Mathis Korseberg; Stang, Espen; Brorson, Sverre Henning; Christensen, Geir Arve & Louch, William Edward [Show all 7 contributors for this article] (2014). SERCA localized near the dyad regulates calcium release in cardiac myocytes.
  • Danielsen, Tore Kristian; Manotheepan, Ravinea; Sadredini, Mani Nikoo; Aronsen, Jan Magnus; Hougen, Karina & Sejersted, Ole M [Show all 8 contributors for this article] (2014). The effect of exercise training on Ca2+ wave probability after myocardial infarction varies with cardiac function at onset of training.
  • Sadredini, Mani Nikoo; Danielsen, Tore Kristian; Aronsen, Jan Magnus; Manotheepan, Ravinea; Sjaastad, Ivar & Stokke, Mathis Korseberg (2013). Ca2+ wave probability is differently affected in cardiomyocytes from rats with failing and non-failing cardiac function after myocardial infarction.
  • Skogestad, Jonas; Aronsen, Jan Magnus; Hougen, Karina; Stokke, Mathis Korseberg; Swift, Fredrik & Sejersted, Ole M [Show all 7 contributors for this article] (2013). Extracellular potassium regulates Ca2+ homeostasis through interaction between NCX and NKA.
  • Danielsen, Tore Kristian; Manotheepan, Ravinea; Sadredini, Mani Nikoo; Aronsen, Jan Magnus; Hougen, Karina & Sejersted, Ole M [Show all 8 contributors for this article] (2013). The effect of exercise training on ca2+ wave probability after myocardial infarction depends on cardiac function at onset of training. Heart Rhythm. ISSN 1547-5271. 10.
  • Manotheepan, Ravinea; Danielsen, Tore Kristian; Sadredini, Mani Nikoo; Lehnart, Stephen; Sjaastad, Ivar & Stokke, Mathis Korseberg (2013). Exercise training reduces Ca2+-calmodulin-dependent protein kinase type II dependent phosphorylation of the cardiac ryanodine receptor and Ca2+ leak from the sarcoplasmic reticulum in mice with mutant cardiac ryanodine receptor 2. Circulation. ISSN 0009-7322. 128.
  • Manotheepan, Ravinea; Danielsen, Tore Kristian; Sadredini, Mani Nikoo; Lehnart, Stephan; Sjaastad, Ivar & Stokke, Mathis Korseberg (2013). Exercise training reduces Ca2+ -calmodulin-dependent protein kinase type II dependent phosphorylation of the cardiac ryanodine receptor and Ca2+ leak from the sarcoplasmic reticulum in mice with mutant cardiac ryanodine receptor.
  • Danielsen, Tore Kristian; Manotheepan, Ravinea; Sadredini, Mani Nikoo; Aronsen, Jan Magnus; Hougen, Karina & Sejersted, Ole M [Show all 8 contributors for this article] (2013). The effect of exercise training on Ca2+ wave probability after myocardial infarction depends on cardiac function at onset of training.
  • Sadredini, Mani Nikoo; Danielsen, Tore Kristian; Aronsen, Jan Magnus; Manotheepan, Ravinea; Sjaastad, Ivar & Stokke, Mathis Korseberg (2013). Ca2+ wave probability is differently affected in cardiomyocytes from rats with failing and non-failing cardiac function after myocardial infarction.
  • Manotheepan, Ravinea; Danielsen, Tore Kristian; Sadredini, Mani Nikoo; Lehnart, Stephan; Sjaastad, Ivar & Stokke, Mathis Korseberg (2013). Can exercise training prevent arrhythmogenic Ca2+ release in RyR2-R2474S mice?
  • Danielsen, Tore Kristian; Manotheepan, Ravinea; Sadredini, Mani Nikoo; Aronsen, Jan Magnus; Hougen, Karina & Sejersted, Ole M [Show all 8 contributors for this article] (2013). The effect of exercise training on Ca2+ wave probability after myocardial infarction depends on cardiac function at onset of training.
  • Skogestad, Jonas; Aronsen, Jan Magnus; Hougen, Karina; Stokke, Mathis Korseberg; Swift, Fredrik & Sejersted, Ole M [Show all 7 contributors for this article] (2012). Extracellular potassium regulates Ca2+ homeostasis through interaction between NCX and NKA.
  • Sadredini, Mani Nikoo; Danielsen, Tore Kristian; Aronsen, Jan Magnus; Sjaastad, Ivar & Stokke, Mathis Korseberg (2012). Ca2+ wave probability in rats with varying levels of cardiac contractile dysfunction after myocardial infarction.
  • Sadredini, Mani Nikoo; Danielsen, Tore Kristian; Aronsen, Jan Magnus; Sjaastad, Ivar & Stokke, Mathis Korseberg (2012). Ca2+ wave probability in rats with varying levels of cardiac contractile dysfunction after myocardial infarction.
  • Sadredini, Mani Nikoo; Danielsen, Tore Kristian; Aronsen, Jan Magnus; Sjaastad, Ivar & Stokke, Mathis Korseberg (2012). Ca2+ wave probability in rats with varying levels of cardiac contractile dysfunction after myocardial infarction.
  • Loose, Kristian; Sadredini, Mani Nikoo; Sejersted, Ole M; Stokke, Mathis Korseberg & Louch, William Edward (2012). Ca2+ wave velocity in cardiomyocytes is regulated by ryanodine receptor Ca2+ sensitivity and SR Ca2+ content.
  • Loose, Kristian; Sadredini, Mani Nikoo; Sejersted, Ole M; Stokke, Mathis Korseberg & Louch, William Edward (2012). Ca2+ wave velocity in cardiomyocytes is regulated by ryanodine receptor Ca2+ sensitivity and SR 2+ content. Biophysical Journal. ISSN 0006-3495. 102(3), p. 99a–100a.
  • Manotheepan, Ravinea; Saberniak, Jorg; Danielsen, Tore Kristian; Edvardsen, Thor; Sjaastad, Ivar & Haugaa, Kristina [Show all 7 contributors for this article] (2012). Beneficial effects on aerobic capacity and threshold heart rate for arrhythmias from exercise training in patients with catecholaminergic polymorphic ventricular tachycardia. Circulation. ISSN 0009-7322. 126, p. A13277–A13277.
  • Manotheepan, Ravinea; Saberniak, Jorg; Danielsen, Tore Kristian; Edvardsen, Thor; Sjaastad, Ivar & Haugaa, Kristina [Show all 7 contributors for this article] (2012). Beneficial effects on aerobic capacity and threshold heart rate for arrhythmias from exercise training in patients with catecholaminergic polymorphic ventricular tachycardia.
  • Danielsen, Tore Kristian; Manotheepan, Ravinea; Sadredini, Mani Nikoo; Aronsen, Jan Magnus; Sejersted, Ole M & Sjaastad, Ivar [Show all 7 contributors for this article] (2012). Short-term protocols are sufficient to induce exercise effects in rodents.
  • Swift, Fredrik; Aronsen, Jan Magnus; Stokke, Mathis Korseberg; Hougen, Karina; Egger, Marcel & Roderick, Llewelyn [Show all 8 contributors for this article] (2012). IP3 receptors in heart failure: arrhythmogenic troublemakers or SR calcium security valves? Biophysical Journal. ISSN 0006-3495. 102(3), p. 101a–101a.
  • Skogestad, Jonas; Aronsen, Jan Magnus; Hougen, Karina; Stokke, Mathis Korseberg; Swift, Fredrik & Sejersted, Ole M [Show all 7 contributors for this article] (2012). Extracellular potassium regulates Ca2+ homeostasis through interaction between NCX and NKA.
  • Swift, Fredrik; Tovsrud, Nils; Aronsen, Jan Magnus; Louch, William Edward; Stokke, Mathis Korseberg & Enger, Ulla Helene [Show all 8 contributors for this article] (2012). Crosstalk between NKA and NCX in a shared microdomain.
  • Øyehaug, Leiv; Jølle, Guro Five; Stokke, Mathis Korseberg; Sejersted, Ole M; Sjaastad, Ivar & Louch, William Edward (2011). Structural remodelling of failing cardiomyocytes and impairment of SERCA function - consequences for dyssynchrony of Ca2+ release.
  • Loose, Kristian; Sadredini, Mani N; Sejersted, Ole M; Stokke, Mathis Korseberg & Louch, William Edward (2011). Ryanodine receptor sensitivity determines Ca2+ wave velocity in cardiomyocytes.
  • Mørk, Halvor Kjeang; Richard, Sylvain; Stokke, Mathis Korseberg; Sjaastad, Ivar; Andersson, Kristin Brevik & Christensen, Geir Arve [Show all 8 contributors for this article] (2011). SERCA2 knockout mice exhibit impaired control of Ca2+ current but not ventricular arrhytmias. Biophysical Journal. ISSN 0006-3495. 100(3), p. 574a–574a.
  • Loose, Kristian; Sadredini, Mani N; Sejersted, Ole M; Stokke, Mathis Korseberg & Louch, William Edward (2011). Ca2+ wave velocity in cardiomyocytes is regulated by ryanodine receptor Ca2+ sensitivity and SR Ca2+ content.
  • Tovsrud, Nils; Stokke, Mathis Korseberg; Sjaastad, Ivar; Sejersted, Ole M & Swift, Fredrik (2011). Stress-induced arrhythmias caused by reduction of ankyrin B.
  • Stokke, Mathis Korseberg; Tovsrud, Nils; Swift, Fredrik; Louch, William Edward; Sejersted, Ole M & Sjaastad, Ivar (2011). L-type Ca2+ current inhibition prevents arrhythmogenic SR Ca2+ release by reducing SR Ca2+ content.
  • Swift, Fredrik; Aronsen, Jan Magnus; Stokke, Mathis Korseberg; Hougen, Karina & Sejersted, Ole M (2011). IP3 receptors in heart failure: Arrhythmogenic troublemakers or SR Ca2+ security valves?
  • Loose, Kristian; Sadredini, Mani N; Sejersted, Ole M; Stokke, Mathis Korseberg & Louch, William Edward (2011). Ca2+ wave velocity in cardiomyocytes is regulated by ryanodine receptor Ca2+ sensitivity and SR Ca2+ content.
  • Louch, William Edward; Li, Liren; Swift, Fredrik; Stokke, Mathis Korseberg; Niederer, Steven A. & Sossalla, Samuel [Show all 11 contributors for this article] (2011). Causes and consequences of cardiomyocyte Na+ loading following SERCA2 knockout.
  • Øyehaug, Leiv; Jølle, Guro five; Stokke, Mathis Korseberg; Sejersted, Ole M; Sjaastad, Ivar & Louch, William Edward (2011). Structural remodelling and decreased SERCA function desynchronize Ca2+ release in failing cardiomyocytes.
  • Øyehaug, Leiv; Jølle, Guro five; Stokke, Mathis Korseberg; Sejersted, Ole M; Sjaastad, Ivar & Louch, William Edward (2011). Structural remodelling and decreased SERCA function desynchronize Ca2+ release in failing cardiomyocytes.
  • Stokke, Mathis Korseberg; Briston, Sarah; Jølle, Guro Five; Louch, William Edward; Christensen, Geir Arve & Eisner, David [Show all 9 contributors for this article] (2010). The arrhythmogenic effect of beta-adrenergic stimulation is potentiated in ventricular myocytes with decreased SERCA2 abundance. European Journal of Heart Failure. Supplements. ISSN 1567-4215. 9, p. S231–S231.
  • Hougen, Karina; Aronsen, Jan Magnus; Stokke, Mathis Korseberg; Enger, Ulla Helene; Nygård, Ståle & Andersson, Kristin Brevik [Show all 9 contributors for this article] (2010). Single dose tamoxifen for Cre-lox gene inactivation minimizes unspecific transcriptional changes and cardiomyopathy in mice.
  • Stokke, Mathis Korseberg; Briston, SJ; Louch, William Edward; Andersson, Kristin Brevik; Christensen, Geir Arve & Sejersted, Ole M [Show all 9 contributors for this article] (2009). The effect of beta adrenergic stimulation on arrhythmogenic Ca2+ release in ventricular cardiomyocytes with reduced SERCA2 abundance. Acta Physiologica. ISSN 1748-1708. 196, p. L34–L34.
  • Stokke, Mathis Korseberg; Hougen, Karina; Sjaastad, Ivar; Louch, William Edward; Andersson, Kristin Brevik & Christensen, Geir Arve [Show all 9 contributors for this article] (2009). Ca2+ wave Development in Ventricular Cardiomyocytes from Mice with Inducible Knockout of SERCA2. Biophysical Journal. ISSN 0006-3495. 96(3).
  • Stokke, Mathis Korseberg; Briston, SJ; Louch, William Edward; Andersson, Kristin Brevik; Christensen, Geir Arve & Sejersted, Ole M [Show all 9 contributors for this article] (2009). The effect of beta adrenergic stimulation on arrhythmogenic Ca2+ release in ventricular cardiomyocytes with reduced SERCA2 abundance.
  • Stokke, Mathis Frøshaug; Hougen, Karina; Sjaastad, Ivar; Louch, William Edward; Andersson, Kristin Brevik & Christensen, Geir Arve [Show all 9 contributors for this article] (2008). Ca2+ wave propagation in an inducible SERCA2 knock-out mouse.
  • Stokke, Mathis Frøshaug; Trafford, Andy; Hougen, Karina; Sejersted, Ole M; Louch, William Edward & Andersson, Kristin Brevik (2008). Breaking the waves? The role of SERCA2 in Ca2+ wave development.
  • Stokke, Mathis Frøshaug; Trafford, Andrew; Hougen, Karina; Sejersted, Ole M; Andersson, Kristin Brevik & Christensen, Geir Arve [Show all 8 contributors for this article] (2007). The role of SERCA2a in calcium wave development.
  • Hougen, Karina; Stokke, Mathis Frøshaug; Birkeland, Jon Arne; Enger, Ulla Helene; Andersson, Kristin Brevik & Sejersted, Ole M [Show all 8 contributors for this article] (2007). Acute loss of SERCA2 induces both diastolic and systolic myocardial failure.
  • Stokke, Mathis Korseberg; Sjaastad, Ivar & Sejersted, Ole M (2011). SERCA2-RyR2 interplay at the heart of Ca²⁺ wave development : experimental studies on mechanisms underlying triggered arrhythmias. Faculty of Medicine, University of Oslo.
  • Stokke, Mathis Korseberg (2011). SERCA2-RyR2 interplay at the heart of Ca2+ wave development. Experimental studies on mechanisms underlying triggered arrythmias. Unipub forlag.

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Published July 5, 2012 12:37 PM - Last modified Jan. 1, 2022 8:55 AM