Ole Henning Skjønsberg

• Hem, Erlend & Skjønsberg, Ole Henning (2024). Clara-celler blir til klubbeceller. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 144(5), s. 1–3. doi: 10.4045/tidsskr.23.0549.
• Barratt-Due, Andreas; Pettersen, Kristin; Dahl, Tuva Børresdatter; Holter, Jan Cato; Grønli, Renathe Henriksen & Dyrhol-Riise, Anne Ma [Vis alle 20 forfattere av denne artikkelen] (2024). Escalated complement activation during hospitalization is associated with higher risk of 60-day mortality in SARS-CoV-2-infected patients. Journal of Internal Medicine. ISSN 0954-6820. doi: 10.1111/joim.13783.
• Ueland, Thor; Michelsen, Annika Elisabet; Tveita, Anders; Kåsine, Trine; Dahl, Tuva Børresdatter & Finbråten, Ane-Kristine [Vis alle 16 forfattere av denne artikkelen] (2023). Coagulopathy and adverse outcomes in hospitalized patients with COVID-19: results from the NOR-Solidarity trial. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 8(1). doi: 10.1016/j.rpth.2023.102289. Fulltekst i vitenarkiv
• Murphy, Sarah Louise Mikalsen; Halvorsen, Bente; Holter, Jan Cato; Huse, Camilla; Tveita, Anders & Trøseid, Marius [Vis alle 24 forfattere av denne artikkelen] (2023). Circulating markers of extracellular matrix remodelling in severe COVID-19 patients. Journal of Internal Medicine. ISSN 0954-6820. 294(6), s. 784–797. doi: 10.1111/joim.13725. Fulltekst i vitenarkiv
• Lerum, Tøri Vigeland; Meltzer, Carin; Rivero, Jezabel Rodriguez; Aaløkken, Trond Mogens; Brønstad, Eivind & Aarli, Bernt Bøgvald [Vis alle 12 forfattere av denne artikkelen] (2023). A prospective study of pulmonary outcomes and chest computed tomography in the first year after COVID-19. European Respiratory Journal Open Research (ERJ Open Research). ISSN 2312-0541. 9(2). doi: 10.1183/23120541.00575-2022. Fulltekst i vitenarkiv
• Kleiven, Anne Louise; Markussen, Heidi Øksnes; Skjønsberg, Ole Henning; Janssens, Jean-Paul & Aarrestad, Sigurd (2022). Effect of Respiratory Events on Health-Related Quality of Life in Patients Treated with Long-Term Noninvasive Ventilation. Respiration. ISSN 0025-7931. 101(12), s. 1099–1109. doi: 10.1159/000527066. Fulltekst i vitenarkiv
• Lekva, Tove; Ueland, Thor; Halvorsen, Bente; Murphy, Sarah Louise Mikalsen; Dyrhol-Riise, Anne Ma & Tveita, Anders Aune [Vis alle 14 forfattere av denne artikkelen] (2022). Markers of cellular senescence is associated with persistent pulmonary pathology after COVID-19 infection. Infectious Diseases. ISSN 2374-4235. 54(12), s. 918–923. doi: 10.1080/23744235.2022.2113135. Fulltekst i vitenarkiv Vis sammendrag

  Background The lungs are the organ most likely to sustain serious injury from coronavirus disease 2019 (COVID-19). However, the mechanisms for long-term complications are not clear. Patients with severe COVID-19 have shorter telomere lengths and higher levels of cellular senescence, and we hypothesized that circulating levels of the telomere-associated senescence markers chitotriosidase, β-galactosidase, cathelicidin antimicrobial peptide and stathmin 1 (STMN1) were elevated in hospitalized COVID-19 patients compared to controls and could be associated with pulmonary sequelae following hospitalization. Methods Ninety-seven hospitalized patients with COVID-19 who underwent assessment for pulmonary sequelae at three-month follow-up were included in the study. β-Galactosidase and chitotriosidase were analysed by fluorescence; stathmin 1 and cathelicidin antimicrobial peptide were analysed by enzyme immuno-assay in plasma samples from the acute phase and after three-months. In addition, the classical senescence markers cyclin-dependent kinase inhibitor 1A and 2A were analysed by enzyme immuno-assay in peripheral blood mononuclear cell lysate after three months. Results We found elevated plasma levels of the senescence markers chitotriosidase and stathmin 1 in patients three months after hospitalization with COVID-19, and these markers in addition to protein levels of cyclin-dependent kinase inhibitor 2A in cell lysate, were associated with pulmonary pathology. The elevated levels of these markers seem to reflect both age-dependent (chitotriosidase) and age-independent (stathmin 1, cyclin-dependent kinase inhibitor 2A) processes. Conclusions We suggest that accelerated ageing or senescence could be important for long-term pulmonary complications of COVID-19, and our findings may be relevant for future research exploring the pathophysiology and management of these patients.

• Tveita, Anders Aune; Murphy, Sarah Louise Mikalsen; Holter, Jan Cato; Kildal, Anders Benjamin; Michelsen, Annika Elisabet & Lerum, Tøri Vigeland [Vis alle 28 forfattere av denne artikkelen] (2022). High Circulating Levels of the Homeostatic Chemokines CCL19 and CCL21 Predict Mortality and Disease Severity in COVID-19. Journal of Infectious Diseases. ISSN 0022-1899. 226(12), s. 2150–2160. doi: 10.1093/infdis/jiac313. Fulltekst i vitenarkiv
• Trøseid, Marius; Dahl, Tuva Børresdatter; Holter, Jan Cato; Kildal, Anders Benjamin; Murphy, Sarah Louise Mikalsen & Yang, Kuan [Vis alle 28 forfattere av denne artikkelen] (2022). Persistent T-cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID-19: Results from two Norwegian cohort studies. Journal of Internal Medicine. ISSN 0954-6820. 292(5), s. 816–828. doi: 10.1111/joim.13549. Fulltekst i vitenarkiv
• Ueland, Thor; Sørvoll, Ingvild Hausberg; Mørtberg, Trude Victoria; Dahl, Tuva Børresdatter; Lerum, Tøri Vigeland & Michelsen, Annika Elisabet [Vis alle 16 forfattere av denne artikkelen] (2022). Anti-PF4/polyanion antibodies in COVID-19 patients are associated with disease severity and pulmonary pathology. Platelets. ISSN 0953-7104. 33(4), s. 640–644. doi: 10.1080/09537104.2022.2042238. Fulltekst i vitenarkiv
• Udjus, Camilla; Sjaastad, Ivar; Hjørnholm, Ulla; Kinne Tunestveit, Torbjørn; Hoffmann, Pavel & Hinojosa, Alexis [Vis alle 11 forfattere av denne artikkelen] (2022). Extreme altitude induces divergent mass reduction of right and left ventricle in mountain climbers. Physiological Reports. ISSN 2051-817X. 10(3). doi: 10.14814/phy2.15184. Fulltekst i vitenarkiv Vis sammendrag

  Mountain climbing at high altitude implies exposure to low levels of oxygen, low temperature, wind, physical and psychological stress, and nutritional insufficiencies. We examined whether right ventricular (RV) and left ventricular (LV) myocardial masses were reversibly altered by exposure to extreme altitude. Magnetic resonance imaging and echocardiography of the heart, dual x-ray absorptiometry scan of body composition, and blood samples were obtained from ten mountain climbers before departure to Mount Everest or Dhaulagiri (baseline), 13.5 ± 1.5 days after peaking the mountain (post-hypoxia), and six weeks and six months after expeditions exceeding 8000 meters above sea level. RV mass was unaltered after extreme altitude, in contrast to a reduction in LV mass by 11.8 ± 3.4 g post-hypoxia (p = 0.001). The reduction in LV mass correlated with a reduction in skeletal muscle mass. After six weeks, LV myocardial mass was restored to baseline values. Extreme altitude induced a reduction in LV end-diastolic volume (20.8 ± 7.7 ml, p = 0.011) and reduced E’, indicating diastolic dysfunction, which were restored after six weeks follow-up. Elevated circulating interleukin-18 after extreme altitude compared to follow-up levels, might have contributed to reduced muscle mass and diastolic dysfunction. In conclusion, the mass of the RV, possibly exposed to elevated afterload, was not changed after extreme altitude, whereas LV mass was reduced. The reduction in LV mass correlated with reduced skeletal muscle mass, indicating a common denominator, and elevated circulating interleukin-18 might be a mechanism for reduced muscle mass after extreme altitude.

• Vestad, Beate; Ueland, Thor; Lerum, Tøri Vigeland; Dahl, Tuva Børresdatter; Holm, Kristian & Barratt-Due, Andreas [Vis alle 37 forfattere av denne artikkelen] (2022). Respiratory dysfunction three months after severe COVID-19 is associated with gut microbiota alterations. Journal of Internal Medicine. ISSN 0954-6820. 291(6), s. 801–812. doi: 10.1111/joim.13458. Fulltekst i vitenarkiv Vis sammendrag

  Background: Although coronavirus disease 2019 (COVID-19) is primarily a respiratory infection, mounting evidence suggests that the gastrointestinal (GI) tract is involved in the disease, with gut barrier dysfunction and gut microbiota alterations being related to disease severity. Whether these alterations persist and are related to long-term respiratory dysfunction remains unknown. Methods: Plasma was collected during hospital admission and after three months from the NOR-Solidarity trial (n = 181) and analysed for markers of gut barrier dysfunction and inflammation. At the three-month follow-up, pulmonary function was assessed by measuring the diffusing capacity of the lungs for carbon monoxide (DLCO ). Rectal swabs for gut microbiota analyses were collected (n = 97) and analysed by sequencing the 16S rRNA gene. Results: Gut microbiota diversity was reduced in COVID-19 patients with respiratory dysfunction, defined as DLCO below the lower limit of normal three months after hospitalisation. These patients also had an altered global gut microbiota composition, with reduced relative abundance of 20 bacterial taxa and increased abundance of five taxa, including Veillonella, potentially linked to fibrosis. During hospitalisation, increased plasma levels of lipopolysaccharide-binding protein (LBP) were strongly associated with respiratory failure, defined as pO2 /fiO2 -(P/F ratio)

• Lerum, Tøri Vigeland; Barratt-Due, Andreas; Aaløkken, Trond Mogens; Skjønsberg, Ole Henning; SOLIDARITY consortium, NOR- & Hoff, Dag Arne Lihaug (2021). Persistent pulmonary pathology after COVID-19 is associated with high viral load, weak antibody response, and high levels of matrix metalloproteinase-9. Scientific Reports. ISSN 2045-2322. doi: 10.1038/s41598-021-02547-x.
• Lerum, Tøri Vigeland; Maltzahn, Niklas; Aukrust, Pål; Trøseid, Marius; Nezvalova-Henriksen, Katerina & Kåsine, Trine [Vis alle 27 forfattere av denne artikkelen] (2021). Persistent pulmonary pathology after COVID-19 is associated with high viral load, weak antibody response, and high levels of matrix metalloproteinase-9. Scientific Reports. ISSN 2045-2322. 11, s. 1–12. doi: 10.1038/s41598-021-02547-x. Fulltekst i vitenarkiv Vis sammendrag

  The association between pulmonary sequelae and markers of disease severity, as well as pro-fibrotic mediators, were studied in 108 patients 3 months after hospital admission for COVID-19. The COPD assessment test (CAT-score), spirometry, diffusion capacity of the lungs (DLCO), and chest-CT were performed at 23 Norwegian hospitals included in the NOR-SOLIDARITY trial, an open-labelled, randomised clinical trial, investigating the efficacy of remdesivir and hydroxychloroquine (HCQ). Thirty-eight percent had a CAT-score ≥ 10. DLCO was below the lower limit of normal in 29.6%. Ground-glass opacities were present in 39.8% on chest-CT, parenchymal bands were found in 41.7%. At admission, low pO2/FiO2 ratio, ICU treatment, high viral load, and low antibody levels, were predictors of a poorer pulmonary outcome after 3 months. High levels of matrix metalloproteinase (MMP)-9 during hospitalisation and at 3 months were associated with persistent CT-findings. Except for a negative effect of remdesivir on CAT-score, we found no effect of remdesivir or HCQ on long-term pulmonary outcomes. Three months after hospital admission for COVID-19, a high prevalence of respiratory symptoms, reduced DLCO, and persistent CT-findings was observed. Low pO2/FiO2 ratio, ICU-admission, high viral load, low antibody levels, and high levels of MMP-9 were associated with a worse pulmonary outcome.

• Tholin, Birgitte; Ghanima, Waleed Khalid; Einvik, Gunnar; Aarli, Bernt Bøgvald; Brønstad, Eivind & Skjønsberg, Ole Henning [Vis alle 7 forfattere av denne artikkelen] (2021). Incidence of thrombotic complications in hospitalised and non-hospitalised patients after COVID-19 diagnosis. British Journal of Haematology. ISSN 0007-1048. 194(3), s. 542–546. doi: 10.1111/bjh.17522. Fulltekst i vitenarkiv
• Lerum, Tøri Vigeland; Aaløkken, Trond M; Brønstad, Eivind; Aarli, Bernt Bøgvald; Ikdahl, Eirik & Lund, Kristine Marie Aarberg [Vis alle 14 forfattere av denne artikkelen] (2020). Dyspnoea, lung function and CT findings three months after hospital admission for COVID-19. European Respiratory Journal. ISSN 0903-1936. doi: 10.1183/13993003.03448-2020. Fulltekst i vitenarkiv
• Torvanger, Ole; Os, Audun; Skjønsberg, Ole Henning & Edvardsen, Elisabeth (2020). Cardiorespiratory fitness on a treadmill in an adult cystic fibrosis population. BMJ Open sport & exercise medicine. ISSN 2055-7647. 6(1). doi: 10.1136/bmjsem-2020-000765. Fulltekst i vitenarkiv Vis sammendrag

  Objectives: (1) To describe the cardiorespiratory fitness (CRF) in an adult cystic fibrosis population related to sex and age, (2) to evaluate the cause of low CRF and (3) to study the association between peak oxygen uptake (VO2peak) and forced expiratory volume in 1 s (FEV1). Methods: A total of 204 cardiopulmonary treadmill exercise tests (CPETs) performed by 116 patients were included. VO2peak, gas exchange, heart rate, oxygen saturation and ventilatory variables were measured. A low CRF was defined as a VO2peak <80% of predicted, ventilatory limitation was defined as a breathing reserve <15%, exercise hypoxaemia was defined as an oxygen saturation <88% and ventilation-perfusion mismatch was defined as a minute ventilation/ventilatory equivalent for carbon dioxide slope ≥34. In patients who had performed three or more CPETs, the annual change in FEV1 and VO2peak were calculated using linear regression. Results: The VO2peak was 40.6±11.5 and 35.2±8.9 mL kg−1 min−1, which was 87±23 and 93±20 in percentage of predicted for men and women, respectively. VO2peak was moderately affected by age, for men (r=−0.36, p<0.001) and women (r=−0.53, p<0.001), respectively. In 45 of 101 tests where CRF was low, no cardiorespiratory limiting factors were identified. The correlation coefficient between VO2peak and FEV1 was r=0.64 (p<0.001). In participants with a low CRF, FEV1 ranged from 20% to 112% of predicted. Conclusions: The correlation between VO2peak and FEV1 was moderate. The majority of the tests resulted in a VO2peak within normal limits. Interestingly, 44% of the tests with a low VO2peak could be explained by deconditioning. Thus, exercise therapy may be beneficial for these patients.

• Udjus, Camilla; Fadila, Cero; Halvorsen, Bente; Behmen, Dina; Carlson, Cathrine Rein & Bendiksen, Bård Andre [Vis alle 14 forfattere av denne artikkelen] (2019). Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension. American Journal of Physiology - Lung cellular and Molecular Physiology. ISSN 1040-0605. 316(6), s. L999–L1012. doi: 10.1152/ajplung.00322.2018. Fulltekst i vitenarkiv
• Sæverud, Håvard Andreassen; Falk, Ragnhild Sørum; Dowrick, Adam; Eriksen, Morten; Aarrestad, Sigurd & Skjønsberg, Ole Henning (2019). Measuring diaphragm movement and respiratory frequency using a novel ultrasound device in healthy volunteers. Journal of Ultrasound. ISSN 1971-3495. s. 1–8. doi: 10.1007/s40477-019-00412-2. Fulltekst i vitenarkiv
• Aarrestad, Sigurd; Qvarfort, Magnus; Kleiven, Anne Louise; Tollefsen, Elin; Skjønsberg, Ole Henning & Janssens, Jean-Paul (2018). Diagnostic accuracy of simple tools in monitoring patients with chronic hypoventilation treated with non-invasive ventilation; a prospective cross-sectional study. Respiratory Medicine. ISSN 0954-6111. 144, s. 30–35. doi: 10.1016/j.rmed.2018.09.015. Fulltekst i vitenarkiv
• Nakstad, Espen Rostrup; Opdahl, Helge; Heyerdahl, Fridtjof; Borchsenius, Fredrik & Skjønsberg, Ole Henning (2017). Manual ventilation and open suction procedures contribute to negative pressures in a mechanical lung model. BMJ Open Respiratory Research. ISSN 2052-4439. 4:e000176, s. 1–7. doi: 10.1136/bmjresp-2016-000176.
• Aarrestad, Sigurd; Qvarfort, Magnus; Kleiven, Anne Louise; Tollefsen, Elin; Skjønsberg, Ole Henning & Janssens, Jean-Paul (2017). Sleep related respiratory events during non-invasive ventilation of patients with chronic hypoventilation. Respiratory Medicine. ISSN 0954-6111. 132, s. 210–216. doi: 10.1016/j.rmed.2017.10.025.
• Nakstad, Espen Rostrup; Aass, Hans Christian; Opdahl, Helge; Witsø, Anne; Borchsenius, Fredrik & Heyerdahl, Fridtjof [Vis alle 7 forfattere av denne artikkelen] (2017). Bronchial wheezing predicts inflammation and respiratory failure in fire smoke victims. Acta Anaesthesiologica Scandinavica. ISSN 0001-5172. 61(9), s. 1142–1154. doi: 10.1111/aas.12962. Vis sammendrag

  BackgroundAcute fire smoke inhalation injury involves inflammatory mediators whose roles are poorly understood. We carried out a prospective observational study of fire smoke victims to identify clinical and biochemical markers that may predict pulmonary dysfunction and investigated possible correlations between dysfunction and cytokines in bronchoalveolar lavage (BAL) fluid and blood. MethodsForty patients with respiratory and/or neurological symptoms following acute fire smoke inhalation had pulmonary function tests and blood gas analyses performed on admission, at discharge, and after 3 months. Cytokines were measured using BioPlex/XMap technology. ResultsOn admission, 30 (75%) patients had dyspnea. Patients presenting with bronchial wheezing (n = 14) had significantly lower PEF (201 l/min, 82-360) than non-wheezing patients (406 l/min, 100-683) (n = 16, P = 0.03). Bronchial wheezing predicted need for ICU treatment with OR = 93.3 at 95% CI (P < 0.001) and was associated with gas exchange impairment, with mean p(a)O(2)/FiO(2) ratio 34.4 (11.8-49.8) kPa on admission and 21.3 (8.3-44.5) kPa 48 h later. Blood HbCO also predicted ICU treatment, with OR = 1.58 at 95% CI (P < 0.001). Serum CRP, IL-6, IL-8, and MCP-1 were significantly higher in wheezing patients after 12-24 h compared with non-wheezing patients and study controls. Cytokine levels were still elevated after 3 months. BAL fluid had significantly higher levels of IL-8, MCP-1, IL-1, and G-CSF compared with healthy controls. ConclusionIn victims of fire smoke inhalation, pulmonary wheezing predicts inflammation, pulmonary dysfunction, respiratory failure, and need for intensive care.

• Edvardsen, Elisabeth; Akerø, Aina; Skjønsberg, Ole Henning & Skrede, Bjørn (2017). Pre-flight evaluation of adult patients with cystic fibrosis: a cross-sectional study. BMC Research Notes. ISSN 1756-0500. 10(84), s. 1–8. doi: 10.1186/s13104-017-2386-2. Fulltekst i vitenarkiv Vis sammendrag

  Background: Air travel may imply a health hazard for patients with cystic fibrosis (CF) due to hypobaric environment in the aircraft cabin. The objective was to identify pre-flight variables, which might predict severe hypoxaemia in adult CF patients during air travel. Methods: Thirty adult CF-patients underwent pre-flight evaluation with spirometry, arterial oxygen tension (PaO2), pulse oximetry (SpO2) and cardiopulmonary exercise testing (CPET) at sea level (SL). The results were related to the PaO2 obtained during a hypoxia-altitude simulation test (HAST) in which a cabin altitude of 2438 m (8000 ft) was simulated by breathing 15.1% oxygen. Results: Four patients fulfilled the criteria for supplemental oxygen during air travel (PaO2 HAST < 6.6 kPa). While walking slowly during HAST, another eleven patients dropped below PaO2 HAST 6.6 kPa. Variables obtained during CPET (PaO2 CPET, SpO2 CPET, minute ventilation/carbon dioxide output, maximal oxygen uptake) showed the strongest correlation to PaO2 HAST. Conclusions: Exercise testing might be of value for predicting in-flight hypoxaemia and thus the need for supplemental oxygen during air travel in CF patients.

• Nakstad, Espen Rostrup; Opdahl, Helge; Heyerdahl, Fridtjof; Borchsenius, Fredrik & Skjønsberg, Ole Henning (2016). Can ventilator settings reduce the negative effects of endotracheal suctioning? Investigations in a mechanical lung model. BMC Anesthesiology. ISSN 1471-2253. 16:30. doi: 10.1186/s12871-016-0196-z.
• Stylianou, Eva; Ueland, Thor; Borchsenius, Fredrik; Michelsen, Annika; Øvstebø, Reidun & Mollnes, Tom Eirik [Vis alle 8 forfattere av denne artikkelen] (2016). Specific allergen immunotherapy: Effect on IgE, IgG4 and chemokines in patients with allergic rhinitis. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 76(2), s. 118–127. doi: 10.3109/00365513.2015.1110856.
• Aarrestad, Sigurd; Tollefsen, Elin; Kleiven, Anne Louise; Qvarfort, Magnus; Janssens, Jean-Paul & Skjønsberg, Ole Henning (2016). Validity of transcutaneous PCO2 in monitoring chronic hypoventilation treated with non-invasive ventilation. Respiratory Medicine. ISSN 0954-6111. 112, s. 112–118. doi: 10.1016/j.rmed.2016.01.017.
• Edvardsen, Elisabeth; Anderssen, Sigmund Alfred; Borchsenius, Fredrik & Skjønsberg, Ole Henning (2015). Reduction in cardiorespiratory fitness after lung resection is not related to the number of lung segments removed. BMJ Open sport & exercise medicine. ISSN 2055-7647. 1(1). doi: 10.1136/bmjsem-2015-000032.
• Fadila, Cero; Hillestad, Vigdis; Sjaastad, Ivar; Yndestad, Arne; Aukrust, Pål & Ranheim, Trine [Vis alle 15 forfattere av denne artikkelen] (2015). Absence of the inflammasone adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice. American Journal of Physiology - Lung cellular and Molecular Physiology. ISSN 1040-0605. 309, s. L378–L387. doi: 10.1152/ajplung.00342.2014.
• Fadila, Cero; Hillestad, Vigdis; Sjaastad, Ivar; Yndestad, Arne; Aukrust, Pål & Ranheim, Trine [Vis alle 15 forfattere av denne artikkelen] (2015). Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice. American Journal of Physiology - Lung cellular and Molecular Physiology. ISSN 1040-0605. 309(4), s. L378–L387. doi: 10.1152/ajplung.00342.2014.
• Edvardsen, Elisabeth; Skjønsberg, Ole Henning; Holme, Ingar Morten K; Nordsletten, Lars; Borchsenius, Fredrik & Anderssen, Sigmund Alfred (2015). High-intensity training following lung cancer surgery: a randomised controlled trial. Thorax. ISSN 0040-6376. 70(3), s. 244–250. doi: 10.1136/thoraxjnl-2014-205944. Vis sammendrag

  Background: Many patients with lung cancer are deconditioned with poor physical fitness. Lung resection reduces physical fitness further, impairing the patient's ability to function in daily life. Methods: We conducted a single-blind randomised controlled trial of high-intensity endurance and strength training (60 min, three times a week, 20 weeks), starting 5–7 weeks after surgery. The control group received standard postoperative care. The primary outcome was the change in peak oxygen uptake measured directly during walking until exhaustion. Other outcomes included changes in pulmonary function, muscular strength by one-repetition maximum (1RM), total muscle mass measured by dual energy X-ray absorptiometry, daily physical functioning and quality of life (QoL). Results: The intention-to-treat analysis of the 61 randomised patients showed that the exercise group had a greater increase in peak oxygen uptake (3.4 mL/kg/min between-group difference, p=0.002), carbon monoxide transfer factor (Tlco) (5.2% predicted, p=0.007), 1RM leg press (29.5 kg, p<0.001), chair stand (2.1 times p<0.001), stair run (4.3 steps, p=0.002) and total muscle mass (1.36 kg, p=0.012) compared with the controls. The mean±SD QoL (SF-36) physical component summary score was 51.8±5.5 and 43.3±11.3 (p=0.006), and the mental component summary score was 55.5±5.3 and 46.6±14.0 (p=0.015) in the exercise and control groups, respectively. Conclusions: In patients recently operated for lung cancer, high-intensity endurance and strength training was well tolerated and induced clinically significant improvements in peak oxygen uptake, Tlco, muscular strength, total muscle mass, functional fitness and QoL. This study may provide a basis for exercise therapy after lung cancer surgery.

• Hillestad, Vigdis; Espe, Emil Knut Stenersen; Fadila, Cero; Larsen, Karl-Otto; Sjaastad, Ivar & Nygård, Ståle [Vis alle 8 forfattere av denne artikkelen] (2015). IL-18 neutralization during alveolar hypoxia improves left ventricular diastolic function in mice. Acta Physiologica. ISSN 1748-1708. 213(2), s. 492–504. doi: 10.1111/apha.12376.
• Sæverud, Håvard Andreassen; Borchsenius, Fredrik; Mellem, H; Finstad, Pål Leyell & Skjønsberg, Ole Henning (2013). the obstructive siblings: Relapsing polychondritis without chondritis. Respiratory Medicine. ISSN 0954-6111. 10, s. 4–6.
• Sæverud, Håvard Andreassen; Borchsenius, Fredrik; Mellem, Harald; Finstad, Pål Leyell & Skjønsberg, Ole Henning (2013). The obstructive siblings; relapsing polychondritis without condritis? Respiratory Medicine. ISSN 0954-6111. 10, s. 4–6. doi: 10.1016/j.rmcr.2013.04.005.
• Edvardsen, Anne; Ryg, Morten; Akerø, Aina; Christensen, Carl Christian & Skjønsberg, Ole Henning (2013). COPD and air travel: does hypoxia-altitude simulation testing predict in-flight respiratory symptoms? European Respiratory Journal. ISSN 0903-1936. 42(5), s. 1216–1223. doi: 10.1183/09031936.00157112.
• Edvardsen, Anne; Akerø, Aina; Christensen, Carl Christian; Ryg, Morten & Skjønsberg, Ole Henning (2012). Air travel and chronic obstructive pulmonary disease: a new algorithm for pre-flight evaluation. Thorax. ISSN 0040-6376. 67(11), s. 964–969. doi: 10.1136/thoraxjnl-2012-201855.
• Fadila, Cero; Hillestad, Vigdis; Løberg, Else Marit; Christensen, Geir Arve; Larsen, Karl-Otto & Skjønsberg, Ole Henning (2012). IL-18 and IL-12 synergy induces matrix degrading enzymes in the lung. Experimental Lung Research. ISSN 0190-2148. 38(8), s. 406–419. doi: 10.3109/01902148.2012.716903.
• Nakstad, Espen Rostrup; Opdahl, Helge; Skjønsberg, Ole Henning & Borchsenius, Fredrik (2011). Intrabronchial airway pressures in intubated patients during bronchoscopy under volume controlled and pressure controlled ventilation. Anaesthesia and Intensive Care. ISSN 0310-057X. 39(3), s. 431–439.
• Larsen, Karl-Otto; Yndestad, Arne; Sjaastad, Ivar; Løberg, Else Marit; Goverud, Ingeborg Løstegaard & Halvorsen, Bente [Vis alle 14 forfattere av denne artikkelen] (2011). Lack of CCR7 induces pulmonary hypertension involving perivascular leukocyte infiltration and inflammation. American Journal of Physiology - Lung cellular and Molecular Physiology. ISSN 1040-0605. 301(1), s. L50–L59. doi: 10.1152/ajplung.00048.2010.
• Akerø, Aina; Edvardsen, Anne; Christense, Carl C.; Owe, Jan Ove; Ryg, Morten & Skjønsberg, Ole Henning (2011). COPD and air travel: Oxygen equipment and pre-flight titration of supplemental oxygen. Chest. ISSN 0012-3692. 140(1), s. 84–90. doi: 10.1378/chest.10-0965.
• Edvardsen, Anne; Akerø, Aina; Hardie, Jon Andrew; Ryg, Morten; Eagan, Tomas Mikal & Skjønsberg, Ole Henning [Vis alle 7 forfattere av denne artikkelen] (2011). High prevalence of respiratory symptoms during air travel in patients with COPD. Respiratory Medicine. ISSN 0954-6111. 105(1), s. 50–56. doi: 10.1016/j.rmed.2010.10.006.
• Yndestad, Arne; Larsen, Karl-Otto; Øie, Erik; Ueland, Thor; Smith, Camilla & Halvorsen, Bente [Vis alle 14 forfattere av denne artikkelen] (2009). Elevated levels of activin A in clinical and experimental pulmonary hypertension. Journal of applied physiology. ISSN 8750-7587. 106(4), s. 1356–1364. doi: 10.1152/japplphysiol.90719.2008.
• Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Arnkværn, Kristin & Florholmen, Geir [Vis alle 11 forfattere av denne artikkelen] (2008). Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A. Cardiovascular Research (CVR). ISSN 0008-6363. 80(1), s. 47–54. doi: 10.1093/cvr/cvn180.
• Nielsen, Hilde Dorthea Grindvik; Skjønsberg, Ole Henning & Lyberg, Torstein (2008). Effect of antioxidant supplementation on leucocyte expression of reactive oxygen species in athletes. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 68(7), s. 526–533. doi: 10.1080/00365510701864602.
• Akerø, Aina; Christensen, Carl C.; Edvardsen, Anne; Ryg, Morten & Skjønsberg, Ole Henning (2008). Pulse oximetry in the preflight evaluation of patients with chronic obstructive pulmonary disease. Aviation, Space and Environmental Medicine. ISSN 0095-6562. 79, s. 508–524.
• Jensen, Torstein; Kierulf, Peter; Sandset, Per Morten; Klingenberg, Olav; Joø, Gun Brit & Godal, Hans Chr [Vis alle 7 forfattere av denne artikkelen] (2007). Fibrinogen and fibrin induce synthesis of proinflammatory cytokines from peripheral blood mononuclear cells. Thrombosis and Haemostasis. ISSN 0340-6245. 97(5), s. 822–829. doi: 10.1160/TH07-01-0039. Vis sammendrag

  Fibrinogen in plasma includes three main fractions; high-molecular-weight (HMW)-fibrinogen, low-molecular-weight (LMW)-fibrinogen, and very-low-molecular-weight (LMW')-fibrinogen. During acute-phase conditions, plasma fibrinogen levels and the HMW-/LMW-fibrinogen ratio increase rapidly due to increased synthesis of HMW-fibrinogen. The consequences of elevated plasma fibrinogen levels and local deposition of fibrin in inflammatory tissues observed during acute-phase conditions are not clear. We wanted to investigate proinflammatory effects of fibrinogen and fibrin on peripheral blood mononuclear cells (PBMC) as reflected by altered mRNA expression and synthesis of the proinflammatory cytokines IL-6, TNF-alpha and IL-1beta, and to explore the significance of altered HMW-/LMW-fibrinogen ratio. PBMC were isolated from whole blood using Lymphoprep((R)). HMW-fibrinogen was separated from unfractioned fibrinogen by ammonium sulphate precipitation. Cells were incubated with unfractioned fibrinogen, HMW-fibrinogen or fibrin. Cytokine levels in cell lysates were determined using ELISA assays. Real-time PCR was used for mRNA quantification. We found that fibrinogen significantly increased mRNA levels, and induced synthesis of the proinflammatory cytokines IL-6 and TNF-alpha in PBMC in a dose dependent manner. Median (25, 75 percentile) IL-6 and TNF-alpha concentrations were 12 (5, 40) pg/ml and 16 (0,61) pg/ml, respectively. Median mRNA quantity was increased 12.3- (6.6, 48.6) and 1.7- (1.5, 6.5) fold for IL-6 and TNF-alpha compared to controls. The stimulatory effect of unfractioned fibrinogen was not significantly different from HMW-fibrinogen. Fibrinogen and fibrin were equally effective in promoting cytokine synthesis from PBMC. The results support that fibrin and fibrinogen may actively modulate the inflammatory process by inducing synthesis of proinflammatory cytokines from PBMC.

• Jensen, Torstein; Retterstøl, Lars; Sandset, Per Morten; Godal, Hans Chr & Skjønsberg, Ole Henning (2006). A daily glass of red wine induces a prolonged reduction in plasma viscosity: a randomized controlled trial. Blood Coagulation and Fibrinolysis. ISSN 0957-5235. 17(6), s. 471–476. Vis sammendrag

  Moderate red wine consumption has been associated with decreased risk of coronary heart disease. Reduced plasma viscosity and fibrinogen levels have been launched as possible contributors to this risk reduction. The effect of moderate red wine consumption on plasma viscosity, however, has not been investigated in a prospective, randomized trial. We wanted to evaluate the effect of moderate red wine consumption on plasma viscosity, fibrinogen concentration and fibrinogen subfractions. Healthy, nonsmoking volunteers were assigned to consume one glass of red wine daily for 3 weeks in a prospective, randomized cross-over study. In the second 3-week period the volunteers abstained from alcohol use. The plasma viscosity, fibrinogen concentration and the distribution of the main fibrinogen subfractions were determined at inclusion, after wine drinking and after abstention. Plasma viscosity was reduced by 0.026 and 0.024 mPa.s in the two groups following wine intake (95% confidence interval, 0.009-0.043, P = 0.004; 95% confidence interval, 0.0083-0.039, P = 0.003). The decrease in plasma viscosity was maintained following 3 weeks of abstention. The fibrinogen concentration was reduced by 0.17 g/l following wine drinking in the group starting with abstention (95% confidence interval, 0.04-0.29, P = 0.01). The distribution of the fibrinogen subfractions remained unaltered. We conclude that a daily glass of red wine for 3 weeks significantly reduces plasma viscosity. Fibrinogen concentrations are also significantly reduced, when preceded by an abstention period. The decreased viscosity levels are maintained after 3 weeks of abstention, suggesting a sustained viscosity lowering effect of red wine.

• Larsen, Karl-Otto; Sjaastad, Ivar; Svindland, A; Krobert, Kurt Allen; Skjønsberg, Ole Henning & Christensen, Geir Arve (2006). Alveolar hypoxia induces left ventricular diastolic dysfunction and reduces phosphorylation of phospholamban in mice. American Journal of Physiology. Heart and Circulatory Physiology. ISSN 0363-6135. 291, s. H507–H516.
• Akerø, A; Christensen, Cc; Edvardsen, A & Skjønsberg, Ole Henning (2005). Hypoxaemia in chronic obstructive pulmonary disease patients during a commercial flight. European Respiratory Journal. ISSN 0903-1936. 25(4), s. 725–730.
• Herland, K; Akselsen, JP; Skjønsberg, Ole Henning & Bjermer, L (2005). How representative are clinical study patients with asthma or COPD for a larger "real life" population of patients with obstructive lung disease? Respiratory Medicine. ISSN 0954-6111. 99(1), s. 11–19.
• Solberg, Geir; Robstad, Bjørn; Skjønsberg, Ole Henning & Borchsenius, F (2005). Respiratory gas exchange indices for estimating the anaerobic threshold. Journal of Sports Science and Medicine. ISSN 1303-2968. 4, s. 29–36.

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• Skjønsberg, Ole Henning (2012). Eksperimentell lungemedisinsk forskning. Norsk forening for lungemedisin. ISBN 9788230322314. 5 s.

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• Kleiven, Anne Louise; Markussen, Heidi Øksnes; Skjønsberg, Ole Henning; Janssens, Jean-Paul & Aarrestad, Sigurd (2023). Respiratory Events and Health-Related Quality of Life in Long-Term Non-Invasive Ventilation: How Can We Optimize and Prevent Failure? Respiration. ISSN 0025-7931. 102(5), s. 400–401. doi: 10.1159/000529196.
• Tveiten, Hallgeir; Lehne, Gustav; Aukrust, Pål; Rivero, Jezabel Rodriguez & Skjønsberg, Ole Henning (2020). En mann i 40-årene med økendepustevansker. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(6), s. 1–7. doi: 10.4045/tidsskr.19.0692.
• Edvardsen, Elisabeth; Anderssen, Sigmund Alfred; Borchsenius, Fredrik Charlo & Skjønsberg, Ole Henning (2018). Long Term Effects of High-Intensity Exercise Training after Lung Cancer Surgery ~ A Five Year Follow-Up of a Randomized Controlled Trial.
• torvanger, ole; Os, Audun; Skjønsberg, Ole Henning & Edvardsen, Elisabeth (2018). Cardiorespiratory Fitness on a Treadmill in an adult Norwegian Cystic Fibrosis Population .
• Udjus, Camilla; Cero, Fadila; Halvorsen, Bente; Aukrust, Pål; Christensen, Geir Arve & Skjønsberg, Ole Henning [Vis alle 7 forfattere av denne artikkelen] (2018). Inhibition of caspase-1 reduces hypoxia-induced pulmonary hypertension by downregulating smooth muscle cell growth.
• Udjus, Camilla; Cero, Fadila; Christensen, Geir Arve; Skjønsberg, Ole Henning & Larsen, Karl-Otto (2015). The role of caspase-1 in pulmonary hypertension.
• Cero, Fadila; Larsen, Karl-Otto; Hillestad, Vigdis; Olsen, Maria Belland; Udjus, Camilla & Sjaastad, Ivar [Vis alle 11 forfattere av denne artikkelen] (2015). The inflammasome adaptor ASC mediates pulmonary artery remodelling.
• Cero, Fadila; Larsen, Karl-Otto; Hillestad, Vigdis; Olsen, Maria Belland; Udjus, Camilla & Yndestad, Arne [Vis alle 10 forfattere av denne artikkelen] (2015). Hypoxic pulmonary hypertension; a role for the inflammasome.
• Edvardsen, Anne; Ryg, Morten; Akerø, Aina; Christensen, Carl Christian & Skjønsberg, Ole Henning (2013). COPD and air travel: does hypoxia-altitude simulation test predict in-flight respiratory symptoms?
• Cero, Fadilla; Larsen, Karl Otto; Sandanger, Øystein; Løberg, Else Marit; Christensen, Geir Arve & Skjønsberg, Ole Henning (2012). Hypoxia induces IL-18 and neutrophil influx in lung parenchyma possibly mediated by MIP-2.
• Edvardsen, Anne; Akerø, Aina; Christensen, Carl Christian; Ryg, Morten & Skjønsberg, Ole Henning (2012). Air Travel and COPD: a new algorithm for pre-flight evaluation.
• Edvardsen, Anne; Akerø, Aina; Christensen, Carl Christian; Ryg, Morten & Skjønsberg, Ole Henning (2011). Hypoxia altitude simulation test (HAST): Arterial blood gases or pulse oximetry?
• Edvardsen, Anne; Akerø, Aina; Christensen, Carl Christian; Ryg, Morten & Skjønsberg, Ole Henning (2011). Air travel and COPD: Exercise SpO2 and walking distance as predictors for in-flight desaturation.
• Hillestad, Vigdis; Larsen, Karl Otto; Sjaastad, Ivar; Nygård, Ståle; Skjønsberg, Ole Henning & Christensen, Geir Arve (2011). Neutralization of circulating interleukin-18 reduces diastolic dysfunction.
• Cero, Fadila; Larsen, Karl Otto; Hillestad, Vigdis; Christensen, Geir Arve & Skjønsberg, Ole Henning (2011). IL-18 and IL-12 induce inflammatory cytokines, chemokine ligand 9 (CXCL9) and T cell infiltration in pulmonary tissue.
• Akerø, Aina; Edvardsen, Anne; Christensen, Carl C.; Owe, Jan Ove; Ryg, Morten & Skjønsberg, Ole Henning (2010). Air travel and COPD: Oxygen equipment and pre-flight titration of supplemental oxygen.
• Edvardsen, Anne; Akerø, Aina; Eagan, Tomas Mikal Lind; Ryg, Morten; Hardie, Jon Andrew & Bakke, Per S. [Vis alle 7 forfattere av denne artikkelen] (2010). Air travel habits in patients with COPD.
• Edvardsen, Anne; Akerø, Aina; Eagan, Tomas Mikal Lind; Hardie, Jon Andrew; Ryg, Morten & Bakke, Per S. [Vis alle 7 forfattere av denne artikkelen] (2010). In-flight respiratory symptoms and pre-flight characteristics in patients with COPD.
• Hillestad, Vigdis; Larsen, Karl-Otto; Sjaastad, Ivar; Nygård, Ståle; Skjønsberg, Ole Henning & Christensen, Geir Arve (2010). Effects of IL-ı8 neutralization in alveolar hypoxia.
• Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Arnkværn, Kristin & Florholmen, Geir [Vis alle 10 forfattere av denne artikkelen] (2009). Mechanisms for cardiac dysfunction in COPD and respiratory failure. Respiratory Medicine. ISSN 0954-6111. 103, s. S6–S7.
• Nielsen, Hilde Grindvik; Skjønsberg, Ole Henning & Lyberg, Torstein (2009). Effekten av fire ukers antioksydanttilskudd på produksjon av frie oksygenradikaler i leukocytter hos kvinnelige og mannlige utholdenhetsutøvere. Idrettsmedisin. 2009(2), s. 23–25.
• Edvardsen, Anne; Akerø, Aina; Eagan, Thomas; Hardie, J; Bakke, Per & Skjønsberg, Ole Henning (2009). Air travel habits in patients with COPD.
• Edvardsen, Elisabeth; homme, jorunn; Skjønsberg, Ole Henning & Skrede, Bjørn (2009). Pre-flight evaluation in adult patients with cystic fibrosis.
• Nielsen, Hilde Dorthea Grindvik; Skjønsberg, Ole Henning & Lyberg, Torstein (2009). Effekten av fire ukers antioksidanttilskudd på produksjon av frie oksygenradikaler i leukocytter hos kvinnelige og mannlige utholdenhetsutøvere. Norsk idrettsmedisin. ISSN 0806-9328.
• Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Arnkværn, Kristin & Florholmen, Geir [Vis alle 11 forfattere av denne artikkelen] (2009). Increased circulating IL-18; a possible mechanism for hypoxia-induced cardiac dysfunction.
• Hillestad, Vigdis; Larsen, Karl-Otto; Sjaastad, Ivar; Nygård, Ståle; Skjønsberg, Ole Henning & Christensen, Geir Arve (2009). IL-18BP; a potential therapeutic agent in right ventricular hypertrophy.
• Edvardsen, Anne; Akerø, Aina; Eagan, Thomas; Ryg, Morten; Hardie, J & Bakke, Per [Vis alle 7 forfattere av denne artikkelen] (2008). Air travel and respiratory related symptoms in patients with COPD and controls.
• Akerø, Aina; Edvardsen, Anne; Ryg, Morten & Skjønsberg, Ole Henning (2008). PaO2 during exerciseas a predictor of in-flight hypoxaemia in COPD patients.
• Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Florholmen, Geir & Arnkværn, Kristin [Vis alle 10 forfattere av denne artikkelen] (2008). Alveolar hypoxia induces cardiac diastolic dysfunction: a role for a reduction in the calcium regulating protein phospholamban induced by IL-18.
• Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Arnkværn, Kristin & Florholmen, Geir [Vis alle 10 forfattere av denne artikkelen] (2008). Mechanisms for cardiac dysfunction in COPD and respiratory failure.
• Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Florholmen, Geir & Arnkværn, Kristin [Vis alle 10 forfattere av denne artikkelen] (2007). Increased PP1 and PP2A mediating reduced Ser16 phosphorylated PLB is a possible mechanism for cardiac dysfunction in alveolar hypoxia. Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 42(6), s. S245–S245.
• Nakstad, Espen R.; Opdahl, Helge; Borchsenius, Fredrik & Skjønsberg, Ole Henning (2007). Intrabronchial airway pressure in intubated patients during bronchoscopy under pressure and volume controlled ventilation.
• Nakstad, Espen R.; Opdahl, Helge; Borchsenius, Fredrik & Skjønsberg, Ole Henning (2007). Intrabronchial airway pressure in intubated patients during bronchoscopy under pressure and volume controlled ventilation.
• Edvardsen, Anne; Christensen, Carl C.; Skjønsberg, Ole Henning & Ryg, Morten (2007). Effect of high dose oxygen on dyspnea and exercise tolerance in patients with COPD given LTOT.
• Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Florholmen, Geir & Arnkværn, Kristin [Vis alle 10 forfattere av denne artikkelen] (2007). Diastolic dysfunction in alveolar hypoxia: A role for interleukin-18 induced increase in protein phosphatase 2A and reduction in phospholamban phosphorylation.
• Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Florholmen, Geir & Arnkværn, Kristin [Vis alle 10 forfattere av denne artikkelen] (2007). Alveolar hypoxia induces cardiac dysfunction, possibly mediated through increased amounts of phosphatases, leading to dephosphorylation of calcium regulatory proteins.
• Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Krobert, Kurt Allen; Florholmen, Geir & Arnkværn, Kristin [Vis alle 10 forfattere av denne artikkelen] (2007). Hypoxia induced cardiac dysfunction maybe caused by increased IL-18 levels leading to dephosphorylation of Ca2+ handling proteins.
• Edvardsen, Elisabeth; Ariansen, Inger; Mellem, Harald; Borchsenius, Fredrik; Gjesdal, Knut & Skjønsberg, Ole Henning (2006). Ventilatory limitation may be over-diagnosed in elderly subjects when MVV is calculated instead of measured. European Respiratory Society.
• Edvardsen, Elisabeth; Ariansen, h; Mellem, Harald; Borchsenius, Fredrik; Skjønsberg, Ole Henning & Gjesdal, Knut (2006). Ventilatory limitation may be over-diagnosed in elderly subjects when MVV is calculated instead of measured;.
• Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Skjønsberg, Ole Henning; Tasken, Kjetil & Christensen, Geir Arve (2006). Chronic alveolar hypoxia reduces the phosphorylation of phospholamban in mouse hearts.
• Larsen, Karl-Otto; Lygren, Birgitte; Sjaastad, Ivar; Tasken, Kjetil; Christensen, Geir Arve & Skjønsberg, Ole Henning (2006). Alveolar hypoxia induces left ventricular diastolic dysfunction in mice.
• Akerø, Aina; Christensen, Carl C.; Edvardsen, Anne; Ryg, Morten & Skjønsberg, Ole Henning (2006). Pulse oximetry as a screening test in the pre-flight evaluation of COPD patients.
• Akerø, Aina; Christensen, Carl C.; Edvardsen, Anne & Skjønsberg, Ole Henning (2005). Development of hypoxaemia in COPD patients during a commercial flight.
• Akerø, Aina; Christensen, Carl C.; Edvardsen, Anne & Skjønsberg, Ole Henning (2005). Hypoxaemia in chronic obstructive pulmonary disease patients during a commercial flight.
• Larsen, Karl Otto; Sjaastad, Ivar; Skjønsberg, Ole Henning & Christensen, Geir Arve (2005). Mechanisms leading to heart failure in pulmonary hypertension.
• Skjønsberg, Ole Henning & Jensen, Torstein (2008). Studies on subfractions of fibrinogen.With special emphasis on fibrinogen quantification, viscicity and inflammation. Unipub forlag.
• Christensen, Carl C. & Skjønsberg, Ole Henning (2006). Effects of low atmospheric pressure and exercise on hypoxaemia in patients with chronic lung disease. Unipub forlag.
• Christensen, Carl C. & Skjønsberg, Ole Henning (2006). Effects of low atmospheric pressure and exercise on hypoxaemia in patients with lung disease. Unipub forlag.

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