Rolf Haye

• Haye, Rolf; Døsen, Liv Kari; TarAngen, Magnus; Gay, Caryl; Pripp, Are Hugo & Shiryaeva, Olga (2025). Septoplasty: defining a desirable clinical outcome according to baseline symptom scores. Frontiers in Surgery. 12. doi: 10.3389/fsurg.2025.1471526. Full text in Research Archive
• Haye, Rolf; Døsen, Liv Kari; TarAngen, Magnus; Gay, Caryl; Pripp, Are Hugo & Shiryaeva, Olga (2023). Clinically important estimates of improvement after septoplasty. Journal of Laryngology and Otology. ISSN 0022-2151. doi: 10.1017/S0022215123000993. Full text in Research Archive
• Haye, Rolf; Døsen, Liv Kari; Tarangen, M; Gay, Caryl; Egeland, M.T. & Shiryaeva, Olga (2021). Septoplasty: Early (first year) and late (fourth year) postoperative results in 604 patients. Journal of Laryngology and Otology. ISSN 0022-2151. p. 1–24. doi: 10.1017/S0022215121003741. Full text in Research Archive
• Haye, Rolf; Døsen, Liv Kari; Gay, Caryl; TarAngen, Magnus & Shiryaeva, Olga (2020). Self-reported complications after tonsillectomy: Comparison of responders and nonresponders to a mailed questionnaire. International Journal of Otolaryngology. ISSN 1687-9201. doi: 10.1155/2020/4561858. Full text in Research Archive Show summary

  Some studies of tonsillectomy outcomes have low response rates to mailed quality control questionnaires. )is study evaluated the effect of nonresponders to mailed questionnaires about posttonsillectomy complications by determining whether mail responders and nonresponders differ. Questionnaires were mailed to patients 3–6 weeks after tonsillectomy to assess postoperative complications, defined as contact with a private practitioner and/or hospital readmission related to postsurgical bleeding, pain, or infection. Nonresponders to the mailed questionnaire were interviewed by telephone 7–11 weeks postoperatively, and responses of mail and telephone responders were compared. Of 818 patients undergoing tonsillectomy during the study period, 66.3% responded by mail, and 29.5% were interviewed by telephone, for a total response rate of 95.7%. )e mail response rate was significantly higher among parents of pediatric patients than among adult patients (71.4% versus 58.7%, p < 0.001). In the pediatric group, overall complication rates were 65% higher among mail responders than telephone responders (20.9% versus 12.7%, p = 0.049), likely due to their higher rates of both visits to private practitioners and infection, as there were no differences in rates of pediatric readmission, bleeding, or pain between the responder groups. Among adult patients, mail and telephone responders did not differ with respect to their overall complication rate (40.9% versus 34.1%, p = 0.226) or their rates of readmission or bleeding. However, similar to the pediatric group, visits to a private practitioner were slightly more common among adult mail responders than telephone responders (30.6% versus 21.1%, p = 0.065), as were reports of pain (p = 0.001) and infection (p = 0.006). Studies relying on mailed questionnaires with low response rates likely overestimate the rate of minor complications handled outside the hospital, but rates of major complications involving readmission are unlikely to be seriously biased by low response rates. Supplementing mailed questionnaires with telephone interviews may increase the validity of surgical outcome studies.

• Haye, Rolf; Egeland, Merete Trollsås; Døsen, Liv Kari; Gay, Caryl; TarAngen, Magnus & Shiryaeva, Olga (2019). Assessment of non-response in quality control of nasal septal surgery. Journal of Laryngology and Otology. ISSN 0022-2151. 133(3), p. 208–212. doi: 10.1017/S002221511900032X. Full text in Research Archive
• Hansen, Aleksander Grande; Zhang, Chi; Loven, Jens Øyvind; Berdal, Hanne; TarAngen, Magnus & Haye, Rolf (2018). A questionnaire using vocal symptoms in quality control of phonosurgery: Vocal surgical questionnaire. BMC Ear, Nose and Throat Disorders. 18(9). doi: 10.1186/s12901-018-0057-0. Full text in Research Archive Show summary

  Background Quality control after phonosurgery is important and may be time consuming. Often questionnaires focusing on quality of life are applied. We aimed at investigating the use of organ specific symptoms, such as hoarseness and voice failure with the use of self-reported visual analogue scales (VAS) and Likert-scales. Methods A vocal surgical questionnaire using VAS and Likert-scales for hoarseness, voice failure and factors that could influence voice quality was given twice consecutively to a group of healthy volunteers (n = 57, 45 female) and a group of voice patients (n = 34, 21 females) for a test/re-test study. Secondly, a group of patients undergoing surgery (n = 90, 61females) answered the questionnaire preoperatively and postoperatively. The difference between test/retest, healthy volunteers and patients, and between pre- and postoperative results were compared. Results There was no significant difference in the test/retest results in healthy volunteers nor in the patient group. There was statistically significant difference between the healthy volunteers and patients, and between the preoperative and postoperative results after phonosurgery. Conclusion This short and organ specific questionnaire clearly demonstrates the effect of phonosurgery, making it an easy and relevant tool in quality control and potentially reducing the need of postoperative controls in the outpatient clinic.

• Haye, Rolf; Døsen, Liv Kari; TarAngen, Magnus & Shiryaeva, Olga (2018). Good correlation between visual analogue scale and numerical rating scale in the assessment of nasal obstruction. Journal of Laryngology and Otology. ISSN 0022-2151. 132(4), p. 327–328. doi: 10.1017/S0022215118000257. Full text in Research Archive Show summary

  Abstract Objective: Results from telephone interviews may be needed to supplement those from mailed questionnaire when response rates are inadequate. Our intention was to assess the visual analogue scale ratings used in mailed questionnaires to numerical rating scale scores used in telephone interviews. Methods: Patients scheduled for nasal septal surgery routinely respond to a visual analogue scale of obstruction during the day and at night. In this study they were also asked to verbally rate their sense of obstruction using whole numbers. Results: There was no significant difference in obstruction scores between VAS and NRS recordings. Conclusion: Ratings of nasal obstruction used with NRS in telephone interviews are comparable to those marked on the VAS used in mailed questionnaires.

• Døsen, Liv Kari; Kvinnesland, Knut; TarAngen, Magnus; Shiryaeva, Olga; Gay, Caryl & Haye, Rolf (2018). Unilateral and bilateral PNIF in quality control of nasal septal surgery. International Journal of Otolaryngology. ISSN 1687-9201. doi: 10.1155/2018/7846843. Full text in Research Archive Show summary

  Abstract The aim of this study was to explore the usefulness of unilateral, combined unilateral (left + right) and bilateral peak nasal inspiratory flow (PNIF) measurements in assessing the results of nasal septal surgery. Nasal obstruction was recorded subjectively and objectively before and 4 months after nasal septoplasty using a visual analogue scale (VAS) and a PNIF meter. Nasal septoplasty (58 patients) and septoplasty with turbinoplasty (68 patients) were performed on 126 patients (85 males, 41 females) with a mean age of 32.8 years. The results showed a significant improvement in VAS scores, as well as unilateral, combined unilateral and bilateral PNIF values after both septoplasty and septoplasty with turbinoplasty. Septoplasty with turbinoplasty showed better improvement in VAS and PNIF scores than septoplasty alone and this was significant for bilateral PNIF scores. The best unilateral pre- and postoperative correlations between VAS and PNIF measurements were found using the lower of the two unilateral PNIF scores, irrespective of side. In the total material, VAS/PNIF correlations were mostly significant, but weak (all r<0.30). We found VAS and PNIF to be useful instruments in reporting results of surgery. The weak correlations between VAS and PNIF measurements suggest that these subjective and objective instruments may target different aspects of nasal obstruction.  

• Shiryaeva, Olga; TarAngen, Magnus; Gay, Caryl; Døsen, Liv Kari & Haye, Rolf (2017). Preoperative Signs and Symptoms as Prognostic Markers in Nasal Septoplasty. International Journal of Otolaryngology. ISSN 1687-9201. doi: 10.1155/2017/4718108. Full text in Research Archive Show summary

  Identification of preoperative signs and symptoms that may predict the outcome of surgery is important, for both patient selection and the development of interventions for improving outcomes. The purpose of this study was to assess the value of some selected preoperative signs and symptoms for predicting outcomes of nasal septoplasty. Patients undergoing septoplasty with or without turbinoplasty responded to the Nasal Surgical Questionnaire (NSQ) preoperatively and six months postoperatively. The questionnaire contains visual analogue scales (VAS) for nasal obstruction during the day and at night. We compared preoperative and postoperative VAS scores in patients with unilateral versus bilateral septal deviation and patients with low versus high preoperative scores. Of 446 patients undergoing septoplasty from September 2014 to December 2015 who had responded to the preoperative NSQ, 286 (64.1%) also returned the postoperative version. There was greater improvement in obstruction in patients with preoperative unilateral compared to bilateral septal deviation (day scores, 𝑝 = 0.04). The grade of deviation and the presence of concomitant bony conchal hypertrophy did not influence results. Patients with lower preoperative VAS scores obtained better end results than those with higher scores (𝑝 = 0.04). Type of septal deviation and preoperative VAS scores may aid in predicting outcome of nasal surgery.

• Egeland, Merete Trollsås; TarAngen, Magnus; Shiryaeva, Olga; Gay, Caryl; Døsen, Liv Kari & Haye, Rolf (2017). Evaluation of strategies for increasing response rates to postal questionnaires in quality control of nasal septal surgery. BMC Research Notes. 10(1). doi: 10.1186/s13104-017-2516-x. Full text in Research Archive Show summary

  Background Postal questionnaires are often used to assess the results of nasal septoplasty, but response rates vary widely. This study assesses strategies designed to increase the response rate. Methods Postoperative questionnaires using visual analogue scales (VAS) for nasal obstruction were mailed to 160 consecutive patients alternately allocated to one of two groups. Group A received the questionnaire in the usual manner and group B received a modified cover letter with hand-written name and signature and a hand-stamped return envelope. Results Of the 80 patients in each group, 47 (58.8%) in group A and 54 (67.5%) in group B returned the questionnaire (p = 0.25). There were no age or gender differences between the groups, nor did the pre- and postoperative VAS scores differ between the groups. Conclusion The strategies used in this study increased the response rate to postal questionnaires by 8.7% points, but this was not a statistically significant or clinically meaningful improvement.

• Egeland, Merete Trollsås; Døsen, Liv Kari; TarAngen, Magnus; Gay, Caryl & Haye, Rolf (2016). Evaluation of non-response in quality control of nasal septal surgery. Journal of Laryngology and Otology. ISSN 0022-2151. 130(12), p. 1130–1136. doi: 10.1017/S002221511600921X. Full text in Research Archive Show summary

  OBJECTIVE: Questionnaires are often used to assess the results of nasal septoplasty, but response rates vary widely. The possible bias caused by non-responders was evaluated to determine the validity of questionnaire results. METHODS: Post-operative questionnaires employing visual analogue scales for nasal obstruction were mailed to 182 patients. The 62 non-responders (34.1 per cent) were contacted by telephone, 58 (93.5 per cent) of whom were contactable and responded orally to the questionnaire. RESULTS: Non-responders were younger, but no different from responders with regard to gender, smoking habits or allergies. Post-operative visual analogue scale obstruction scores were slightly, but not statistically, higher in non-responders. However, because non-responders' pre-operative scores were lower, obstruction scores improved less than in responders. The main reason for not responding was forgetfulness. Some would have preferred an electronic version of the questionnaire. CONCLUSION: Although post-operative obstruction scores did not differ between the groups, nasal obstruction scores improved more among responders than non-responders. Thus, low response rates may cause bias

• Døsen, Liv Kari; Jebsen, Peter Wilhelm; Dingsør, Bernt & Haye, Rolf (2015). IgG4-Related Nasal Pseudotumor. Case Reports in Otolaryngology. ISSN 2090-6765. doi: 10.1155/2015/749890. Full text in Research Archive
• Haye, Rolf; TarAngen, Magnus; Døsen, Liv Kari & Shiryaeva, Olga (2015). Evaluation of the Nasal Surgical Questionnaire for Monitoring Results of Septoplasty. International Journal of Otolaryngology. ISSN 1687-9201. doi: 10.1155/2015/563639. Full text in Research Archive
• Haye, Rolf; Døsen, Liv Kari; Shiryaeva, Olga & Amlie, Einar Johan Braém (2015). Evaluation of a nasal surgical questionnaire designed for monitoring surgical outcomes and comparing different techniques. Journal of Laryngology and Otology. ISSN 0022-2151. 129(7), p. 656–661. doi: 10.1017/S0022215115001188. Full text in Research Archive
• Døsen, Liv Kari & Haye, Rolf (2012). Endonasal surgery after cocaine abuse: Safe at any interval? Case Reports in Otolaryngology. ISSN 2090-6765. doi: 10.1155/2012/823470. Full text in Research Archive
• Døsen, Liv Kari & Haye, Rolf (2011). Surgical closure of nasal septal perforation, early and long term observations. Rhinology. ISSN 0300-0729. 49(4), p. 486–491. doi: 10.4193/Rhino10.081. Full text in Research Archive
• Haye, Rolf; Jebsen, Peter Wilhelm & Dingsør, B (2011). Fibro-hyaline extensions from the bony nasal aperture, causing nasal obstruction. Journal of Laryngology and Otology. ISSN 0022-2151. 125(10), p. 1067–1069. doi: 10.1017/S0022215111001897. Full text in Research Archive
• Døsen, Liv Kari & Haye, Rolf (2008). Silicone button in nasal septal perforation. Long term observations. Rhinology. ISSN 0300-0729. 46, p. 324–327. Full text in Research Archive
• Døsen, Liv Kari & Haye, Rolf (2007). Nasal septal perforation 1981-2005: Changes in etiology, and size. BMC Ear, Nose and Throat Disorders. 7. Full text in Research Archive
• Haye, Rolf & Døsen, Liv Kari (2005). Insect sting allergy. A study from 1980 to 2003 of patients who started treatment with venom immunotherapy between 1980 and 1998. Clinical and Molecular Allergy. Full text in Research Archive
• Haye, Rolf; Høye, K; Berg, O; Frønes, S & Ødegaard, T (2005). Morning versus evening dosing of desloratadine in seasonal allergic rhinitis: a randomized controlled study. Clinical and Molecular Allergy. Full text in Research Archive
• Jahnsen, Frode Lars; Gran, E; Haye, Rolf & Brandtzæg, Per (2004). Human nasal mucosa contains antigen-presenting cells of strikingly different functional phenotypes. American Journal of Respiratory Cell and Molecular Biology. ISSN 1044-1549. 30, p. 31–37. Full text in Research Archive
• Hagtvedt, Trond; Aaløkken, Trond Mogens; Nøtthellen, Jacob; Kolbenstvedt, Alf & Haye, Rolf (2003). Røntgen bihuler og lavdose-CT ved akutt sinusitt. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. p. 3362–3364. Full text in Research Archive
• Haye, Rolf & Aanesen, Jens Ph. (2000). Koanalatresi - erfaring med tidlig operasjon. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 120(6), p. 666–667. Full text in Research Archive
• Jahnsen, Frode Lars; Lund-Johansen, Fridtjof; Dunne, John F.; Farkas, Lorant; Haye, Rolf & Brandtzæg, Per (2000). Experimentally Induced Recruitment of Plasmacytoid (CD123<SUP>high</SUP>) Dendritic Cells in Human Nasal Allergy. Journal of Immunology. ISSN 0022-1767. 165(7), p. 4062–4068. Full text in Research Archive
• Jahnsen, Frode Lars; Haye, Rolf; Gran, Einar; Brandtzæg, Per & Johansen, Finn Eirik (1999). Glucocorticosteroids Inhibit mRNA Expression for Eotaxin, Eotaxin-2, and Monocyte-Chemotactic Protein-4 in Human Airway Inflammation with Eosinophilia. Journal of Immunology. ISSN 0022-1767. 163, p. 1545–1551. Full text in Research Archive
• Jahnsen, Frode Lars; Lund-Johansen, Fridtjof; Haye, Rolf & Brandtzæg, Per (1999). Extensive recruitment of IL-3R_a<SUP>high</SUP> dendritic-cell precursors to allergic nasal mucosa during allergen challenge. Allergy. European Journal of Allergy and Clinical Immunology. ISSN 0105-4538. 54(Suppl. 50), p. 13–13. Full text in Research Archive
• Jahnsen, Frode Lars; Haraldsen, Guttorm; Haye, Rolf & Brandtzæg, Per (1997). Nasal polyps: adhesion molecules and recruitment of eosinophils. In Mygind, N & Lindholt, T (Ed.), Nasal Polyposis. An Inflammatory Disease and its Treatment. Munksgaard, Copenhagen. p. 88–97. Full text in Research Archive
• Haraldsen, Guttorm; Brandtzæg, Per; Bakka, Arne; Haye, Rolf & Jahnsen, Frode Lars (1997). Endothelial cell functional studies: Reactivity of the endothelial cell panel of monoclonal antibodies with human mucosal endothelium in situ and in vitro, Leukocyte Typing IV. Garland Publishing Inc., New York. p. 778–779. Full text in Research Archive
• Jahnsen, Frode Lars; Brandtzæg, Per; Haye, Rolf & Haraldsen, Guttorm (1997). Expression of functional VCAM-1 by cultured nasal polyp-derived microvascular endothelium. American Journal of Pathology. ISSN 0002-9440. 150, p. 2113–2123. Full text in Research Archive
• Jahnsen, Frode Lars; Haraldsen, Guttorm; Farstad, Inger Nina; Nilsen, Ellen M.; Johansen, Finn Eirik & Brandtzæg, Per [Show all 9 contributors for this article] (1996). Patogenetiske mekanismer ved kronisk allergiske luftveissykdommer. Allergologen. ISSN 0332-8295. p. 6–16. Full text in Research Archive
• Haye, Rolf; Lingaas, Egil; Høivik, H.O. & Ødegård, T. (1996). Efficacy and safety of azithromycin versus phenoxymethylpenicillin in the treatment of acute maxillary sinusitis. European Journal of Clinical Microbiology and Infectious Diseases. ISSN 0934-9723. 15, p. 849–853. Full text in Research Archive
• Haye, Rolf; Lingaas, Egil; Høivik, H.O. & Ødegård, T. (1996). The efficacy and safety of azithromycin versus phenoxymethylpenicillin in acute maxillary sinusitis. European Journal of Clinical Microbiology and Infectious Diseases. ISSN 0934-9723. Full text in Research Archive

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• Haye, Rolf; Døsen, Liv Kari; TarAngen, Magnus; Shiryaeva, Olga & Lingaas, Egil (2016). Antibiotics in septoplasty. Full text in Research Archive
• Haye, Rolf (2003). P-16-9 Seasonal Allergic Rhinitis (SAR) - Circadian Variation - Timing of Desloratadine (DL) dosen. Full text in Research Archive
• Farkas, Lorant; Kvale, Espen Østhagen; Haye, Rolf; Brandtzæg, Per; Jahnsen, Frode Lars & Lund-Johansen, Fridtjof (2002). Plasmacytoid dendritic cells present grass pollen allergen and induce Th2 recall responses in allergic individuals. Full text in Research Archive Show summary

  Plasmacytoid dendritic cells (P-DCs) induce production of Th2 cytokines in naïve allogeneic CD4+ T cells following incubation with IL-3 and CD40L. It has therefore been suggested that these cells play a role in allergic diseases. In support of this view, we recently demonstrated that P-DCs accumulate in nasal mucosa during allergen-challenged allergic rhinitis. To further investigate the possible role of P-DCs in airway allergy, we examined whether P-DCs can present grass pollen allergens to autologous T cells from allergic individuals, and whether the cytokine response in vitro correlated with cytokine production after allergen challenge in vivo. Peripheral blood was obtained from 3 patients and nasal allergen challenge was performed daily for 7 days in 11 patients, all with a typical history of allergic rhinitis and a strong positive skin prick test. P-DCs and CD4+ T cells were isolated and co-cultured in the presence of purified grass pollen extracts (ALK, Denmark). Using carboxyfluorescein diacetate succinimidyl ester (CFSE) labeling, we found that P-DCs induced extensive antigen-dependent T cell proliferation in primary cultures. The proliferation was associated with prominent production of IL-5, but not TNF-alpha or IFN-gamma. Interestingly, IL-5 became detectable in serum at day 2 through day 7 after challenge in 5 of the 11 patients. Collectively, our results demonstrated that P-DCs are present at sites of pollen exposure, and have the ability to induce a Th2 recall response in sensitized individuals which corresponds to the in vivo response. P-DCs may thus be potential targets for future therapeutic modulation of allergic rhinitis.

• Farkas, Lorant; Kvale, Espen Østhagen; Haye, Rolf; Brandtzæg, Per; Lund-Johansen, Fridtjof & Jahnsen, Frode Lars (2002). PLASMACYTOID AND CD11C+ DENDRITIC CELLS INDUCE DIFFERENT MEMORY T HELPER CELL RESPONSES TO MUMPS VIRUS ANTIGENS. Full text in Research Archive Show summary

  Dendritic cell (DC) subsets induce different cytokine profiles in naïve T cells. Thus, various DC subsets may determine the differentiation of naïve cells into memory cells with distinct T helper (Th) cell responses. In contrast, recall responses are believed to be mediated by terminally differentiated memory Th cells producing a fixed set of cytokines. Here we show that recall CD4+ T cell responses to mumps virus antigens depend on the type of DC used as antigen-presenting cells (APCs). Plasmacytoid DCs and CD11c+ DCs isolated from peripheral blood of adults and co-cultured under identical conditions with purified autologous CD4+ T cells, both induced antigen-dependent T cell proliferation, but the cytokines produced by the CD4+ T cells differed significantly. While CD11c+ DCs stimulated T cells to produce high levels IL-5 and IFN-gamma, plasmacytoid DCs induced high levels of IL-10 and IFN-gamma, and lower levels of IL-2. Thus, DC subsets appear capable of influencing Th memory immune responses. This may have important implications for modulation of hypersensitivity reactions such as allergy and autoimmune disease.

• Jahnsen, Frode Lars; Haraldsen, Guttorm; Haye, Rolf; Nilsen, Ellen M. & Johansen, Finn Eirik (1997). Endothelial expression of eotaxin in nasal polyps and its dependency on cytokines in vitro. Full text in Research Archive
• Jahnsen, Frode Lars; Johansen, Finn Eirik; Haraldsen, Guttorm; Haye, Rolf; Nilsen, Ellen M. & Brandtzæg, Per (1997). Endothelial expression of eotaxin in nasal polyps and its in vitro regulation. Full text in Research Archive

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