Jens Bollerslev

• Bollerslev, Jens; Pretorius, Mikkel & Heck, Ansgar (2018). Parathyroid hormone independent hypercalcemia in adults. Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism.  ISSN 1521-690X.  In Press, Corrected Proof, s 1- 18 . doi: 10.1016/j.beem.2018.06.005
• Dal, Jakob; Klose, Marianne; Heck, Ansgar; Andersen, Marianne; Kistorp, Caroline; Nielsen, Eigil H.; Bollerslev, Jens; Feldt-Rasmussen, Ulla & Jørgensen, Jens O.L. (2018). Targeting either GH or IGF-I during somatostatin analogue treatment in patients with acromegaly: A randomized multicentre study. European Journal of Endocrinology.  ISSN 0804-4643.  178(1), s 65- 74 . doi: 10.1530/EJE-17-0546
• Von Düring, Marit Elizabeth; Jenssen, Trond Geir; Bollerslev, Jens; Godang, Kristin; Hartmann, Anders & Åsberg, Anders (2018). Arterial stiffness is associated with visceral fat mass in kidney transplanted patients—A nationwide cohort study. Clinical Transplantation.  ISSN 0902-0063.  32(8) . doi: 10.1111/ctr.13341
• Walker, Marcella D. & Bollerslev, Jens (2018). Vitamin D and Primary Hyperparathyroidism. Frontiers of Hormone Research.  ISSN 0301-3073.  50, s 125- 137 . doi: 10.1159/000486076
• A. Touw, Wilhelmina; Ueland, Thor; Bollerslev, Jens; Schousboe, John; Lim, Wai H.; Wong, Germaine; Thompson, Peter; Prince, Richard L.; Kiel, Douglas P.; Rivadeneira, Fernando & Lewis, Joshua R. (2017). Association of Circulating Wnt Antagonists With Severe Abdominal Aortic Calcification in Elderly Women. Journal of the Endocrine Society.  ISSN 2472-1972.  1(1), s 26- 28 . doi: 10.1210/js.2016-1040
• Christensen, Jacob J.; Ulven, Stine Marie; Retterstøl, Kjetil; Narverud, Ingunn; Bogsrud, Martin Prøven; Henriksen, Tore; Bollerslev, Jens; Halvorsen, Bente; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Comprehensive lipid and metabolite profiling of children with and without familial hypercholesterolemia: A cross-sectional study. Atherosclerosis.  ISSN 0021-9150.  266, s 48- 57 . doi: 10.1016/j.atherosclerosis.2017.09.021
• Falch, Camilla Maria; Meenakshi Sundaram, Arvind Yegambaram; Øystese, Kristin Astrid Berland; Normann, Kjersti Ringvoll; Lekva, Tove; Silamikelis, Ivars; Eieland, Alexander Kirkeby; Andersen, Marianne; Bollerslev, Jens & Olarescu, Nicoleta Cristina (2017). Gene expression profiling of fast- and slow-growing non-functioning gonadotroph pituitary adenomas. European Journal of Endocrinology.  ISSN 0804-4643.  178(3), s 295- 307 . doi: 10.1530/EJE-17-0702
• Lekva, Tove; Michelsen, Annika; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens & Ueland, Thor (2017). Leptin and adiponectin as predictors of cardiovascular risk after gestational diabetes mellitus. Cardiovascular Diabetology.  ISSN 1475-2840.  16:5(1), s 1- 10 . doi: 10.1186/s12933-016-0492-4 Fulltekst i vitenarkiv.
• Lekva, Tove; Michelsen, Annika; Aukrust, Pål; Roland, Marie Cecilie; Henriksen, Tore; Bollerslev, Jens & Ueland, Thor (2017). CXC chemokine ligand 16 is increased in gestational diabetes mellitus and preeclampsia and associated with lipoproteins in gestational diabetes mellitus at 5 years follow-up. Diabetes & vascular disease research.  ISSN 1479-1641.  14(6), s 525- 533 . doi: 10.1177/1479164117728011
• Lekva, Tove; Roland, Marie Cecilie; Michelsen, Annika; Friis, Camilla Margrethe; Aukrust, Pål; Bollerslev, Jens; Henriksen, Tore & Ueland, Thor (2017). Large reduction in adiponectin during pregnancy is associated with large-for-gestational-age newborns. Journal of Clinical Endocrinology and Metabolism.  ISSN 0021-972X.  102(7), s 2552- 2559 . doi: 10.1210/jc.2017-00289
• Lundstam, Karolina; Heck, Ansgar; Godang, Kristin; Mollerup, Charlotte; Baranowski, Marek; Pernow, Ylva; Aas, Turid; Hessman, Ola; Rosén, Thord; Nordenström, Jörgen; Jansson, Svante; Hellström, Mikael & Bollerslev, Jens (2017). Effect of surgery versus observation: skeletal 5-year outcomes in a randomized trial of patients with primary HPT (the SIPH Study). Journal of Bone and Mineral Research.  ISSN 0884-0431.  32(9), s 1907- 1914 . doi: 10.1002/jbmr.3177
• Polyzos, Stergios A; Duntas, Leonidas & Bollerslev, Jens (2017). The intriguing connections of leptin to hyperparathyroidism. Endocrine (Basingstoke).  ISSN 1355-008X.  s 1- 12 . doi: 10.1007/s12020-017-1374-6
• Ragnarsson, Oskar; Stomby, Andreas; Dahlqvist, Per; Evang, Johan Arild; Ryberg, Mats; Olsson, Tommy; Bollerslev, Jens; Nyberg, Lars & Jóhannsson, Guðmundur (2017). Decreased prefrontal functional brain response during memory testing in women with Cushing's syndrome in remission. Psychoneuroendocrinology.  ISSN 0306-4530.  82, s 117- 125 . doi: 10.1016/j.psyneuen.2017.05.010
• Selland, Mette; Smeland, Knut Bjøro; Bjøro, Trine; Falk, Ragnhild Sørum; Fosså, Sophie Dorothea; Gjesdal, Clara Gram; Godang, Kristin; Holte, Harald; Svartberg, Johan; Syversen, Unni; Bollerslev, Jens & Kiserud, Cecilie E. (2017). Bone mineral density is close to normal for age in long-term lymphoma survivors treated with high-dose therapy with autologous stem cell transplantation. Acta Oncologica.  ISSN 0284-186X.  56(4), s 590- 598 . doi: 10.1080/0284186X.2016.1267870
• Smerud, Knut Terje; Åsberg, Anders; Kile, Håkon; Pasch, Andreas; Dahle, Dag Olav; Bollerslev, Jens; Godang, Kristin & Hartmann, Anders (2017). A rapid and sustained improvement of calcification propensity score (serum T50) after successful kidney transplantation: Reanalysis of a randomized controlled trial of ibandronate. Clinical Transplantation.  ISSN 0902-0063.  31(12) . doi: 10.1111/ctr.13131 Fulltekst i vitenarkiv.
• Valassi, Elena; Franz, Holger; Brue, Thierry; Feelders, Richard A.; Netea-Maier, Romana; Tsagarakis, Stylianos; Webb, Susan M.; Yaneva, Maria; Reincke, Martin; Droste, Michael; Komerdus, Irina; Maiter, Dominique; Kastelan, Darko; Chanson, Philippe; Pfeifer, Marija; Strasburger, Christian J.; Tóth, Miklós; Chabre, Olivier; Tabarin, Antoine; Krsek, Michal; Fajardo, Carmen; Bolanowski, Marek; Santos, Alicia; Wass, John A.H.; Trainer, Peter J.; Bollerslev, Jens & Evang, Johan Arild (2017). Diagnostic tests for Cushing's syndrome differ from published guidelines: Data from ERCUSYN. European Journal of Endocrinology.  ISSN 0804-4643.  176(5), s 613- 624 . doi: 10.1530/EJE-16-0967
• Von Düring, Marit Elizabeth; Jenssen, Trond Geir; Bollerslev, Jens; Åsberg, Anders; Godang, Kristin & Hartmann, Anders (2017). Visceral fat is strongly associated with post-transplant diabetes mellitus and glucose metabolism 1 year after kidney transplantation. Clinical Transplantation.  ISSN 0902-0063.  31:e12869(1), s 1- 9 . doi: 10.1111/ctr.12869 Fulltekst i vitenarkiv.
• Øystese, Kristin Astrid Berland; Casar-Borota, Olivera; Normann, Kjersti Ringvoll; Zucknick, Manuela; Berg, Jens Petter & Bollerslev, Jens (2017). Estrogen Receptor α, a Sex-Dependent Predictor of Aggressiveness in Nonfunctioning Pituitary Adenomas: SSTR and Sex Hormone Receptor Distribution in NFPA. Journal of Clinical Endocrinology and Metabolism.  ISSN 0021-972X.  102(9), s 3581- 3590 . doi: 10.1210/jc.2017-00792
• Øystese, Kristin Astrid Berland; Zucknick, Manuela; Casar-Borota, Olivera; Ringstad, Geir & Bollerslev, Jens (2017). Early postoperative growth in non-functioning pituitary adenomas; A tool to tailor safe follow-up. Endocrine (Basingstoke).  ISSN 1355-008X.  57(1), s 35- 45 . doi: 10.1007/s12020-017-1314-5
• Christensen, Jacob J.; Retterstøl, Kjetil; Godang, Kristin; Roland Paasche, Marie Cecilie; Qvigstad, Elisabeth; Bollerslev, Jens; Ueland, Thor; Henriksen, Tore & Holven, Kirsten Bjørklund (2016). LDL cholesterol in early pregnancy and offspring cardiovascular disease risk factors. Journal of Clinical Lipidology.  ISSN 1933-2874.  10(6), s 1369- 1378 . doi: 10.1016/j.jacl.2016.08.016 Vis sammendrag

  Background Vast amounts of data show associations between maternal obesity, dysglycemia, diabetes, and undernutrition during pregnancy and increased cardiovascular disease risk in offspring. However, elevated maternal LDL cholesterol (LDL-C) in pregnancy and offspring cardiovascular disease (CVD) risk has scarcely been studied. Objective Our objective was to investigate the associations between elevated maternal LDL-C in pregnancy and CVD risk factors in 6-to-13-year-old offspring. Methods We recruited 6-to-13-year-old children whose mothers attended a pregnancy cohort and who had high or low cholesterol in pregnancy, defined as LDL-C over the 90th percentile or below the 10th percentile within the pregnancy cohort, respectively. We measured CVD risk factors in the children in the 2 groups. Results Maternal plasma LDL-C at gestational week 14 to 16 was 4.0 and 1.4 mmol/L in the hypercholesterolemic (n = 27) and hypocholesterolemic (n = 34) groups, respectively (P < .001). Interestingly, offspring plasma LDL-C was 0.4 mmol/L higher in children whose mothers had hypercholesterolemia during pregnancy (P < .01). We found no difference in birthweight or any other clinical or biochemical CVD risk factors or dietary intake between the children at 6–13 years. Conclusions Women with elevated LDL-C during early pregnancy have offspring with higher LDL-C already at the age of 6–13 years. Unless cholesterol-reducing measures are successfully implemented, the affected children may be at increased cardiovascular risk.

• Godang, Kristin; Olarescu, Nicoleta Cristina; Bollerslev, Jens & Heck, Ansgar (2016). Treatment of acromegaly increases BMD but reduces trabecular bone score: A longitudinal study. European Journal of Endocrinology.  ISSN 0804-4643.  175(2), s 155- 164 . doi: 10.1530/EJE-16-0340
• Haugen, Guttorm; Bollerslev, Jens & Henriksen, Tore (2016). Human umbilical and fetal cerebral blood flow velocity waveforms following maternal glucose loading: A cross-sectional observational study. Acta Obstetricia et Gynecologica Scandinavica.  ISSN 0001-6349.  95(6), s 683- 689 . doi: 10.1111/aogs.12913
• Hofsø, Dag; Bollerslev, Jens; Sandbu, Rune; Jørgensen, Anders; Godang, Kristin; Hjelmesæth, Jøran & Ueland, Thor (2016). Bone resorption following weight loss surgery is associated with treatment procedure and changes in secreted Wnt antagonists. Endocrine (Basingstoke).  ISSN 1355-008X.  53(1), s 313- 321 . doi: 10.1007/s12020-016-0903-z
• Jørgensen, Hanne Skou; Eide, Ivar Anders; Hartmann, Anders; Åsberg, Anders; Christensen, Jeppe H.; Schmidt, Erik B.; Godang, Kristin; Bollerslev, Jens & Svensson, My Hanna Sofia (2016). Plasma n-3 Polyunsaturated Fatty Acids and Bone Mineral Density in Renal Transplant Recipients. Journal of renal nutrition.  ISSN 1051-2276.  26(3), s 196- 203 . doi: 10.1053/j.jrn.2015.11.007
• Khan, Aliya A.; Hanley, David Arthur; Rizzoli, René; Bollerslev, Jens; Young, J.E.M.; Rejnmark, Lars; Thakker, Rajesh; D'Amour, Pierre; Paul, Terri L.; van Uum, Stan H.M.; Shrayyef, M. Zakaria; Goltzman, David; Kaiser, Stephanie M.; Cusano, Natalie E.; Bouillon, Roger; Mosekilde, Leif; Kung, Annie W.; Rao, Sudhaker D.; Bhadada, Sanjay Kumar R.; Clarke, Bart L.; Liu, Jianmin; Duh, Quanyang; Lewiecki, Edward Michael; Bandeira, Francisco A.F.; Eastell, Richard; Marcocci, Claudio; Silverberg, Shonni J.; Udelsman, Robert D.; Davison, Kenneth Shawn; Potts, John T.; Brandi, Maria Luisa & Bilezikian, John P. (2016). Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus. Osteoporosis International.  ISSN 0937-941X.  28(1), s 1- 19 . doi: 10.1007/s00198-016-3716-2
• Lekva, Tove; Lyle, Robert; Paasche, Marie Cecilie; Friis, Camilla Margrethe; Bianchi, Diana W.; Jaffe, Iris Z.; Norwitz, Errol R.; Bollerslev, Jens; Henriksen, Tore & Ueland, Thor (2016). Gene expression in term placentas is regulated more by spinal or epidural anesthesia than by late-onset preeclampsia or gestational diabetes mellitus. Scientific Reports.  ISSN 2045-2322.  6:29715 . doi: 10.1038/srep29715
• Lekva, Tove; Michelsen, Annika; Bollerslev, Jens; Norwitz, Errol R.; Aukrust, Pål; Henriksen, Tore & Ueland, Thor (2016). Low circulating pentraxin 3 levels in pregnancy is associated with gestational diabetes and increased apoB/apoA ratio: A 5-year follow-up study. Cardiovascular Diabetology.  ISSN 1475-2840.  15(23) . doi: 10.1186/s12933-016-0345-1
• Losa, Marco & Bollerslev, Jens (2016). Pros and cons in endocrine practice: pre-surgical treatment with somatostatin analogues in acromegaly. Endocrine (Basingstoke).  ISSN 1355-008X.  52(3), s 451- 457 . doi: 10.1007/s12020-015-0853-x Vis sammendrag

  The aim of this commentary is to balance the pros and cons for pre-surgical SSA treatment in a modern perspective ending up with a pragmatic recommendation for treatment based on the current evidence and expertise of the authors. Even though prospective and randomized studies in this particular area are hampered by obvious limitations, the interpretation of the four published trials has in general been in favor of pre-treatment with SSA, showing a better outcome following surgery. However, major drawbacks of these studies, such as non-optimal diagnostic criteria for cure, potential selection bias, and timing of the postoperative evaluation in SSA pre-treated patients, limit their overall interpretation. Three matched-controlled studies showed remarkably similar results with no apparent beneficial effect of SSA pre-treatment on surgical outcome. Both prospective, randomized studies and retrospective studies did not find any significant difference in the rate of endocrine and non-endocrine complications related to surgery, despite the beneficial clinical effects of SSA treatment in most acromegalic patients. The newly diagnosed patient with acromegaly should be carefully evaluated in the trans-disciplinary neuroendocrine team and treatment individualized accordingly. The issue of SSA pre-treatment to improve surgical outcome is yet to be settled and further methodologically sound studies are probably necessary to clarify this point.

• Normann, Kjersti Ringvoll; Øystese, Kristin Astrid Berland; Berg, Jens Petter; Lekva, Tove; Berg-Johnsen, Jon; Bollerslev, Jens & Olarescu, Nicoleta Cristina (2016). Selection and validation of reliable reference genes for RT-qPCR analysis in a large cohort of pituitary adenomas. Molecular and Cellular Endocrinology.  ISSN 0303-7207.  437, s 183- 189 . doi: 10.1016/j.mce.2016.08.030
• Olarescu, Nicoleta Cristina & Bollerslev, Jens (2016). The Impact of Adipose Tissue on Insulin Resistance in Acromegaly. Trends in endocrinology and metabolism.  ISSN 1043-2760.  27(4), s 226- 237 . doi: 10.1016/j.tem.2016.02.005
• Olarescu, Nicoleta Cristina; Heck, Ansgar; Godang, Kristin; Ueland, Thor & Bollerslev, Jens (2016). The Metabolic Risk in Patients Newly Diagnosed with Acromegaly Is Related to Fat Distribution and Circulating Adipokines and Improves after Treatment. Neuroendocrinology.  ISSN 0028-3835.  103(3-4), s 197- 206 . doi: 10.1159/000371818
• Wyller, Vegard Bruun; Vitelli, Valeria; Sulheim, Dag; Fagermoen, Frode Even; Winger, Anette; Godang, Kristin & Bollerslev, Jens (2016). Altered neuroendocrine control and association to clinical symptoms in adolescent chronic fatigue syndrome: a cross-sectional study. Journal of Translational Medicine.  ISSN 1479-5876.  14(121) . doi: 10.1186/s12967-016-0873-1 Fulltekst i vitenarkiv.
• Øystese, Kristin Astrid Berland; Evang, Johan Arild & Bollerslev, Jens (2016). Non-functioning pituitary adenomas: growth and aggressiveness. Endocrine (Basingstoke).  ISSN 1355-008X.  53(1), s 28- 34 . doi: 10.1007/s12020-016-0940-7
• Bollerslev, Jens; Rejnmark, Lars; Marcocci, Claudio; Shoback, Dolores M.; Sitges-Serra, Antonio; Van Biesen, Wim & Dekkers, Olaf M. (2015). European Society of Endocrinology clinical guideline: Treatment of chronic hypoparathyroidism in adults. European Journal of Endocrinology.  ISSN 0804-4643.  173(2), s G1- G20 . doi: 10.1530/EJE-15-0628
• Heck, Ansgar; Emblem, Kyrre Eeg; Casar-Borota, Olivera; Bollerslev, Jens & Ringstad, Geir (2015). Quantitative analyses of T2-weighted MRI as a potential marker for response to somatostatin analogs in newly diagnosed acromegaly. Endocrine (Basingstoke).  ISSN 1355-008X. . doi: 10.1007/s12020-015-0766-8
• Helseth, Ragnhild Merckoll; Carlsen, Sven Magnus; Bollerslev, Jens; Svartberg, Johan; Øksnes, Marianne; Skeie, Svein & Fougner, Stine Lyngvi (2015). Preoperative octreotide therapy and surgery in acromegaly: associations between glucose homeostasis and treatment response. Endocrine (Basingstoke).  ISSN 1355-008X.  Published ahead of print . doi: 10.1007/s12020-015-0679-6
• Kiserud, Cecilie E.; Selland, Mette; Holte, Harald; Fosså, Alexander; Fosså, Sophie Dorothea; Bollerslev, Jens; Bjøro, Trine & Loge, Jon Håvard (2015). Fatigue in male lymphoma survivors differs between diagnostic groups and is associated with latent hypothyroidism. Acta Oncologica.  ISSN 0284-186X.  54(1), s 49- 59 . doi: 10.3109/0284186X.2014.948057
• Lekva, Tove; Berg, Jens Petter; Lyle, Robert; Heck, Ansgar; Bollerslev, Jens & Ueland, Thor (2015). Alternative splicing of placental lactogen (CSH2) in somatotroph pituitary adenomas. Neuro - endocrinology letters.  ISSN 0172-780X.  36(2), s 136- 142 Vis sammendrag

  OBJECTIVES: Somatotroph adenomas secrete supraphysiological amounts of GH, causing acromegaly. We have previously shown epithelial splicing regulator 1 (ESRP1) to play a role in epithelial mesenchymal transition (EMT) progression in these adenomas and account for poor treatment response. We evaluated if the mRNA levels of the GH/CSH gene cluster in somatotroph adenomas are associated with an epithelial phenotype and response to SA treatment. METHODS: We investigated the associations between ESRP1 and the growth hormone/chorionic somatomammotropin (GH/CSH) gene cluster by RNA sequencing (RNAseq). CSH2 isoform 3 mRNA was further evaluated in 65 somatotroph adenomas and associations with disease severity and treatment response. RESULTS: mRNA for all genes in the GH/CSH cluster were expressed, however, only chorionic somatomammotropin 2/placental lactogen 2 (CSH2) displayed an alternative splicing pattern. CSH2 isoform 3 was associated with a dense granulation pattern and an epithelial phenotype with high levels of ESRP1 and E-cadherin expression. Further, CSH2 isoform 3 was associated with reduced serum GH and IGF-I levels after somatostatin analog treatment. CONCLUSIONS: Attenuated CSH2 isoform 3 was associated with mesenchymal phenotype and a blunted clinical response to somatostatin analog treatment in patients with acromegaly.

• Lekva, Tove; Bollerslev, Jens; Godang, Kristin; Paasche, Marie Cecilie; Friis, Camilla Margrethe; Voldner, Nanna; Henriksen, Tore & Ueland, Thor (2015). β-cell dysfunction in women with previous gestational diabetes is associated with visceral adipose tissue distribution. European Journal of Endocrinology.  ISSN 0804-4643.  173(1), s 63- 70 . doi: 10.1530/EJE-15-0153
• Lekva, Tove; Bollerslev, Jens; Norwitz, Errol R.; Aukrust, Pål; Henriksen, Tore & Ueland, Thor (2015). Aortic stiffness and cardiovascular risk in women with previous gestational diabetes mellitus. PLoS ONE.  ISSN 1932-6203.  10:e0136892(8) . doi: 10.1371/journal.pone.0136892
• Lekva, Tove; Bollerslev, Jens; Norwitz, Erroll R; Aukrust, Pål; Henriksen, Tore & Ueland, Thor (2015). Aortic stiffness and cardiovascular risk in women with previous gestational diabetes mellitus. PLoS ONE.  ISSN 1932-6203.  10(8) . doi: 10.1371/journal.pone.0136892
• Lewis, Joshua R.; Lim, Wai H.; Ueland, Thor; Wong, Germaine; Zhu, Kun; Lim, Ee M.; Bollerslev, Jens & Prince, Richard L. (2015). Elevated circulating osteoprotegerin and renal dysfunction predict 15-year cardiovascular and all-cause mortality: A prospective study of elderly women. PLoS ONE.  ISSN 1932-6203.  10:e0134266(7) . doi: 10.1371/journal.pone.0134266
• Lundstam, Karolina; Heck, Ansgar; Mollerup, Charlotte; Godang, Kristin; Baranowski, Marek; Pernow, Ylva; Varhaug, Jan Erik; Hessman, Ola; Rosén, Thord; Nordenström, Jörgen; Jansson, Svante; Hellström, Mikael; Bollerslev, Jens; Lundgren, Ewa; Åkerström, Göran; Tørring, Ove; Farnebo, Lars Ove; Mosekilde, Leif; Falch, Jan Arvid; Pfeffer, Per F & Aanderud, Sylvi (2015). Effects of parathyroidectomy versus observation on the development of vertebral fractures in mild primary hyperparathyroidism. Journal of Clinical Endocrinology and Metabolism.  ISSN 0021-972X.  100(4), s 1359- 1367 . doi: 10.1210/jc.2014-3441
• Olarescu, Nicoleta Cristina; Berryman, Darlene E.; Householder, Lara A.; Lubbers, Ellen R.; List, Edward O.; Benencia, Fabian; Kopchick, John J. & Bollerslev, Jens (2015). GH action influences adipogenesis of mouse adipose tissue-derived mesenchymal stem cells. Journal of Endocrinology.  ISSN 0022-0795.  226(1), s 13- 23 . doi: 10.1530/JOE-15-0012
• Petersenn, Stephan; Beckers, Albert; Ferone, Diego; van der Lely, Aart; Bollerslev, Jens; Boscaro, Marco; Brue, Thierry; Bruzzi, Paolo; Casanueva, Felipe F.; Chanson, Philippe; Colao, Annamaria; Reincke, Martin; Stalla, Günter & Tsagarakis, Stelios (2015). Outcomes in patients with Cushing's disease undergoing transsphenoidal surgery: Systematic review assessing criteria used to define remission and recurrence. European Journal of Endocrinology.  ISSN 0804-4643.  172(6), s R227- R239 . doi: 10.1530/EJE-14-0883
• Petersenn, Stephan; Beckers, Albert; Ferone, Diego; van der Lely, Aart; Bollerslev, Jens; Boscaro, Marco; Brue, Thierry; Bruzzi, Paolo; Casanueva, Felipe F; Chanson, Philippe; Colao, Annamaria; Reincke, Martin; Stalla, Günter & Tsagarakis, Stelios (2015). Therapy of endocrine disease: outcomes in patients with Cushing's disease undergoing transsphenoidal surgery: systematic review assessing criteria used to define remission and recurrence.. European Journal of Endocrinology.  ISSN 0804-4643.  172(6), s R227- R239 . doi: 10.1530/EJE-14-0883
• Ramm-Pettersen, Jon-Terje; Halvorsen, Helene; Evang, Johan Arild; RØNNING, PÅL ANDRE; Hol, Per Kristian; Bollerslev, Jens; Berg-Johnsen, Jon & Helseth, Eirik (2015). Low immediate postoperative serum-cortisol nadir predicts the short-term, but not long-term, remission after pituitary surgery for Cushing's disease. BMC Endocrine Disorders.  ISSN 1472-6823.  15:62 . doi: 10.1186/s12902-015-0055-9 Vis sammendrag

  Background: Cushing’s disease is an ACTH-producing pituitary adenoma, and the primary treatment is microscopic or endoscopic transsphenoidal selective adenectomy. The aims of the present study were to evaluate whether the early postoperative S-cortisol level can serve as a prognostic marker for short- and long-term remission, and retrospectively review our own short and long term results after surgery for Cushing’s disease. Methods: This single centre, retrospective study consists of 19 consecutive patients with Cushing’s disease who underwent transsphenoidal surgery. S-cortisol was measured every 6 h after the operation without any glucocorticoid replacement. We have follow-up on all patients, with a mean follow-up of 68 months. Results: At the three-month follow-up, 16 patients (84 %) were in remission; at 12 months, 18 (95 %) were in remission and at the final follow-up (mean 68 months), 13 (68 %) were in remission. Five-years recurrence rate was 26 %. The mean postoperative S-cortisol nadir was significantly lower in the group of patients in remission than in the non-remission group at 3 months, but there was no difference between those in long-term remission compared to those in long-term non-remission. The optimal cut-off value for classifying 3-month remission was 74 nmol/l. Conclusion: We achieved a 95 % 1-year remission rate with transsphenoidal surgery for Cushing’s disease in this series of consecutive patients. However, the 5-year recurrence rate was 26 %, showing the need for regular clinical and biochemical controls in this patient group. The mean postoperative serum-cortisol nadir was significantly lower in patients in remission at 3 months compared to patients not in remission at 3 months, but a low postoperative S-cortisol did not predict long-term remission.

• Selland, Mette; Bjøro, Trine; Furre, Torbjørn; Schreiner, Thomas; Bollerslev, Jens; Fosså, Sophie Dorothea; Loge, Jon Håvard; Holte, Harald & Kiserud, Cecilie E. (2015). Hormonal dysfunction is frequent in cancer survivors treated with radiotherapy to the head and neck region. Journal of cancer survivorship.  ISSN 1932-2259.  9(4), s 630- 640 . doi: 10.1007/s11764-015-0439-x
• Selland, Mette; Holte, Harald; Bjøro, Trine; Schreiner, Thomas; Bollerslev, Jens; Loge, Jon Håvard; Fosså, Sophie Dorothea & Kiserud, Cecilie E. (2015). Chronic fatigue is prevalent and associated with hormonal dysfunction in long-term non-Hodgkin lymphoma survivors treated with radiotherapy to the head and neck region. Leukemia and Lymphoma.  ISSN 1042-8194.  56(12), s 3306- 3314 . doi: 10.3109/10428194.2015.1036258 Vis sammendrag

  The purposes of this study were to assess the prevalence of chronic fatigue (CF) in irradiated survivors of non-Hodgkin lymphoma, analyze for associations between hormonal dysfunction and CF, and to investigate the associations between CF and functioning. Invited survivors were all treated with radiation to the head and neck region, with or without additional chemotherapy. The participants (n =98) responded to questionnaires measuring CF, mental distress (HADS), and functioning (SF-36), and had blood drawn for analyses of four hormonal axes. Hormonal status was categorized as normal, hormone dysfunction in one or more axes, or hormone replacement therapy. A total of 29% of the survivors had CF. In multivariate analyses there was an increased risk of CF among survivors with untreated hormone dysfunction (OR 3.87, 95% CI: 1.20–12.51, P 0.02). Survivors on hormone substitution did not have increased risk for CF compared to survivors with normal hormonal status. CF was significantly associated with reduced functioning.

• Ueland, Thor; Olarescu, Nicoleta Cristina; Jørgensen, Anders Palmstrøm; Otterdal, Kari; Aukrust, Pål; Godang, Kristin; Lekva, Tove & Bollerslev, Jens (2015). Increased serum and bone matrix levels of the secreted Wnt antagonist DKK-1 in patients with growth hormone deficiency in response to growth hormone treatment. Journal of Clinical Endocrinology and Metabolism.  ISSN 0021-972X.  100(2), s 736- 743 . doi: 10.1210/jc.2014-2912
• Von Düring, Marit Elizabeth; Jenssen, Trond Geir; Bollerslev, Jens; Åsberg, Anders; Godang, Kristin; Eide, Ivar Anders; Dahle, Dag Olav & Hartmann, Anders (2015). Visceral fat is better related to impaired glucose metabolism than body mass index after kidney transplantation. Transplant International.  ISSN 0934-0874.  28(10), s 1162- 1171 . doi: 10.1111/tri.12606
• Andersen, Thomas Levin; Hauge, Ellen; Rolighed, Lars; Bollerslev, Jens; Kjærsgaard-Andersen, Per & Delaissé, Jean-Marie (2014). Correlation between absence of bone remodeling compartment canopies, reversal phase arrest, and deficient bone formation in post-menopausal osteoporosis. American Journal of Pathology.  ISSN 0002-9440.  184(4), s 1142- 1151 . doi: 10.1016/j.ajpath.2013.12.005
• Fougner, Stine Lyngvi; Bollerslev, Jens; Svartberg, Johan; Øksnes, Marianne; Cooper, John & Carlsen, Sven Magnus (2014). Preoperative octreotide treatment of acromegaly: Long-term results of a randomised controlled trial. European Journal of Endocrinology.  ISSN 0804-4643.  171(2), s 229- 235 . doi: 10.1530/EJE-14-0249
• Frøslie, Kathrine Frey; Røislien, Jo; Qvigstad, Elisabeth; Godang, Kristin; Bollerslev, Jens; Henriksen, Tore & Veierød, Marit Bragelien (2014). Shape information in repeated glucose curves during pregnancy provided significant physiological information for neonatal outcomes. PLoS ONE.  ISSN 1932-6203.  9(3) . doi: 10.1371/journal.pone.0090798
• Godang, Kristin; Frøslie, Kathrine Frey; Henriksen, Tore; Qvigstad, Elisabeth & Bollerslev, Jens (2014). Seasonal variation in maternal and umbilical cord 25(OH) vitamin D and their associations with neonatal adiposity. European Journal of Endocrinology.  ISSN 0804-4643.  170(4), s 609- 617 . doi: 10.1530/EJE-13-0842
• Halvorsen, Helene; Ramm-Pettersen, Jon-Terje; Josefsen, Roger; RØNNING, PÅL ANDRE; Reinlie, Sissel; Meling, Torstein; Berg-Johnsen, Jon; Bollerslev, Jens & Helseth, Eirik (2014). Surgical complications after transsphenoidal microscopic and endoscopic surgery for pituitary adenoma: A consecutive series of 506 procedures. Acta Neurochirurgica.  ISSN 0001-6268.  156(3), s 441- 449 . doi: 10.1007/s00701-013-1959-7
• Haugen, Guttorm; Bollerslev, Jens & Henriksen, Tore (2014). Human fetoplacental and fetal liver blood flow after maternal glucose loading: A cross-sectional observational study. Acta Obstetricia et Gynecologica Scandinavica.  ISSN 0001-6349.  93(8), s 778- 785 . doi: 10.1111/aogs.12419
• Heimdal, Ketil Riddervold; Sanchez Guixe, Monica; Aukrust, Ingvild; Bollerslev, Jens; Bruland, Ove; Jablonski, Greg; ERICHSEN, ANNE KJERSTI; Gude, Einar; Koht, Jeanette; Erdal, Sigrid; Fiskerstrand, Torunn; Haukanes, Bjørn Ivar; Boman, Helge; Bjørkhaug, Lise; Tallaksen, Chantal; Knappskog, Per & Johansson, Stefan (2014). STUB1 mutations in autosomal recessive ataxias - evidence for mutation-specific clinical heterogeneity. Orphanet Journal of Rare Diseases.  ISSN 1750-1172.  9:146 . doi: 10.1186/s13023-014-0146-0 Fulltekst i vitenarkiv.
• Hjelle, Anja Myhre; Apalset, Ellen M; Mielnik, Pawel Franciszek; Bollerslev, Jens; Lundin, Knut E A & Tell, Grethe S (2014). Celiac disease and risk of fracture in adults-a review. Osteoporosis International.  ISSN 0937-941X.  25(6), s 1667- 1676 . doi: 10.1007/s00198-014-2683-8
• Jensen, Pia Rosgaard; Andersen, Thomas Levin; Hauge, Ellen Margrethe; Bollerslev, Jens & Delaissé, Jean-Marie (2014). A joined role of canopy and reversal cells in bone remodeling - Lessons from glucocorticoid-induced osteoporosis. Bone.  ISSN 8756-3282.  73, s 16- 23 . doi: 10.1016/j.bone.2014.12.004
• Jørgensen, Anders Palmstrøm; Ueland, Thor; Sode-Carlsen, Rasmus; Schreiner, Thomas; Rabben, Kai Fr.; Farholt, Stense; Høybye, Charlotte; Christiansen, Jens Sandahl & Bollerslev, Jens (2014). Glucose homeostasis in adults with Prader-Willi syndrome during treatment with growth hormone: Results from a 12-month prospective study. Growth Hormone & IGF Research.  ISSN 1096-6374.  24(1), s 16- 21 . doi: 10.1016/j.ghir.2013.11.002
• Lewis, J.R.; Lim, W.H.; Zhu, K.; Wong, G.; Dhaliwal, S.S.; Lim, E.M.; Ueland, Thor; Bollerslev, Jens & Prince, R.L. (2014). Elevated osteoprotegerin predicts declining renal function in e. American Journal of Nephrology.  ISSN 0250-8095.  39(1), s 66- 74 . doi: 10.1159/000357787
• Marcocci, Claudio; Bollerslev, Jens; Khan, A. & Shoback, Dolores (2014). Medical management of primary hyperparathyroidism: proceedings of the fourth International Workshop on the Management of Asymptomatic Primary Hyperparathyroidism. Journal of Clinical Endocrinology and Metabolism.  ISSN 0021-972X.  99(10), s 3607- 3618 . doi: 10.1210/jc.2014-1417
• Olarescu, Nicoleta Cristina; Jørgensen, Anders Palmstrøm; Godang, Kristin; Jurik, Anne Grethe; Frøslie, Kathrine Frey & Bollerslev, Jens (2014). Dual-energy X-ray absorptiometry is a valid method to estimate visceral adipose tissue in adult patients with Prader-Willi syndrome during treatment with growth hormone. Journal of Clinical Endocrinology and Metabolism.  ISSN 0021-972X.  99(9), s E1727- E1731 . doi: 10.1210/jc.2014-2059
• Olarescu, Nicoleta Cristina; Ueland, Thor; Godang, Kristin; Lindberg-Larsen, Rune; Jørgensen, Jens Otto L & Bollerslev, Jens (2014). Inflammatory adipokines contribute to insulin resistance in active acromegaly and respond differently to different treatment modalities. European Journal of Endocrinology.  ISSN 0804-4643.  170(1), s 39- 48 . doi: 10.1530/EJE-13-0523 Vis sammendrag

  Background Active acromegaly is associated with insulin resistance, but it is uncertain whether inflammation in adipose tissue is a contributing factor. Aim To test if GH/IGF1 promotes inflammation in adipocytes, and if this is relevant for systemic insulin resistance in acromegaly. Furthermore, to investigate the effect of treatment modalities (transsphenoidal surgery (TS), somatostatin analogs (SAs), and pegvisomant (PGV)) on glucose metabolism and inflammatory biomarkers in acromegaly. Methods The in vitro effects of GH/IGF1 on gene expression of adipokines in human adipocytes were investigated. Body composition, glucose metabolism, and circulating adipokines (adiponectin (AD), high-molecular weight AD (HMWAD), leptin, vascular endothelial growth factor-A (VEGF-A), monocyte chemotactic protein 1 (MCP1), and thioredoxin (TRX)) were measured in 37 patients with active acromegaly before and after treatment. Results In vitro GH, but not IGF1, increased VEGF and MCP1 in human adipocytes. In all treatment groups, body fat increased and IGF1 decreased to the same extent. Fasting glucose decreased in the TS (P=0.016) and PGV (P=0.042) groups, but tended to increase in the SA group (P=0.078). Insulin and HOMA-IR decreased in both TS and SA groups, while the PGV group showed no changes. Serum VEGF and MCP1 decreased significantly in the TS group only (P=0.010, P=0.002), while HMWAD increased with PGV treatment only (P=0.018). A multivariate analysis model identified the changes in GH and VEGF as predictors of improvement in HOMA-IR after treatment (R2=0.39, P=0.002). Conclusions i) GH directly promotes inflammation of human adipocytes by increasing VEGF and MCP1 levels; ii) glucose metabolism and inflammation (VEGF and MCP1) improve to some extent after treatment, despite an increase in adipose tissue mass; and iii) the decrease in insulin resistance after therapy in acromegaly depends, to some extent, on treatment modalities.

• Paasche, Marie Cecilie; Friis, Camilla Margrethe; Godang, Kristin; Bollerslev, Jens; Haugen, Guttorm & Henriksen, Tore (2014). Maternal factors associated with fetal growth and birthweight are independent determinants of placental weight and exhibit differential effects by fetal sex. PLoS ONE.  ISSN 1932-6203.  9(2) . doi: 10.1371/journal.pone.0087303
• Petersenn, Stephan; Bollerslev, Jens; Arafat, Ayman M.; Schopohl, Jochen; Serri, Omar; Katznelson, Laurence; Lasher, Janet; Hughes, Gareth; Hu, Ke; Shen, G.; Resendiz, Karina H.; Giannone, Vanessa & Beckers, A (2014). Pharmacokinetics, pharmacodynamics, and safety of pasireotide LAR in patients with acromegaly: a randomized, multicenter, open-label, phase I study. Journal of clinical pharmacology.  ISSN 0091-2700.  54(11), s 1308- 1317 . doi: 10.1002/jcph.326
• Andersen, Thomas Levin; Abdelgawad, Mohamed E; Kristensen, Helene B; Hauge, Ellen M.; Rolighed, Lars; Bollerslev, Jens; Kjærsgaard-Andersen, Per & Delaissé, Jean-Marie (2013). Understanding Coupling between Bone Resorption and Formation: Are Reversal Cells the Missing Link?. American Journal of Pathology.  ISSN 0002-9440.  183(1), s 235- 246 . doi: 10.1016/j.ajpath.2013.03.006
• Bollerslev, Jens; Henriksen, Kim; Nielsen, Morten Frost; Brixen, Kim & van Hul, Wim (2013). Autosomal dominant osteopetrosis revisited: lessons from recent studies. European Journal of Endocrinology.  ISSN 0804-4643.  169(2), s R39- R57 . doi: 10.1530/EJE-13-0136
• Casar-Borota, Olivera; Heck, Ansgar; Schulz, S; Nesland, Jahn M; Ramm-Pettersen, Jon-Terje; Lekva, Tove; Alafuzoff, I & Bollerslev, Jens (2013). Expression of SSTR2a, but not of SSTRs 1, 3, or 5 in Somatotroph Adenomas Assessed by Monoclonal Antibodies Was Reduced by Octreotide and Correlated With the Acute and Long-Term Effects of Octreotide. Journal of Clinical Endocrinology and Metabolism.  ISSN 0021-972X.  98(11), s E1730- E1739 . doi: 10.1210/jc.2013-2145
• Evang, Johan Arild; Bollerslev, Jens; Casar-Borota, Olivera; Lekva, Tove; Ramm-Pettersen, Jon-Terje & Berg, Jens Petter (2013). Different levels of various glucocorticoid-regulated genes in corticotroph adenomas. Endocrine (Basingstoke).  ISSN 1355-008X.  44(1), s 220- 227 . doi: 10.1007/s12020-012-9871-0
• Friis, Camilla Margrethe; Paasche, Marie Cecilie; Godang, Kristin; Ueland, Thor; Tanbo, Tom Gunnar; Bollerslev, Jens & Henriksen, Tore (2013). Adiposity-Related Inflammation: Effects of Pregnancy. Obesity.  ISSN 1930-7381.  21(1), s E124- E130 . doi: 10.1002/oby.20120
• Friis, Camilla Margrethe; Qvigstad, Elisabeth; Paasche, Marie Cecilie; Godang, Kristin; Voldner, Nanna; Bollerslev, Jens & Henriksen, Tore (2013). Newborn Body Fat: Associations with Maternal Metabolic State and Placental Size. PLoS ONE.  ISSN 1932-6203.  8(2) . doi: 10.1371/journal.pone.0057467
• Frøslie, Kathrine Frey; Røislien, Jo; Qvigstad, Elisabeth; Godang, Kristin; Bollerslev, Jens; Voldner, Nanna; Henriksen, Tore & Veierød, Marit Bragelien (2013). Shape information from glucose curves: Functional data analysis compared with traditional summary measures. BMC Medical Research Methodology.  ISSN 1471-2288.  13 . doi: 10.1186/1471-2288-13-6
• Godang, Kristin; Frøslie, Kathrine Frey; Henriksen, Tore; Isaksen, Gunhild Aker; Voldner, Nanna; Lekva, Tove; Ueland, Thor & Bollerslev, Jens (2013). Umbilical cord levels of sclerostin, placental weight and birth weight are predictors of total Bone Mineral Content in neonates. European Journal of Endocrinology.  ISSN 0804-4643.  168(3), s 371- 378 . doi: 10.1530/EJE-12-0531
• Jørgensen, Anders Palmstrøm; Ueland, Thor; Sode-Carlsen, Rasmus; Schreiner, Thomas; Rabben, Kai Fr.; Farholt, S.; Höybye, Charlotte; Christiansen, Jørgen Schou & Bollerslev, Jens (2013). Two Years of Growth Hormone Treatment in Adults With Prader-Willi Syndrome Do Not Improve the Low BMD. Journal of Clinical Endocrinology and Metabolism.  ISSN 0021-972X.  98(4), s E753- E760 . doi: 10.1210/jc.2012-3378
• Lekva, Tove; Berg, Jens Petter; Heck, Ansgar; Fougner, Stine Lyngvi; Olstad, Ole Kristoffer; Ringstad, Geir Andre; Bollerslev, Jens & Ueland, Thor (2013). Attenuated RORC expression in the presence of EMT progression in somatotroph adenomas following treatment with somatostatin analogs is associated with poor clinical recovery. PLoS ONE.  ISSN 1932-6203.  8(6) . doi: 10.1371/journal.pone.0066927
• Lekva, Tove; Berg, Jens Petter; Lyle, Robert; Heck, Ansgar; Ringstad, Geir Andre; Olstad, Ole Kristoffer; Michelsen, Annika; Casar-Borota, Olivera; Bollerslev, Jens & Ueland, Thor (2013). Epithelial Splicing Regulator Protein 1 and Alternative Splicing in Somatotroph Adenomas. Endocrinology.  ISSN 0013-7227.  154(9), s 3331- 3343 . doi: 10.1210/en.2013-1051
• Lekva, Tove; Bollerslev, Jens; Sahraoui, Afaf; Scholz, Hanne Bjørnson; Bøyum, Hege Hestetun; Evang, Johan Arild; Godang, Kristin; Aukrust, Pål & Ueland, Thor (2013). Thioredoxin Interacting Protein Is a Potential Regulator of Glucose and Energy Homeostasis in Endogenous Cushing's Syndrome. PLoS ONE.  ISSN 1932-6203.  8(5) . doi: 10.1371/journal.pone.0064247
• Borota, Olivera Casar; Fougner, Stine Lyngvi; Bollerslev, Jens & Nesland, Jahn M (2012). KIT protein expression and mutational status of KIT gene in pituitary adenomas. Virchows Archiv.  ISSN 0945-6317.  460(2), s 171- 181 . doi: 10.1007/s00428-011-1185-8

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• Christensen, Jacob J.; Retterstøl, Kjetil; Godang, Kristin; Roland, Marie Cecilie; Qvigstad, Elisabeth; Bollerslev, Jens; Ueland, Thor; Henriksen, Tore & Holven, Kirsten B. (2017). LDL cholesterol in early pregnancy and offspring cardiovascular disease risk factors.
• Christensen, Jacob J.; Ulven, Stine M.; Retterstøl, Kjetil; Narverud, Ingunn; Bogsrud, Martin P.; Henriksen, Tore; Bollerslev, Jens; Halvorsen, Bente; Aukrust, Pål & Holven, Kirsten Bjørklund (2017). Comprehensive lipid and metabolite profiling of children with and without familial hypercholesterolemia: A cross-sectional study.
• Sjöstedt, Evelina; Bollerslev, Jens; Mulder, Jan; Lindskog, Cecilia; Pontén, Fredrik & Casar-Borota, Olivera (2017). A specific antibody to detect transcription factor T-Pit: a reliable marker of corticotroph cell differentiation and a tool to improve the classification of pituitary neuroendocrine tumours. Acta Neuropathologica.  ISSN 0001-6322.  134(4), s 675- 677 . doi: 10.1007/s00401-017-1768-9
• Wyller, Vegard Bruun Bratholm; Vitelli, Valeria; Sulheim, Dag; Fagermoen, Frode Even; Winger, Anette; Godang, Kristin & Bollerslev, Jens (2017). Altered neuroendocrine control and association to clinical symptoms in adolescent chronic fatigue syndrome: A cross-sectional study. Journal of Translational Medicine.  ISSN 1479-5876.  15(157) . doi: 10.1186/s12967-017-1261-1
• Christensen, Jacob J.; Retterstøl, Kjetil; Godang, Kristin; Roland, Marie Cecilie Paasche; Qvigstad, Elisabeth; Bollerslev, Jens; Ueland, Thor; Henriksen, Tore & Holven, Kirsten Bjørklund (2016). LDL cholesterol in early pregnancy and offspring cardiovascular disease risk factors.
• Christensen, Jacob J.; Retterstøl, Kjetil; Godang, Kristin; Roland, Marie Cecilie Paasche; Qvigstad, Elisabeth; Bollerslev, Jens; Ueland, Thor; Henriksen, Tore & Holven, Kirsten Bjørklund (2016). LDL cholesterol in early pregnancy and offspring cardiovascular disease risk factors.
• Christensen, Jacob J.; Retterstøl, Kjetil; Godang, Kristin; Roland, Marie Cecilie Paasche; Qvigstad, Elisabeth; Bollerslev, Jens; Ueland, Thor; Henriksen, Tore & Holven, Kirsten Bjørklund (2016). Women with elevated LDL-C in early pregnancy have offspring with elevated LDL-C at 6-13 years of age.
• Christensen, Jacob J.; Retterstøl, Kjetil; Godang, Kristin; Roland, Marie Cecilie Paasche; Qvigstad, Elisabeth; Bollerslev, Jens; Ueland, Thor; Henriksen, Tore & Holven, Kirsten Bjørklund (2016). Women with elevated LDL-C in early pregnancy have offspring with elevated LDL-C at 6-13 years of age.
• Christensen, Jacob J.; Retterstøl, Kjetil; Godang, Kristin; Roland, Marie Cecilie Paasche; Qvigstad, Elisabeth; Bollerslev, Jens; Ueland, Thor; Henriksen, Tore & Holven, Kirsten Bjørklund (2016). Women with elevated LDL-C in early pregnancy have offspring with elevated LDL-C at 6-13 years of age.
• Christensen, Jacob J.; Retterstøl, Kjetil; Godang, Kristin; Roland, Marie Cecilie Paasche; Qvigstad, Elisabeth; Bollerslev, Jens; Ueland, Thor; Henriksen, Tore & Holven, Kirsten Bjørklund (2016). Women with elevated LDL-C in early pregnancy have offspring with elevated LDL-C at 6-13 years of age.
• Haugen, Guttorm; Bollerslev, Jens & Henriksen, Tore (2016). Human uterine blood flow velocity waveforms following maternal glucose loading related to fetal size: a cross-sectional observational study.
• Heck, Ansgar; Emblem, Kyrre Eeg; Casar-Borota, Olivera; Ringstad, Geir & Bollerslev, Jens (2016). MRI T2 characteristics in somatotroph adenomas following somatostatin analog treatment in acromegaly. Endocrine (Basingstoke).  ISSN 1355-008X.  53(1), s 327- 330 . doi: 10.1007/s12020-015-0816-2
• Hjelle, Anja Myhre; Mielnik, Pawel Franciszek; Apalset, Ellen M; Bollerslev, Jens & Tell, Grethe S. (2016). Osteoporosis and Celiac disease in Patients with Distal Radius and Ankle Fractures.. Vis sammendrag

  Background: Patients suffering a distal radial fracture have a high prevalence of osteoporosis [1]. Ankle fractures have traditionally not been considered to be an osteoporotic fracture, however more recent studies suggest otherwise [2, 3]. Patients with celiac disease (CD) have low bone mineral bone density (BMD), and overall findings indicate an increased risk of fracture [4, 5]. Objectives: To investigate and compare the prevalence of osteoporosis in patients with acute distal radius or ankle fracture and describe risk factors for osteoporosis in the two groups. Methods: 400 consecutive patients over the age of 40 with acute distal radius or ankle fracture were included in this study after referral from the orthopedic department at Forde General Hospital, Norway. BMD of the hips and spine was measured and history of previous fracture, comorbidities, medication, physical activity, smoking habits, body mass index (BMI) and nutritional factors were registered. Serum analysis to detect secondary osteoporosis including IgA tissue transglutaminase was performed. Results: The prevalence of osteoporosis was 44.7 % in the patients with distal radius fracture (n=293) compared to 23.4 % in the ankle fracture group (n=107). Significant risk factors for having osteoporosis when having suffered a distal radius fracture were older age, female gender, lower BMI, and celiac disease (defined as either known celiac disease AND/OR positive IgA tissue transglutaminase). Elevated PTH or low vitamin D was not significant. The patients with radius fracture and osteoporosis had a higher prevalence of celiac disease (7.6%) than the ones with radius fracture and osteopenia or normal BMD (0.6%). In the ankle fracture patients with osteoporosis there were no celiac disease cases, versus 3.7% in the ankle fracture patients with osteopenia/normal BMD. In the ankle fracture group, low BMI was a significant risk factor for being osteoporotic, but no other significant risk factors were found. Conclusions: The prevalence of osteoporosis was higher among persons suffering a distal radius fracture than among those with acute ankle fracture. Several well-known risk factors for osteoporosis were associated with being osteoporotic among subjects suffering a distal radius fracture, but only BMI was associated with osteoporosis in the ankle fracture group.

• Annexstad, Ellen Johanne; Westvik, Jostein; Myhre, Anne Grethe; Bollerslev, Jens; Holm, Inger & Rasmussen, Magnhild (2015). The evaluation of bone age in patients with Duchenne muscular dystrophy on long-term glucocorticoid treatment..
• Hofsø, Dag; Birkeland, Kåre I.; Holst, Jens J.; Bollerslev, Jens; Sandbu, Rune; Røislien, Jo & Hjelmesæth, Jøran (2015). Gastric bypass surgery has a weight-loss independent effect on post-challenge serum glucose levels. Diabetology and Metabolic Syndrome.  ISSN 1758-5996.  7:69 . doi: 10.1186/s13098-015-0066-8
• Witzcak, Birgit; Godang, Kristin; Schwartz, Thomas; Flatø, Berit; Bollerslev, Jens; Sjaastad, Ivar & Sanner, Helga (2015). In adults with juvenile onset dermatomyositis, visceral adipose tissue is increased compared with controls, and is associated with serum lipids.
• Ramm-Pettersen, Jon-Terje; Halvorsen, Helene; Josefsen, Roger; RØNNING, PÅL ANDRE; Reinlie, Sissel; Meling, Torstein Ragnar; Berg-Johnsen, Jon; Bollerslev, Jens & Helseth, Eirik (2014). Endoscopic or microscopic transsphenoidal surgery?.
• Bollerslev, Jens (2013). The important players in primary hyperparathyroidism. Clinical Endocrinology.  ISSN 0300-0664.  79(6), s 774- 775 . doi: 10.1111/cen.12291
• Seland, Mette; Holte, Harald; Bjoro, Trine; Schreiner, Thomas; Bollerslev, Jens; Loge, Jon Håvard; Furre, Torbjørn & Kiserud, Cecilie E. (2013). Endocrinological late effects after radiotherapy. European Journal of Cancer.  ISSN 0959-8049.  49, s S225- S225
• Smerud, Knut Terje; Dolgos, Szilviszter; Wiik, Lisa; Meland, Nils; Olsen, I.; Åsberg, Anders; Reisæter, Anna Varberg; Midtvedt, Karsten; Pfeffer, Per F; Isaksen, G.; Bollerslev, Jens & Hartmann, Anders (2013). No Clinically Significant Effects of Calcium/ Calcitriol Supplementation on Loss of Bone Mass during the First Year after Renal Transplantation. American Journal of Transplantation.  ISSN 1600-6135.  13, s 208- 208

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