Ingrid Marie Egner

Bilde av Ingrid Marie Egner
English version of this page
Brukernavn
Besøksadresse Sognsvannsveien 20 Rikshospitalet 0372 OSLO
Postadresse Postboks 4950 Nydalen 0424 OSLO

Education and Research Experience

Postdoc. Department of Biosciences, University of Oslo (UIO), K Gundersen lab (2015-2018)
Project: Overload-induced hypertrophy leads to an increase in myonuclear number, but it has been debated if satellite cells are necessary for hypertrophy. In this project we used a transgenic model to ablate muscle stem cells and found that muscle stem cell-ablation blocked overload-induced hypertrophy, demonstrating that hypertrophy requires the recruitment of muscle stem cells.

Postdoc. Stanford University School of Medicine, USA, TA Rando lab (2016-2018)

Project 1: Transcriptional profiling of quiescent muscle stem cells in vivo. Many stem cell populations, including muscle stem cells (MuSCs), exist in a quiescent state in vivo, exiting quiescence and entering the cell cycle in response to specific stimuli. However, most of the analyses of quiescent stem cells have come from assays ex vivo. We have examined the transcriptome of MuSCs in vivo utilizing muscle stem cell-specific labelling of RNA with 4-thiouracil. We show that the ex vivo transcriptome remains largely reflective of the in vivo transcriptome. Together, these data provide a novel view of the molecular regulation of the quiescent state at the transcriptional level, demonstrate the utility of these tools for probing transcriptional dynamics.

Project 2: Aging leads to loss of muscle stem cell function and we have found that exercise (running) benefits aged muscle stem cell function. Not published.

2014. Received The Research Council of Norway Personal Postdoc Grant (3-year FRIPRO postdoc grant with a <9% score)

PhD. Department of Molecular Biosciences, University of Oslo, K Gundersen lab (2008-2014)

Project: Previous strength training facilitates subsequent re-acquisition of muscle mass after periods of inactivity. For long this “memory” was attributed to neural adaption only. This work was the first to describe a muscle intrinsic memory mechanism related to the elevated number of myonuclei after strength training.

MSc. Norwegian School of Sport Sciences (2005-2007)

BSc. Norwegian School of Sport Sciences (2002-2005)

Course coordinator and lecturer, University of Oslo (2014-2015)

Visiting researcher National Institute of Health, USA, A Buonanno lab (2010)

 

Publikasjoner

  • Gundersen, Kristian; Bruusgaard, Jo C.; Egner, Ingrid Marie; Eftestøl, Einar & Bengtsen, Mads (2018). Muscle memory: virtues of your youth?. Journal of Physiology.  ISSN 0022-3751.  596(18), s 4289- 4290 . doi: 10.1113/JP276354
  • Markworth, James F.; D'Souza, Randall F.; Aasen, Kirsten M.M.; Mitchell, Sarah M.; Durainayagam, Brenan R.; Sinclair, Andrew J.; Peake, Jonathan M.; Egner, Ingrid Marie; Raastad, Truls; Cameron-Smith, David & Mitchell, Cameron J. (2018). Arachidonic acid supplementation transiently augments the acute inflammatory response to resistance exercise in trained men. Journal of applied physiology.  ISSN 8750-7587.  125(2), s 271- 286 . doi: 10.1152/japplphysiol.00169.2018 Vis sammendrag
  • Mitchell, Cameron J; D'Souza, Randall F; Figueiredo, Vandre C.; Chan, Alex; Aasen, Kirsten MM; Durainayagam, Brenan; Mitchell, Sarah M.; Sinclair, Andrew J.; Egner, Ingrid Marie; Raastad, Truls; Cameron-Smith, David & Markworth, James F. (2018). The effect of dietary arachidonic acid supplementation on acute muscle adaptive responses to resistance exercise in trained men: a randomized controlled trial. Journal of applied physiology.  ISSN 8750-7587.  124(4), s 1080- 1091 . doi: 10.1152/japplphysiol.01100.2017 Vis sammendrag
  • Peake, Jonathan M.; Roberts, Llion A.; Figueiredo, Vandré C.; Egner, Ingrid Marie; Krog Christensen, Simone; Aas, Sigve Nyvik; Suzuki, Katsuhiko; Markworth, James F.; Coombes, Jeff S.; Cameron-Smith, David & Raastad, Truls (2017). The effects of cold water immersion and active recovery on inflammation and cell stress responses in human skeletal muscle after resistance exercise. Journal of Physiology.  ISSN 0022-3751.  595(3), s 695- 711 . doi: 10.1113/JP272881 Vis sammendrag
  • van Velthoven, Cindy TJ; de Morree, Antoine; Egner, Ingrid Marie; Brett, Jamie O & Rando, Thomas A (2017). Transcriptional Profiling of Quiescent Muscle Stem Cells In Vivo. Cell reports.  ISSN 2211-1247.  21(7), s 1994- 2004 . doi: 10.1016/j.celrep.2017.10.037 Fulltekst i vitenarkiv.
  • Eftestøl, Einar; Egner, Ingrid Marie; Lunde, Ida Gjervold; Ellefsen, Stian; Andersen, Tom; Sjåland, Cecilie; Gundersen, Kristian & Bruusgaard, Jo C. (2016). Increased hypertrophic response with increased mechanical load in skeletal muscles receiving identical activity patterns. American Journal of Physiology - Cell Physiology.  ISSN 0363-6143.  311(4), s C616- C629 . doi: 10.1152/ajpcell.00016.2016
  • Egner, Ingrid Marie; Bruusgaard, Jo C. & Gundersen, Kristian (2016). Satellite cell depletion prevents fiber hypertrophy in skeletal muscle. Development.  ISSN 0950-1991.  143(16), s 2898- 2906 . doi: 10.1242/dev.134411
  • Roberts, Llion A.; Raastad, Truls; Markworth, James F.; Figueiredo, Vandre C.; Egner, Ingrid Marie; Shield, Anthony; Cameron-Smith, David; Coombes, Jeff S. & Peake, Jonathan M. (2015). Post-exercise cold water immersion attenuates acute anabolic signalling and long-term adaptations in muscle to strength training. Journal of Physiology.  ISSN 0022-3751.  593(18), s 4285- 4301 . doi: 10.1113/JP270570
  • Egner, Ingrid Marie; Bruusgaard, Jo C.; Eftestøl, Einar & Gundersen, Kristian (2013). A cellular memory mechanism aids overload hypertrophy in muscle long after an episodic exposure to anabolic steroids. Journal of Physiology.  ISSN 0022-3751.  591(24), s 6221- 6230 . doi: 10.1113/jphysiol.2013.264457
  • Paulsen, Gøran; Egner, Ingrid Marie; Raastad, Truls; Reinholt, Finn P.; Owe, Simen Gylterud; Lauritzen, Fredrik; Brorson, Sverre Henning & Koskinen, Satu (2013). Inflammatory markers CD11b, CD16, CD66b, CD68, myeloperoxidase and neutrophil elastase in eccentric exercised human skeletal muscles. Histochemistry and Cell Biology.  ISSN 0948-6143.  139(5), s 691- 715 . doi: 10.1007/s00418-012-1061-x
  • Bruusgaard, Jo C.; Egner, Ingrid Marie; Klungervik, Tove; Dupre-Aucouturier, S; Desplanches, D & Gundersen, Kristian (2012). No change in myonuclear number during muscle unloading and reloading. Journal of applied physiology.  ISSN 8750-7587.  113(2), s 290- 296 . doi: 10.1152/japplphysiol.00436.2012
  • Bruusgaard, Jo C.; Johansen, Ida Beitnes; Egner, Ingrid Marie; Rana, Zaheer Ahmad & Gundersen, Kristian (2010). Myonuclei acquired by overload exercise precede hypertrophy and are not lost on detraining. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  107(34), s 15111- 15116 . doi: 10.1073/pnas.0913935107
  • Paulsen, Gøran; Egner, Ingrid; Drange, Mads; Langberg, Henning; Benestad, Haakon Breien; Fjeld, Jan Gunnar; Hallén, Jostein & Raastad, Truls (2010). A COX-2 inhibitor reduces muscle soreness, but does not influence recovery and adaptation after eccentric exercise. Scandinavian Journal of Medicine & Science in Sports.  ISSN 0905-7188.  20(1, online), s 195 Vis sammendrag

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  • Egner, Ingrid Marie; Bruusgaard, Jo C. & Gundersen, Kristian (2017). An apparent lack of effect of satellite cell depletion on hypertrophy could be due to methodological limitations. Response to `Methodological issues limit interpretation of negative effects of satellite cell depletion on adult muscle hypertrophy?. Development.  ISSN 0950-1991.  144(8), s 1365- 1367 . doi: 10.1242/dev.148163
  • Eftestøl, Einar; Egner, Ingrid Marie; Ellefsen, Stian; Andersen, Tom; Gundersen, Kristian & Bruusgaard, Jo C. (2016). The importance of mechanosensation in skeletal muscle hypertrophy.
  • Egner, Ingrid Marie; Bruusgaard, Jo C.; Eftestøl, Einar & Gundersen, Kristian (2012). Effects of anabolic steroid on nuclear number and muscle mass.
  • Gundersen, Kristian; Eftestøl, Einar; Egner, Ingrid Marie & Bruusgaard, Jo C. (2011). The effect of testosterone propionate on overloaded skeletal muscle.
  • Bruusgaard, Jo C.; Johansen, Ida Beitnes; Egner, Ingrid Marie & Gundersen, Kristian (2009). Are myonuclei forever?. Journal of Muscle Research and Cell Motility.  ISSN 0142-4319.  30(1), s 307
  • Egner, Ingrid Marie (2009). Steng dem ute!. Dagbladet.  ISSN 0805-3766.
  • Egner, Ingrid; Paulsen, Gøran; Koskinen, Satu & Raastad, Truls (2007). LEUKOCYTE MYOFIBER-INFILTRATION IS NOT THE MAIN CAUSE OF HALTED RECOVERY OF FORCE GENERATION CAPACITY AFTER HIGH-FORCE ECCENTRIC EXERCISE. Vis sammendrag
  • Egner, Ingrid; Paulsen, Gøran; Koskinen, Satu & Raastad, Truls (2007). Leukocyte myofiber-infiltration is not the main cause of halted recovery of force generation capacity after high-force eccentric exercise, In  Book of abstracts : 12th Annual Congress of the European College of Sport Science.  Likes Research Center.  s 293 Vis sammendrag
  • Paulsen, Gøran; Egner, Ingrid; Drange, Mads; Langberg, Henning; Ugelstad, Ingrid; Hallén, Jostein & Raastad, Truls (2007). VIL INNTAK AV EN COX-2-HEMMER PÅVIRKE SKADEOMFANG OG RESTITUSJON AV SKJELETTMUSKULATUR ETTER ARBEIDSINDUSERTE MUSKELSKADER?. Vis sammendrag
  • Paulsen, Gøran; Egner, Ingrid; Drange, Mads; Langberg, Henning; Ugelstad, Ingrid; Hallén, Jostein & Raastad, Truls (2007). Vil inntak av en COX-2-hemmer påvirke skadeomfang og restitusjon av skjelettmuskulatur etter arbeidsinduserte muskelskader?. Norsk idrettsmedisin.  ISSN 0806-9328.  (3), s 24 Vis sammendrag

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Publisert 5. nov. 2018 12:28 - Sist endret 23. mai 2019 20:44