Monica Aasrum

Senioringeniør - Avdeling for farmakologi
Bilde av Monica Aasrum
English version of this page
Telefon +47 22840220
Brukernavn
Besøksadresse Sognsvannsveien 20 Rikshospitalet 0372 Oslo
Postadresse Postboks 1057 Blindern 0316 Oslo

Arbeidsområder

Aktivering av signalveier i kreftceller og hjerteceller; protein-fosforylering, protein-protein interaksjoner, reseptor-internalisering.

Bakgrunn

Dr.philos., Institutt for klinisk medisin, UiO, 2016

Cand.scient., Biokjemisk Institutt, UiO, 1994

Emneord: Molekylærbiologi, Cellebiologi, Kreftforskning, Farmakologi

Publikasjoner

  • Manfra, Ornella; Calamera, Gaia; Froese, Alexander; Arunthavarajah, Dulasi; Surdo, Nicoletta C. & Meier, Silja [Vis alle 14 forfattere av denne artikkelen] (2022). CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI: difference from BNP visualized by targeted cGMP biosensors. Journal of Cardiovascular Research. ISSN 2059-0385. 118(6), s. 1506–1519. doi: 10.1093/cvr/cvab167.
  • Amrutkar, Manoj; Vethe, Nils Tore; Verbeke, Caroline Sophie; Aasrum, Monica; Vefferstad, Anette & Santha, Petra [Vis alle 7 forfattere av denne artikkelen] (2020). Differential gemcitabine sensitivity in primary human pancreatic cancer cells and paired stellate cells is driven by heterogenous drug uptake and processing. Cancers. ISSN 2072-6694. 12:3628(12), s. 1–18. doi: 10.3390/cancers12123628. Fulltekst i vitenarkiv
  • Amrutkar, Manoj; Larsen, Emma Kristine; Aasrum, Monica; Finstadsveen , Anette Vefferstad; Andresen, Per Arne & Verbeke, Caroline Sophie [Vis alle 7 forfattere av denne artikkelen] (2020). Establishment and Characterization of Paired Primary Cultures of Human Pancreatic Cancer Cells and Stellate Cells Derived from the Same Tumor. Cells. ISSN 2073-4409. 9:227(1), s. 1–18. doi: 10.3390/cells9010227. Fulltekst i vitenarkiv
  • Lenggenhager, Daniela; Amrutkar, Manoj; Santha, Petra; Aasrum, Monica; Löhr, Johannes-Matthias & Gladhaug, Ivar Prydz [Vis alle 7 forfattere av denne artikkelen] (2019). Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions With Pancreatic Cancer Cells. Cells. ISSN 2073-4409. 8:E23(1), s. 1–18. doi: 10.3390/cells8010023. Fulltekst i vitenarkiv
  • Amrutkar, Manoj; Aasrum, Monica; Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2019). Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells. BMC Cancer. ISSN 1471-2407. 19(596). doi: 10.1186/s12885-019-5803-1. Fulltekst i vitenarkiv
  • Aasrum, Monica; Thoresen, G. Hege; Christoffersen, Thoralf & Brusevold, Ingvild Johnsen (2018). p38 differentially regulates ERK, p21, and mitogenic signalling in two pancreatic carcinoma cell lines. Journal of cell communication and signaling. ISSN 1873-9601. 12(4), s. 699–707. doi: 10.1007/s12079-017-0444-0. Fulltekst i vitenarkiv
  • Ødegård, John; Sondresen, Jan Erik; Aasrum, Monica; Tveteraas, Ingun Heiene; Guren, Tormod Kyrre & Christoffersen, Thoralf [Vis alle 7 forfattere av denne artikkelen] (2017). Differential effects of epidermal growth factor (EGF) receptor ligands on receptor binding, downstream signalling pathways and DNA synthesis in hepatocytes . Growth Factors. ISSN 0897-7194. 35(6), s. 239–248. doi: 10.1080/08977194.2018.1453506.
  • Tjomsland, Vegard; Aasrum, Monica; Christoffersen, Thoralf & Gladhaug, Ivar Prydz (2017). Functional heterogeneity in tumor-derived human pancreatic stellate cells: Differential expression of HGF and implications for mitogenic signaling and migration in pancreatic cancer cells. OncoTarget. ISSN 1949-2553. 8, s. 71672–71684. doi: 10.18632/oncotarget.17800.
  • Aasrum, Monica; Brusevold, Ingvild Johnsen; Christoffersen, Thoralf & Thoresen, G. Hege (2016). HGF-induced DNA synthesis in hepatocytes is suppressed by p38. Growth Factors. ISSN 0897-7194. 34(5-6), s. 217–223. doi: 10.1080/08977194.2017.1285765.
  • Tjomsland, Vegard; Pomianowska, Ewa; Aasrum, Monica; Sandnes, Dagny Lise; Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2016). Profile of MMP and TIMP expression in human pancreatic stellate cells: regulation by IL-1? and TGF? and implications for migration of pancreatic cancer cells. Neoplasia. ISSN 1522-8002. 18(7), s. 447–456. doi: 10.1016/j.neo.2016.06.003.
  • Tjomsland, Vegard; Sandnes, Dagny Lise; Pomianowska, Ewa; Cizmovic, Smiljana Torbica; Aasrum, Monica & Brusevold, Ingvild Johnsen [Vis alle 8 forfattere av denne artikkelen] (2016). The TGFβ-SMAD3 pathway inhibits IL-1α induced interactions between human pancreatic stellate cells and pancreatic carcinoma cells and restricts cancer cell migration. Journal of Experimental & Clinical Cancer Research. ISSN 1756-9966. 35:122, s. 1–12. doi: 10.1186/s13046-016-0400-5.
  • Aasrum, Monica; Tjomsland, Vegard; Thoresen, G. Hege; De Angelis, Paula; Christoffersen, Thoralf & Brusevold, Ingvild Johnsen (2016). PI3K is required for both basal and LPA-induced DNA synthesis in oral carcinoma cells. Journal of Oral Pathology & Medicine. ISSN 0904-2512. 45(6), s. 425–432. doi: 10.1111/jop.12384.
  • Tveteraas, Ingun Heiene; Aasrum, Monica; Brusevold, Ingvild Johnsen; Ødegård, John; Christoffersen, Thoralf & Sandnes, Dagny Lise (2016). Lysophosphatidic acid induces both EGFR-dependent and EGFR-independent effects on DNA synthesis and migration in pancreatic and colorectal carcinoma cells. Tumour Biology. ISSN 1010-4283. 37(2), s. 2519–2526. doi: 10.1007/s13277-015-4010-1.
  • Aasrum, Monica; Ødegård, John; Thoresen, G. Hege; Brusevold, Ingvild Johnsen; Sandnes, Dagny Lise & Christoffersen, Thoralf (2015). Gab1 amplifies signaling in response to low-intensity stimulation by HGF. Cell Biology International. ISSN 1065-6995. 39(10), s. 1177–1184. doi: 10.1002/cbin.10511.
  • Pomianowska, Ewa; Sandnes, Dagny Lise; Grzyb, Krzysztof; Schjølberg, Aasa Rambæk; Aasrum, Monica & Tveteraas, Ingun Heiene [Vis alle 9 forfattere av denne artikkelen] (2014). Inhibitory effects of prostaglandin E<sub>2</sub> on collagen synthesis and cell proliferation in human stellate cells from pancreatic head adenocarcinoma. BMC Cancer. ISSN 1471-2407. 14(1). doi: 10.1186/1471-2407-14-413.
  • Brusevold, Ingvild Johnsen; Tveteraas, Ingun Heiene; Aasrum, Monica; Ødegård, John; Sandnes, Dagny Lise & Christoffersen, Thoralf (2014). Role of LPAR3, PKC and EGFR in LPA-induced cell migration in oral squamous carcinoma cells. BMC Cancer. ISSN 1471-2407. 14(1). doi: 10.1186/1471-2407-14-432.
  • Aasrum, Monica; Ødegård, John; Sandnes, Dagny Lise & Christoffersen, Thoralf (2013). The involvement of the docking protein Gab1 in mitogenic signalling induced by EGF and HGF in rat hepatocytes. Biochimica et Biophysica Acta. ISSN 0006-3002. 1833(12), s. 3286–3294. doi: 10.1016/j.bbamcr.2013.10.004.
  • Ødegård, John; Aasrum, Monica; Tveteraas, Ingun Heiene; Bharath, Suman Preet; Sandnes, Dagny Lise & Christoffersen, Thoralf (2012). Role of ErbB2 in the prostaglandin E-2-induced enhancement of the mitogenic response to epidermal growth factor in cultured hepatocytes. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 421(2), s. 255–260. doi: 10.1016/j.bbrc.2012.03.148.
  • Brusevold, Ingvild Johnsen; Aasrum, Monica; Bryne, Magne & Christoffersen, Thoralf (2012). Migration induced by epidermal and hepatocyte growth factors in oral squamous carcinoma cells in vitro: role of MEK/ERK, p38 and PI-3 kinase/Akt. Journal of Oral Pathology & Medicine. ISSN 0904-2512. 41(7), s. 547–558. doi: 10.1111/j.1600-0714.2012.01139.x.
  • Tveteraas, Ingun Heiene; Müller, Kristin Meisdalen; Aasrum, Monica; Ødegård, John; Dajani, Olav & Guren, Tormod Kyrre [Vis alle 8 forfattere av denne artikkelen] (2012). Mechanisms involved in PGE2-induced transactivation of the epidermal growth factor receptor in MH1C1 hepatocarcinoma cells. Journal of Experimental and Clinical Cancer Research. ISSN 0392-9078. 31, s. 72–72. doi: 10.1186/1756-9966-31-72. Fulltekst i vitenarkiv
  • Müller, Kristin Meisdalen; Tveteraas, Ingun Heiene; Aasrum, Monica; Ødegård, John; Dawood, Mona & Dajani, Olav [Vis alle 8 forfattere av denne artikkelen] (2011). Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells. BMC Cancer. ISSN 1471-2407. 11. doi: 10.1186/1471-2407-11-421.
  • Dajani, Olav; Meisdalen, Kristin; Guren, Tormod Kyrre; Aasrum, Monica; Tveteraas, Ingun Heiene & Lilleby, Peggy [Vis alle 9 forfattere av denne artikkelen] (2008). Prostaglandin E2 upregulates EGF-stimulated signaling in mitogenic pathways involving Akt and ERK in hepatocytes. Journal of Cellular Physiology. ISSN 0021-9541. 214. doi: 10.1002/jcp.21205.

Se alle arbeider i Cristin

  • Brusevold, Ingvild Johnsen; Aasrum, Monica; Tveteraas, Ingun Heiene; Bryne, Magne & Christoffersen, Thoralf (2011). Signalling Mechanisms Mediating EGF- and HGF-induced Migration in Carcinoma Cells in Vitro.
  • Brusevold, Ingvild Johnsen; Aasrum, Monica; Bryne, Magne & Christoffersen, Thoralf (2011). Signalmekanismer som medierer EGF- og HGF-indusert migrasjon i orale plateepitelkarsinomceller in vitro.
  • Tveteraas, Ingun Heiene; Müller, Kristin Meisdalen; Dajani, Olav; Guren, Tormod Kyrre; Aasrum, Monica & Ødegård, John [Vis alle 8 forfattere av denne artikkelen] (2010). Mechanisms of prostaglandin E2-induced transactivation of the EGF receptor in MH1C1 hepatoma cells.
  • Ødegård, John; Aasrum, Monica; Bharath, Suman Preet; Tveteraas, Ingun Heiene; Sandnes, Dagny Lise & Christoffersen, Thoralf (2010). Prostaglandin E2 regulates ErbB2 and ErbB3 in hepatocytes.
  • Sandnes, Dagny Lise; Müller, Kristin Meisdalen; Tveteraas, Ingun Heiene; Aasrum, Monica; Dawood, Mona & Dajani, Olav [Vis alle 7 forfattere av denne artikkelen] (2010). Protein kinase C and epidermal growth factor receptor signalling mediate growth stimulation by neurotensin in the colon carcinoma cell line HCT116. European Journal of Cancer. ISSN 0959-8049. 8(5), s. 166–166.
  • Ødegård, John; Aasrum, Monica; Bharath, Suman Preet; Tveteraas, Ingun Heiene; Sandnes, Dagny Lise & Christoffersen, Thoralf (2010). Prostaglandin E2 upregulates ErbB2 and enhances EGF-stimulated DNA synthesis in hepatocytes. European Journal of Cancer. ISSN 0959-8049. 8(5), s. 124–125.
  • Tveteraas, Ingun Heiene; Müller, Kristin Meisdalen; Dajani, Olav; Guren, Tormod Kyrre; Aasrum, Monica & Ødegård, John [Vis alle 8 forfattere av denne artikkelen] (2010). Mechanisms of prostaglandin E2-induced transactivation of the EGF receptor in MH1C1 hepatoma cells. European Journal of Cancer. ISSN 0959-8049. 8(5), s. 141–141.

Se alle arbeider i Cristin

Publisert 13. apr. 2011 11:09 - Sist endret 7. nov. 2018 10:58