For å studere disse utløsende og regulerende for cholangitt benyttes humant materiale, ulike musemodeller for cholangitt og organ-on-a-chip systemer.
Vi benytter også sekvenseringsbaserte teknikker med spatial transcriptomics og single-cell sequencing.
Les mer om forskningen vår på våre engelske gruppesider.
Publikasjoner
Under finner du forskergruppens siste publikasjoner i PubMed.
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Zonation Hallmarks in Human PSC-Derived Hepatic Organoids Integrated into an Immune-Compatible Organ-on-Chip for Liver Injury Modeling 12. okt. 2026 11:00Aizenshtadt A, Dalmao-Fernández A, Stokowiec J, Kømurcu KS, Ali TML, Erlandsson TM, Skottvoll FS, Busek M, Golovin A, Øynebråten I, Ferencevic K, Chung BK, Øgaard J, Corthay A, Røberg-Larsen H, Melum E, Wilson SR, Krauss S (2026) Zonation Hallmarks in Human PSC-Derived Hepatic Organoids Integrated into an Immune-Compatible Organ-on-Chip for Liver Injury Modeling Adv Healthc Mater, e71834 PubMed 42860581 DOI 10.1002/adhm.71834
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Temporal assessment of spatial and single-cell transcriptomes identifies CD226-NECTIN2 T cell-cholangiocyte interaction in bile duct inflammation 5. okt. 2026 11:00Jördens MS, Nordhus KS, Øgaard J, Amundsen-Isaksen E, Ramberg OH, Yeoh J, Holm K, Jiang X, Luedde T, Karlsen TH, Chung BK, Melum E (2026) Temporal assessment of spatial and single-cell transcriptomes identifies CD226-NECTIN2 T cell-cholangiocyte interaction in bile duct inflammation J Hepatol PubMed 42833310 DOI 10.1016/j.jhep.2026.09.021
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Gut microbiota-derived imidazole propionate promotes primary sclerosing cholangitis via p38 signalling 5. sep. 2026 11:00Molinaro A, Braadland PR, Carpino G, Carreras A, Nikolaidis M, Hanzely P, Beck KR, Ali AH, Bossen L, Frank A, Lundqvist A, Juran BD, Overi D, Geng L, Amundsen-Isaksen E, Reims HM, Björk I, Grzyb K, Abildgaard A, Folseraas T, Cornillet M, Helgadóttir H, McCauley BM, Cristoferi L, Carbone M, Cardinale V, Høivik ML, Engesæter LK, Tjønnfjord SKV, McCann A, Ueland PM, Vesterhus M, Karlsen TH, Grønbæk H, Gaudio E, Lazaridis KN, Bergquist A, Melum E, Bäckhed F, Hov JR (2026) Gut microbiota-derived imidazole propionate promotes primary sclerosing cholangitis via p38 signalling Nat Metab, 8 (9), 1910-1925 PubMed 42698000 DOI 10.1038/s42255-026-01600-1
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Liver transplantation in primary sclerosing cholangitis with hepatobiliary neoplasia: survival outcomes and impact of diagnostic uncertainty 4. aug. 2026 11:00Breder S, Wang B, Villard C, Båve A, Lindström-Älgå L, Eide E, Engesæter LK, Reims HM, Grzyb K, Aabakken L, Melum E, Line PD, Wiencke K, Folseraas T, Bergquist A (2026) Liver transplantation in primary sclerosing cholangitis with hepatobiliary neoplasia: survival outcomes and impact of diagnostic uncertainty Scand J Gastroenterol, 1-12 PubMed 42549941 DOI 10.1080/00365521.2026.2709611
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Intrahepatic T cell analysis reveals Th17 and MAIT17 enrichment in primary sclerosing cholangitis 19. apr. 2026 11:00Brynjulfsen LRV, ElAbd H, Øgaard J, Jördens MS, Bozward AG, Kearns D, Jiang X, Folseraas T, Trivedi PJ, Oo YH, Franke A, Karlsen TH, Melum E, Chung BK (2026) Intrahepatic T cell analysis reveals Th17 and MAIT17 enrichment in primary sclerosing cholangitis JHEP Rep, 8 (9), 101857 PubMed 42002038 DOI 10.1016/j.jhepr.2026.101857
Her finner du en komplett publikasjonsliste.
