Større forskningsprosjekter
Under er et utvalg av de viktigste forskningsprosjektene.
- Establishment of a national database and biobank for patients resected for esophageal cancer as part of the NORECa project (Norwegian Esophageal Expert Consortium).
- Monitoring complications/survival after resection for esophageal- and gastric cancer – local registry.
- Monitoring introduction and use of robotic assisted gastroesophageal resections. Collaboration with international registries.
- Continuous local biobanking (blood/tumor tissue) for esophageal cancer, ongoing analyses of sample quality and research projects.
- Studies on esophageal cancer on biomarkers /local treatment of dysplasia and early cancer.
- NEEDS trial. Neoadjuvant chemoradiotherapy for squamous cell carcinoma of the esophagus versus definitive chemoradiotherapy with salvage surgery as needed. Multicenter randomised controlled trial studythat started in 2021.
- The upper GI International Robotic Association (UGIRA) - International Registry for Robot-Assisted Minimally Gastrectomy and Esophagectomy (RAMIG and RAMIE) for cancer.
- kiNETiC trial – a Scandinavian Randomized Controlled Trial- Ng-tube post–EsophagecTomy.
- Nordic NEC registry (neuroendocrine carcinoma of the GI-tract (GEP-NEC)) (NNTG).
- SARONG-II trial: randomized controlled trial investigating intense vs standard or more limited follow up. Primary endpoint overall survival.
- Observational study on the use of gastropexy for patients with paraesophageal hernias.
- Studies in pipeline include several randomized controlled trials:
- IPa Gastric (intraperitoneal chemotherapy + standard chemotherapy vs standard systemic chemotherapy only with carcinomatosis for gastric cancer) with primary end point overall survival.
- OMEC-5 trial: short versus prolonged chemotherapy prior to surgery for gastroesophageal cancer with oligo (limited) metastatic disease with primary end point progression free survival.
- BALANCE trial (epidural vs paravertebral block for analgesia post esophagectomy) with primary end point anastomotic leak.
- JEDI study is a planned observational study of functional outcome of the gastric conduit post esophagectomy.
Ph.d.prosjekter
Ingrid Vikan Sjurgard: “Molecular- and immuno-profiling of esophageal adenocarcinoma”. Avd. for Molecular Oncology, OUS/UiO.