Rolf Haye

• Haye, Rolf; Egeland, Merete Trollsås; Døsen, Liv Kari; Gay, Caryl; TarAngen, Magnus & Shiryaeva, Olga (2019). Assessment of non-response in quality control of nasal septal surgery. Journal of Laryngology and Otology.  ISSN 0022-2151.  133(3), s 208- 212 . doi: 10.1017/S002221511900032X
• Døsen, Liv Kari; Kvinnesland, Knut; TarAngen, Magnus; Shiryaeva, Olga; Gay, Caryl & Haye, Rolf (2018). Unilateral and bilateral PNIF in quality control of nasal septal surgery. International Journal of Otolaryngology.  ISSN 1687-9201. . doi: 10.1155/2018/7846843 Full text in Research Archive. Show summary

  Abstract The aim of this study was to explore the usefulness of unilateral, combined unilateral (left + right) and bilateral peak nasal inspiratory flow (PNIF) measurements in assessing the results of nasal septal surgery. Nasal obstruction was recorded subjectively and objectively before and 4 months after nasal septoplasty using a visual analogue scale (VAS) and a PNIF meter. Nasal septoplasty (58 patients) and septoplasty with turbinoplasty (68 patients) were performed on 126 patients (85 males, 41 females) with a mean age of 32.8 years. The results showed a significant improvement in VAS scores, as well as unilateral, combined unilateral and bilateral PNIF values after both septoplasty and septoplasty with turbinoplasty. Septoplasty with turbinoplasty showed better improvement in VAS and PNIF scores than septoplasty alone and this was significant for bilateral PNIF scores. The best unilateral pre- and postoperative correlations between VAS and PNIF measurements were found using the lower of the two unilateral PNIF scores, irrespective of side. In the total material, VAS/PNIF correlations were mostly significant, but weak (all r<0.30). We found VAS and PNIF to be useful instruments in reporting results of surgery. The weak correlations between VAS and PNIF measurements suggest that these subjective and objective instruments may target different aspects of nasal obstruction.  

• Hansen, Aleksander Grande; Zhang, Chi; Loven, Jens Øyvind; Berdal, Hanne; TarAngen, Magnus & Haye, Rolf (2018). A questionnaire using vocal symptoms in quality control of phonosurgery: Vocal surgical questionnaire. BMC Ear, Nose and Throat Disorders.  ISSN 1472-6815.  18(9) . doi: 10.1186/s12901-018-0057-0 Full text in Research Archive.
• Haye, Rolf; Døsen, Liv Kari; TarAngen, Magnus & Shiryaeva, Olga (2018). Good correlation between visual analogue scale and numerical rating scale in the assessment of nasal obstruction.. Journal of Laryngology and Otology.  ISSN 0022-2151.  132(4), s 327- 328 . doi: 10.1017/S0022215118000257 Show summary

  Abstract Objective: Results from telephone interviews may be needed to supplement those from mailed questionnaire when response rates are inadequate. Our intention was to assess the visual analogue scale ratings used in mailed questionnaires to numerical rating scale scores used in telephone interviews. Methods: Patients scheduled for nasal septal surgery routinely respond to a visual analogue scale of obstruction during the day and at night. In this study they were also asked to verbally rate their sense of obstruction using whole numbers. Results: There was no significant difference in obstruction scores between VAS and NRS recordings. Conclusion: Ratings of nasal obstruction used with NRS in telephone interviews are comparable to those marked on the VAS used in mailed questionnaires.

• Egeland, Merete Trollsås; TarAngen, Magnus; Shiryaeva, Olga; Gay, Caryl; Døsen, Liv Kari & Haye, Rolf (2017). Evaluation of strategies for increasing response rates to postal questionnaires in quality control of nasal septal surgery. BMC Research Notes.  ISSN 1756-0500.  10(1) . doi: 10.1186/s13104-017-2516-x Full text in Research Archive.
• Shiryaeva, Olga; TarAngen, Magnus; Gay, Caryl; Døsen, Liv Kari & Haye, Rolf (2017). Preoperative Signs and Symptoms as Prognostic Markers in Nasal Septoplasty. International Journal of Otolaryngology.  ISSN 1687-9201. . doi: 10.1155/2017/4718108 Full text in Research Archive.
• Egeland, Merete Trollsås; Døsen, Liv Kari; TarAngen, Magnus; Gay, Caryl & Haye, Rolf (2016). Evaluation of non-response in quality control of nasal septal surgery. Journal of Laryngology and Otology.  ISSN 0022-2151.  130(12), s 1130- 1136 . doi: 10.1017/S002221511600921X Show summary

  OBJECTIVE: Questionnaires are often used to assess the results of nasal septoplasty, but response rates vary widely. The possible bias caused by non-responders was evaluated to determine the validity of questionnaire results. METHODS: Post-operative questionnaires employing visual analogue scales for nasal obstruction were mailed to 182 patients. The 62 non-responders (34.1 per cent) were contacted by telephone, 58 (93.5 per cent) of whom were contactable and responded orally to the questionnaire. RESULTS: Non-responders were younger, but no different from responders with regard to gender, smoking habits or allergies. Post-operative visual analogue scale obstruction scores were slightly, but not statistically, higher in non-responders. However, because non-responders' pre-operative scores were lower, obstruction scores improved less than in responders. The main reason for not responding was forgetfulness. Some would have preferred an electronic version of the questionnaire. CONCLUSION: Although post-operative obstruction scores did not differ between the groups, nasal obstruction scores improved more among responders than non-responders. Thus, low response rates may cause bias

• Døsen, Liv Kari; Jebsen, Peter Wilhelm; Dingsør, Bernt & Haye, Rolf (2015). IgG4-Related Nasal Pseudotumor. Case reports in otolaryngology.  ISSN 2090-6765. . doi: 10.1155/2015/749890
• Haye, Rolf; Døsen, Liv Kari; Shiryaeva, Olga & Amlie, Einar Johan Braém (2015). Evaluation of a nasal surgical questionnaire designed for monitoring surgical outcomes and comparing different techniques. Journal of Laryngology and Otology.  ISSN 0022-2151.  129(7), s 656- 661 . doi: 10.1017/S0022215115001188
• Haye, Rolf; TarAngen, Magnus; Døsen, Liv Kari & Shiryaeva, Olga (2015). Evaluation of the Nasal Surgical Questionnaire for Monitoring Results of Septoplasty. International Journal of Otolaryngology.  ISSN 1687-9201. . doi: 10.1155/2015/563639
• Døsen, Liv Kari & Haye, Rolf (2012). Endonasal surgery after cocaine abuse: Safe at any interval?. Case reports in otolaryngology.  ISSN 2090-6765. . doi: 10.1155/2012/823470
• Døsen, Liv Kari & Haye, Rolf (2011). Surgical closure of nasal septal perforation, early and long term observations. Rhinology.  ISSN 0300-0729.  49(4), s 486- 491 . doi: 10.4193/Rhino10.081
• Haye, Rolf; Jebsen, Peter Wilhelm & Dingsør, B (2011). Fibro-hyaline extensions from the bony nasal aperture, causing nasal obstruction. Journal of Laryngology and Otology.  ISSN 0022-2151.  125(10), s 1067- 1069 . doi: 10.1017/S0022215111001897
• Døsen, Liv Kari & Haye, Rolf (2008). Silicone button in nasal septal perforation. Long term observations. Rhinology.  ISSN 0300-0729.  46, s 324- 327
• Døsen, Liv Kari & Haye, Rolf (2007). Nasal septal perforation 1981-2005: Changes in etiology, and size. BMC Ear, Nose and Throat Disorders.  ISSN 1472-6815.  7
• Haye, Rolf & Døsen, Liv Kari (2005). Insect sting allergy. A study from 1980 to 2003 of patients who started treatment with venom immunotherapy between 1980 and 1998. Clinical and Molecular Allergy.  ISSN 1476-7961.
• Haye, Rolf; Høye, K; Berg, O; Frønes, S & Ødegaard, T (2005). Morning versus evening dosing of desloratadine in seasonal allergic rhinitis: a randomized controlled study. Clinical and Molecular Allergy.  ISSN 1476-7961.
• Jahnsen, Frode Lars; Gran, E; Haye, Rolf & Brandtzæg, Per (2004). Human nasal mucosa contains antigen-presenting cells of strikingly different functional phenotypes. American Journal of Respiratory Cell and Molecular Biology.  ISSN 1044-1549.  30, s 31- 37
• Hagtvedt, Trond; Aaløkken, Trond Mogens; Nøtthellen, Jacob; Kolbenstvedt, Alf & Haye, Rolf (2003). Røntgen bihuler og lavdose-CT ved akutt sinusitt. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  (23), s 3362- 3364
• Haye, Rolf & Aanesen, Jens Ph. (2000). Koanalatresi - erfaring med tidlig operasjon. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  120(6), s 666- 667
• Jahnsen, Frode Lars; Lund-Johansen, Fridtjof; Dunne, John F.; Farkas, Lorant; Haye, Rolf & Brandtzæg, Per (2000). Experimentally Induced Recruitment of Plasmacytoid (CD123<SUP>high</SUP>) Dendritic Cells in Human Nasal Allergy. Journal of Immunology.  ISSN 0022-1767.  165(7), s 4062- 4068
• Jahnsen, Frode Lars; Haye, Rolf; Gran, Einar; Brandtzæg, Per & Johansen, Finn Eirik (1999). Glucocorticosteroids Inhibit mRNA Expression for Eotaxin, Eotaxin-2, and Monocyte-Chemotactic Protein-4 in Human Airway Inflammation with Eosinophilia. Journal of Immunology.  ISSN 0022-1767.  163, s 1545- 1551
• Jahnsen, Frode Lars; Lund-Johansen, Fridtjof; Haye, Rolf & Brandtzæg, Per (1999). Extensive recruitment of IL-3R_a<SUP>high</SUP> dendritic-cell precursors to allergic nasal mucosa during allergen challenge. Allergy. European Journal of Allergy and Clinical Immunology.  ISSN 0105-4538.  54(Suppl. 50), s 13
• Haraldsen, Guttorm; Brandtzæg, Per; Bakka, Arne; Haye, Rolf & Jahnsen, Frode Lars (1997). Endothelial cell functional studies: Reactivity of the endothelial cell panel of monoclonal antibodies with human mucosal endothelium in situ and in vitro, In  Leukocyte Typing IV.  Garland Publishing Inc., New York.  s 778 - 779
• Jahnsen, Frode Lars; Brandtzæg, Per; Haye, Rolf & Haraldsen, Guttorm (1997). Expression of functional VCAM-1 by cultured nasal polyp-derived microvascular endothelium. American Journal of Pathology.  ISSN 0002-9440.  150, s 2113- 2123
• Jahnsen, Frode Lars; Haraldsen, Guttorm; Haye, Rolf & Brandtzæg, Per (1997). Nasal polyps: adhesion molecules and recruitment of eosinophils, In N Mygind & T Lindholt (ed.),  Nasal Polyposis. An Inflammatory Disease and its Treatment.  Munksgaard, Copenhagen.  s 88 - 97
• Jahnsen, Frode Lars; Haraldsen, Guttorm; Farstad, Inger Nina; Nilsen, Ellen M.; Johansen, Finn Eirik; Brandtzæg, Per; Gran, E.; Aanesen, J. P. & Haye, Rolf (1996). Patogenetiske mekanismer ved kronisk allergiske luftveissykdommer. Allergologen.  ISSN 0332-8295.  (1), s 6- 16
• Haye, Rolf; Lingaas, Egil; Høivik, H.O. & Ødegård, T. (1996). Efficacy and safety of azithromycin versus phenoxymethylpenicillin in the treatment of acute maxillary sinusitis. European Journal of Clinical Microbiology and Infectious Diseases.  ISSN 0934-9723.  15, s 849- 853
• Haye, Rolf; Lingaas, Egil; Høivik, H.O. & Ødegård, T. (1996). The efficacy and safety of azithromycin versus phenoxymethylpenicillin in acute maxillary sinusitis. European Journal of Clinical Microbiology and Infectious Diseases.  ISSN 0934-9723.

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• Haye, Rolf; Døsen, Liv Kari; TarAngen, Magnus; Shiryaeva, Olga & Lingaas, Egil (2016). Antibiotics in septoplasty.
• Haye, Rolf (2003). P-16-9 Seasonal Allergic Rhinitis (SAR) - Circadian Variation - Timing of Desloratadine (DL) dosen.
• Farkas, Lorant; Kvale, Espen Østhagen; Haye, Rolf; Brandtzæg, Per; Jahnsen, Frode Lars & Lund-Johansen, Fridtjof (2002). Plasmacytoid dendritic cells present grass pollen allergen and induce Th2 recall responses in allergic individuals. Show summary

  Plasmacytoid dendritic cells (P-DCs) induce production of Th2 cytokines in naïve allogeneic CD4+ T cells following incubation with IL-3 and CD40L. It has therefore been suggested that these cells play a role in allergic diseases. In support of this view, we recently demonstrated that P-DCs accumulate in nasal mucosa during allergen-challenged allergic rhinitis. To further investigate the possible role of P-DCs in airway allergy, we examined whether P-DCs can present grass pollen allergens to autologous T cells from allergic individuals, and whether the cytokine response in vitro correlated with cytokine production after allergen challenge in vivo. Peripheral blood was obtained from 3 patients and nasal allergen challenge was performed daily for 7 days in 11 patients, all with a typical history of allergic rhinitis and a strong positive skin prick test. P-DCs and CD4+ T cells were isolated and co-cultured in the presence of purified grass pollen extracts (ALK, Denmark). Using carboxyfluorescein diacetate succinimidyl ester (CFSE) labeling, we found that P-DCs induced extensive antigen-dependent T cell proliferation in primary cultures. The proliferation was associated with prominent production of IL-5, but not TNF-alpha or IFN-gamma. Interestingly, IL-5 became detectable in serum at day 2 through day 7 after challenge in 5 of the 11 patients. Collectively, our results demonstrated that P-DCs are present at sites of pollen exposure, and have the ability to induce a Th2 recall response in sensitized individuals which corresponds to the in vivo response. P-DCs may thus be potential targets for future therapeutic modulation of allergic rhinitis.

• Farkas, Lorant; Kvale, Espen Østhagen; Haye, Rolf; Brandtzæg, Per; Lund-Johansen, Fridtjof & Jahnsen, Frode Lars (2002). PLASMACYTOID AND CD11C+ DENDRITIC CELLS INDUCE DIFFERENT MEMORY T HELPER CELL RESPONSES TO MUMPS VIRUS ANTIGENS. Show summary

  Dendritic cell (DC) subsets induce different cytokine profiles in naïve T cells. Thus, various DC subsets may determine the differentiation of naïve cells into memory cells with distinct T helper (Th) cell responses. In contrast, recall responses are believed to be mediated by terminally differentiated memory Th cells producing a fixed set of cytokines. Here we show that recall CD4+ T cell responses to mumps virus antigens depend on the type of DC used as antigen-presenting cells (APCs). Plasmacytoid DCs and CD11c+ DCs isolated from peripheral blood of adults and co-cultured under identical conditions with purified autologous CD4+ T cells, both induced antigen-dependent T cell proliferation, but the cytokines produced by the CD4+ T cells differed significantly. While CD11c+ DCs stimulated T cells to produce high levels IL-5 and IFN-gamma, plasmacytoid DCs induced high levels of IL-10 and IFN-gamma, and lower levels of IL-2. Thus, DC subsets appear capable of influencing Th memory immune responses. This may have important implications for modulation of hypersensitivity reactions such as allergy and autoimmune disease.

• Jahnsen, Frode Lars; Haraldsen, Guttorm; Haye, Rolf; Nilsen, Ellen M. & Johansen, Finn Eirik (1997). Endothelial expression of eotaxin in nasal polyps and its dependency on cytokines in vitro.
• Jahnsen, Frode Lars; Johansen, Finn Eirik; Haraldsen, Guttorm; Haye, Rolf; Nilsen, Ellen M. & Brandtzæg, Per (1997). Endothelial expression of eotaxin in nasal polyps and its in vitro regulation.

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