Ole Henning Skjønsberg

• Lerum, Tøri Vigeland; Aaløkken, Trond M; Brønstad, Eivind; Aarli, Bernt Bøgvald; Ikdahl, Eirik; Lund, Kristine Marie Aarberg; Durheim, Michael; Rivero, Jezabel Rodriguez; Meltzer, Carin; Tonby, Kristian; Stavem, Knut; Skjønsberg, Ole Henning; Ashraf, Haseem & Einvik, Gunnar (2020). Dyspnoea, lung function and CT findings three months after hospital admission for COVID-19. European Respiratory Journal.  ISSN 0903-1936. . doi: 10.1183/13993003.03448-2020
• Torvanger, Ole; Os, Audun; Skjønsberg, Ole Henning & Edvardsen, Elisabeth (2020). Cardiorespiratory fitness on a treadmill in an adult cystic fibrosis population. BMJ Open sport & exercise medicine.  ISSN 2055-7647.  6(1) . doi: 10.1136/bmjsem-2020-000765 Full text in Research Archive. Show summary

  Objectives: (1) To describe the cardiorespiratory fitness (CRF) in an adult cystic fibrosis population related to sex and age, (2) to evaluate the cause of low CRF and (3) to study the association between peak oxygen uptake (VO2peak) and forced expiratory volume in 1 s (FEV1). Methods: A total of 204 cardiopulmonary treadmill exercise tests (CPETs) performed by 116 patients were included. VO2peak, gas exchange, heart rate, oxygen saturation and ventilatory variables were measured. A low CRF was defined as a VO2peak <80% of predicted, ventilatory limitation was defined as a breathing reserve <15%, exercise hypoxaemia was defined as an oxygen saturation <88% and ventilation-perfusion mismatch was defined as a minute ventilation/ventilatory equivalent for carbon dioxide slope ≥34. In patients who had performed three or more CPETs, the annual change in FEV1 and VO2peak were calculated using linear regression. Results: The VO2peak was 40.6±11.5 and 35.2±8.9 mL kg−1 min−1, which was 87±23 and 93±20 in percentage of predicted for men and women, respectively. VO2peak was moderately affected by age, for men (r=−0.36, p<0.001) and women (r=−0.53, p<0.001), respectively. In 45 of 101 tests where CRF was low, no cardiorespiratory limiting factors were identified. The correlation coefficient between VO2peak and FEV1 was r=0.64 (p<0.001). In participants with a low CRF, FEV1 ranged from 20% to 112% of predicted. Conclusions: The correlation between VO2peak and FEV1 was moderate. The majority of the tests resulted in a VO2peak within normal limits. Interestingly, 44% of the tests with a low VO2peak could be explained by deconditioning. Thus, exercise therapy may be beneficial for these patients.

• Sæverud, Håvard Andreassen; Falk, Ragnhild Sørum; Dowrick, Adam; Eriksen, Morten; Aarrestad, Sigurd & Skjønsberg, Ole Henning (2019). Measuring diaphragm movement and respiratory frequency using a novel ultrasound device in healthy volunteers. Journal of Ultrasound.  ISSN 1971-3495.  s 1- 8 . doi: 10.1007/s40477-019-00412-2 Full text in Research Archive.
• Udjus, Camilla; Fadila, Cero; Halvorsen, Bente; Behmen, Dina; Carlson, Cathrine Rein; Bendiksen, Bård Andre; Espe, Emil Knut Stenersen; Sjaastad, Ivar; Løberg, Else Marit; Yndestad, Arne; Aukrust, Pål; Christensen, Geir Arve; Skjønsberg, Ole Henning & Larsen, Karl-Otto (2019). Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension. American Journal of Physiology - Lung cellular and Molecular Physiology.  ISSN 1040-0605.  316(6), s L999- L1012 . doi: 10.1152/ajplung.00322.2018 Full text in Research Archive.
• Aarrestad, Sigurd; Qvarfort, Magnus; Kleiven, Anne Louise; Tollefsen, Elin; Skjønsberg, Ole Henning & Janssens, Jean-Paul (2018). Diagnostic accuracy of simple tools in monitoring patients with chronic hypoventilation treated with non-invasive ventilation; a prospective cross-sectional study. Respiratory Medicine.  ISSN 0954-6111.  144, s 30- 35 . doi: 10.1016/j.rmed.2018.09.015 Full text in Research Archive.
• Aarrestad, Sigurd; Qvarfort, Magnus; Kleiven, Anne Louise; Tollefsen, Elin; Skjønsberg, Ole Henning & Janssens, Jean-Paul (2017). Sleep related respiratory events during non-invasive ventilation of patients with chronic hypoventilation. Respiratory Medicine.  ISSN 0954-6111.  132, s 210- 216 . doi: 10.1016/j.rmed.2017.10.025
• Edvardsen, Elisabeth; Akerø, Aina; Skjønsberg, Ole Henning & Skrede, Bjørn (2017). Pre-flight evaluation of adult patients with cystic fibrosis: a cross-sectional study. BMC Research Notes.  ISSN 1756-0500.  10(84), s 1- 8 . doi: 10.1186/s13104-017-2386-2 Full text in Research Archive. Show summary

  Background: Air travel may imply a health hazard for patients with cystic fibrosis (CF) due to hypobaric environment in the aircraft cabin. The objective was to identify pre-flight variables, which might predict severe hypoxaemia in adult CF patients during air travel. Methods: Thirty adult CF-patients underwent pre-flight evaluation with spirometry, arterial oxygen tension (PaO2), pulse oximetry (SpO2) and cardiopulmonary exercise testing (CPET) at sea level (SL). The results were related to the PaO2 obtained during a hypoxia-altitude simulation test (HAST) in which a cabin altitude of 2438 m (8000 ft) was simulated by breathing 15.1% oxygen. Results: Four patients fulfilled the criteria for supplemental oxygen during air travel (PaO2 HAST < 6.6 kPa). While walking slowly during HAST, another eleven patients dropped below PaO2 HAST 6.6 kPa. Variables obtained during CPET (PaO2 CPET, SpO2 CPET, minute ventilation/carbon dioxide output, maximal oxygen uptake) showed the strongest correlation to PaO2 HAST. Conclusions: Exercise testing might be of value for predicting in-flight hypoxaemia and thus the need for supplemental oxygen during air travel in CF patients.

• Nakstad, Espen Rostrup; Aass, Hans Christian; Opdahl, Helge; Witsø, Anne; Borchsenius, Fredrik; Heyerdahl, Fridtjof & Skjønsberg, Ole Henning (2017). Bronchial wheezing predicts inflammation and respiratory failure in fire smoke victims. Acta Anaesthesiologica Scandinavica.  ISSN 0001-5172.  61(9), s 1142- 1154 . doi: 10.1111/aas.12962 Show summary

  BackgroundAcute fire smoke inhalation injury involves inflammatory mediators whose roles are poorly understood. We carried out a prospective observational study of fire smoke victims to identify clinical and biochemical markers that may predict pulmonary dysfunction and investigated possible correlations between dysfunction and cytokines in bronchoalveolar lavage (BAL) fluid and blood. MethodsForty patients with respiratory and/or neurological symptoms following acute fire smoke inhalation had pulmonary function tests and blood gas analyses performed on admission, at discharge, and after 3 months. Cytokines were measured using BioPlex/XMap technology. ResultsOn admission, 30 (75%) patients had dyspnea. Patients presenting with bronchial wheezing (n = 14) had significantly lower PEF (201 l/min, 82-360) than non-wheezing patients (406 l/min, 100-683) (n = 16, P = 0.03). Bronchial wheezing predicted need for ICU treatment with OR = 93.3 at 95% CI (P < 0.001) and was associated with gas exchange impairment, with mean p(a)O(2)/FiO(2) ratio 34.4 (11.8-49.8) kPa on admission and 21.3 (8.3-44.5) kPa 48 h later. Blood HbCO also predicted ICU treatment, with OR = 1.58 at 95% CI (P < 0.001). Serum CRP, IL-6, IL-8, and MCP-1 were significantly higher in wheezing patients after 12-24 h compared with non-wheezing patients and study controls. Cytokine levels were still elevated after 3 months. BAL fluid had significantly higher levels of IL-8, MCP-1, IL-1, and G-CSF compared with healthy controls. ConclusionIn victims of fire smoke inhalation, pulmonary wheezing predicts inflammation, pulmonary dysfunction, respiratory failure, and need for intensive care.

• Nakstad, Espen Rostrup; Opdahl, Helge; Heyerdahl, Fridtjof; Borchsenius, Fredrik & Skjønsberg, Ole Henning (2017). Manual ventilation and open suction procedures contribute to negative pressures in a mechanical lung model. BMJ Open Respiratory Research.  ISSN 2052-4439.  4:e000176, s 1- 7 . doi: 10.1136/bmjresp-2016-000176
• Aarrestad, Sigurd; Tollefsen, Elin; Kleiven, Anne Louise; Qvarfort, Magnus; Janssens, Jean-Paul & Skjønsberg, Ole Henning (2016). Validity of transcutaneous PCO2 in monitoring chronic hypoventilation treated with non-invasive ventilation. Respiratory Medicine.  ISSN 0954-6111.  112, s 112- 118 . doi: 10.1016/j.rmed.2016.01.017
• Nakstad, Espen Rostrup; Opdahl, Helge; Heyerdahl, Fridtjof; Borchsenius, Fredrik & Skjønsberg, Ole Henning (2016). Can ventilator settings reduce the negative effects of endotracheal suctioning? Investigations in a mechanical lung model. BMC Anesthesiology.  ISSN 1471-2253.  16:30 . doi: 10.1186/s12871-016-0196-z
• Stylianou, Eva; Ueland, Thor; Borchsenius, Fredrik; Michelsen, Annika; Øvstebø, Reidun; Mollnes, Tom Eirik; Skjønsberg, Ole Henning & Aukrust, Pål (2016). Specific allergen immunotherapy: Effect on IgE, IgG4 and chemokines in patients with allergic rhinitis. Scandinavian Journal of Clinical and Laboratory Investigation.  ISSN 0036-5513.  76(2), s 118- 127 . doi: 10.3109/00365513.2015.1110856
• Edvardsen, Elisabeth; Skjønsberg, Ole Henning; Holme, Ingar Morten K; Nordsletten, Lars; Borchsenius, Fredrik & Anderssen, Sigmund Alfred (2015). High-intensity training following lung cancer surgery: a randomised controlled trial. Thorax.  ISSN 0040-6376.  70(3), s 244- 250 . doi: 10.1136/thoraxjnl-2014-205944 Show summary

  Background: Many patients with lung cancer are deconditioned with poor physical fitness. Lung resection reduces physical fitness further, impairing the patient's ability to function in daily life. Methods: We conducted a single-blind randomised controlled trial of high-intensity endurance and strength training (60 min, three times a week, 20 weeks), starting 5–7 weeks after surgery. The control group received standard postoperative care. The primary outcome was the change in peak oxygen uptake measured directly during walking until exhaustion. Other outcomes included changes in pulmonary function, muscular strength by one-repetition maximum (1RM), total muscle mass measured by dual energy X-ray absorptiometry, daily physical functioning and quality of life (QoL). Results: The intention-to-treat analysis of the 61 randomised patients showed that the exercise group had a greater increase in peak oxygen uptake (3.4 mL/kg/min between-group difference, p=0.002), carbon monoxide transfer factor (Tlco) (5.2% predicted, p=0.007), 1RM leg press (29.5 kg, p<0.001), chair stand (2.1 times p<0.001), stair run (4.3 steps, p=0.002) and total muscle mass (1.36 kg, p=0.012) compared with the controls. The mean±SD QoL (SF-36) physical component summary score was 51.8±5.5 and 43.3±11.3 (p=0.006), and the mental component summary score was 55.5±5.3 and 46.6±14.0 (p=0.015) in the exercise and control groups, respectively. Conclusions: In patients recently operated for lung cancer, high-intensity endurance and strength training was well tolerated and induced clinically significant improvements in peak oxygen uptake, Tlco, muscular strength, total muscle mass, functional fitness and QoL. This study may provide a basis for exercise therapy after lung cancer surgery.

• Fadila, Cero; Hillestad, Vigdis; Sjaastad, Ivar; Yndestad, Arne; Aukrust, Pål; Ranheim, Trine; Lunde, Ida Gjervold; Olsen, Maria Belland; Lien, Egil; Zhang, Lili; Haugstad, Solveig Bjærum; Løberg, Else Marit; Christensen, Geir Arve; Larsen, Karl-Otto & Skjønsberg, Ole Henning (2015). Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice. American Journal of Physiology - Lung cellular and Molecular Physiology.  ISSN 1040-0605.  309(4), s L378- L387 . doi: 10.1152/ajplung.00342.2014
• Fadila, Cero; Hillestad, Vigdis; Sjaastad, Ivar; Yndestad, Arne; Aukrust, Pål; Ranheim, Trine; Lunde, Ida Gjervold; Olsen, Maria Belland; Lien, Egil; Zhang, Lili; Haugstad, Solveig Bjærum; Løberg, Else Marit; Christensen, Geir Arve; Larsen, Karl-Otto & Skjønsberg, Ole Henning (2015). Absence of the inflammasone adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice. American Journal of Physiology - Lung cellular and Molecular Physiology.  ISSN 1040-0605.  309, s L378- L387 . doi: 10.1152/ajplung.00342.2014
• Hillestad, Vigdis; Espe, Emil Knut Stenersen; Fadila, Cero; Larsen, Karl-Otto; Sjaastad, Ivar; Nygård, Ståle; Skjønsberg, Ole Henning & Christensen, Geir Arve (2015). IL-18 neutralization during alveolar hypoxia improves left ventricular diastolic function in mice. Acta Physiologica.  ISSN 1748-1708.  213(2), s 492- 504 . doi: 10.1111/apha.12376
• Edvardsen, Anne; Ryg, Morten; Akerø, Aina; Christensen, Carl Christian & Skjønsberg, Ole Henning (2013). COPD and air travel: does hypoxia-altitude simulation testing predict in-flight respiratory symptoms?. European Respiratory Journal.  ISSN 0903-1936.  42(5), s 1216- 1223 . doi: 10.1183/09031936.00157112
• Sæverud, Håvard Andreassen; Borchsenius, Fredrik; Mellem, H; Finstad, Pål Leyell & Skjønsberg, Ole Henning (2013). the obstructive siblings: Relapsing polychondritis without chondritis. Respiratory Medicine.  ISSN 0954-6111.  10, s 4- 6
• Sæverud, Håvard Andreassen; Borchsenius, Fredrik; Mellem, Harald; Finstad, Pål Leyell & Skjønsberg, Ole Henning (2013). The obstructive siblings; relapsing polychondritis without condritis?. Respiratory Medicine.  ISSN 0954-6111.  10, s 4- 6 . doi: 10.1016/j.rmcr.2013.04.005
• Edvardsen, Anne; Akerø, Aina; Christensen, Carl Christian; Ryg, Morten & Skjønsberg, Ole Henning (2012). Air travel and chronic obstructive pulmonary disease: a new algorithm for pre-flight evaluation. Thorax.  ISSN 0040-6376.  67(11), s 964- 969 . doi: 10.1136/thoraxjnl-2012-201855
• Fadila, Cero; Hillestad, Vigdis; Løberg, Else Marit; Christensen, Geir Arve; Larsen, Karl-Otto & Skjønsberg, Ole Henning (2012). IL-18 and IL-12 synergy induces matrix degrading enzymes in the lung. Experimental Lung Research.  ISSN 0190-2148.  38(8), s 406- 419 . doi: 10.3109/01902148.2012.716903
• Edvardsen, Anne; Akerø, Aina; Hardie, Jon Andrew; Ryg, Morten; Eagan, Tomas Mikal; Skjønsberg, Ole Henning & Bakke, Per S. (2011). High prevalence of respiratory symptoms during air travel in patients with COPD. Respiratory Medicine.  ISSN 0954-6111.  105(1), s 50- 56 . doi: 10.1016/j.rmed.2010.10.006
• Akerø, Aina; Edvardsen, Anne; Christense, Carl C.; Owe, Jan Ove; Ryg, Morten & Skjønsberg, Ole Henning (2011). COPD and air travel: Oxygen equipment and pre-flight titration of supplemental oxygen. Chest.  ISSN 0012-3692.  140(1), s 84- 90 . doi: 10.1378/chest.10-0965
• Larsen, Karl-Otto; Yndestad, Arne; Sjaastad, Ivar; Løberg, Else Marit; Goverud, Ingeborg Løstegaard; Halvorsen, Bente; Jia, Jing; Andreassen, Arne K.; Husberg, Cathrine; Jonasson, Sofia; Lipp, Martin; Christensen, Geir Arve; Aukrust, Pål & Skjønsberg, Ole Henning (2011). Lack of CCR7 induces pulmonary hypertension involving perivascular leukocyte infiltration and inflammation. American Journal of Physiology - Lung cellular and Molecular Physiology.  ISSN 1040-0605.  301(1), s L50- L59 . doi: 10.1152/ajplung.00048.2010
• Nakstad, Espen Rostrup; Opdahl, Helge; Skjønsberg, Ole Henning & Borchsenius, Fredrik (2011). Intrabronchial airway pressures in intubated patients during bronchoscopy under volume controlled and pressure controlled ventilation. Anaesthesia and Intensive Care.  ISSN 0310-057X.  39(3), s 431- 439
• Yndestad, Arne; Larsen, Karl-Otto; Øie, Erik; Ueland, Thor; Smith, Camilla; Halvorsen, Bente; Sjaastad, Ivar; Skjønsberg, Ole Henning; Pedersen, Turid Margrethe; Anfinsen, Ole-Gunnar; Damås, Jan Kristian; Christensen, Geir Arve; Aukrust, Pål & Andreassen, Arne K. (2009). Elevated levels of activin A in clinical and experimental pulmonary hypertension. Journal of applied physiology.  ISSN 8750-7587.  106(4), s 1356- 1364 . doi: 10.1152/japplphysiol.90719.2008
• Akerø, Aina; Christensen, Carl C.; Edvardsen, Anne; Ryg, Morten & Skjønsberg, Ole Henning (2008). Pulse oximetry in the preflight evaluation of patients with chronic obstructive pulmonary disease. Aviation, Space and Environmental Medicine.  ISSN 0095-6562.  79, s 508- 524
• Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Arnkværn, Kristin; Florholmen, Geir; Ruud Larsen, Ann-Kristin; Levy, Finn Olav; Tasken, Kjetil; Skjønsberg, Ole Henning & Christensen, Geir Arve (2008). Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A. Cardiovascular Research (CVR).  ISSN 0008-6363.  80(1), s 47- 54 . doi: 10.1093/cvr/cvn180
• Nielsen, Hilde Dorthea Grindvik; Skjønsberg, Ole Henning & Lyberg, Torstein (2008). Effect of antioxidant supplementation on leucocyte expression of reactive oxygen species in athletes. Scandinavian Journal of Clinical and Laboratory Investigation.  ISSN 0036-5513.  68(7), s 526- 533 . doi: 10.1080/00365510701864602
• Jensen, Torstein; Kierulf, Peter; Sandset, Per Morten; Klingenberg, Olav; Joø, Gun Brit; Godal, Hans Chr & Skjønsberg, Ole Henning (2007). Fibrinogen and fibrin induce synthesis of proinflammatory cytokines from peripheral blood mononuclear cells. Thrombosis and Haemostasis.  ISSN 0340-6245.  97(5), s 822- 829 . doi: 10.1160/TH07-01-0039 Show summary

  Fibrinogen in plasma includes three main fractions; high-molecular-weight (HMW)-fibrinogen, low-molecular-weight (LMW)-fibrinogen, and very-low-molecular-weight (LMW')-fibrinogen. During acute-phase conditions, plasma fibrinogen levels and the HMW-/LMW-fibrinogen ratio increase rapidly due to increased synthesis of HMW-fibrinogen. The consequences of elevated plasma fibrinogen levels and local deposition of fibrin in inflammatory tissues observed during acute-phase conditions are not clear. We wanted to investigate proinflammatory effects of fibrinogen and fibrin on peripheral blood mononuclear cells (PBMC) as reflected by altered mRNA expression and synthesis of the proinflammatory cytokines IL-6, TNF-alpha and IL-1beta, and to explore the significance of altered HMW-/LMW-fibrinogen ratio. PBMC were isolated from whole blood using Lymphoprep((R)). HMW-fibrinogen was separated from unfractioned fibrinogen by ammonium sulphate precipitation. Cells were incubated with unfractioned fibrinogen, HMW-fibrinogen or fibrin. Cytokine levels in cell lysates were determined using ELISA assays. Real-time PCR was used for mRNA quantification. We found that fibrinogen significantly increased mRNA levels, and induced synthesis of the proinflammatory cytokines IL-6 and TNF-alpha in PBMC in a dose dependent manner. Median (25, 75 percentile) IL-6 and TNF-alpha concentrations were 12 (5, 40) pg/ml and 16 (0,61) pg/ml, respectively. Median mRNA quantity was increased 12.3- (6.6, 48.6) and 1.7- (1.5, 6.5) fold for IL-6 and TNF-alpha compared to controls. The stimulatory effect of unfractioned fibrinogen was not significantly different from HMW-fibrinogen. Fibrinogen and fibrin were equally effective in promoting cytokine synthesis from PBMC. The results support that fibrin and fibrinogen may actively modulate the inflammatory process by inducing synthesis of proinflammatory cytokines from PBMC.

• Jensen, Torstein; Retterstøl, Lars; Sandset, Per Morten; Godal, Hans Chr & Skjønsberg, Ole Henning (2006). A daily glass of red wine induces a prolonged reduction in plasma viscosity: a randomized controlled trial. Blood Coagulation and Fibrinolysis.  ISSN 0957-5235.  17(6), s 471- 476 Show summary

  Moderate red wine consumption has been associated with decreased risk of coronary heart disease. Reduced plasma viscosity and fibrinogen levels have been launched as possible contributors to this risk reduction. The effect of moderate red wine consumption on plasma viscosity, however, has not been investigated in a prospective, randomized trial. We wanted to evaluate the effect of moderate red wine consumption on plasma viscosity, fibrinogen concentration and fibrinogen subfractions. Healthy, nonsmoking volunteers were assigned to consume one glass of red wine daily for 3 weeks in a prospective, randomized cross-over study. In the second 3-week period the volunteers abstained from alcohol use. The plasma viscosity, fibrinogen concentration and the distribution of the main fibrinogen subfractions were determined at inclusion, after wine drinking and after abstention. Plasma viscosity was reduced by 0.026 and 0.024 mPa.s in the two groups following wine intake (95% confidence interval, 0.009-0.043, P = 0.004; 95% confidence interval, 0.0083-0.039, P = 0.003). The decrease in plasma viscosity was maintained following 3 weeks of abstention. The fibrinogen concentration was reduced by 0.17 g/l following wine drinking in the group starting with abstention (95% confidence interval, 0.04-0.29, P = 0.01). The distribution of the fibrinogen subfractions remained unaltered. We conclude that a daily glass of red wine for 3 weeks significantly reduces plasma viscosity. Fibrinogen concentrations are also significantly reduced, when preceded by an abstention period. The decreased viscosity levels are maintained after 3 weeks of abstention, suggesting a sustained viscosity lowering effect of red wine.

• Larsen, Karl-Otto; Sjaastad, Ivar; Svindland, A; Krobert, Kurt Allen; Skjønsberg, Ole Henning & Christensen, Geir Arve (2006). Alveolar hypoxia induces left ventricular diastolic dysfunction and reduces phosphorylation of phospholamban in mice. American Journal of Physiology. Heart and Circulatory Physiology.  ISSN 0363-6135.  291, s H507- H516
• Akerø, A; Christensen, Cc; Edvardsen, A & Skjønsberg, Ole Henning (2005). Hypoxaemia in chronic obstructive pulmonary disease patients during a commercial flight. European Respiratory Journal.  ISSN 0903-1936.  25(4), s 725- 730
• Herland, K; Akselsen, JP; Skjønsberg, Ole Henning & Bjermer, L (2005). How representative are clinical study patients with asthma or COPD for a larger "real life" population of patients with obstructive lung disease?. Respiratory Medicine.  ISSN 0954-6111.  99(1), s 11- 19
• Solberg, Geir; Robstad, Bjørn; Skjønsberg, Ole Henning & Borchsenius, F (2005). Respiratory gas exchange indices for estimating the anaerobic threshold. Journal of Sports Science and Medicine.  ISSN 1303-2968.  4, s 29- 36
• Christensen, Carl C.; Ryg, Morten; Edvardsen, Anne & Skjønsberg, Ole Henning (2004). Effect of exercise mode on oxygen uptake and blood gses in COPD patients. Respiratory Medicine.  ISSN 0954-6111.  98, s :656- 660
• Christensen, Carl C.; Ryg, Morten; Edvardsen, Anne & Skjønsberg, Ole Henning (2004). Relationship between exercise desaturation and pulmonary haemodynamics in COPD patients. Eur Respir J.  24, s 1- 7
• Christensen, Carl C.; Ryg, Morten; Edvardsen, Anne & Skjønsberg, Ole Henning (2004). Relationsship between exercise desaturation and pulmonary haemodynamics in COPD patients. European Respiratory Journal.  ISSN 0903-1936.  24, s 1- 7
• Christensen, Cc; Ryg, Morten; Edvardsen, Anne & Skjønsberg, Ole Henning (2004). Effect of exercise mode on oxygen uptake and blood gases in COPD patients. Respiratory Medicine.  ISSN 0954-6111.  98, s 656- 660
• Jensen, Torstein; Halvorsen, Sigrun; Godal, HC; Sandset, Per Morten & Skjønsberg, Ole Henning (2004). The viscosity of fibrinogen subfractions and of EDTA denatured fibrinogen do not differ from that of native fibrinogen. Thrombosis Research.  ISSN 0049-3848.  113, s 51- 56
• Røsjø, Helge; Hov, Johannes espolin; Borchsenius, Fredrik & Skjønsberg, Ole Henning (2003). Vaksinasjon mot vepseallergi-evaluering av ehandling ved en sykehuspoliklinikk. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  8, s 1075- 1077
• Christensen, Carl Christian; Ryg, Morten; Refvem, Olav Kaare & Skjønsberg, Ole Henning (2002). Effect of hypobaric hypoxia on blood gases in patients with restrictive lung disease. European Respiratory Journal.  ISSN 0903-1936.  20, s 300- 306
• Finsnes, Finn; Lyberg, Torstein; Christensen, Geir Arve & Skjønsberg, Ole Henning (2002). Leukotrien antagonism reduces the generation of endothelin-1 and interferon-gamma and inhibits eosinophilic airway infalammation. Respiratory Medicine.  ISSN 0954-6111.  96, s 901- 906
• Finsnes, Finn; Lyberg, Torstein; Christensen, Geir Arve & Skjønsberg, Ole Henning (2002). Leukotriene antagonism reduces the generation of endothelin-1 and interferon-gamma and inhibits eosinophilic airway inflammation. Respiratory Medicine.  ISSN 0954-6111.  96, s 901- 906
• Jensen, Torstein; Halvorsen, Sigrun; Godal, Hans Christian & Skjønsberg, Ole Henning (2002). Influence of freeze-drying on clotting properties of fibrinogen i plasma. Thrombosis Research.  ISSN 0049-3848.  105, s 499- 502
• Finsnes, Finn; Lyberg, Torstein; Christensen, Geir Arve & Skjønsberg, Ole Henning (2001). The effect of endothelin antagonism on the production of cytokines in eosinophilic airway inflammation. American Journal of Physics (AJP).  ISSN 0002-9505.  280, s 659- 665

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• Skjønsberg, Ole Henning (2012). Eksperimentell lungemedisinsk forskning. Norsk forening for lungemedisin.  ISBN 9788230322314.  5 s.

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• Edvardsen, Elisabeth; Anderssen, Sigmund Alfred; Borchsenius, Fredrik Charlo & Skjønsberg, Ole Henning (2018). Long Term Effects of High-Intensity Exercise Training after Lung Cancer Surgery ~ A Five Year Follow-Up of a Randomized Controlled Trial..
• torvanger, ole; Os, Audun; Skjønsberg, Ole Henning & Edvardsen, Elisabeth (2018). Cardiorespiratory Fitness on a Treadmill in an adult Norwegian Cystic Fibrosis Population ..
• Udjus, Camilla; Cero, Fadila; Halvorsen, Bente; Aukrust, Pål; Christensen, Geir Arve; Skjønsberg, Ole Henning & Larsen, Karl-Otto (2018). Inhibition of caspase-1 reduces hypoxia-induced pulmonary hypertension by downregulating smooth muscle cell growth.
• Cero, Fadila; Larsen, Karl-Otto; Hillestad, Vigdis; Olsen, Maria Belland; Udjus, Camilla; Sjaastad, Ivar; Yndestad, Arne; Aukrust, Pål; Løberg, Else Marit; Christensen, Geir Arve & Skjønsberg, Ole Henning (2015). The inflammasome adaptor ASC mediates pulmonary artery remodelling.
• Cero, Fadila; Larsen, Karl-Otto; Hillestad, Vigdis; Olsen, Maria Belland; Udjus, Camilla; Yndestad, Arne; Aukrust, Pål; Løberg, Else Marit; Christensen, Geir Arve & Skjønsberg, Ole Henning (2015). Hypoxic pulmonary hypertension; a role for the inflammasome.
• Udjus, Camilla; Cero, Fadila; Christensen, Geir Arve; Skjønsberg, Ole Henning & Larsen, Karl-Otto (2015). The role of caspase-1 in pulmonary hypertension.
• Edvardsen, Anne; Ryg, Morten; Akerø, Aina; Christensen, Carl Christian & Skjønsberg, Ole Henning (2013). COPD and air travel: does hypoxia-altitude simulation test predict in-flight respiratory symptoms?.
• Cero, Fadilla; Larsen, Karl Otto; Sandanger, Øystein; Løberg, Else Marit; Christensen, Geir Arve & Skjønsberg, Ole Henning (2012). Hypoxia induces IL-18 and neutrophil influx in lung parenchyma possibly mediated by MIP-2.
• Edvardsen, Anne; Akerø, Aina; Christensen, Carl Christian; Ryg, Morten & Skjønsberg, Ole Henning (2012). Air Travel and COPD: a new algorithm for pre-flight evaluation.
• Cero, Fadila; Larsen, Karl Otto; Hillestad, Vigdis; Christensen, Geir Arve & Skjønsberg, Ole Henning (2011). IL-18 and IL-12 induce inflammatory cytokines, chemokine ligand 9 (CXCL9) and T cell infiltration in pulmonary tissue.
• Edvardsen, Anne; Akerø, Aina; Christensen, Carl Christian; Ryg, Morten & Skjønsberg, Ole Henning (2011). Air travel and COPD: Exercise SpO2 and walking distance as predictors for in-flight desaturation.
• Edvardsen, Anne; Akerø, Aina; Christensen, Carl Christian; Ryg, Morten & Skjønsberg, Ole Henning (2011). Hypoxia altitude simulation test (HAST): Arterial blood gases or pulse oximetry?.
• Hillestad, Vigdis; Larsen, Karl Otto; Sjaastad, Ivar; Nygård, Ståle; Skjønsberg, Ole Henning & Christensen, Geir Arve (2011). Neutralization of circulating interleukin-18 reduces diastolic dysfunction.
• Edvardsen, Anne; Akerø, Aina; Eagan, Tomas Mikal Lind; Hardie, Jon Andrew; Ryg, Morten; Bakke, Per S. & Skjønsberg, Ole Henning (2010). In-flight respiratory symptoms and pre-flight characteristics in patients with COPD.
• Edvardsen, Anne; Akerø, Aina; Eagan, Tomas Mikal Lind; Ryg, Morten; Hardie, Jon Andrew; Bakke, Per S. & Skjønsberg, Ole Henning (2010). Air travel habits in patients with COPD.
• Akerø, Aina; Edvardsen, Anne; Christensen, Carl C.; Owe, Jan Ove; Ryg, Morten & Skjønsberg, Ole Henning (2010). Air travel and COPD: Oxygen equipment and pre-flight titration of supplemental oxygen.
• Hillestad, Vigdis; Larsen, Karl-Otto; Sjaastad, Ivar; Nygård, Ståle; Skjønsberg, Ole Henning & Christensen, Geir Arve (2010). Effects of IL-ı8 neutralization in alveolar hypoxia.
• Edvardsen, Anne; Akerø, Aina; Eagan, Thomas; Hardie, J; Bakke, Per & Skjønsberg, Ole Henning (2009). Air travel habits in patients with COPD.
• Edvardsen, Elisabeth; homme, jorunn; Skjønsberg, Ole Henning & Skrede, Bjørn (2009). Pre-flight evaluation in adult patients with cystic fibrosis.
• Hillestad, Vigdis; Larsen, Karl-Otto; Sjaastad, Ivar; Nygård, Ståle; Skjønsberg, Ole Henning & Christensen, Geir Arve (2009). IL-18BP; a potential therapeutic agent in right ventricular hypertrophy.
• Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Arnkværn, Kristin; Florholmen, Geir; Larsen, A; Levy, Finn Olav; Tasken, Kjetil; Skjønsberg, Ole Henning & Christensen, Geir Arve (2009). Increased circulating IL-18; a possible mechanism for hypoxia-induced cardiac dysfunction.
• Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Arnkværn, Kristin; Florholmen, Geir; Levy, Finn Olav; Tasken, Kjetil; Christensen, Geir Arve & Skjønsberg, Ole Henning (2009). Mechanisms for cardiac dysfunction in COPD and respiratory failure. Respiratory Medicine.  ISSN 0954-6111.  103, s S6- S7
• Nielsen, Hilde Grindvik; Skjønsberg, Ole Henning & Lyberg, Torstein (2009). Effekten av fire ukers antioksydanttilskudd på produksjon av frie oksygenradikaler i leukocytter hos kvinnelige og mannlige utholdenhetsutøvere. Idrettsmedisin.  2009(2), s 23- 25
• Akerø, Aina; Edvardsen, Anne; Ryg, Morten & Skjønsberg, Ole Henning (2008). PaO2 during exerciseas a predictor of in-flight hypoxaemia in COPD patients.
• Edvardsen, Anne; Akerø, Aina; Eagan, Thomas; Ryg, Morten; Hardie, J; Bakke, Per & Skjønsberg, Ole Henning (2008). Air travel and respiratory related symptoms in patients with COPD and controls.
• Skjønsberg, Ole Henning & Jensen, Torstein (2008). Studies on subfractions of fibrinogen.With special emphasis on fibrinogen quantification, viscicity and inflammation.
• Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Arnkværn, Kristin; Florholmen, Geir; Levy, Finn Olav; Tasken, Kjetil; Christensen, Geir Arve & Skjønsberg, Ole Henning (2008). Mechanisms for cardiac dysfunction in COPD and respiratory failure.
• Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Florholmen, Geir; Arnkværn, Kristin; Levy, Finn Olav; Skjønsberg, Ole Henning; Tasken, Kjetil & Christensen, Geir Arve (2008). Alveolar hypoxia induces cardiac diastolic dysfunction: a role for a reduction in the calcium regulating protein phospholamban induced by IL-18.
• Edvardsen, Anne; Christensen, Carl C.; Skjønsberg, Ole Henning & Ryg, Morten (2007). Effect of high dose oxygen on dyspnea and exercise tolerance in patients with COPD given LTOT.
• Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Florholmen, Geir; Arnkværn, Kristin; Levy, Finn Olav; Skjønsberg, Ole Henning; Tasken, Kjetil & Christensen, Geir Arve (2007). Alveolar hypoxia induces cardiac dysfunction, possibly mediated through increased amounts of phosphatases, leading to dephosphorylation of calcium regulatory proteins.
• Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Florholmen, Geir; Arnkværn, Kristin; Levy, Finn Olav; Skjønsberg, Ole Henning; Tasken, Kjetil & Christensen, Geir Arve (2007). Diastolic dysfunction in alveolar hypoxia: A role for interleukin-18 induced increase in protein phosphatase 2A and reduction in phospholamban phosphorylation.
• Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Florholmen, Geir; Arnkværn, Kristin; Levy, Finn Olav; Skjønsberg, Ole Henning; Tasken, Kjetil & Christensen, Geir Arve (2007). Hypoxia induced cardiac dysfunction maybe caused by increased IL-18 levels leading to dephosphorylation of Ca2+ handling proteins.
• Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Florholmen, Geir; Arnkværn, Kristin; Levy, Finn Olav; Skjønsberg, Ole Henning; Tasken, Kjetil & Christensen, Geir Arve (2007). Increased PP1 and PP2A mediating reduced Ser16 phosphorylated PLB is a possible mechanism for cardiac dysfunction in alveolar hypoxia. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  42(6), s S245- S245
• Nakstad, Espen R.; Opdahl, Helge; Borchsenius, Fredrik & Skjønsberg, Ole Henning (2007). Intrabronchial airway pressure in intubated patients during bronchoscopy under pressure and volume controlled ventilation.
• Nakstad, Espen R.; Opdahl, Helge; Borchsenius, Fredrik & Skjønsberg, Ole Henning (2007). Intrabronchial airway pressure in intubated patients during bronchoscopy under pressure and volume controlled ventilation.
• Akerø, Aina; Christensen, Carl C.; Edvardsen, Anne; Ryg, Morten & Skjønsberg, Ole Henning (2006). Pulse oximetry as a screening test in the pre-flight evaluation of COPD patients.
• Christensen, Carl C. & Skjønsberg, Ole Henning (2006). Effects of low atmospheric pressure and exercise on hypoxaemia in patients with chronic lung disease.
• Christensen, Carl C. & Skjønsberg, Ole Henning (2006). Effects of low atmospheric pressure and exercise on hypoxaemia in patients with lung disease.
• Edvardsen, Elisabeth; Ariansen, h; Mellem, Harald; Borchsenius, Fredrik; Skjønsberg, Ole Henning & Gjesdal, Knut (2006). Ventilatory limitation may be over-diagnosed in elderly subjects when MVV is calculated instead of measured;.
• Edvardsen, Elisabeth; Ariansen, Inger; Mellem, Harald; Borchsenius, Fredrik; Gjesdal, Knut & Skjønsberg, Ole Henning (2006). Ventilatory limitation may be over-diagnosed in elderly subjects when MVV is calculated instead of measured. European Respiratory Society.
• Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Skjønsberg, Ole Henning; Tasken, Kjetil & Christensen, Geir Arve (2006). Chronic alveolar hypoxia reduces the phosphorylation of phospholamban in mouse hearts.
• Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Tasken, Kjetil; Christensen, Geir Arve & Skjønsberg, Ole Henning (2006). Alveolar hypoxia induces left ventricular diastolic dysfunction in mice.
• Akerø, Aina; Christensen, Carl C.; Edvardsen, Anne & Skjønsberg, Ole Henning (2005). Development of hypoxaemia in COPD patients during a commercial flight.
• Akerø, Aina; Christensen, Carl C.; Edvardsen, Anne & Skjønsberg, Ole Henning (2005). Hypoxaemia in chronic obstructive pulmonary disease patients during a commercial flight.
• Larsen, Karl Otto; Lygren, Birgitte; Sjaastad, Ivar; Skjønsberg, Ole Henning; Tasken, Kjetil & Christensen, Geir Arve (2005). Chronic hypoxia alters the phosphorylation of phospholamban in mouse hearts.
• Larsen, Karl Otto; Lygren, Birgitte; Sjaastad, Ivar; Skjønsberg, Ole Henning; Tasken, Kjetil & Christensen, Geir Arve (2005). Chronic pulmonary hypoxia alters calcium handling proteins in mouse hearts.
• Larsen, Karl Otto; Lygren, Birgitte; Sjaastad, Ivar; Skjønsberg, Ole Henning; Tasken, Kjetil & Christensen, Geir Arve (2005). Chronic pulmonary hypoxia alters the phosphorylation of phospholamban in mouse hearts.
• Larsen, Karl Otto; Lygren, Birgitte; Sjaastad, Ivar; Skjønsberg, Ole Henning; Tasken, Kjetil & Christensen, Geir Arve (2005). Chronic pulmonary hypoxia reduces serine-16 phosphorylated phospholamban in both ventricles.
• Larsen, Karl Otto; Sjaastad, Ivar; Skjønsberg, Ole Henning & Christensen, Geir Arve (2005). Mechanisms leading to heart failure in pulmonary hypertension.
• Jensen, Torstein; Halvorsen, Sigrun; Godal, Hans Christian & Skjønsberg, Ole Henning (2002). Influence of freeze-dryingon clotting properties of fibrinogen in plasma.
• Christensen, Carl Christian; Ryg, Morten; Refvem, Olav Kaare & Skjønsberg, Ole Henning (2001). Pronounced in-flight hypoxaemia in patients with restrictive lung disease.
• Christensen, Carl Christian; Ryg, Morten; Refvem, Olav Kaare & Skjønsberg, Ole Henning (2001). Pronounced in-flight hypoxaemia in patients with restrictive lung disease.
• Finsnes, Finn; Skjønsberg, Ole Henning & Christensen, Geir Arve (2001). The role of endothelin-1 in an experimental asthma-like airway inflammation.

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