Tuula Anneli Nyman

Image of Tuula Anneli Nyman
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Visiting address Sognsvannsveien 20 Rikshospitalet 0372 OSLO
Postal address Postboks 4950 Nydalen 0424 OSLO

Head of Proteomics Core Facility since 1.5.2016 

Primary fields of research: proteomics, biological mass spectrometry, bioinformatics, innate immunity, cell signaling

 

Tags: innate immunity, mass spectrometry, proteomics, Cell Signaling

Publications

Selected recent publications

Lorey MB, Rossi K, Eklund KK, Nyman TA*, Matikainen S*. Global characterization of protein secretion from human macrophages following non-canonical caspase-4/5 inflammasome activation. Mol Cell Proteomics. 2017 Feb 14. [Epub ahead of print]

Cypryk W, Lorey M, Puustinen A, Nyman TA, Matikainen S. Proteomic and Bioinformatic Characterization of Extracellular Vesicles Released from Human Macrophages upon Influenza A Virus Infection. J Proteome Res. 2017;16:217-227

Söderholm S, Fu Y, Gaelings L, Belanov S, Yetukuri L, Berlinkov M, Cheltsov AV, Anders S, Aittokallio T, Nyman TA, Matikainen S, Kainov DE. Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction.Viruses. 2016 Sep 29;8(10). pii: E269. Review.

Välimäki E, Cypryk W, Virkanen J, Nurmi K, Turunen PM, Eklund KK, Åkerman KE, Nyman TA, Matikainen S. Calpain Activity Is Essential for ATP-Driven Unconventional Vesicle-Mediated Protein Secretion and Inflammasome Activation in Human Macrophages. J Immunol. 2016;197:3315-3325

Söderholm S, Kainov DE, Öhman T, Denisova OV, Schepens B, Kulesskiy E, Imanishi SY, Corthals G, Hintsanen P, Aittokallio T, Saelens X, Matikainen S*, Nyman TA*. Phosphoproteomics to characterize host response during influenza A virus infection of human macrophages. Mol Cell Proteomics. 2016;15:3203-3219

Christensen MH, Jensen SB, Miettinen JJ, Luecke S, Prabakaran T, Reinert LS, Mettenleiter T, Chen ZJ, Knipe DM, Sandri-Goldin RM, Enquist LW, Hartmann R, Mogensen TH, Rice SA, Nyman TA, Matikainen S, Paludan SR. HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression. EMBO J. 2016;35:1385-99.

Öhman T, Söderholm S, Paidikondala M, Lietzén N, Matikainen S, Nyman TA. Phosphoproteome characterization reveals that Sendai-virus infection activates mTOR signaling in human epithelial cells. Proteomics. 2015;15:2087-97.

Öhman T, Söderholm S, Hintsanen P, Välimäki E, Lietzén N, MacKintosh C, Aittokallio T, Matikainen S, Nyman TA. Phosphoproteomics Combined with Quantitative 14-3-3-affinity Capture Identifies SIRT1 and RAI as Novel Regulators of Cytosolic dsRNA Recognition Pathway. Mol Cell Proteomics. 2014;13,2604-17.

Cypryk W, Öhman T, Eskelinen E-L, Matikainen S, Nyman TA. Quantitative proteomics of extracellular vesicles released from human monocyte-derived macrophages upon β-glucan stimulation. J Proteome Res. 2014;13:2468-77.

Öhman T, Teirilä L, Lahesmaa AM, Kankkunen P, Veckman V, Saijo S, Wolff H, Hautaniemi S, Nyman TA*, Matikainen S*. Dectin-1 pathway activates robust autophagy-dependent unconventional protein secretion in human macrophages, J Immunol. 2014;192:5952-62.

Välimäki E, Miettinen J, Lietzén N, Matikainen S*, Nyman TA*. Monosodium urate activates Src/Pyk2/PI3 kinase and cathepsin dependent unconventional protein secretion from human primary macrophages. Mol Cell Proteomics. 2013;12:749-63.

Miettinen JJ, Matikainen S, Nyman TA. Global secretome characterisation of Herpes simplex virus 1 infected human primary macrophages, J Virol. 2012;86:12770-8.

Lietzén N, Öhman T*, Rintahaka J*, Julkunen I, Aittokallio T, Matikainen S*, Nyman TA*. Quantitative subcellular proteome and secretome profiling of Influenza A virus-infected human primary macrophages. PLoS Pathogens 2011 May;7(5):e1001340.

*equal contribution

  • Mathiesen, Sabrina Bech; Lunde, Marianne; Aronsen, Jan Magnus; Romaine, Andreas; Kaupang, Anita; Martinsen, Marita; De Souza, Gustavo Antonio; Nyman, Tuula Anneli; Sjaastad, Ivar; Christensen, Geir Arve & Carlson, Cathrine Rein (2019). The cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP). Journal of Biological Chemistry.  ISSN 0021-9258.  294(22), s 8717- 8731 . doi: 10.1074/jbc.RA118.006423
  • Nassa, Giovanni; Salvati, Annamaria; Tarallo, Roberta; Gigantino, Valerio; Alexandrova, Elena; Memoli, Domenico; Sellitto, Assunta; Rizzo, Francesca; Malanga, Donatella; Mirante, Teresa; Morelli, Eugenio; Nees, Matthias; Åkerfelt, Malin; Kangaspeska, Sara; Nyman, Tuula Anneli; Milanesi, Luciano; Giurato, Giorgio & Weisz, Alessandro (2019). Inhibition of histone methyltransferase DOT1L silences ER gene and blocks proliferation of antiestrogen-resistant breast cancer cells. Indian Journal of Pure & Applied Physics.  ISSN 0019-5596.  5(2), s 1- 14 . doi: 10.1126/sciadv.aav5590
  • Richter, Uwe; Ng, Kah Ying; Suomi, Fumi; Marttinen, Paula; Turunen, Taina; Jackson, Christopher; Suomalainen, Anu; Vihinen, Helena; Jokitalo, Eija; Nyman, Tuula Anneli; Isokallio, Marita A.; Stewart, James B.; Mancini, Cecilia; Brusco, Alfredo; Seneca, Sara; Lombès, Anne; Taylor, Robert W. & Battersby, Brendan J. (2019). Mitochondrial stress response triggered by defects in protein synthesis quality control. Life Science Alliance (LSA).  ISSN 2575-1077.  2:e201800219(1), s 1- 17 . doi: 10.26508/lsa.201800219
  • Cypryk, Wojciech; Nyman, Tuula Anneli & Matikainen, Sampsa (2018). From inflammasome to exosome-does extracellular vesicle secretion constitute an inflammasome-dependent immune response?. Frontiers in Immunology.  ISSN 1664-3224.  9:2188, s 1- 8 . doi: 10.3389/fimmu.2018.02188 Show summary
  • Frohnmeyer, Esther; Deptula, Paulina; Nyman, Tuula Anneli; Laine, Pia K.S.; Vihinen, Helena; Paulin, Lars; Auvinen, Petri; Jokitalo, Eija; Piironen, Vieno; Varmanen, Pekka & Savijoki, Kirsi (2018). Secretome profiling of Propionibacterium freudenreichii reveals highly variable responses even among the closely related strains. Microbial Biotechnology.  ISSN 1751-7907.  11(3), s 510- 526 . doi: 10.1111/1751-7915.13254 Full text in Research Archive. Show summary
  • Giurato, Giorgio; Nassa, Giovanni; Salvati, Annamaria; Alexandrova, Elena; Rizzo, Francesca; Nyman, Tuula Anneli; Weisz, Alessandro & Tarallo, Roberta (2018). Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. Scientific Data.  ISSN 2052-4463.  5:180031, s 1- 9 . doi: 10.1038/sdata.2018.31 Show summary
  • Nassa, Giovanni; Giurato, Giorgio; Cimmino, Giovanni; Rizzo, Francesca; Ravo, Maria; Salvati, Annamaria; Nyman, Tuula Anneli; Zhu, Yafeng; Vesterlund, Mattias; Lehtiö, Janne; Golino, Paolo; Weisz, Alessandro & Tarallo, Roberta (2018). Splicing of platelet resident pre-mRNAs upon activation by physiological stimuli results in functionally relevant proteome modifications. Scientific Reports.  ISSN 2045-2322.  8:498, s 1- 12 . doi: 10.1038/s41598-017-18985-5 Show summary
  • Sikorski, Krzysztof; Mehta, Adi; Inngjerdingen, Marit; Thakor, Flourina Kumar; Kling, Simon; Kalina, Tomas; Nyman, Tuula Anneli; Stensland, Maria; Zhou, Wei; De Souza, Gustavo Antonio; Holden, Lars; Stuchly, Jan; Templin, Markus & Lund-Johansen, Fridtjof (2018). A high-throughput pipeline for validation of antibodies. Nature Methods.  ISSN 1548-7091.  15(11), s 909- 912 . doi: 10.1038/s41592-018-0179-8 Full text in Research Archive. Show summary
  • Bulanova, Daria; Ianevski, Aleksandr; Bugai, Andrii; Akimov, Yevhen; Kuivanen, Suvi; Paavilainen, Henrik; Kakkola, Laura; Nandania, Jatin; Turunen, Laura; Ohman, Tiina; Ala-Hongisto, Hanna; Pesonen, Hanna M; Kuisma, Marika S; Honkimaa, Anni; Walton, Emma Louise; Oksenych, Valentyn; Lorey, Martina B.; Guschin, Dmitry; Shim, Jungmin; Kim, Jinhee; Than, Thoa T; Chang, So Young; Hukkanen, Veijo; Kulesskiy, Evgeny; Marjomaki, Varpu S; Julkunen, Ilkka; Nyman, Tuula Anneli; Matikainen, Sampsa; Saarela, Jani S; Sane, Famara; Hober, Didier; Gabriel, Gulsah; De Brabander, Jef K; Martikainen, Miika; Windisch, Marc P; Min, Ji-Young; Bruzzone, Roberto; Aittokallio, Tero; Vaha-Koskela, Markus; Vapalahti, Olli; Pulk, Arto; Velagapudi, Vidya & Kainov, Denis (2017). Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins. Viruses.  ISSN 1999-4915.  9(10) . doi: 10.3390/v9100271 Full text in Research Archive.
  • Gaelings, Lana; Söderholm, Sandra; Bugai, Andrii; Fu, Yu; Nandania, Jatin; Schepens, Bert; Lorey, Martina B.; Tynell, Janne; Vande Ginste, Liesbeth; Le Goffic, Ronan; Miller, Matthew S.; Kuisma, Marika; Marjomäki, Varpu; De Brabander, Jef; Matikainen, Sampsa; Nyman, Tuula Anneli; Bamford, Dennis H.; Saelens, Xavier; Julkunen, Ilkka; Paavilainen, Henrik; Hukkanen, Veijo; Velagapudi, Vidya & Kainov, Denis (2017). Regulation of kynurenine biosynthesis during influenza virus infection. The FEBS Journal.  ISSN 1742-464X.  284(2), s 222- 236 . doi: 10.1111/febs.13966
  • Nyman, Tuula Anneli; Cypryk, Wojciech; Lorey, Martina B.; Puustinen, Anne & Matikainen, Sampsa (2017). Proteomic and bioinformatic characterization of extracellular vesicles released from human macrophages upon influenza A virus infection. Journal of Proteome Research.  ISSN 1535-3893. . doi: https://doi.org/10.1021/acs.jproteome.6b00596 Show summary
  • Nyman, Tuula Anneli & Matikainen, Sampsa (2017). Proteomics to study macrophage response to viral infection. Journal of Proteomics.  ISSN 1874-3919.  180, s 99- 107 . doi: 10.1016/j.jprot.2017.06.018 Show summary
  • Nyman, Tuula Anneli; Matikainen, Sampsa; Cypryk, Wojciech & Lorey, Martina B. (2017). Mass spectrometry-based proteomic exploration of the human immune system -focus on the inflammasome, global protein secretion, and T cells.. Espert Review of Proteomics.  ISSN 1478-9450. . doi: https://doi.org/10.1080/14789450.2017.1319768 Show summary
  • Nyman, Tuula Anneli; Matikainen, Sampsa; Lorey, Martina B.; Rossi, M & Eklund, Kari K. (2017). Global characterization of protein secretion from human macrophages following non-canonical caspase-4/5 inflammasome activation. Molecular & Cellular Proteomics.  ISSN 1535-9476. . doi: https://doi.org/10.1074/mcp.M116.064840 Full text in Research Archive. Show summary
  • Nyman, Tuula Anneli; Nassa, Giovanni; Tarallo, Roberta; Giurato, Giorgio; Bruno, G; Ravo, Maria; Rizzo, Francesca; Salvati, Annamaria; Ricciardi, Luca; Marchese, Giovanna; Cordella, Angela; Rocco, Teresa; Gigantino, Valerio; Pierri, Biancamaria; Cimmino, Giovanni; Milanesi, Luciano; Ambrosino, Concetta & Weisz, Alessandro (2017). The nuclear receptor ERβ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading. Genome Biology.  ISSN 1465-6906. . doi: https://doi.org/10.1186/s13059-017-1321-0 Full text in Research Archive. Show summary
  • Nyman, Tuula Anneli; Söderholm, Sandra; Kainov, Denis; Ohman, Tiina; Denisova, Oxana V.; Schepens, Bert; Kulesskiy, Evgeny; Imanishi, Susumu Y.; Corthals, Garry; Hintsanen, Petteri; Aittokallio, Tero; Saelens, Xavier & Matikainen, Sampsa (2016). Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages. Molecular & Cellular Proteomics.  ISSN 1535-9476. . doi: Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages Full text in Research Archive. Show summary

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  • Borowicz, Pawel; Sundvold-Gjerstad, Vibeke; Abrahamsen, Greger; Kjelstrup, Hanna; Nyman, Tuula Anneli & Spurkland, Anne (2018). Lck’s interactome is influenced by phosphorylation of Tyr192 in the Lck SH2 domain.
  • Borowicz, Pawel; Sundvold-Gjerstad, Vibeke; Abrahamsen, Greger; Kjelstrup, Hanna; Nyman, Tuula Anneli & Spurkland, Anne (2018). Lck’s interactome is influenced by phosphorylation of Tyr192 in the Lck SH2 domain.
  • Borowicz, Pawel; Sundvold-Gjerstad, Vibeke; Abrahamsen, Greger; Kjelstrup, Hanna; Nyman, Tuula Anneli & Spurkland, Anne (2018). Lck’s interactome is influenced by phosphorylation of Tyr192 in the Lck SH2 domain.

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Published May 13, 2016 10:39 AM - Last modified Feb. 27, 2017 2:20 PM