About the group
We combine laboratory-based studies of animal models with clinical observations and interventions in patients.
As part of this strategy, we collaborate closely with other research groups with expertise from basic research and clinical medicine. This provides us an opportunity to understand biological processes involved in pathological electrophysiology on a molecular, cellular, organ and organism level.
Our goal is that this insight will lead to improved diagnostics and therapy for patients with cardiac disease.
Our goals
We want to understand, predict, prevent and treat heart failure and arrhythmias.
Research methods
We combine clinical observations with animal models and laboratory-based methods to understand mechanisms for arrhythmias, and improve diagnostics and treatment.
This combination of methods is possible because the personnel in our group have different academic backgrounds and specific know-how, and because we work closely with clinical and academic partners.
Projects
Here is an overview of our current projects.
Ventricular arrhythmias after myocardial infarction
• Studies of post-infarction ventricular arrhythmias in a porcine model of ischemia and reperfusion
• Scar-dependent ventricular arrhythmias after myocardial infarction (SCAR-MI)
• Sex-dependent differences in ventricular arrhythmias after myocardial infarction
• SERCA-RyR balance in calcium-dependent arrhythmias
Cardiac fibrosis and the stiff heart
• The role of versican in cardiac fibrosis
• Cardiovascular Function in Connective Tissue Disease
• CHOIR - paCemaker therapy for Hypertrophic ObstructIve cardiomyopathy
• Cardiovascular Function in Connective Tissue Disease
• The role of versican in cardiac fibrosis Chloe Rixon: The role of lumican in hypertrophic cardiomyopathy
• Heart muscle function in combined hypertrophic cardiomyopathy and diabetes
Ageing and sex in cardiac health and disease
• AGORA - Ageing and Operated Rats
Clinical studies on premature ventricular complexes and atrial fibrillation
• Tristan Hellstrand: Quantification of SERCA-RyR balance in calcium-dependent arrhythmias
• Predictors of outcome of catheter ablation for premature ventricular complexes
• Relationship between heart rate and premature ventricular complexes
• Utility of cardiac MRI in evaluation of patients with premature ventricular complexes
• Mechanisms for post-infarction ventricular arrhythmias
• New interventions to limit infarct size
• Effect of radiofrequency ablation therapy for atrial fibrillation in the elderly
Cooperation
Our research group has collaboration with several national and international institutions.
National
- Department of Cardiology, OUH Rikshospitalet
- Department of Cardiology, OUH Ullevål
- Department of Cardiothoracic surgery, OUH Rikshospitalet
- Department of Rheumatology, OUH Rikshospitalet
- Department of Cardiology, Østfold Hospital
International
- Stephan E. Lehnart, University of Göttingen, Germany
- Prof. Godfrey Smith, University of Glasgow
- Prof. Llewelyn Roderick, KU Leuven, Belgium
- Ass. Prof. Julien Ochala, University of Copenhagen
