Ibrahim Akkouh

• Akkouh, Ibrahim; Hughes, Timothy; Steen, Vidar Martin; Glover, Joel; Andreassen, Ole Andreas; Djurovic, Srdjan & Szabo, Attila (2021). Transcriptome analysis reveals disparate expression of inflammation-related miRNAs and their gene targets in iPSC-astrocytes from people with schizophrenia. Brain, behavior, and immunity.  ISSN 0889-1591. . doi: 10.1016/j.bbi.2021.01.037
• de Assis, Denis; Szabo, Attila; Osete, Jordi Requena; Puppo, Francesca; O'Connell, Kevin S.; Akkouh, Ibrahim; Hughes, Timothy; Frei, Evgeniia; Andreassen, Ole Andreas & Djurovic, Srdjan (2021). Using iPSC Models to Understand the Role of Estrogen in Neuron–Glia Interactions in Schizophrenia and Bipolar Disorder. Cells.  ISSN 2073-4409.  10(2) . doi: 10.3390/cells10020209 Fulltekst i vitenarkiv.
• Akkouh, Ibrahim; Ueland, Thor; Hansson, Lars; Inderhaug, Elin; Hughes, Timothy; Steen, Nils Eiel; Aukrust, Pål; Andreassen, Ole Andreas; Szabo, Attila & Djurovic, Srdjan (2020). Decreased IL-1β-induced CCL20 response in human iPSC-astrocytes in schizophrenia: Potential attenuating effects on recruitment of regulatory T cells. Brain, behavior, and immunity.  ISSN 0889-1591.  87, s 634- 644 . doi: 10.1016/j.bbi.2020.02.008 Fulltekst i vitenarkiv.
• Hughes, Timothy; Hansson, Lars Johan Axel; Akkouh, Ibrahim; Hajdarevic, Riad; Bringsli, Jorunn; Torsvik, Anja; Inderhaug, Elin; Steen, Vidar Martin & Djurovic, Srdjan (2020). Runaway multi-allelic copy number variation at the α-defensin locus in African and Asian populations. Scientific Reports.  ISSN 2045-2322.  10(9101), s 1- 8 . doi: 10.1038/s41598-020-65675-w Fulltekst i vitenarkiv. Vis sammendrag

  Alpha defensins are anti-microbial peptides of the innate immune system. The defensin A1 and A3 genes are located in a repeat array of variable copy number (the DEFA1A3 locus) and encode the human neutrophil peptides 1, 2 and 3. The possibility that copy number variation (CNV) may be associated with infection susceptibility and autoimmune pathology motivated the study of DEFA1A3 CNV across populations. We enhanced two existing methods (one qPCR-based and one sequencingbased) to enable copy number estimation that discriminates between DEFA1 and DEFA3 genes. We used these methods to quantify A1/A3 copy number variation in 2504 samples from the 1000 Genomes high-coverage dataset as well as performing FiberFISH assays on selected samples to visualize the haplotypes. These methods produce accurate estimates and show that there are substantial diferences between populations. The African population is a clear outlier with a high frequency of the ancestral pure DEFA1 haplotype, but also harbours exceptionally long haplotypes of 24 copies of both DEFA1 and DEFA3, whilst the East Asian population displays the highest mean level of DEFA3 copy number. Further, our fndings demonstrate that qPCR can be an accurate method for CNV estimation and that defensins substantially extend the known range of copy number variation for a human protein-coding gene.

• Szabo, Attila; Akkouh, Ibrahim; Ueland, Thor; Lagerberg, Trine Vik; Dieset, Ingrid; Bjella, Thomas; Aukrust, Pål; Le Hellard, Stephanie; Stavrum, Anne-Kristin; Melle, Ingrid; Andreassen, Ole Andreas & Djurovic, Srdjan (2020). Cannabis Use Is Associated With Increased Levels of Soluble gp130 in Schizophrenia but Not in Bipolar Disorder. Frontiers in Psychiatry.  ISSN 1664-0640.  11, s 1- 10 . doi: 10.3389/fpsyt.2020.00642 Fulltekst i vitenarkiv.
• Akkouh, Ibrahim; Skrede, Silje; Holmgren, Asbjørn; Ersland, Kari Merete; Hansson, Lars Johan Axel; Bahrami, Shahram; Andreassen, Ole Andreas; Steen, Vidar Martin; Djurovic, Srdjan & Hughes, Timothy (2019). Exploring lithium's transcriptional mechanisms of action in bipolar disorder: a multi-step study. Neuropsychopharmacology.  ISSN 0893-133X.  s 1- 9 . doi: 10.1038/s41386-019-0556-8 Fulltekst i vitenarkiv.
• Akkouh, Ibrahim; Ueland, Torill; Andreassen, Ole Andreas; Brattbakk, Hans-Richard; Steen, Vidar Martin; Hughes, Timothy & Djurovic, Srdjan (2018). Expression of TCN1 in Blood is Negatively Associated with Verbal Declarative Memory Performance. Scientific Reports.  ISSN 2045-2322.  8:12654, s 1- 11 . doi: 10.1038/s41598-018-30898-5 Fulltekst i vitenarkiv.

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