hjsmith

• Bøker, Tordis; Kirkhus, Eva; Pripp, Are Hugo; Rand-Hendriksen, Svend; Paus, Benedicte & Smith, Hans Jørgen [Vis alle 7 forfattere av denne artikkelen] (2025). The natural history of protrusio acetabuli in Marfan syndrome and other hereditary connective tissue disorders: a 10-year follow-up CT study. Orphanet Journal of Rare Diseases. 20(1). doi: 10.1186/s13023-025-03628-0. Fulltekst i vitenarkiv Vis sammendrag

  Objectives To explore the natural history of protrusio acetabuli (PA) in adults with Marfan syndrome (MFS) via a prospective 10-year follow-up study. Methods 2014 through 2015, 62 of 87 survivors from a nationwide cross-sectional study of 105 adults with presumed MFS were re-examined. At follow-up, MFS was diagnosed in 46 participants, and other hereditary connective tissue disorders in 12 participants. As in the baseline study, matched hospital controls were collected for comparison. CT images were obtained of the hips. PA was evaluated quantitatively and qualitatively. Measurements were performed according to the circle-wall distance method. The data was analysed with paired t test, and McNemar’s test. A receiver operating characteristic (ROC) curve was constructed for the circle-wall distance. Results There was no increase in the number of hips diagnosed with PA or in the circle-wall distance. PA was diagnosed in 58 of 87 hips in patients with MFS and in 71 of 111 hips in all patients with hereditary connective tissue disorders. Significantly more patients with MFS than controls had PA. Conclusion The prevalence and degree of PA remained unchanged after 10 years. The circle-wall distance seems to have a good ability to discriminate between individuals with MFS and individuals without any known connective tissue disorder. Suggested cutoff level for the circle-wall distance: 2 mm.

• Moosmeyer, Stefan; Lund, Gerty; Seljom, Unni Sire; Haldorsen, Benjamin; Svege, I.C & Hennig, Toril [Vis alle 8 forfattere av denne artikkelen] (2024). Fifteen-Year Results of a Comparative Analysis of Tendon Repair Versus Physiotherapy for Small-to-Medium-Sized Rotator Cuff Tears A Concise Follow-up of Previous Reports. Journal of Bone and Joint Surgery. American volume. ISSN 0021-9355. doi: 10.2106/JBJS.24.00065. Fulltekst i vitenarkiv
• Smith, Hans-Jørgen (2021). The history of magnetic resonance imaging and its reflections in Acta Radiologica. Acta Radiologica. ISSN 0284-1851. 62(11), s. 1481–1498. doi: 10.1177/02841851211050857. Fulltekst i vitenarkiv Vis sammendrag

  Abstract The first reports in Acta Radiologica on magnetic resonance imaging (MRI) were published in 1984, four years after the first commercial MR scanners became available. For the first two years, all MR papers originated from the USA. Nordic contributions started in 1986, and until 2020, authors from 44 different countries have published MR papers in Acta Radiologica. Papers on MRI have constituted, on average, 30%–40% of all published original articles in Acta Radiologica, with a high of 49% in 2019. The MR papers published since 1984 document tremendous progress in several areas such as magnet and coil design, motion compensation techniques, faster image acquisitions, new image contrast, contrast-enhanced MRI, functional MRI, and image analysis. In this historical review, all of these aspects of MRI are discussed and related to Acta Radiologica papers.

• Böker, Tordis; Vanem, Thy Thy; Pripp, Are Hugo; Rand-Hendriksen, Svend; Paus, Benedicte & Smith, Hans-Jørgen [Vis alle 7 forfattere av denne artikkelen] (2019). Dural ectasia in Marfan syndrome and other hereditary connective tissue disorders: a 10-year follow-up study. The spine journal. ISSN 1529-9430. 19(8), s. 1412–1421. doi: 10.1016/j.spinee.2019.04.010. Fulltekst i vitenarkiv Vis sammendrag

  BACKGROUND CONTEXT Dural ectasia is widening of the dural sac often seen in patients with Marfan syndrome and other hereditary connective tissue disorders. Dural ectasia can cause specific symptoms and is associated with surgical complications. The knowledge on how and at which age dural ectasia develops is incomplete. There is no established gold standard for diagnosing dural ectasia, making it difficult to compare results from different studies. PURPOSE Our primary aim was to explore whether the radiological findings of dural ectasia changed after 10 years in an adult cohort with suspected Marfan syndrome. Our secondary aim was to re-evaluate the radiological criteria of dural ectasia. STUDY DESIGN Prospective cohort study. PATIENT SAMPLE Sixty-two persons from a cross-sectional study of 105 persons with suspected Marfan syndrome were included in a 10-year follow-up of dural ectasia. Forty-six were diagnosed with Marfan syndrome, 7 with Loeys-Dietz syndrome, and 5 with other hereditary connective tissue disorders. For comparison 64 matched hospital controls were evaluated. OUTCOME MEASURES Previously used radiological criteria for dural ectasia based on quantitative measurements of the lumbosacral spine. METHODS MRI of the lumbosacral spine was performed if not contraindicated, and if so then CT was performed. Differences in the study group between baseline and follow-up were assessed with paired Student t test, Wilcoxon rank signed test, and McNemar test. Receiver operating characteristic curves were constructed to assess the ability of radiological measurement to differentiate between the study and control group. RESULTS Fifty-two of 58 patients with hereditary connective tissue disorders and 11 controls had dural ectasia at follow-up. Forty-five Marfan patients had dural ectasia at follow-up vs. 41 at baseline. Five Loeys-Dietz patients had dural ectasia at follow-up vs. four at baseline. Twenty-four Marfan and 2 Loeys-Dietz patients had anterior sacral meningocele at follow-up, compared with 21 and 1, respectively, at baseline. Three Marfan patients developed herniation of a nerve root sleeve during follow-up. This was not seen in other individuals. The dural sac ended significantly lower at follow-up, and the dural sac ratio at level L5 was significantly increased from baseline in the Marfan patients. CONCLUSIONS In Marfan and Loeys-Dietz syndrome, dural ectasia may present or worsen during adulthood. The cut-off value of dural sac ratio at level S1 is suggested elevated to 0.64. The results from the present study may help as guidance for appropriate follow-up of patients with dural ectasia.

• Vanem, Thy Thy; Böker, Tordis; Sandvik, Gunhild Falleth; Kirkhus, Eva Astrid; Smith, Hans-Jørgen & Andersen, Kai [Vis alle 13 forfattere av denne artikkelen] (2019). Marfan syndrome: Evolving organ manifestations-A 10-year follow-up study. American Journal of Medical Genetics. Part A. ISSN 1552-4825. 182(2), s. 397–408. doi: 10.1002/ajmg.a.61441. Fulltekst i vitenarkiv Vis sammendrag

  The age‐dependent penetrance of organ manifestations in Marfan syndrome (MFS) is not known. The aims of this follow‐up study were to explore how clinical features change over a 10‐year period in the same Norwegian MFS cohort. In 2003–2004, we investigated 105 adults for all manifestations in the 1996 Ghent nosology. Ten years later, we performed follow‐up investigations of the survivors (n = 48) who consented. Forty‐six fulfilled the revised Ghent criteria. Median age: females 51 years, range 32–80 years; males 45 years, range 30–67 years. New aortic root dilatation was detected in patients up to 70 years. Ascending aortic pathology was diagnosed in 93 versus 72% at baseline. Sixty‐five percent had undergone aortic surgery compared to 39% at baseline. Pulmonary trunk mean diameter had increased significantly compared to baseline. From inclusion to follow‐up, two patients (three eyes) developed ectopia lentis, four developed dural ectasia, four developed scoliosis, three developed incisional or recurrent herniae, and 14 developed hindfoot deformity. No changes were found regarding protrusio acetabuli, spontaneous pneumothorax, or striae atrophicae. The study confirms that knowledge of incidence and progression of organ manifestations throughout life is important for diagnosis, treatment, and follow‐up of patients with verified or suspected MFS.

• Moosmeyer, Stefan; Lund, Gerty; Seljom, Unni Sire; Haldorsen, Benjamin; Svege, Ida & Hennig, Toril [Vis alle 8 forfattere av denne artikkelen] (2019). At a 10-Year Follow-up, Tendon Repair Is Superior to Physiotherapy in the Treatment of Small and Medium-Sized Rotator Cuff Tears. Journal of Bone and Joint Surgery. American volume. ISSN 0021-9355. 101(12), s. 1050–1060. doi: 10.2106/JBJS.18.01373. Fulltekst i vitenarkiv
• Kirkhus, Eva; Arvidsson, Linda Zamoline; Smith, Hans-Jørgen; Flatø, Berit; Hetlevik, Siri Opsahl & Larheim, Tore Arne (2016). Disk abnormality coexists with any degree of synovial and osseous abnormality in the temporomandibular joints of children with juvenile idiopathic arthritis. Pediatric Radiology. ISSN 0301-0449. 46(3), s. 331–341. doi: 10.1007/s00247-015-3493-7. Fulltekst i vitenarkiv Vis sammendrag

  Background MRI manifestation of temporomandibular joint arthritis is frequently reported in children with juve- nile idiopathic arthritis. However, little attention has been paid to temporomandibular joint disk abnormalities. Objective To assess combinations of MRI findings in the symptomatic temporomandibular joint in children with ju- venile idiopathic arthritis with focus on disk abnormalities. Materials and methods This was a retrospective study of 46 patients with juvenile idiopathic arthritis, mean age 12 years (range: 5-17 years). Mean disease duration was 70 months (standard deviation: 61 months). MR images of 92 tempo- romandibular joints were scored for thickness of abnormal- ly enhancing synovium (synov itis), joint effusion, bone marrow oedema, abnormal bone shape, bone erosion and disk abnormalities. Results The 92 temporomandibular joints were categorized as A: No synovitis and normal bone shape (30/92; 33%), B: Synovitis and normal bone shape (14/92: 15%), C: Synovi- tis and abnormal bone shape (38/92; 41%) and D: No syno- vitis but abnormal bone shape (10/92; 11%). Thirty-six of the 46 patients (78%) had synovitis and 33/46 (72%) had abnormal bone shape, most frequently in combination (30/ 46; 65%). Disk abnormalities (flat disk, fragmented disk, adherent disk and displaced disk) were found in 29/46 pa- tients (63%). Disk abnormalities were found in all catego- ries of juvenile idiopathic arthritis involved temporoman- dibular joints (B: 8/14 [57%]; C: 25/38 [66%] and D: 7/10 [70%]). Disk displacement was found in half of the joints (7/14) in category B. Synovitis was most pronounced in this category. Conclusion Disk abnormalities were frequent. Disk displace- ment also occurred in joints with early temporomandibular joint arthritis, i.e., with normal bone shape. Other disk abnor- malities were found in joints with bone abnormalities. Atten- tion should be paid to disk abnormalities both in early and long-standing temporomandibular joint arthritis in children with juvenile idiopathic arthritis

• Kirkhus, Eva; Gunderson, Ragnhild B.; Smith, Hans-Jørgen; Flatø, Berit; Hetlevik, Siri Opsahl & Larheim, Tore Arne [Vis alle 7 forfattere av denne artikkelen] (2016). Temporomandibular joint involvement in childhood arthritis: comparison of ultrasonography-assessed capsular width and MRI-assessed synovitis. Dentomaxillofacial Radiology. ISSN 0250-832X. 45(8). doi: 10.1259/dmfr.20160195. Fulltekst i vitenarkiv Vis sammendrag

  Objectives: Ultrasonography is an effective, low-cost, low-threshold and convenient diagnostic tool in childhood arthritis, but its value in temporomandibular joint (TMJ) involvement is not clear. The purpose of our study was to explore the reliability of ultrasonography to assess TMJ inflammation using contrast-enhanced MRI as reference standard, in order to deduce cut-off values for TMJ capsular width to detect enhanced synovial thickening (synovitis). Methods: 124 ultrasonography and MRI examinations in 55 patients [mean age 12.4 ± 3.5 years (±standard deviation)], the majority obtained within 1 day, were scored for subcondylar and condylar capsular width (ultrasonography images) and amount of synovitis (MR images). The correlations of these findings were calculated. A receiver operating characteristic (ROC) curve analysis, with MRI findings as reference standard, was obtained. Results: The correlation between ultrasonography-assessed capsular width and MRI-assessed amount of synovitis was moderate both at the subcondylar and condylar level [Spearman's rho (ρ): 0.483; p < 0.001 and 0.347; p < 0.001 respectively]. The ROC curve indicated the best discriminatory ability at the subcondylar level with an area under the curve of 0.77 (95% confidence interval 0.69–0.85) and a cut-off value of 1.2 mm (sensitivity 72%, specificity 70%) for the capsular width. Conclusions: A moderate correlation between ultrasonography-assessed capsular width and MRI-assessed synovitis was found in childhood arthritis with the best discriminatory ability at the subcondylar level. This indicates that ultrasonography may be a valuable diagnostic tool in the initial assessment of TMJ inflammation.

• Broch, Kaspar; Askevold, Erik Tandberg; Gjertsen, Erik; Ueland, Thor; Yndestad, Arne & Godang, Kristin [Vis alle 13 forfattere av denne artikkelen] (2014). The effect of rosuvastatin on inflammation, matrix turnover and left ventricular remodeling in dilated cardiomyopathy: A randomized, controlled trial. PLOS ONE. 9(2). doi: 10.1371/journal.pone.0089732. Fulltekst i vitenarkiv Vis sammendrag

  Background Dilated cardiomyopathy is characterized by left ventricular dilatation and dysfunction. Inflammation and adverse remodeling of the extracellular matrix may be involved in the pathogenesis. Statins reduce levels of low density lipoprotein cholesterol, but may also attenuate inflammation and affect matrix remodeling. We hypothesized that treatment with rosuvastatin would reduce or even reverse left ventricular remodeling in dilated cardiomyopathy. Materials and Methods In this multicenter, randomized, double blind, placebo-controlled study, 71 patients were randomized to 10 mg of rosuvastatin or matching placebo. Physical examination, blood sampling, echocardiography and cardiac magnetic resonance imaging were performed at baseline and at six months’ follow-up. The pre-specified primary end point was the change in left ventricular ejection fraction from baseline to six months. Results Over all, left ventricular ejection fraction improved 5 percentage points over the duration of the study, but there was no difference in the change in left ventricular ejection fraction between patients allocated to rosuvastatin and those allocated to placebo. Whereas serum low density lipoprotein cholesterol concentration fell significantly in the treatment arm, rosuvastatin did not affect plasma or serum levels of a wide range of inflammatory variables, including C-reactive protein. The effect on markers of extracellular matrix remodeling was modest. Conclusion Treatment with rosuvastatin does not improve left ventricular ejection fraction in patients with dilated cardiomyopathy.

• Almaas, Vibeke Marie; Haugaa, Kristina; Strøm, Erik Heyerdahl; Scott, Helge; Smith, Hans-Jørgen & Dahl, Christen Peder [Vis alle 11 forfattere av denne artikkelen] (2014). Noninvasive assessment of myocardial fibrosis in patients with obstructive hypertrophic cardiomyopathy. Heart. ISSN 1355-6037. 100(8), s. 631–638. doi: 10.1136/heartjnl-2013-304923. Fulltekst i vitenarkiv Vis sammendrag

  ABSTRACT Objective Late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) imaging is the reference standard for non-invasive assessment of fibrosis. In hypertrophic cardiomyopathy (HCM) patients the histological substrate for LGE is still unknown. The aim of this study was to assess the ability of LGE and strain echocardiography to detect type and extent of myocardial fibrosis in obstructive HCM patients undergoing septal myectomy. Methods Thirty-two HCM patients (age 60±10) were included in this cross-sectional study and preoperatively examined by speckle-tracking strain echocardiography and LGE-CMR (n=21). Histological fibrosis was classified as interstitial, replacement and total. Results Histological fibrosis was present in 31 patients. The percentage of total, interstitial and replacement fibrosis was 15(7, 31)%, 11(5, 24)% and 3(1, 6)%, respectively. Reduced longitudinal septal strain correlated with total (r=0.50, p=0.01) and interstitial (r=0.40, p=0.03), but not with replacement fibrosis (r=0.28, p=0.14). Septal LGE was detected in 13/21 (62%), but percentage LGE did not correlate with total fibrosis (r=0.25, p=0.28). Extent of fibrosis did not differ between patients with and without septal LGE (20(9, 58)% versus 14(5, 19)% p=0.41). Patients with ventricular arrhythmias (n=8) had lower septal longitudinal strain and increased extent total and interstitial fibrosis in myectomy specimens, but no differences were demonstrated in LGE. Reduced longitudinal septal strain and increased extent of interstitial fibrosis predicted ventricular arrhythmias independently of age and gender. Conclusions In myectomised HCM patients, reduced longitudinal septal strain correlated better with interstitial and total fibrosis in myectomy specimens, and was a more powerful tool to predict arrhythmias than LGE.

• Hagtvedt, Trond; Seierstad, Therese; Lund, Kjersti Vassmo; Løndalen, Ayca Muftuler; Bogsrud, Trond & Smith, Hans-Jørgen [Vis alle 9 forfattere av denne artikkelen] (2014). Diffusion-weighted MRI compared to FDG PET/CT for assessment of early treatment response in lymphoma. Acta Radiologica. ISSN 0284-1851. 56(2), s. 152–158. doi: 10.1177/0284185114526087. Fulltekst i vitenarkiv
• Hopp, Einar & Smith, Hans-Jørgen (2014). Magnetisk resonans av hjertet. Hjerteforum. ISSN 0802-1465. 27, s. 97–109. Fulltekst i vitenarkiv
• Saberniak, Jørg; Hasselberg, Nina Eide; Borgquist, Rasmus; Platonov, Pyotr G; Sarvari, Sebastian Imre & Smith, Hans-Jørgen [Vis alle 10 forfattere av denne artikkelen] (2014). Vigorous physical activity impairs myocardial function in patients with arrhythmogenic right ventricular cardiomyopathy and in mutation positive family members. European Journal of Heart Failure. ISSN 1388-9842. 16(12), s. 1337–1344. doi: 10.1002/ejhf.181. Fulltekst i vitenarkiv Vis sammendrag

  Aims: Exercise increases risk of ventricular arrhythmia in subjects with arrhythmogenic right ventricular cardiomyopathy (ARVC). We aimed to investigate the impact of exercise on myocardial function in ARVC subjects. Methods and Results: We included 110 subjects (age 42±17 years), 65 ARVC patients and 45 mutation-positive family members. Athletes were defined as subjects with ≥4 h vigorous exercise/week [≥1440 metabolic equivalents (METs × minutes/week)] during a minimum of 6 years. Athlete definition was fulfilled in 37/110 (34%) subjects. We assessed right ventricular (RV) and left ventricular (LV) myocardial function by echocardiography, and by magnetic resonance imaging (MRI). The RV function by RV fractional area change (FAC), RV global longitudinal strain (GLS) by echocardiography, and RV ejection fraction (EF) by MRI was reduced in athletes compared with non-athletes (FAC 34±9% vs. 40±11%, RVGLS –18.3±6.1% vs. –22.0±4.8%, RVEF 32±8% vs. 43±10%, all P<0.01). LV function by LVEF and LVGLS was reduced in athletes compared with non-athletes (LVEF by echocardiography 50±10% vs. 57±5%, LVEF by MRI 46±6% vs. 53±8%, and LVGLS –16.7±4.2% vs. –19.4±2.9%, all P <0.01). The METs × minutes/week correlated with reduced RV and LV function by echocardiography and MRI (all P <0.01). The LVEF by MRI was also reduced in subgroups of athlete index patients (46±7% vs. 54±10%, P=0.02) and in athlete family members (47±3% vs. 52±6%, P <0.05). Conclusion: Athletes showed reduced biventricular function compared with non-athletes in ARVC patients and in mutation-positive family members. The amount and intensity of exercise activity was associated with impaired LV and RV function. Exercise may aggravate and accelerate myocardial dysfunction in ARVC.

• Kjelstrup, Trygve; Hol, Per Kristian; Courivaud, Fredric A A; Smith, Hans-Jørgen; Røkkum, Magne & Klaastad, Øivind (2014). MRI of axillary brachial plexus blocks: A randomised controlled study. European Journal of Anaesthesiology. ISSN 0265-0215. 31(11), s. 611–619. doi: 10.1097/EJA.0000000000000122. Fulltekst i vitenarkiv
• Stankovic, Ivan; Aarønæs, Marit; Smith, Hans-Jørgen; Voros, Gabor; Kongsgård, Erik & Neskovic, Aleksander [Vis alle 9 forfattere av denne artikkelen] (2014). Dynamic relationship of left-ventricular dyssynchrony and contractile reserve in patients undergoing cardiac resynchronization therapy. European Heart Journal. ISSN 0195-668X. 35(1), s. 48–+. doi: 10.1093/eurheartj/eht294. Fulltekst i vitenarkiv
• Moosmeyer, Stefan; Lund, Gerty; Seljom, Unni Sire; Haldorsen, Benjamin; Svege, Ida Charlott & Hennig, Toril [Vis alle 8 forfattere av denne artikkelen] (2014). Tendon Repair Compared with Physiotherapy in the Treatment of Rotator Cuff Tears: A Randomized Controlled Study in 103 Cases with a Five-Year Follow-up. Journal of Bone and Joint Surgery. American volume. ISSN 0021-9355. 96(18), s. 1504–1514. doi: 10.2106/JBJS.M.01393. Fulltekst i vitenarkiv
• Gjesdal, Ola; Almeida, Andre L.C.; Hopp, Einar; Beitnes, Jan Otto; Lunde, Ketil & Smith, Hans-Jørgen [Vis alle 8 forfattere av denne artikkelen] (2013). Long axis strain by MRI and echocardiography in a postmyocardial infarct population. Journal of Magnetic Resonance Imaging. ISSN 1053-1807. 40(5), s. 1247–1251. doi: 10.1002/jmri.24485. Fulltekst i vitenarkiv
• Moosmeyer, Stefan; Tariq, Rana; Stiris, Morten Georg & Smith, Hans-Jørgen (2013). The Natural History of Asymptomatic Rotator Cuff Tears A Three-Year Follow-up of Fifty Cases. Journal of Bone and Joint Surgery. American volume. ISSN 0021-9355. 95A(14), s. 1249–1255. doi: 10.2106/JBJS.L00185. Fulltekst i vitenarkiv
• Gullestad, Lars; Ørn, Stein; Dickstein, Kenneth; Eek, Christian; Edvardsen, Thor & Aakhus, Svend [Vis alle 14 forfattere av denne artikkelen] (2013). Intravenous immunoglobulin does not reduce left ventricular remodeling in patients with myocardial dysfunction during hospitalization after acute myocardial infarction. International Journal of Cardiology. ISSN 0167-5273. 168(1), s. 212–218. doi: 10.1016/j.ijcard.2012.09.092. Fulltekst i vitenarkiv Vis sammendrag

  BACKGROUND: Left ventricular (LV) remodeling takes place after acute myocardial infarction (MI), potentially leading to overt heart failure (HF). Enhanced inflammation may contribute to LV remodeling. Our hypothesis was that the immunomodulating effects of intravenous immunoglobulin (IVIg) would be beneficial in patients with impaired myocardial function after MI by reducing myocardial remodeling and improving myocardial function. METHODS: Sixty-two patients with acute MI treated by percutaneous coronary intervention, with depressed LV ejection fraction (LVEF) were randomized in a double-blinded fashion to IVIg as induction therapy and thereafter as monthly infusions or placebo for 26weeks. The primary end point was changes in LVEF from baseline to 6months as assessed by MRI. RESULTS: Our main findings were: (i) LVEF increased significantly from 38±10 (mean±SD) to 45±13% after IVIg and from 42±9 to 49±12% after placebo with no difference between the groups. (ii) The scar area decreased significantly by 3% and 5% in the IVIg and placebo group, respectively, with no difference between the groups. (iii) During the induction therapy (baseline to day 5), IVIg induced both inflammatory (e.g., increase in tumor necrosis factor α and monocyte chemoattractant protein-1) and anti-inflammatory (e.g., increase in interleukin-10 and decrease in leukocyte counts) variables, but during maintenance therapy there were no differences in changes of inflammatory mediators between IVIg and placebo. CONCLUSIONS: IVIg therapy after ST elevation MI managed by primary PCI does not affect LV remodeling or function. This illustrates the challenges of therapeutic intervention directed against the cytokine network, to prevent post-MI remodeling.

• Hopp, Einar; Bjørnerud, Atle; Lunde, Ketil; Solheim, Svein; Aakhus, Svend & Arnesen, Harald [Vis alle 9 forfattere av denne artikkelen] (2013). Perfusion MRI at rest in subacute and chronic myocardial infarct. Acta Radiologica. ISSN 0284-1851. 54(4), s. 401–411. doi: 10.1177/0284185113475605. Fulltekst i vitenarkiv
• Hagtvedt, Trond; Aaløkken, Trond Mogens; Smith, Hans-Jørgen; Graff, Bjørn Anton; Holte, Harald & Kolbenstvedt, Alf (2013). Enhancement characteristics of retroperitoneal lymphomatous lymph nodes. Acta Radiologica. ISSN 0284-1851. 54(3), s. 333–339. doi: 10.1258/ar.2012.120679. Fulltekst i vitenarkiv
• Berstad, Audun Elnæs; Smith, Hans-Jørgen & Abildgaard, Andreas (2012). Imaging of Complications After Laparoscopic Hepatobiliary Surgery. Current Medical Imaging. ISSN 1573-4056. 8(2), s. 117–121. doi: 10.2174/157340512800672234. Fulltekst i vitenarkiv
• Lundby, Rigmor; Rand-Hendriksen, Svend; Hald, John K; Pripp, Are Hugo & Smith, Hans-Jørgen (2012). The pulmonary artery in patients with Marfan syndrome: a cross-sectional study. Genetics in Medicine. ISSN 1098-3600. 14(11), s. 922–927. doi: 10.1038/gim.2012.82. Fulltekst i vitenarkiv
• Vartdal, Trond; Pettersen, Eirik; Helle-Valle, Thomas Michael; Lyseggen, Erik; Andersen, Kai & Smith, Hans-Jørgen [Vis alle 9 forfattere av denne artikkelen] (2012). Identification of Viable Myocardium in Acute Anterior Infarction Using Duration of Systolic Lengthening by Tissue Doppler Strain: A Preliminary Study. Journal of the American Society of Echocardiography. ISSN 0894-7317. 25(7), s. 718–725. doi: 10.1016/j.echo.2012.04.016. Fulltekst i vitenarkiv
• Hopp, Einar; Lunde, Ketil; Solheim, Svein; Aakhus, Svend; Arnesen, Harald & Forfang, Kolbjørn [Vis alle 8 forfattere av denne artikkelen] (2011). Regional myocardial function after intracoronary bone marrow cell injection in reperfused anterior wall infarction - a cardiovascular magnetic resonance tagging study. Journal of Cardiovascular Magnetic Resonance. ISSN 1097-6647. 13. doi: 10.1186/1532-429X-13-22. Fulltekst i vitenarkiv Vis sammendrag

  Background Trials have brought diverse results of bone marrow stem cell treatment in necrotic myocardium. This substudy from the Autologous Stem Cell Transplantation in Acute Myocardial Infarction trial (ASTAMI) explored global and regional myocardial function after intracoronary injection of autologous mononuclear bone marrow cells (mBMC) in acute anterior wall myocardial infarction treated with percutaneous coronary intervention. Methods Cardiovascular magnetic resonance (CMR) tagging was performed 2-3 weeks and 6 months after revascularization in 15 patients treated with intracoronary stem cell injection (mBMC group) and in 13 controls without sham injection. Global and regional left ventricular (LV) strain and LV twist were correlated to cine CMR and late gadolinium enhancement (LGE). Results In the control group myocardial function as measured by strain improved for the global LV (6 months: -13.1 ± 2.4 versus 2-3 weeks: -11.9 ± 3.4%, p = 0.014) and for the infarct zone (-11.8 ± 3.0 versus -9.3 ± 4.1%, p = 0.001), and significantly more than in the mBMC group (inter-group p = 0.027 for global strain, respectively p = 0.009 for infarct zone strain). LV infarct mass decreased (35.7 ± 20.4 versus 45.7 ± 29.5 g, p = 0.024), also significantly more pronounced than the mBMC group (inter-group p = 0.034). LV twist was initially low and remained unchanged irrespective of therapy. Conclusions LGE and strain findings quite similarly demonstrate subtle differences between the mBMC and control groups. Intracoronary injection of autologous mBMC did not strengthen regional or global myocardial function in this substudy. Trial registration ClinicalTrials.gov: NCT00199823

• Kirkhus, Eva; Flatø, Berit; Riise, Øystein Rolandsen; Reiseter, Tor & Smith, Hans-Jørgen (2011). Differences in MRI findings between subgroups of recent-onset childhood arthritis. Pediatric Radiology. ISSN 0301-0449. 41(4), s. 432–440. doi: 10.1007/s00247-010-1897-y. Fulltekst i vitenarkiv Vis sammendrag

  Background MRI is sensitive for joint inflammation, but its ability to separate subgroups of arthritis in children has been questioned. Infectious arthritis (IA), postinfectious arthritis (PA), transient arthritis (TA) and juvenile idiopathic arthritis (JIA) are subgroups that may need early, different treatment. Objective To determine whether MRI findings differ in IA, PA/TA and JIA in recent-onset childhood arthritis. Materials and methods Fifty-nine children from a prospective study of incidence of arthritis (n = 216) were, based on clinical and biochemical criteria, examined by MRI. Joint fluid, synovium, bone marrow, soft tissue and cartilage were scored retrospectively and analysed by Pearson chi-square test and logistic regression analysis. Results Fifty-nine children had MRI of one station. IA was suggested by bone marrow oedema (OR 7.46, P = 0.011) and absence of T1-weighted and T2-weighted low signal intensity synovial tissue (OR 0.06, P = 0.015). Furthermore, soft-tissue oedema and reduced contrast enhancement in the epiphyses were more frequent in children with IA. JIA correlated positively with low signal intensity synovial tissue (OR 13.30, P < 0.001) and negatively with soft-tissue oedema (OR 0.20, P = 0.018). No significant positive determinants were found for PA/TA, but bone marrow oedema, soft-tissue oedema, irregular thickened synovium and low signal intensity synovial tissue was less frequent than in IA/JIA. Conclusion In children with high clinical suspicion of recent onset arthritis, there was a significant difference in the distribution of specific MRI features among the diagnostic groups. Open Access This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

• Fangberget, Anne; Nilsen, Line; Hole, Knut Håkon; Holmen, Marit Muri; Engebråten, Olav & Naume, Bjørn [Vis alle 9 forfattere av denne artikkelen] (2011). Neoadjuvant chemotherapy in breast cancer-response evaluation and prediction of response to treatment using dynamic contrast-enhanced and diffusion-weighted MR imaging. European Radiology. ISSN 0938-7994. 21(6), s. 1188–1199. doi: 10.1007/s00330-010-2020-3. Fulltekst i vitenarkiv Vis sammendrag

  Objective To explore the predictive value of MRI parameters and tumour characteristics before neoadjuvant chemotherapy (NAC) and to compare changes in tumour size and tumour apparent diffusion coefficient (ADC) during treatment, between patients who achieved pathological complete response (pCR) and those who did not. Methods Approval by the Regional Ethics Committee and written informed consent were obtained. Thirty-one patients with invasive breast carcinoma scheduled for NAC were enrolled (mean age, 50.7; range, 37–72). Study design included MRI before treatment (Tp0), after four cycles of NAC (Tp1) and before surgery (Tp2). Data in pCR versus non-pCR groups were compared and cut-off values for pCR prediction were evaluated. Results Before NAC, HER2 overexpression was the single significant predictor of pCR (p=0.006). At Tp1 ADC, tumour size and changes in tumour size were all significantly different in the pCR and non-pCR groups. Using 1.42×10−3 mm2/s as the cut-off value for ADC, pCR was predicted with sensitivity and specificity of 88% and 80%, respectively. Using a cut-off value of 83% for tumour volume reduction, sensitivity and specificity for pCR were 91% and 80%. Conclusion ADC, tumour size and tumour size reduction at Tp1 were strong independent predictors of pCR.

• Lundby, Rigmor; Kirkhus, Eva; Rand-Hendriksen, Svend; Hald, John K; Pripp, Are Hugo & Smith, Hans-Jørgen (2011). CT of the hips in the investigation of protrusio acetabuli in Marfan syndrome. A case control study. European Radiology. ISSN 0938-7994. 21(7), s. 1485–1491. doi: 10.1007/s00330-011-2073-y. Fulltekst i vitenarkiv
• Aarønæs, Marit; Gullestad, Lars; Aakhus, Svend; Ueland, Thor; Skårdal, Rita & Aass, Halfdan [Vis alle 10 forfattere av denne artikkelen] (2011). Prognostic value of cardiac troponin T in patients with moderate to severe heart failure scheduled for cardiac resynchronization therapy. American Heart Journal. ISSN 0002-8703. 161(6), s. 1031–1037. doi: 10.1016/j.ahj.2010.09.021. Fulltekst i vitenarkiv
• Hagtvedt, Trond; Aaløkken, Trond Mogens; Smith, Hans-Jørgen; Graff, Bjørn Anton; Holte, Harald & Kolbenstvedt, Alf (2011). Enhancement Characteristics of Lymphomatous Lymph Nodes of the Mediastinum. Acta Radiologica. ISSN 0284-1851. 52(10), s. 1113–1118. doi: 10.1258/ar.2011.110265. Fulltekst i vitenarkiv
• Arvidsson, Linda Zamoline; Smith, Hans-Jørgen; Flatø, Berit & Larheim, Tore Arne (2010). Temporomandibular Joint Findings in Adults with Long-standing Juvenile Idiopathic Arthritis: CT and MR Imaging Assessment. Radiology. ISSN 0033-8419. 256(1), s. 191–200. doi: 10.1148/radiol.10091810. Fulltekst i vitenarkiv
• Fjeld, Morten; Arvidsson, Linda Zamoline; Smith, Hans-Jørgen; Flatø, Berit; Øgaard, Bjørn & Larheim, Tore Arne (2010). Relationship between disease course in the temporomandibular joints and mandibular growth rotation in patients with juvenile idiopathic arthritis followed from childhood to adulthood. Pediatric Rheumatology. s. 13–13. doi: 10.1186/1546-0096-8-13. Fulltekst i vitenarkiv Vis sammendrag

  Objective To investigate the relationship between radiographic JIA disease course in the TMJs and mandibular growth rotation, compared with growth in healthy individuals. Methods From a larger series of JIA patients followed from childhood to adulthood, 26 were included; 11 without and 15 with bilateral radiographic TMJ involvement. Joint morphology and function were assessed at baseline, 2-, 4-, 6- and 27 years follow-up. Mandibular growth rotation (anterior, posterior or none) was assessed from cephalometric evaluations at childhood and adulthood, with observations from 16 healthy individuals as controls. TMJ disease course and mandibular growth rotation were assessed independently and their relationship analysed. Non-parametric statistical methods were applied to test differences between groups. Results In the normal TMJ group of JIA patients the joint morphology was similar at the follow-ups and all patients had good function both in childhood and in adulthood. The mandibular growth rotation was similar to that of healthy controls, i.e. predominantly in anterior direction. In the abnormal TMJ group different JIA TMJ disease courses were observed and associated with changes in the mandibular growth rotation (p = 0.007). Progressing JIA TMJ disease course was related to posterior mandibular growth rotation and improving disease course to anterior mandibular growth rotation. Conclusion A relationship was found between JIA disease course in the TMJs and mandibular growth rotation, suggesting that a favourable growth could be regained in patients with improvement in TMJ morphology and/or TMJ function. To confirm this, further research on larger patient series is needed.

• Moosmeyer, Stefan; Lund, Gunnar; Seljom, U; Svege, IC; Nerhus, KT & Kise, N [Vis alle 9 forfattere av denne artikkelen] (2010). Comparison between surgery and physiotherapy in the treatment of small and medium-sized tears of the rotator cuff: A RANDOMISED CONTROLLED STUDY OF 103 PATIENTS WITH ONE-YEAR FOLLOW-UP. Journal of Bone and Joint Surgery (JBJS). ISSN 0301-620X. 92-B(1), s. 83–91. doi: 10.1302/0301-620X.92B1.22609. Fulltekst i vitenarkiv
• Eek, Christian; Grenne, Bjørnar Leangen; Brunvand, Harald; Aakhus, Svend; Endresen, Knut & Hol, Per Kristian [Vis alle 10 forfattere av denne artikkelen] (2010). Strain Echocardiography and Wall Motion Score Index Predicts Final Infarct Size in Patients With Non-ST-Segment-Elevation Myocardial Infarction. Circulation Cardiovascular Imaging. ISSN 1941-9651. 3(2), s. 187–194. doi: 10.1161/CIRCIMAGING.109.910521. Fulltekst i vitenarkiv
• Arvidsson, Linda Zamoline; Fjeld, Morten; Smith, Hans-Jørgen; Flatø, Berit; Øgaard, Bjørn & Larheim, Tore Arne (2010). Craniofacial growth disturbance is related to temporomandibular joint abnormality in patients with juvenile idiopathic arthritis, but normal facial profile was also found at the 27-year follow-up. Scandinavian Journal of Rheumatology. ISSN 0300-9742. 39(5), s. 373–379. doi: 10.3109/03009741003685624. Fulltekst i vitenarkiv
• Moosmeyer, Stefan; Tariq, Rana; Stiris, Morten Georg & Smith, Hans-Jørgen (2010). MRI of symptomatic and asymptomatic full-thickness rotator cuff tears A comparison of findings in 100 subjects. Acta Orthopaedica. ISSN 1745-3674. 81(3), s. 361–366. doi: 10.3109/17453674.2010.483993. Fulltekst i vitenarkiv
• Hagtvedt, Trond; Aaløkken, Trond Mogens; Smith, Hans-Jørgen; Graff, Bjørn Anton; Holte, Harald & Kolbenstvedt, Alf (2010). Enhancement characteristics of lymphomatous lymph nodes of the neck. Acta Radiologica. ISSN 0284-1851. 51(5), s. 555–562. doi: 10.3109/02841851003698198. Fulltekst i vitenarkiv
• Helle-Valle, Thomas Michael; Remme, Espen W.; Lyseggen, Erik; Pettersen, Eirik; Vartdal, Trond & Opdahl, Anders [Vis alle 11 forfattere av denne artikkelen] (2009). Clinical Assessment of Left Ventricular Rotation and Strain - A Novel Approach for Quantification of Function in Infarcted Myocardium and its Border Zones. American Journal of Physiology. Heart and Circulatory Physiology. ISSN 0363-6135. 297(1), s. H257–H267. doi: 10.1152/ajpheart.01116.2008. Fulltekst i vitenarkiv
• Larheim, Tore Arne & Smith, Hans-Jørgen (2009). Avansert maxillofacial bildediagnostikk med vekt på MR (magnetisk resonans) tomografi. Tandlægebladet. ISSN 0039-9353. 113(2), s. 118–133. Fulltekst i vitenarkiv
• Larheim, Tore Arne & Smith, Hans-Jørgen (2009). Avansert maksillofacial bildediagnostikk med vekt på magnetisk resonanstomografi. Den norske tannlegeforenings Tidende. ISSN 0029-2303. 112, s. 94–105. Fulltekst i vitenarkiv
• Larheim, Tore Arne & Smith, Hans-Jørgen (2009). Avancerad maxillofacial bilddiagnostik. Tandläkartidningen. ISSN 0039-6982. 101(2), s. 54–66. Fulltekst i vitenarkiv
• Gjesdal, Ola; Vartdal, Trond; Hopp, Einar; Lunde, Ketil; Brunvand, H. & Smith, Hans-Jørgen [Vis alle 7 forfattere av denne artikkelen] (2009). Left Ventricle Longitudinal Deformation Assessment by Mitral Annulus Displacement or Global Longitudinal Strain in Chronic Ischemic Heart Disease: Are They Interchangeable? Journal of the American Society of Echocardiography. ISSN 0894-7317. 22(7), s. 823–830. doi: 10.1016/j.echo.2009.04.023. Fulltekst i vitenarkiv
• Pettersen, Eirik; Fredriksen, PM; Urheim, S; Thaulow, Erik; Smith, Hans-Jørgen & Smevik, B. [Vis alle 8 forfattere av denne artikkelen] (2009). Ventricular Function in Patients With Transposition of the Great Arteries Operated With Arterial Switch. American Journal of Cardiology. ISSN 0002-9149. 104(4), s. 583–589. doi: 10.1016/j.amjcard.2009.04.029. Fulltekst i vitenarkiv
• Lundby, Rigmor; Rand-Hendriksen, Svend; Hald, John K; Lilleås, Finn G.; Pripp, Are Hugo & Skaar, Sigrun [Vis alle 9 forfattere av denne artikkelen] (2009). Dural Ectasia in Marfan Syndrome: A Case Control Study. American Journal of Neuroradiology. ISSN 0195-6108. 30(8), s. 1534–1540. doi: 10.3174/ajnr.A1620. Fulltekst i vitenarkiv
• Rand-Hendriksen, Svend; Lundby, Rigmor; Tjeldhorn, Lena; Andersen, Kai; Offstad, Jon & Semb, Svein Ove [Vis alle 9 forfattere av denne artikkelen] (2009). Prevalence data on all Ghent features in a cross-sectional study of 87 adults with proven Marfan syndrome. European Journal of Human Genetics. ISSN 1018-4813. 17(10), s. 1222–1230. doi: 10.1038/ejhg.2009.30. Fulltekst i vitenarkiv
• Gjesdal, Ola; Helle-Valle, Thomas Michael; Hopp, Einar; Lunde, Ketil; Vartdal, Trond & Aakhus, Svend [Vis alle 9 forfattere av denne artikkelen] (2008). Noninvasive Separation of Large, Medium, and Small Myocardial Infarcts in Survivors of Reperfused ST-Elevation Myocardial Infarction A Comprehensive Tissue Doppler and Speckle-Tracking Echocardiography Study. Circulation Cardiovascular Imaging. ISSN 1941-9651. 1, s. 189–196. doi: 10.1161/CIRCIMAGING.108.784900. Fulltekst i vitenarkiv Vis sammendrag

  Background— The objective of the study was to evaluate the ability of established and new parameters of global systolic left ventricle function to estimate myocardial infarct size. Increasing infarct extent is associated with impaired prognosis in chronic ischemic heart disease. Systolic myocardial deformation is a complex 3D process that is mainly influenced by the amount and transmural distribution of viable myocardium. Speckle-tracking echocardiography (2D-STE) enables deformation assessment along the 3 main cardiac axes independent of insonation angle. Methods and Results— Global longitudinal, circumferential, and radial strain and left ventricle twist by 2D-STE, global longitudinal strain rate and strain by tissue Doppler imaging, and left ventricle ejection fraction and wall motion score index were assessed in 40 patients 8.5±5.4 months after a first myocardial infarct and compared with global myocardial infarct mass assessed by contrast-enhanced MRI. Longitudinal and circumferential strain by 2D-STE and longitudinal strain and strain rate by tissue Doppler imaging significantly separated medium-sized infarcts from small or large infarcts at the global level (P<0.05). All deformation indices correlated significantly with global infarct mass (P<0.01). Circumferential and longitudinal strains by 2D-STE demonstrated the best ability to identify medium-sized global myocardial infarcts. Conclusions— Circumferential and longitudinal strains by 2D-STE correlate with myocardial infarct mass and significantly differentiate among large, medium, and small myocardial infarcts.

• Pettersen, Eirik; Lindberg, Harald; Smith, Hans-Jørgen; Smevik, Bjarne; Edvardsen, Thor & Smiseth, Otto A. [Vis alle 7 forfattere av denne artikkelen] (2008). Left ventricular function in patients with transposition of the great arteries operated with atrial switch. Pediatric Cardiology. ISSN 0172-0643. 29(3), s. 597–603. doi: 10.1007/s00246-007-9156-1. Fulltekst i vitenarkiv Vis sammendrag

  In patients operated with atrial switch for transposition of the great arteries (TGA), the left ventricle (LV) supports the pulmonary circulation and is thus pressure unloaded. Evaluation of LV function in this setting is of importance, as LV functional abnormalities have been documented and might contribute to development of symptoms. The ventricular contraction pattern in 14 Senning-operated TGA patients and 14 healthy controls was studied using tissue Doppler and magnetic resonance imaging. In the subpulmonary LV free wall, longitudinal strain was greater than circumferential strain (-23.6 +/- 3.6% vs. -19.1 +/- 3.2%, p = 0.002) as in the normal right ventricle (RV) (-30.7 +/- 3.3% vs. -15.8 +/- 1.3%, p < 0.001), but opposite to findings in the normal LV (-16.5 +/- 1.7% vs. -25.7 +/- 3.1%, p < 0.001). Subpulmonary strain and strain rate values were intermediate between those in the normal LV and RV. Ventricular free-wall torsion was reduced in the subpulmonary LV compared with both the normal LV (5.7 +/- 3.2 degrees vs. 16.7 +/- 5.6 degrees , p < 0.001) and RV (5.7 +/- 3.2 degrees vs. 11.4 +/- 2.6 degrees , p < 0.05). Furthermore, early diastolic filling of the subpulmonary LV differed from that of the normal LV. The subpulmonary LV displayed predominantly longitudinal shortening, as did its functional counterpart, the normal RV. However, the degree and rate of both longitudinal and circumferential shortening were intermediate between those of the normal LV and RV. This could represent a partial adaptation to the reduced pressure load. Decreased ventricular torsion and diastolic abnormalities might indicate subclinical ventricular dysfunction.

• Dorenberg, EJ; Jakobsen, Jarl Åsbjørn; Brabrand, K; Hafsahl, G & Smith, Hans-Jørgen (2007). The feasibility of contrast-enhanced ultrasound during uterine artery embolization: A pilot study. Cardiovascular and Interventional Radiology. ISSN 0174-1551. 30, s. 882–887. doi: 10.1007/s00270-007-9007-8. Fulltekst i vitenarkiv
• Vartdal, Trond; Brunvand, H; Pettersen, Eirik; Smith, Hans-Jørgen; Lyseggen, Erik & Helle-Valle, Thomas [Vis alle 9 forfattere av denne artikkelen] (2007). Early prediction of infarct size by strain Doppler echocardiography after coronary reperfusion. Journal of the American College of Cardiology. ISSN 0735-1097. 49. doi: 10.1016/j.jacc.2006.12.047. Fulltekst i vitenarkiv
• Pettersen, Eirik; Helle-Valle, Thomas; Edvardsen, Thor; Lindberg, Harald; Smith, Hans-Jørgen & Smevik, Bjarne [Vis alle 8 forfattere av denne artikkelen] (2007). Contraction pattern of the systemic right ventricle - Shift from longitudinal to circumferential shortening and absent global ventricular torsion. Journal of the American College of Cardiology. ISSN 0735-1097. 49, s. 2450–2456. doi: 10.1016/j.jacc.2007.02.062. Fulltekst i vitenarkiv
• Moosmayer, S; Heir, S & Smith, Hans-Jørgen (2007). Sonography of the rotator cuff in painful shoulders performed without knowledge of clinical information: Results from 58 sonographic examinations with surgical correlation. Journal of Clinical Ultrasound. ISSN 0091-2751. 35, s. 20–26. doi: 10.1002/jcu.20286. Fulltekst i vitenarkiv
• Gjesdal, Ola; Hopp, Einar; Vartdal, Trond; Lunde, Ketil; Helle-Valle, Thomas & Aakhus, Svend [Vis alle 9 forfattere av denne artikkelen] (2007). Global longitudinal strain by two-dimensional speckle tracking echocardiography is closely related to myocardial infarct size in chronic ischaemic heart disease. Clinical Science. ISSN 0143-5221. 113, s. 287–296. doi: 10.1042/CS20070066. Fulltekst i vitenarkiv
• Munkeby, Berit Holthe; Smith, Hans-Jørgen; Winther-Larssen, Eldrid Hugaas; Bjørnerud, Atle & Bjerkås, I (2006). Magnetic resonance imaging of the Harderian gland in piglets. Journal of Anatomy. ISSN 0021-8782. 209, s. 699–705. doi: 10.1111/j.1469-7580.2006.00642. Fulltekst i vitenarkiv Vis sammendrag

  The main purpose of the present study was to investigate the value and effectiveness of functional and morphological magnetic resonance imaging (MRI), in order to assess the extent of brain injury in a hypoxic–ischaemic piglet model, and further to validate that the ischaemic injury was successfully induced. In this way, we also characterized the Harderian gland. MRI was performed at 1.5 T in anaesthetized piglets (n = 10, 12–36 h of age). Magnetic resonance perfusion and diffusion imaging were performed at different time points, before, during and after the induction of hypoxia–ischaemia. The effects following bilateral clamping of the carotid arteries were also assessed by contrast-enhanced magnetic resonance angiography. Morphological assessment included T1- and T2-weighted imaging, and fat-suppressed T1-weighted imaging before and after contrast medium enhancement. Morphological MRI revealed a prominent, well-defined structure located at the eyeball. Magnetic resonance angiography reconstructed with volume rendering showed this structure to be partially enclosed by large venous sinuses. At dissection, when compared with the magnetic resonance images, the deep gland of the third eyelid, the Harderian gland, corresponded to this structure both in topography and in size. By contrast, the lacrimal gland proper presented as a small, soft and pale structure that was difficult to distinguish from the surrounding connective tissue. At histological examination, the Harderian gland consisted mainly of compact areas of tubuloacinar glands with abundant eosinophilic granules. The present MRI demonstration of the Harderian gland was an accidental finding during an investigation to assess the extent of brain injury in a hypoxic–ischaemic piglet model. The combination of MRI and histology made it possible to detect and describe the Harderian gland in pig. It has generally been studied in rodents and lower vertebrates and is reported to possess various endocrine and exocrine functions

• Larheim, Tore Arne; Westesson, Per-Lennart; Smith, Hans-Jørgen & Koppang, Hanna Strømme (2006). Benign Jaw Tumors and Tumor-like Conditions, Maxillofacial Imaging. Springer. ISSN 9783540254232. s. 39–86. Fulltekst i vitenarkiv
• Larheim, Tore Arne; Westesson, Per-Lennart; Smith, Hans-Jørgen & Koppang, Hanna Strømme (2006). Jaw Cysts, Maxillofacial Imaging. Springer. ISSN 9783540254232. s. 21–37. Fulltekst i vitenarkiv
• Larheim, Tore Arne; Westesson, Per-Lennart; Kakimoto, Naoya & Smith, Hans-Jørgen (2006). Maxillofacial Imaging Anatomy, Maxillofacial Imaging. Springer. ISSN 9783540254232. s. 1–20. Fulltekst i vitenarkiv
• Larheim, Tore Arne; Westesson, Per-Lennart; Smith, Hans-Jørgen & Støre, Geir (2006). Malignant Tumors in the Jaws, Maxillofacial Imaging. Springer. ISSN 9783540254232. s. 87–118. Fulltekst i vitenarkiv
• Glomset, Otto; Hellesnes, J; Heimland, N; Hafsahl, Geir & Smith, Hans-Jørgen (2006). Assessment of organ radiation dose associated with uterine artery embolization. Acta Radiologica. ISSN 0284-1851. 47(2), s. 179–185. Fulltekst i vitenarkiv
• Kirkhus, Eva; Bjørnerud, Atle; Thoen, Jørn; Johnston, Virginia; Dale, Knut & Smith, Hans-Jørgen (2006). Contrast-enhanced dynamic magnetic resonance imaging of finger joints in osteoarthritis and rheumatoid arthritis: an analysis based on pharmacokinetic modeling. Acta Radiologica. ISSN 0284-1851. 47(8), s. 845–851. Fulltekst i vitenarkiv
• Berstad, Audun Elnæs; Aabakken, Lars; Smith, Hans-Jørgen; Aasen, Steinar; Boberg, Kirsten Muri & Schrumpf, Erik (2006). Diagnostic accuracy of magnetic resonance and endoscopic retrograde cholangiography in primary sclerosing cholangitis. Clinical Gastroenterology and Hepatology. ISSN 1542-3565. 4(4), s. 514–520. Fulltekst i vitenarkiv
• Sauter, Axel Rudolf; Smith, Hans-Jørgen; Stubhaug, Audun; Dodgson, Michael S. & Klaastad, Øivind (2006). Use of Magnetic Resonance Imaging to Define the Anatomical Location Closest to All Three Cords of the Infraclavicular Brachial Plexus. Anesthesia and Analgesia. ISSN 0003-2999. 103, s. 1574–1576. Fulltekst i vitenarkiv
• Lingaas, Per Snorre; Hol, Per Kristian; Lundblad, Runar; Rein, Kjell Arne; Mathisen, Lars & Smith, Hans-Jørgen [Vis alle 14 forfattere av denne artikkelen] (2006). Clinical and Radiological Outcome of Off-Pump Coronary Surgery at 12 Months Follow-Up: A Prospective Randomized Trial. Annals of Thoracic Surgery. ISSN 0003-4975. 81(6), s. 289–295. doi: 10.1016/j.athoracsur.2005.12.003. Fulltekst i vitenarkiv
• Lunde, Ketil; Solheim, S; Aakhus, Svend; Arnesen, Harald; Abdelnoor, M & Egeland, T [Vis alle 20 forfattere av denne artikkelen] (2006). Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. New England Journal of Medicine. ISSN 0028-4793. 355(12), s. 1199–1209. Fulltekst i vitenarkiv

Se alle arbeider i NVA

• Abildgaard, Andreas; Hopp, Einar; Sakinis, Tomas; Roterud, Håvard; Bjørnerud, Atle & Beyer, Mona K. [Vis alle 7 forfattere av denne artikkelen] (2018). Vil radiologer bli erstattet av kunstig intelligens? 138(17). doi: 10.4045/tidsskr.18.0587. Fulltekst i vitenarkiv
• Johansen, Anna Karin; Larheim, Tore Arne; Arvidsson, Linda Zamoline & Smith, Hans-Jørgen (2012). TMJ osteoarthritis development - does disc displacement play a role? Fulltekst i vitenarkiv
• Helle-Valle, Thomas Michael; Smith, Hans-Jørgen; Hopp, Einar; Lunde, Ketil; Vartdal, Trond & Gjesdal, Ola [Vis alle 8 forfattere av denne artikkelen] (2011). Transmural infarct distribution in reperfused myocardium after STEMI. Fulltekst i vitenarkiv
• Lundby, Rigmor; Rand-Hendriksen, Svend; Smith, Hans-Jørgen & Hald, John K (2010). Assessment of Dural Ectasia in Marfan Syndrome. Fulltekst i vitenarkiv
• Arvidsson, Linda Zamoline; Fjeld, Morten; Smith, Hans-Jørgen; Flatø, Berit; Øgaard, Bjørn & Larheim, Tore Arne (2010). Relationship between disease course in the temporomandibular joints and mandibular growth rotation in patients with juvenile idiopathic arthritis followed from childhood to adulthood. Fulltekst i vitenarkiv
• Moosmeyer, Stefan; Lund, G; Seljom, U; Svege, I; Hennig, T & Tariq, R [Vis alle 7 forfattere av denne artikkelen] (2010). Surgery Was Superior to Physiotherapy for Small and Medium-Size Rotator Cuff Tears. Journal of Bone and Joint Surgery. American volume. ISSN 0021-9355. 92A(10), s. 1997–1997. doi: 10.2106/JBJS.9210.ebo181. Fulltekst i vitenarkiv
• Arvidsson, Linda Zamoline; Fjeld, Morten; Smith, Hans-Jørgen; Flatø, Berit; Øgaard, Bjørn & Larheim, Tore Arne (2009). Associations between CT and MRI assessments of the temporomandibular joint and craniofacial growth disturbances: a 27 year follow-up of patients with juvenile idiopathic arthritis. Fulltekst i vitenarkiv
• Arvidsson, Linda Zamoline; Fjeld, Morten; Smith, Hans-Jørgen; Flatø, Berit; Øgaard, Bjørn & Larheim, Tore Arne (2009). Temporomandibular joint involvement and craniofacial morphology in 60 adult patients with juvenile idiopathic arthritis. Fulltekst i vitenarkiv
• Arvidsson, Linda Zamoline; Fjeld, Morten; Smith, Hans-Jørgen; Flatø, Berit; Øgaard, Bjørn & Larheim, Tore Arne (2009). Temporomandibular joint involvement and craniofacial morphology in 60 adult patients with juvenile idiopathic arthritis. Fulltekst i vitenarkiv
• Helle-Valle, Thomas Michael; Pettersen, Eirik; Vartdal, Trond; Lyseggen, Erik; Opdahl, Anders & Remme, Espen W. [Vis alle 11 forfattere av denne artikkelen] (2009). Strain Mapping by Speckle Tracking Echocardiography: A Novel Approach for Detailed Quanti. cation of Infarct Transmurality Irregularities After STEMI. Journal of the American College of Cardiology. ISSN 0735-1097. 53(10), s. A259–A260. Fulltekst i vitenarkiv
• Eek, Christian; Grenne, Bjørnar Leangen; Smith, Hans-Jørgen; Brunvand, H.; Aakhus, Svend & Smiseth, Otto A. [Vis alle 8 forfattere av denne artikkelen] (2009). Global strain is a strong predictor of infarct size in patients hospitalized with NSTEMI. Fulltekst i vitenarkiv
• Beitnes, JO; Hopp, Einar; Lunde, Ketil; Smith, Hans-Jørgen; Solheim, Svein & Arnesen, Harald [Vis alle 9 forfattere av denne artikkelen] (2008). Long-term follow-up of left ventricular function after acute myocardial infarction treated with intracoronary injection of autologous bone marrow cells. The ASTAMI Study. Fulltekst i vitenarkiv
• Lundby, Rigmor; Rand-Hendriksen, Svend; Skaar, Sigrun; Lilleås, Finn G.; Pripp, Are Hugo & Smith, Hans-Jørgen [Vis alle 7 forfattere av denne artikkelen] (2008). Dural Ectasia in Marfan Syndrome: A Case Control Study. Fulltekst i vitenarkiv Vis sammendrag

  Abstract: Purpose Marfan syndrome (MFS) is a hereditary connective tissue disorder involving several organ systems. The diagnosis should be based upon the Gent criteria. Dural ectasia (DE) is one of the major criteria for MFS, but no gold standard for the assessment of DE exists, and this may contribute to the widely differing prevalences of DE between different reports. The purpose of this study was to establish the prevalence of DE in an adult population of patients fulfilling the Gent criteria for MFS. Materials & Methods A case control study was approved by the local ethics committee. One hundred five adult patients with suspected MFS were included. MR imaging at 1.5 T including sagittal T1- and T2-weighted images, was performed unless contraindicated, when CT was obtained instead. Anteroposterior vertebral body diameter (VBD) and dural sac diameter (DSD) at midcorpus level of L3, L4, L5, and S1 were measured on sagittal MR images perpendicular to the long axes of the vertebral bodies. Dural sac ratios (DSR = DSD/VBD) were calculated. Scalloping, anterior meningoceles and herniations of the nerve root sleeves were characterized. One hundred one sex- and age-matched patients without MFS or disease of the lumbosacral spine, examined with MRI at 1.5 T, including sagittal T1- and T2-weighted images were included as controls. Results Three patient groups and one control group were identified (Table): (1) Fulfilling Gent criteria independent of DE (n=73), (2) Fulfilling Gent dependent on DE (n=14), (3) Suspected MFS, not fulfilling Gent (n=18), and (4) Controls (n=101). At every level mean DSRs were significantly higher in Gent positive patients than in suspected MFS patients not fulfilling Gent criteria (group 3), and controls (p < 0.001). Herniations of the nerve root sleeves were present at one or more levels in 73% in group 1, 71% in group 2, 11% in group 3, and 1% in group 4. Anterior meningoceles were found in 37% in group 1 and 14% in group 2. There were no meningoceles in group 3 and 4. Table. DSRs at level L3 - S1 in four different patient groups. At each level, difference in annotation (a-c) indicates statistically significant difference. DE: dural ectasia. Fulfilling Gent independent of DE Fulfilling Gent dependent on DE Suspected MFS, not fulfilling Gent Controls n Mean DSR SD n Mean DSR SD N Mean DSR SD n Mean DSR SD L3 69 0.50b c 0,11 14 0,53c 0,06 18 0,43a 0,08 101 0,46a b 0,07 L4 71 0.50b 0,12 13 0,50b 0,05 18 0,41a 0,06 101 0,43a 0,07 L5 68 0.57b 0,18 14 0,65b 0,2 18 0,39a 0,09 101 0,42a 0,08 S1 61 0.93b 0,72 13 1,02b 0,77 12 0,40a 0,12 96 0,41a 0,13 Conclusion Dural ectasia was found in 89% of patients fulfilling the Gent criteria independent of the major criterion DE. MR imaging of the spine is encouraged to identify MFS patients dependent on DE to fulfill the Gent criteria. Herniation of dura through the nerve root sleeve is one of the most frequent pathologic findings in DE. References 1. Weigang E, Ghanem N, Chang XC, Richter H, Frydrychowicz A, Szabo G, et al. Evaluation of three different measurement methods for dural ectasia in Marfan syndrome. Clin Radiol 2006;61(11):971-978

• Gjesdal, Ola; Vartdal, Trond; Helle-Valle, Thomas Michael; Lunde, Ketil; Hopp, Einar & Smith, Hans-Jørgen [Vis alle 8 forfattere av denne artikkelen] (2008). Global strain is superior to mitral annulus displacement to quantify myocardial infarct mass in chronic ischemic heart disease. Fulltekst i vitenarkiv
• Gjesdal, Ola; Helle-Valle, Thomas Michael; Lunde, Ketil; Hopp, Einar; Vartdal, Trond & Smith, Hans-Jørgen [Vis alle 8 forfattere av denne artikkelen] (2008). Segment analyses improves the accuracy of global deformation assessment in ischemic heart disease. Fulltekst i vitenarkiv
• Vartdal, Trond; Pettersen, Eirik; Helle-Valle, Thomas Michael; Lyseggen, Erik; Smith, Hans-Jørgen & Ihlen, Halfdan [Vis alle 9 forfattere av denne artikkelen] (2008). Early prediction of tissue viability in acute myocardial infarction by strain Doppler. Fulltekst i vitenarkiv
• Smedsrud, Marit Kristine; Remme, Espen W.; Lyseggen, Erik; Helle-Valle, Thomas; Gjesdal, Ola & Smith, Hans-Jørgen [Vis alle 8 forfattere av denne artikkelen] (2007). Apical rocking in patients with myocardial infarction. Fulltekst i vitenarkiv
• Gjesdal, Ola; Helle-Valle, Thomas; Lunde, Ketil; Hopp, Einar; Vartdal, Trond & Smith, Hans-Jørgen [Vis alle 8 forfattere av denne artikkelen] (2007). Echocardiographic strain parameters in 3 dimensions predict the extent of scar transmurality in chronic ischaemic heart disease. Fulltekst i vitenarkiv
• Gjesdal, Ola; Helle-Valle, Thomas; Lunde, Ketil; Hopp, Einar; Vartdal, Trond & Smith, Hans-Jørgen [Vis alle 8 forfattere av denne artikkelen] (2007). Global strain reflects the extent of scar in patients with myocardial infarcts. A comparison of longitudinal, circumferential and radial strain measurements. Fulltekst i vitenarkiv
• Vartdal, Trond; Brunvand, Harald; Pettersen, Eirik; Smith, Hans-Jørgen; Lyseggen, Erik & Helle-Valle, Thomas [Vis alle 9 forfattere av denne artikkelen] (2007). Early prediction of infarct size by strain Doppler echocardiography after coronary reperfusion. Fulltekst i vitenarkiv
• Helle-Valle, Thomas; Remme, Espen W.; Lyseggen, Erik; Vartdal, Trond; Pettersen, Eirik & Opdahl, Anders [Vis alle 11 forfattere av denne artikkelen] (2007). Combined assessment of left ventricular strain and rotation - A novel approach for assessment of function in infarcted myocardium and its border zones. Fulltekst i vitenarkiv
• Gjesdal, Ola; Helle-Valle, Thomas; Lunde, Ketil; Hopp, Einar; Vartdal, Trond & Smith, Hans-Jørgen [Vis alle 8 forfattere av denne artikkelen] (2007). Global strain gjenspeiler infarktstørrelsen hos pasienter med gjennomgått hjerteinfarkt. Kontraktil funksjon i 3 dimensjoner. Fulltekst i vitenarkiv
• Vartdal, Trond; Gjesdal, Ola; Helle-Valle, Thomas; Lunde, Ketil; Hopp, Einar & Smith, Hans-Jørgen [Vis alle 8 forfattere av denne artikkelen] (2007). Global LV Strain Is An Accurate Measure For Scar Extent After Myocardial Infarct. A Comparison of Longitudinal, Circumferential And Radial Strain Measurements. Fulltekst i vitenarkiv
• Vartdal, Trond; Pettersen, Eirik; Helle-Valle, Thomas; Lyseggen, Erik; Smith, Hans-Jørgen & Andersen, Kai [Vis alle 8 forfattere av denne artikkelen] (2007). Improved Detection of Viable Myocardium by a Novel Strain Doppler Measure in Patients with Acute Myocardial Infarction. Fulltekst i vitenarkiv
• Arvidsson, Linda Zamoline; Knutsen, Bjørn Mork; Koppang, Hanna Strømme; Smith, Hans-Jørgen; Johannessen, Stein & Madsen, Martin [Vis alle 10 forfattere av denne artikkelen] (2006). Ameloblastoma of the mandible with malignant features(?)and oral mucosa involvement: A case report of a very rare tumor. Fulltekst i vitenarkiv
• Smith, Hans-Jørgen (2006). MR av hjertet. Fulltekst i vitenarkiv
• Smith, Hans-Jørgen (2006). MR av lever, galleveier og pancreas - en oversikt. Fulltekst i vitenarkiv
• Smith, Hans-Jørgen (2006). MR av thorax og hjerte. Fulltekst i vitenarkiv
• Smith, Hans-Jørgen (2006). MR i kardiologien. Struktur, perfusjon, dagens status i kardiologien. Fulltekst i vitenarkiv
• Gjesdal, Ola; Hopp, Einar; Vartdal, Trond; Lunde, Ketil; Helle-Valle, Thomas & Smith, Hans-Jørgen [Vis alle 8 forfattere av denne artikkelen] (2006). Strain Analyzes by Speckle Tracking Echocardiography Predicts Infarct Size and Level of Transmurality. Fulltekst i vitenarkiv
• Helle-Valle, Thomas; Vartdal, Trond; Smith, Hans-Jørgen; Ihlen, Halfdan; Smiseth, Otto A. & Edvardsen, Thor (2006). Differentiation between transmural and non-transmural infarction by assessment of circumferential strain by speckle tracking echocardiography. Fulltekst i vitenarkiv
• Pettersen, Eirik; Helle-Valle, Thomas; Smith, Hans-Jørgen & Andersen, Kai (2006). Interventricular septal function in patients with systemic right ventricle. Fulltekst i vitenarkiv
• Gjesdal, Ola; Hopp, Einar; Vartdal, Trond; Lunde, Ketil; Helle-Valle, Thomas & Smith, Hans-Jørgen [Vis alle 8 forfattere av denne artikkelen] (2006). Global Longitudinal Strain by Speckle Tracking Echocardiography Correlates to Myocardial Infarct Size by MRI in Chronic Ischemic Heart Disease. Fulltekst i vitenarkiv
• Helle-Valle, Thomas; Vartdal, Trond; Smith, Hans-Jørgen; Lunde, Ketil; Ihlen, Halfdan & Smiseth, Otto A. [Vis alle 7 forfattere av denne artikkelen] (2006). Circumferential Strain by Speckle Tracking Echocardiography reflects transmural infarct extent. Fulltekst i vitenarkiv
• Vartdal, Trond; Pettersen, Eirik; Smith, Hans-Jørgen; Lyseggen, Erik; Helle-Valle, Thomas & Ihlen, Halfdan [Vis alle 8 forfattere av denne artikkelen] (2006). Can strain Doppler echocardiography predict viability in patients with acute myocardial infarction? Fulltekst i vitenarkiv
• Pettersen, Eirik; Helle-Valle, T; Edvardsen, Thor; Smith, Hans-Jørgen; Smiseth, Otto A. & Andersen, Kai (2006). Lack of global ventricular torsion in the systemic right ventricle. Fulltekst i vitenarkiv
• Moosmeyer, Stefan & Smith, Hans-Jørgen (2010). Tears of the rotator cuff – diagnosis, treatment and symptomatic status. Universitetet i Oslo. ISSN 9788282641043. Fulltekst i vitenarkiv

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