Signe Søvik

• Søvik, Signe; Barratt-Due, Andreas; Kåsine, Trine; Olasveengen, Theresa M.; Strand, Marianne Wigernes & Tveita, Anders Aune [Show all 16 contributors for this article] (2022). Corticosteroids and superinfections in COVID-19 patients on invasive mechanical ventilation. Journal of Infection. ISSN 0163-4453. 85(1), p. 57–63. doi: 10.1016/j.jinf.2022.05.015. Full text in Research Archive
• Zhang, Chi; Eken, Torsten; Jørgensen, Silje Bakken; Thoresen, Magne & Søvik, Signe (2022). Effects of patient-level risk factors, departmental allocation and seasonality on intrahospital patient transfer patterns: network analysis applied on a Norwegian single-centre data set. BMJ Open. ISSN 2044-6055. 12(3). doi: 10.1136/bmjopen-2021-054545. Full text in Research Archive Show summary

  Objectives Describe patient transfer patterns within a large Norwegian hospital. Identify risk factors associated with a high number of transfers. Develop methods to monitor intrahospital patient flows to support capacity management and infection control. Design Retrospective observational study of linked clinical data from electronic health records. Setting Tertiary care university hospital in the Greater Oslo Region, Norway. Participants All adult (≥18 years old) admissions to the gastroenterology, gastrointestinal surgery, neurology and orthopaedics departments at Akershus University Hospital, June 2018 to May 2019. Methods Network analysis and graph theory. Poisson regression analysis. Outcome measures Primary outcome was network characteristics at the departmental level. We describe location-to-location transfers using unweighted, undirected networks for a full-year study period. Weekly networks reveal changes in network size, density and key categories of transfers over time. Secondary outcome was transfer trajectories at the individual patient level. We describe the distribution of transfer trajectories in the cohort and associate number of transfers with patient clinical characteristics. Results The cohort comprised 17 198 hospital stays. Network analysis demonstrated marked heterogeneity across departments and throughout the year. The orthopaedics department had the largest transfer network size and density and greatest temporal variation. More transfers occurred during weekdays than weekends. Summer holiday affected transfers of different types (Emergency department-Any location/Bed ward-Bed ward/To-From Technical wards) differently. Over 75% of transferred patients followed one of 20 common intrahospital trajectories, involving one to three transfers. Higher number of intrahospital transfers was associated with emergency admission (transfer rate ratio (RR)=1.827), non-prophylactic antibiotics (RR=1.108), surgical procedure (RR=2.939) and stay in intensive care unit or high-dependency unit (RR=2.098). Additionally, gastrosurgical (RR=1.211), orthopaedic (RR=1.295) and neurological (RR=1.114) patients had higher risk of many transfers than gastroenterology patients (all effects: p<0.001). Conclusions Network and transfer chain analysis applied on patient location data revealed logistic and clinical associations highly relevant for hospital capacity management and infection control.

• Myhre, Peder Langeland; Prebensen, Christian; Strand, Heidi; Røysland, Ragnhild; Jonassen, Christine M. & Rangberg, Anbjørg [Show all 12 contributors for this article] (2020). Growth Differentiation Factor-15 Provides Prognostic Information Superior to Established Cardiovascular and Inflammatory Biomarkers in Unselected Patients Hospitalized with COVID-19. Circulation. ISSN 0009-7322. doi: 10.1161/CIRCULATIONAHA.120.050360.
• Søvik, Signe; Bådstøløkken, Per Martin; Sørensen, Vibecke; Myhre, Peder Langeland; Prebensen, Christian & Omland, Torbjørn [Show all 7 contributors for this article] (2020). A single‐centre, prospective cohort study of COVID‐19 patients admitted to ICU for mechanical ventilatory support. Acta Anaesthesiologica Scandinavica. ISSN 0001-5172. doi: 10.1111/aas.13726. Full text in Research Archive
• Omland, Torbjørn; Prebensen, Christian; Røysland, Ragnhild; Søvik, Signe; Sørensen, Vibecke & Røsjø, Helge [Show all 9 contributors for this article] (2020). Established Cardiovascular Biomarkers Provide Limited Prognostic Information in Unselected Patients Hospitalized with COVID-19. Circulation. ISSN 0009-7322. 19, p. 1878–1880. doi: 10.1161/CIRCULATIONAHA.120.050089.
• Hui, David & Søvik, Signe (2020). Postoperative pain course after paediatric tonsillectomy: A prospective observational study comparing one behavioural and one numerical pain assessment tool. International Journal of Pediatric Otorhinolaryngology. ISSN 0165-5876. 138. doi: 10.1016/j.ijporl.2020.110395. Full text in Research Archive
• Skytioti, Maria; Elstad, Maja & Søvik, Signe (2019). Internal Carotid Artery Blood Flow Response to Anesthesia, Pneumoperitoneum, and Head-up Tilt during Laparoscopic Cholecystectomy. Anesthesiology. ISSN 0003-3022. 131, p. 512–520. doi: 10.1097/ALN.0000000000002838. Full text in Research Archive
• Søvik, Signe; Isachsen, Marie Susanna; Nordhuus, Kine Marie Byman; Tveiten, Christine Kooy; Eken, Torsten & Sunde, Kjetil [Show all 8 contributors for this article] (2019). Acute kidney injury in trauma patients admitted to the ICU: a systematic review and meta-analysis. Intensive Care Medicine. ISSN 0342-4642. 45(4), p. 407–419. doi: 10.1007/s00134-019-05535-y. Full text in Research Archive
• Røislien, Jo; Søvik, Signe & Eken, Torsten (2018). Seasonality in trauma admissions - Are daylight and weather variables better predictors than general cyclic effects? PLOS ONE. ISSN 1932-6203. 13(2). doi: 10.1371/journal.pone.0192568. Full text in Research Archive
• Skytioti, Maria; Søvik, Signe & Elstad, Maja (2018). Dynamic cerebral autoregulation is preserved during isometric handgrip and head-down tilt in healthy volunteers. Physiological Reports. ISSN 2051-817X. 6(6). doi: 10.14814/phy2.13656. Full text in Research Archive
• Skytioti, Maria; Søvik, Signe & Elstad, Maja (2018). Respiratory pump maintains cardiac stroke volume during hypovolemia in young, healthy volunteers. Journal of applied physiology. ISSN 8750-7587. 124(5), p. 1319–1325. doi: 10.1152/japplphysiol.01009.2017. Full text in Research Archive
• Skaga, Nils Oddvar; Eken, Torsten & Søvik, Signe (2018). Validating performance of TRISS, TARN and NORMIT survival prediction models in a Norwegian trauma population. Acta Anaesthesiologica Scandinavica. ISSN 0001-5172. 62(2), p. 253–266. doi: 10.1111/aas.13029. Full text in Research Archive
• Wikjord, Kristina Seo; Dahl, Vegard & Søvik, Signe (2017). Effects on nutritional care practice after implementation of a flow chart-based nutrition support protocol in an intensive care unit. Nursing Open. ISSN 2054-1058. doi: 10.1002/nop2.99. Full text in Research Archive
• Skytioti, Maria; Søvik, Signe & Elstad, Maja (2017). Respiration-related cerebral blood flow variability increases during control-mode non-invasive ventilation in normovolemia and hypovolemia. European Journal of Applied Physiology. ISSN 1439-6319. 117(11), p. 2237–2249. doi: 10.1007/s00421-017-3711-0. Full text in Research Archive
• Skytioti, Maria; Søvik, Signe & Elstad, Maja (2016). Internal carotid artery blood flow in healthy awake subjects is reduced by simulated hypovolemia and noninvasive mechanical ventilation. Physiological Reports. ISSN 2051-817X. 4(19). doi: 10.14814/phy2.12969.
• Bilben, Bente; Grandal, Linda & Søvik, Signe (2016). National Early Warning Score (NEWS) as an emergency department predictor of disease severity and 90-day survival in the acutely dyspneic patient - a prospective observational study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. ISSN 1757-7241. 24:80, p. 1–8. doi: 10.1186/s13049-016-0273-9.
• Staff, Trine; Eken, Torsten; Wik, Lars; Røislien, Jo & Søvik, Signe (2014). Physiologic, demographic and mechanistic factors predicting New Injury Severity Score (NISS) in motor vehicle accident victims. Injury. ISSN 0020-1383. 45(1), p. 9–15. doi: 10.1016/j.injury.2012.11.010.
• Søvik, Signe; Skaga, Nils Oddvar; Hanoa, Rolf Otto Høe & Eken, Torsten (2014). Sudden survival improvement in critical neurotrauma: An exploratory analysis using a stratified statistical process control technique. Injury. ISSN 0020-1383. 45(11), p. 1722–1730. doi: 10.1016/j.injury.2014.05.038. Full text in Research Archive
• Jones, J. Mary; Skaga, Nils Oddvar; Søvik, Signe; Lossius, Hans Morten & Eken, Torsten (2014). Norwegian survival prediction model in trauma: Modelling effects of anatomic injury, acute physiology, age, and co-morbidity. Acta Anaesthesiologica Scandinavica. ISSN 0001-5172. 58(3), p. 303–315. doi: 10.1111/aas.12256.
• Staff, Trine; Eken, Torsten; Hansen, Trond Boye; Steen, Petter Andreas & Søvik, Signe (2012). A field evaluation of real-life motor vehicle accidents: Presence of unrestrained objects and their association with distribution and severity of patient injuries. Accident Analysis and Prevention. ISSN 0001-4575. 45, p. 529–538. doi: 10.1016/j.aap.2011.09.007.
• Staff, Trine & Søvik, Signe (2011). A retrospective quality assessment of pre-hospital emergency medical documentation in motor vehicle accidents in south-eastern Norway. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. ISSN 1757-7241. 19. doi: 10.1186/1757-7241-19-20.
• Skaga, Nils Oddvar; Eken, Torsten; Søvik, Signe; Jones, Mary & Steen, Petter Andreas (2007). Pre-injury ASA physical status classification is an independent predictor of mortality after trauma. Journal of Trauma. ISSN 0022-5282. 63, p. 972–978.
• Søvik, Signe & Lossius, Kristin (2004). Development of ventilatory response to transient hypercapnia and hypercapnic hypoxia in term infants. Pediatric Research. ISSN 0031-3998. 55, p. 302–309. Show summary

  Whereas peripheral chemoreceptor oxygen sensitivity increases markedly after birth, previous studies of ventilatory responses to CO(2) in term infants have shown no postnatal development. However, the hypercapnic challenges applied have usually been long-term, which meant that the effect of central chemoreceptors dominated. Oscillatory breathing, apneas, and sighs cause transient Pco(2) changes, probably primarily stimulating peripheral chemoreceptors. We wanted to assess whether the immediate ventilatory responses to step changes in inspired CO(2) and O(2) in term infants undergo postnatal developmental changes. Twenty-six healthy term infants were studied during natural sleep 2 d and 8 wk postnatally. Ventilatory responses to a randomized sequence of 15 s hypercapnia (3% CO(2)), hypoxia (15% O(2)), and hypercapnic hypoxia (3% CO(2) + 15% O(2)) were recorded breath-by-breath using a pneumotachometer. Response rate, stimulus-response time, and response magnitude were analyzed with ANOVA after coherent averaging. Response rate increased with age by 30% (hypercapnia), 318% (hypoxia), and 302% (hypercapnic hypoxia). Response rate during hypercapnic hypoxia exceeded rate during hypercapnia plus rate during hypoxia in wk 8, but not on d 2. Time to half-maximum response decreased by 3.4 s with age for the two hypercapnic stimuli but was unchanged for hypoxia. Response magnitude was unchanged for hypercapnia, but increased for the two hypoxic stimuli. In conclusion, an interaction between the effects of hypercapnia and hypoxia on ventilatory response rate emerged between postnatal d 2 and wk 8 in term infants. Concomitantly, stimulus-response time to hypercapnic stimuli declined markedly. The development of a prompt response to transient hypercapnia may be important for infant respiratory stability

• Eggesbø, Heidi Beate; Søvik, Signe; Dølvik, Sverre; Eiklid, Kristin Louise & Kolmannskog, Finn (2003). Proposal of a CT scoring system of the paranasal sinuses in diagnosing cystic fibrosis. European Radiology. ISSN 0938-7994. 13(6), p. 1451–1460. doi: 10.1007/s00330-003-1825-8.
• Eggesbø, Heidi Beate; Søvik, Signe; Dølvik, Sverre & Kolmannskog, Finn (2002). CT characterization of inflammatory paranasal sinus disease in cystic fibrosis. Acta Radiologica. ISSN 0284-1851. 43(1), p. 21–28.

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• Holme, Nathalie Linn Anikken; Skytioti, Maria; Søvik, Signe & Elstad, Maja (2020). Induced respiratory variability in arterial blood pressure lowers cerebral blood flow in healthy humans. Show summary

  In this study we examined the effect of respiratory oscillations in arterial blood pressure and cardiac output, induced by oscillatory lower body negative pressure, on cerebral blood flow in healthy humans. We found that respiratory oscillations in arterial blood pressure and cardiac output lowered the median cerebral blood flow. In addition, as oscillations in cerebral blood flow increased during oscillatory lower body negative pressure, we conclude that respiratory oscillations in arterial blood pressure and cardiac output are transferred to the cerebral circulation. Induced respiratory oscillations in arterial blood pressure and in flow therefore lower cerebral blood flow in healthy humans.

• Ottestad, William Arne & Søvik, Signe (2020). COVID-19 patients with respiratory failure: what can we learn from aviation medicine? British Journal of Anaesthesia. ISSN 0007-0912. doi: 10.1016/j.bja.2020.04.012.
• Skytioti, Maria; Elstad, Maja & Søvik, Signe (2019). Blodflow i arteria carotis interna faller parallelt med cardiac index under laparoskopisk cholecystectomi, uavhengig av blodtrykket.
• Holme, Nathalie Linn Anikken; Lehre, Martin Andreas; Søvik, Signe; Skytioti, Maria & Elstad, Maja (2019). Cerebral Autoregulation Fails to Maintain Cerebral Blood Flow During Arterial Blood Pressure Oscillations at Respiratory Frequency.
• Haines, Ryan W.; Harrois, Anatole; Prowle, John R.; Søvik, Signe & Beitland, Sigrid (2019). Deserved attention for acute kidney injury after major trauma. Intensive Care Medicine. ISSN 0342-4642. 45(6), p. 907–908. doi: 10.1007/s00134-019-05609-x.
• Hui, David & Søvik, Signe (2018). Postoperativt smerteforløp etter dagkirurgisk tonsillektomi hos barn, vurdert gjennom telefonintervju av foreldre.
• Søvik, Signe; Isachsen, Marie Susanna; Nordhuus, Kine Marie Byman; Tveiten, Christine Kooy; Eken, Torsten & Sunde, Kjetil [Show all 8 contributors for this article] (2018). Acute kidney injury in trauma patients admitted to the intensive care unit: a systematic review and meta-analysis. Intensive Care Medicine Experimental. ISSN 2197-425X. 6, p. 474–474. doi: 10.1186/s40635-018-0201-6.
• Holme, Nathalie Linn Anikken; Lehre, Martin Andreas; Søvik, Signe; Elstad, Maja & Skytioti, Maria (2018). Responses in cardiac stroke volume index and cardiac index do not differ between genders during moderate central hypovolemia.
• Skytioti, Maria; Søvik, Signe & Elstad, Maja (2018). Differential response of internal carotid artery blood flow to cardiac output changes.
• Skytioti, Maria; Søvik, Signe & Elstad, Maja (2017). Den respiratoriske sirkulasjonspumpen opprettholder hjertets slagvolum ved hypovolemi hos friske individer.
• Skytioti, Maria; Søvik, Signe & Elstad, Maja (2017). Internal carotid artery blood flow response to isometric handgrip and head down tilt in healthy volunteers.
• Skytioti, Maria; Søvik, Signe & Elstad, Maja (2016). Respiratory sinus arrhythmia buffers variability in cerebral blood flow.
• Skytioti, Maria; Søvik, Signe & Elstad, Maja (2015). CEREBRAL BLOOD FLOW CHANGES IN RESPONSE TO MILD HYPOVOLEMIA AND POSITIVE PRESSURE VENTILATION.
• Stensby, Ellen Kristine; Søvik, Signe; Loewhagen, Bjørn & Dahl, Vegard (2013). The successful reversal of a fulminant anaphyactic reaction to rocuronium with suggammadex in an 11 year old boy: A case report. Acta Anaesthesiologica Scandinavica. ISSN 0001-5172. 57, p. 15–15.

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