English version of this page

Tumor-vertbiologi

Vi studerer cellulære mekanismer for hvordan epiteliale tumorer utvikler seg og interagerer med organismen (vert) under kreftutvikling.

Vi kombinerer menneskeceller i kultur og bananfluen som dyremodell for å besvare to hovedspørsmål.

  • Hvilke cellulære prosesser fører til nedbrytning av epitelial karakter og transformasjon til tumorceller ved mutasjon i tumor-suppressorer og proto-onkogener?
  • Hvordan interagerer tumor med resten av organismen?

Tumorceller er avhengige av organismen (verten/pasienten) for dens vekst og har dramtisk påvirkning på fysiologi og overlevelse.

Vi søker å forstå de underliggende mekanismene i disse interaksjonene med de umiddelbare nabocellene og med resten av kroppen.    

Langsiktig mål

Vårt langsiktige mål er å identifisere mekanismer for tumor-vert-interaksjoner som er nødvendig for tumorvekst, samt identifisere effekt på fysiologi og organfunksjon (kreft kakeksi). Dette kan danne basis for translasjonsstudier.

Prosjekter

  • Mechanisms of Receptor Tyrosine Kinase-induced malignant epithelial transformation. We explore the mechanisms of RTK-induced epithelial deconstruction in flies and human cells.
  • Autophagy and tumor growth. Using flies and human cells, we pursue the regulation and function of autophagy in cancer models.
  • Tumor-microenvironment interaction. Exploring the communication between tumor and host cells of the microenvironment using a combination of forward genetics and hypothesis-based approaches.
  • Mechanisms of cancer cachexia. We aim at understanding the communication between tumor and host physiology and somatic organs using a combination of explorative (genetic screens) and hypothesis-based approaches.

Samarbeid

  • Andreas Brech, Institute of Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Norway
  • Heinrich Jasper, Buck Institute of Aging, Novato, California, USA
  • Eyal Gottlieb, Beatson Institute, Glasgow, Scotland, UK
  • Harald Stenmark, Department of Molecular Cell Biology, Institute of Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital
  • Stein Kaasa, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Norway
  • Åslaug Helland, Department of Cancer Genetics,  Institute of Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Norway
  • Terje Johansen, Department of Medical Biology, Faculty of Medicine, University of Tromsø, Norway
  • Anne Simonsen, Institute for Basic Medical Sciences, Faculty of Medicine, University of Oslo, Norway
  • Geir Bjørkøy, Department of Biomedical Laboratory Science, Faculty of Natural Sciences, University of Trondheim, Norway
  • Christos Samakovlis, University of Stockholm, Sweden

Utvalgte publikasjoner

  • Microenvironmental autophagy promotes tumor growth. Katheder N.,  O´Farrell F., Khezri R., Schultz SW., Jain A., Johansen T., Juhasz G., Bilder D., Brech A., Stenmark H., Rusten TE.  Nature, 2017 (cf commentary in Dev. Cell, Cell metabolism and Science Signaling)
  • p62/Sequestosome-1, Autophagy-related Gene 8, and Autophagy in Drosophila Are Regulated by Nuclear Factor Erythroid 2-related Factor 2 (NRF2), Independent of Transcription Factor TFEB. Jain A, Rusten TE*, Katheder N, Elvenes J, Bruun JA, Sjøttem E, Lamark T, Johansen T*. Journal of Biological Chemistry. 2015  *Co-corresponding author
  • Two-tiered control of epithelial growth and autophagy by the Insulin Receptor and the Ret-like Receptor, Stitcher. Ofarrell, F., Wang, S. Katheder, S. Rusten, TE*, Samakovlis, S*. PLoS Biology, 2013. *Co-last author
  • ESCRTs and Fab1 regulate distinct steps of autophagy. Rusten TE, Vaccari T, Lindmo K, Rodahl LM, Nezis IP, Sem-Jacobsen C, Wendler F, Vincent JP, Brech A, Bilder D, Stenmark H. Current  Biology. 2007
  • Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors. Rusten TE, Rodahl LM, Pattni K, Englund C, Samakovlis C, Dove S, Brech A, Stenmark H. Molecular Biology of the Cell. 2006
  • Rusten TE, Lindmo K, Juhász G, Sass M, Seglen PO, Brech A, Stenmark H. Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Developmental Cell. 2004  (cf commentary in  Nature, 431, 31-32 (2004)  and a comment in Nature Reviews Molecular Cell Biology 5 (2004)

Reviews

  • Microenvironment and tumors-a nurturing relationship. Katheder N, Rusten, TE.  Autophagy, 2017
  • Shaping development with ESCRTs. Rusten TE, Vaccari, T., Stenmark, H. Nature Cell Biology. 2011
  • p62, an autophagy hero or culprit? Rusten TE, Stenmark H. Nature Cell Biology. 2010
  • Developmental biology: moonlighting at the pole. Rusten TE, Stenmark H. Nature. 2007
Publisert 17. okt. 2017 15:03 - Sist endret 2. apr. 2019 14:09

Kontakt

Gruppeleder

Deltakere

  • Tor Erik Rusten
  • Fergal O'Farrell
  • Ashish Jain
  • Mahidur Mohammed Rahman
  • Nadja Katheder
  • Royjar Khezri
Detaljert oversikt over deltakere