lmorkrid

• Tangeraas, Trine; Kristensen, Erle; Mørkrid, Lars; Elind, Elisabeth; Bliksrud, Yngve Thomas & Eide, Lars (2023). Fasting and non-fasting plasma levels of monomethyl branched chain fatty acids: Implications for maple syrup urine disease. The Journal of Inherited Metabolic Disease (JIMD). ISSN 0141-8955. 64(5), s. 360–366. doi: 10.1002/jmd2.12380. Fulltekst i vitenarkiv Vis sammendrag

  The branched-chain amino acids (BCAA) leucine, valine, and isoleucine provide precursors for monomethyl branched-chain fatty acids (BCFA). Established reference ranges for BCFAs are lacking. In maple syrup urine disease (MSUD), a rare inborn error of BCAA metabolism, the endogen production is impaired and MSUD patients are treated with a low protein (low BCAA) diet. The protein restriction may affect the dietary intake of BCFA, depending on the dietary choices made. Patients with MSUD are prescribed a more or less protein-restricted diet depending on the severity of the disease. The combination of a protein-restricted diet and subsequent impaired endogenous synthesis may render MSUD patients sensitive to BCFA deficiency, with yet unknown implications. To investigate the possibility of lower circulatory BCFA levels in MSUD that favors dietary BCFA supplementation, we first established fasting-state reference ranges for selected BCFAs and saturated/unsaturated fatty acids in plasma. Then, the effect of fasting on BCFA levels was evaluated by comparing the distribution in a fasting versus a non-fasting cohort. To test the hypothesis that BCFA deficiency could contribute to MSUD pathophysiology, we recruited patients with intermittent, intermediate, and classical form of MSUD and analyzed the corresponding BCFA z-scores. None of the BCFA species had |z-scores| > 2 relative to the reference range. Our findings do not support the requirement of BCFA supplementation in MSUD patients. The origin of BCFAs is discussed. Impaired capacity to synthesize BCFA do not manifest as reduced plasma levels in MSUD, suggesting that endogenous synthesis is dispensable for plasma levels.

• Tangeraas, Trine; Constante, Juliana R.; Backe, Paul Hoff; Oyarzábal, Alfonso; Neugebauer, Julia & Weinhold, Natalie [Vis alle 31 forfattere av denne artikkelen] (2023). BCKDK deficiency: a treatable neurodevelopmental disease amenable to newborn screening. Brain. ISSN 0006-8950. 146(7), s. 3003–3013. doi: 10.1093/brain/awad010.
• Salvador, Cathrin Lytomt; Flemmen, Per Trygge Kjelland; Tøndel, Camilla; Bliksrud, Yngve Thomas; Tsui, Ellen Fun Fong & Brun, Atle [Vis alle 8 forfattere av denne artikkelen] (2023). Renal function, sex and age influence purines and pyrimidines in urine and could lead to diagnostic misinterpretation. Molecular Genetics and Metabolism. ISSN 1096-7192. 140(3). doi: 10.1016/j.ymgme.2023.107649. Fulltekst i vitenarkiv
• Eskild, Anne; Sommerfelt, Silje; Gjesdal, Kjell Inge; Borthne, Arne Sigmund; Mørkrid, Lars & Hillestad, Vigdis (2022). Percentiles of intrauterine placental volume and placental volume relative to fetal volume: A prospective magnetic resonance imaging study. Placenta. ISSN 0143-4004. doi: 10.1016/j.placenta.2022.02.023.
• Mikkelsen, Audun; Møinichen, Unn Inger; Reims, Henrik Mikael; Grzyb, Krzysztof; Aabakken, Lars & Mørkrid, Lars [Vis alle 8 forfattere av denne artikkelen] (2022). Clinical variables as indicative factors for endoscopy in adolescents with esophageal atresia. Journal of Pediatric Surgery. ISSN 0022-3468. 00(0), s. 1–9. doi: 10.1016/j.jpedsurg.2022.10.003. Fulltekst i vitenarkiv Vis sammendrag

  Introduction Gastro-esophageal reflux disease (GERD) occurs frequently in patients operated for esophageal atresia (EA). Longstanding esophagitis may lead to dysphagia, strictures, columnar metaplasia, and dysplasia with an increased risk of adenocarcinoma. Are clinical factors and non-invasive assessments reliable indicators for follow-up with endoscopy? Material and method A follow-up study with inclusion of EA adolescents in Norway born between 1996 and 2002 was conducted. Clinical assessment with pH monitoring, endoscopy with biopsies, along with interviews and questionnaires regarding gastroesophageal reflux disease (GERD) and dysphagia were performed. Results We examined 68 EA adolescents. 62% reported GERD by interview, 22% by questionnaire. 85% reported dysphagia by interview, 71% by questionnaire. 24-hour pH monitoring detected pathological reflux index (RI) (>7%) in 7/59 (12%). By endoscopy with biopsy 62 (92%) had histologic esophagitis, of whom 3 (4%) had severe esophagitis. Gastric metaplasia was diagnosed in twelve (18%) adolescents, intestinal metaplasia in only one (1.5%). None had dysplasia or carcinoma. Dysphagia and GERD were statistically correlated to esophagitis and metaplasia, but none of the questionnaires or interviews alone were good screening instruments with high combined sensitivity and specificity. A compound variable made by simply taking the mean of rescaled RI and dysphagia by interview showed to be the best predictor of metaplasia (85% sensitivity, 67% specificity). Conclusion The questionnaires and interviews used in the present study were not good screening instruments alone. However, combining dysphagia score by interview and RI may be helpful in assessing which patients need endoscopy with biopsy at each individual follow-up examination. Level of Evidence Level II prognostic study Keywords Esophageal atresia Gastroesophageal reflux Dysphagia Metaplasia Endoscopy Columnar metaplasia ROC-curve

• Møinichen, Unn Inger; Mikkelsen, Audun; Gunderson, Ragnhild B.; Kibsgård, Thomas Johan; Mørkrid, Lars & IJsselstijn, Hanneke [Vis alle 7 forfattere av denne artikkelen] (2022). New insights in the prevalence of scoliosis and musculoskeletal asymmetries in adolescents with esophageal atresia. Journal of Pediatric Surgery. ISSN 0022-3468. s. 1–8. doi: 10.1016/j.jpedsurg.2022.10.002. Fulltekst i vitenarkiv Vis sammendrag

  Background Increased risk of scoliosis and musculoskeletal abnormalities in adolescents with esophageal atresia (EA) is reported, but the impact of these abnormalities on physical fitness and motor skills are not known. Methods Scoliosis was assessed radiographically and shoulder and chest abnormalities by a standardized protocol. Physical fitness was evaluated with Grippit, Six-minute walk test, and International Physical Activity Questionnaire and motor skills by Motor Assessment Battery for Children. Results Sixty-seven EA adolescents median 16 (13–20) years participated. The prevalence of significant scoliosis (≥ 20º) was 12% (8/67) whereas 22% (15/67) had mild scoliosis (10–19º). Vertebral anomalies occurred in 18/67 (27%), eight of them (44%) had scoliosis. The majority of adolescents (15/23) with scoliosis did not have vertebral anomalies. Musculoskeletal abnormalities were detected in 22–78%. Balance problems occurred three times more frequently than expected (44% vs. 15%, p = 0.004). Submaximal exercise capacity was significantly reduced compared to reference values (p < 0.001). Scoliosis ≥ 20º was related to reduced physical activity (p = 0.008), and musculoskeletal abnormalities to reduced physical activity and impaired motor skills (p = 0.042 and p < 0.038, respectively). Conclusions Significant scoliosis was diagnosed in 12% of the EA adolescents and related to reduced physical activity. Musculoskeletal abnormalities identified in more than half of the patients, were related to reduced physical activity and impaired motor skills, and exercise capacity was significantly below reference group. EA patients with and without vertebral anomalies need health-promoting guidance to prevent impaired motor skills and consequences of reduced physical activity. Level of evidence: Prognostic Study, Level II Keywords Scoliosis Musculoskeletal abnormalities Physical fitness Motor skills Esophageal atresia

• Sumathipala, Dulika Sanjeewani; Strømme, Petter; Fattahi, Zohreh; Lüders, Torben; Sheng, Ying & Kahrizi, Kimia [Vis alle 20 forfattere av denne artikkelen] (2022). ZBTB11 dysfunction: Spectrum of brain abnormalities, biochemical signature and cellular consequences. Brain. ISSN 0006-8950. 145(7), s. 2602–2616. doi: 10.1093/brain/awac034. Fulltekst i vitenarkiv
• Yazdani, Mazyar; Distante, Sonia; Mørkrid, Lars; Ulvik, Rune Johan & Bolann, Bjørn Johan (2022). Bloodlettings in Hemochromatosis Result in Increased Blood Lead (Pb) Concentrations. Biological Trace Element Research. ISSN 0163-4984. 00(0). doi: 10.1007/s12011-022-03424-y. Fulltekst i vitenarkiv Vis sammendrag

  Hemochromatosis is a hereditary disorder, most often associated with mutations of the HFE (High FErrum) gene. If left untreated, it can result in severe parenchymal iron accumulation. Bloodletting is the mainstay treatment. We have previously shown that treatment of hemochromatosis by repeated bloodlettings may induce changes in the serum levels of several trace elements. The aim of this work was to evaluate if whole blood concentrations of the environmental pollutants lead (Pb), mercury (Hg), and cadmium (Cd) could be affected by bloodlettings. We recruited 28 patients and 21 healthy individuals (control group). Whole blood and urine levels of Pb, Hg, and Cd were measured before the start and after the completion of treatment using inductively coupled plasma mass spectrometry, together with serum iron and liver function tests. Concentrations of blood Pb, but not Hg or Cd, were significantly increased after treatment. The increase in Pb was higher in C282Y homozygous patients than in the other patients, and it was positively correlated with the serum concentration of alkaline phosphatase. Bloodlettings in hemochromatosis result in an increase in the blood concentration of Pb. Augmented absorption due to iron loss or Pb mobilization from bone may contribute to the higher blood Pb level.

• Eskild, Anne; Mørkrid, Lars; Mortensen, Siri Beisland & Leegaard, Truls Michael (2022). Prevalence of antibodies against SARS-CoV-2 among pregnant women in Norway during the period December 2019 through December 2020. Epidemiology and Infection. ISSN 0950-2688. 150, s. 1–3. doi: 10.1017/S0950268822000073. Fulltekst i vitenarkiv Vis sammendrag

  We studied severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence among pregnant women in Norway by including all women who were first trimester pregnant (n = 6520), each month from December 2019 through December 2020, in the catchment region of Norway's second-largest hospital. We used sera that had been frozen stored after compulsory testing for syphilis antibodies in antenatal care. The sera were analysed with the Elecsys® Anti-SARS-CoV-2 immunoassay (Roche Diagnostics, Cobas e801). This immunoassay detects IgG/IgM against SARS-CoV-2 nucleocapsid antigen. Sera with equivocal or positive test results were retested with the Liaison® SARS-CoV-2 S1/S2 IgG (DiaSorin), which detects IgG against the spike (S)1 and S2 protein on the SARS-CoV-2 virus. In total, 98 women (adjusted prevalence 1.7%) had SARS CoV-2 antibodies. The adjusted seroprevalence increased from 0.3% (1/445) in December 2019 to 5.7% (21/418) in December 2020. Out of the 98 seropositive women, 36 (36.7%) had serological signs of current SARS-CoV-2 infection at the time of serum sampling, and the incidence remained low during the study period. This study suggests that SARS CoV-2 was present in the first half of December 2019, 6 weeks before the first case was recognised in Norway. The low occurrence of SARS-CoV-2 infection during 2020, may be explained by high compliance to extensive preventive measures implemented early in the epidemic.

• Peterson, Helene Fjeldvik; Eskild, Anne; Sommerfelt, Silje; Gjesdal, Kjell Inge; Borthne, Arne Sigmund & Mørkrid, Lars [Vis alle 7 forfattere av denne artikkelen] (2022). Percentiles of intrauterine placental volume and placental volume relative to fetal volume: A prospective magnetic resonance imaging study. Placenta. ISSN 0143-4004. 121, s. 40–45. doi: 10.1016/j.placenta.2022.02.023. Fulltekst i vitenarkiv Vis sammendrag

  Introduction We aimed to provide percentiles of intrauterine placental growth and placental growth relative to fetal growth (placental to fetal ratio) by measuring placental and fetal volumes by magnetic resonance imaging (MRI). Methods In this prospective study, 107 unselected singleton pregnancies were examined by MRI at gestational week 27 and 37. Based on the estimated volumes of the placenta and the fetus, we calculated median and percentiles at gestational weeks 27 and 37. Results Median placental volume at gestational week 27 was 513 cm3 (Inter Quartile Range (IQR) 182 cm3), and 831 cm3 (IQR 252 cm3) at week 37. The 10th – 90th percentiles included placental volumes between 392 and 717 cm3 at gestational week 27, and 631–1087 cm3 at week 37. The placental to fetal ratio was significantly higher at gestational week 27 than at week 37, with a median ratio of 0.54 (IQR 0.18) and 0.31 (IQR 0.08), respectively (p < 0.001). The 10th-90th percentiles included placental to fetal ratios between 0.43 and 0.73 at gestational week 27 and 0.25–0.39 at week 37. Discussion At gestational week 27, the placental volume was about half the size of the fetal volume, whereas at week 37, the placental volume was about one third of the fetal volume. This finding suggests that placental growth was less prominent than fetal growth after gestational week 27. Knowledge about the distribution of intrauterine placental size in the general population of pregnancies are prerequisites for diagnosing abnormal placental size.

• Krogstad, Veronica; Elgstøen, Katja B. Prestø; Johnsen, Linda Flaa; Hartmann, Anders; Mørkrid, Lars & Åsberg, Anders (2022). High Plasma Oxalate Levels Early After Kidney Transplantation Are Associated With Impaired Long-Term Outcomes. Transplant International. ISSN 0934-0874. 35. doi: 10.3389/ti.2022.10240. Fulltekst i vitenarkiv Vis sammendrag

  Background: Elevated levels of oxalate are common in renal failure patients and non-hyperoxaluria disease, and may cause damage after transplantation. We examined outcomes after 15 years for 167 kidney transplant recipients who had plasma oxalate measured early after transplantation. Analyses included plasma oxalate, recipient age, donor age, live donor, HLA-DR mismatch, mGFR, and smoking. Results: Median age was 52 years (range 18–81), 63% were male and 38% had live donors. Median plasma oxalate concentration 10 weeks after transplantation was 9.0 μmol/L (range 2.7–53.0), one third above the upper reference limit (11.0 μmol/L). Multivariable analysis revealed upper quartile plasma oxalate (>13.0 μmol/L, p = 0.008), recipient age (p < 0.001), deceased donor (p = 0.003), and current smoking (p < 0.001) as significant factors associated with patient survival. Upper quartile plasma oxalate (p = 0.021), recipient age (p = 0.001), deceased donor kidney (p = 0.001), HLA-DR mismatch (p = 0.015), and current smoking (p = 0.014) were also associated with graft loss. Factors associated with death censored graft losses were donor age (p = 0.012), deceased donor (p = 0.032), and HLA-DR mis-matched kidneys (p = 0.005) but plasma oxalate was not (p = 0.188). Conclusions: Plasma oxalate in the upper quartile early after transplantation was significantly associated with impaired long-term patient survival and graft losses, but not when censored for death.

• Ljungblad, Ulf Wike; Astrup, Henriette; Mørkrid, Lars; Hager, Helle Borgstrøm; Lindberg, Morten & Eklund, Erik A. [Vis alle 9 forfattere av denne artikkelen] (2022). Breastfed Infants With Spells, Tremor, or Irritability: Rule Out Vitamin B12 Deficiency. Pediatric Neurology. ISSN 0887-8994. 131, s. 4–12. doi: 10.1016/j.pediatrneurol.2022.03.003. Fulltekst i vitenarkiv Vis sammendrag

  Background In Norway, 5-10% of neonates and infants have biomarkers suggesting vitamin B12 deficiency from newborn screening tests and unselected clinical screening, respectively. Aims The aims were to identify risk factors and describe presenting symptoms and biochemical profiles in infants diagnosed with vitamin B12 deficiency. Methods In this case-control study, we searched hospital medical records for infants younger than one year born in 2011-2018, diagnosed with vitamin B12 deficiency. We compared 85 cases with a control group of 252 infants aged 3-7 months. Parents completed questionnaires. Results Of the 85 cases with vitamin B12 deficiency, 80% presented with spells (37%) of apneas, motor seizures, or absences within the first two months of life. Tremor (29%) and irritability (18%) were the most common findings at the first examination. Serum total homocysteine ≥10 μmol/L was found in 77% of cases compared to 28% of controls (P < 0.001). None of the mothers were vegetarians, but 25% reported a previous history of vitamin B12 deficiency and 7% had celiac disease. The dose of nitrous oxide given during labor was significantly associated with infant serum total homocysteine level at diagnosis (r = 0.37, 95% confidence interval = 0.16-0.55, P < 0.001) for cases, but not for controls. Conclusion Spells, tremor, and irritability are common findings in early infant vitamin B12 deficiency. Nitrous oxide given during labor is proposed as a contributing risk factor to the development of early infant vitamin B12 deficiency.

• Ljungblad, Ulf Wike; Paulsen, Henriette; Mørkrid, Lars; Pettersen, Rolf Dagfinn; Hager, Helle Borgstrøm & Lindberg, Morten [Vis alle 11 forfattere av denne artikkelen] (2021). The prevalence and clinical relevance of hyperhomocysteinemia suggesting vitamin B12 deficiency in presumed healthy infants. European journal of paediatric neurology. ISSN 1090-3798. 35, s. 137–146. doi: 10.1016/j.ejpn.2021.10.008. Fulltekst i vitenarkiv Vis sammendrag

  Background: Previous studies have demonstrated a high prevalence of biochemical vitamin B12 deficiency in infants in Norway. Increased total homocysteine (tHcy) is the most important marker of B12 deficiency in infants. There is a need to evaluate its clinical relevance. Aims: To investigate the prevalence of hyperhomocysteinemia (S-tHcy > 8 μmol/L) suggestive of suboptimal B12 status and the prevalence of clinically relevant hyperhomocysteinemia in presumed healthy infants in Norway. Further, to evaluate risk factors, presence of symptoms and psychomotor development in these children. Methods: In a prospective study we clinically examined 252 infants aged 3-7 months using standardized neurological and psychomotor tests prior to analyzing biochemical B12 deficiency markers in 250 infants. Results: Twenty-five of 250 (10%) infants had hyperhomocysteinemia combined with clinically relevant symptoms suggestive of B12 deficiency. Hyperhomocysteinemia was associated with tremor, excessive sleep, and sub-normal scores in the fine motor section of the Ages and Stages Questionnaire. One-hundred and fourteen of 250 (46%) infants had hyperhomocysteinemia. Multiple regression analysis showed months of infant formula use as the strongest negative predictor for hyperhomocysteinemia. Conclusion: We have demonstrated associations between symptoms suggestive of infant B12 deficiency and increased levels of tHcy in presumed healthy infants The combination of hyperhomocysteinemia and associated relevant symptoms suggestive of B12 deficiency was a common finding, albeit most infants with hyperhomocysteinemia did not show symptoms.

• Rowe, Alexander D.; Stoway, Stephanie D.; Åhlman, Henrik; Arora, Vaneet; Caggana, Michele & Fornari, Anna [Vis alle 24 forfattere av denne artikkelen] (2021). A novel approach to improve newborn screening for congenital hypothyroidism by integrating covariate-adjusted results of different tests into CLIR customized interpretive tools. International Journal of Neonatal Screening (IJNS). 7:23(2), s. 1–20. doi: 10.3390/ijns7020023. Fulltekst i vitenarkiv Vis sammendrag

  Newborn screening for congenital hypothyroidism remains challenging decades after broad implementation worldwide. Testing protocols are not uniform in terms of targets (TSH and/or T4) and protocols (parallel vs. sequential testing; one or two specimen collection times), and specificity (with or without collection of a second specimen) is overall poor. The purpose of this retrospective study is to investigate the potential impact of multivariate pattern recognition software (CLIR) to improve the post-analytical interpretation of screening results. Seven programs contributed reference data (N = 1,970,536) and two sets of true (TP, N = 1369 combined) and false (FP, N = 15,201) positive cases for validation and verification purposes, respectively. Data were adjusted for age at collection, birth weight, and location using polynomial regression models of the fifth degree to create three-dimensional regression surfaces. Customized Single Condition Tools and Dual Scatter Plots were created using CLIR to optimize the differential diagnosis between TP and FP cases in the validation set. Verification testing correctly identified 446/454 (98%) of the TP cases, and could have prevented 1931/5447 (35%) of the FP cases, with variable impact among locations (range 4% to 50%). CLIR tools either as made here or preferably standardized to the recommended uniform screening panel could improve performance of newborn screening for congenital hypothyroidism.

• Mellembakken, Jan Roar; Mahmoudan, azita; Mørkrid, Lars; Sundström-Poromaa, Inger; Morin-Papunen, Laure & Tapanainen, Juha S. [Vis alle 14 forfattere av denne artikkelen] (2021). Higher blood pressure in normal weight women with pcos compared to controls. Endocrine Connections. ISSN 2049-3614. 10(2), s. 154–163. doi: 10.1530/EC-20-0527. Fulltekst i vitenarkiv Vis sammendrag

  Objective Obesity is considered to be the strongest predictive factor for cardio-metabolic risk in women with polycystic ovary syndrome (PCOS). The aim of the study was to compare blood pressure (BP) in normal weight women with PCOS and controls matched for age and BMI. Methods From a Nordic cross-sectional base of 2615 individuals of Nordic ethnicity, we studied a sub cohort of 793 normal weight women with BMI < 25 kg/m2 (512 women with PCOS according to Rotterdam criteria and 281 age and BMI-matched controls). Participants underwent measurement of BP and body composition (BMI, waist-hip ratio), lipid status, and fasting BG. Data were presented as median (quartiles). Results The median age for women with PCOS were 28 (25, 32) years and median BMI was 22.2 (20.7, 23.4) kg/m2. Systolic BP was 118 (109, 128) mmHg in women with PCOS compared to 110 (105, 120) mmHg in controls and diastolic BP was 74 (67, 81) vs 70 (64, 75) mmHg, both P < 0.001. The prevalence of women with BP ≥ 140/90 mmHg was 11.1% (57/512) in women with PCOS vs 1.8% (5/281) in controls, P < 0.001. In women ≥ 35 years the prevalence of BP ≥ 140/90 mmHg was comparable in women with PCOS and controls (12.7% vs 9.8%, P = 0.6). Using multiple regression analyses, the strongest association with BP was found for age, waist circumference, and total cholesterol in women with PCOS. Conclusions Normal weight women with PCOS have higher BP than controls. BP and metabolic screening are relevant also in young normal weight women with PCOS.

• Møinichen, Unn Inger; Mikkelsen, Audun; Faugli, Anne; Mørkrid, Lars; Ijsselstijn, Hanneke & Emblem, Ragnhild (2020). Impaired motor performance in adolescents with esophageal atresia. Journal of Pediatric Surgery. ISSN 0022-3468. s. 1–6. doi: 10.1016/j.jpedsurg.2020.11.026. Fulltekst i vitenarkiv
• Strand, Janne Maren; Gul, Kiran Aftab; Erichsen, Hans Christian; Lundman, Emma; Berge, Mona C. & Trømborg, Anette Kjoshagen [Vis alle 28 forfattere av denne artikkelen] (2020). Second-Tier Next Generation Sequencing Integrated in Nationwide Newborn Screening Provides Rapid Molecular Diagnostics of Severe Combined Immunodeficiency. Frontiers in Immunology. ISSN 1664-3224. 11. doi: 10.3389/fimmu.2020.01417. Fulltekst i vitenarkiv
• Backe, Paul Hoff; Lærdahl, Jon Kristen; Kittelsen, Lene Svendsen; Dalhus, Bjørn; Mørkrid, Lars & Bjørås, Magnar (2020). Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the α-D-phosphohexomutase superfamily. Scientific Reports. ISSN 2045-2322. 10(1). doi: 10.1038/s41598-020-62548-0. Fulltekst i vitenarkiv
• Mikkelsen, Audun; Boye, Birgitte; Diseth, Trond H; Malt, Ulrik Fredrik; Mørkrid, Lars & Ijsselstijn, Hanneke [Vis alle 7 forfattere av denne artikkelen] (2020). Traumatic stress, mental health and quality of life in adolescents with esophageal atresia. Journal of Pediatric Surgery. ISSN 0022-3468. 15(26), s. 1–9. doi: 10.1016/j.jpedsurg.2020.10.029. Fulltekst i vitenarkiv
• Conte, Federica; Morava, Eva; Bakar, Nurulamin Abu; Wortmann, Saskia B.; Poerink, Anne Jonge & Grunewald, Stephanie [Vis alle 19 forfattere av denne artikkelen] (2020). Phosphoglucomutase-1 deficiency: Early presentation, metabolic management and detection in neonatal blood spots. Molecular Genetics and Metabolism. ISSN 1096-7192. 131(1-2), s. 135–146. doi: 10.1016/j.ymgme.2020.08.003. Fulltekst i vitenarkiv
• Hope, Sigrun; Nærland, Terje; Høyland, Anne Lise; Torske, Tonje; Malt, Eva & Abrahamsen, Tore G [Vis alle 16 forfattere av denne artikkelen] (2020). Higher vitamin B12 levels in neurodevelopmental disorders than in healthy controls and schizophrenia A comparison among participants between 2 and 53 years. The FASEB Journal. ISSN 0892-6638. 34(6), s. 8114–8124. doi: 10.1096/fj.201900855RRR. Fulltekst i vitenarkiv
• Kvisvik, Brede Alexander; Aagaard, Erika Nerdrum; Mørkrid, Lars; Røsjø, Helge; Lyngbakken, Magnus & Smedsrud, Marit Kristine [Vis alle 11 forfattere av denne artikkelen] (2019). Mechanical dispersion as a marker of left ventricular dysfunction and prognosis in stable coronary artery disease. The International Journal of Cardiovascular Imaging. ISSN 1569-5794. 35, s. 1265–1275. doi: 10.1007/s10554-019-01583-z. Fulltekst i vitenarkiv
• Lundar, Live; Aksnes, Gunnar; Mørkrid, Lars & Emblem, Ragnhild (2019). Prenatal extravasation of urine seems to preserve renal function in boys with posterior urethral valves. Journal of Pediatric Urology. ISSN 1477-5131. s. 1–7. doi: 10.1016/j.jpurol.2019.02.010.
• Minter Baerg, Melissa M; Stoway, Stephanie D; Hart, Jeremy; Mott, Lea; Peck, Dawn S & Nett, Stephanie L [Vis alle 16 forfattere av denne artikkelen] (2018). Precision newborn screening for lysosomal disorders. Genetics in Medicine. ISSN 1098-3600. 20(8), s. 847–854. doi: 10.1038/gim.2017.194.
• Ashikov, Angel; Bakar, Nurulamin Abu; Wen, Xiao-Yan; Niemeijer, Marco; Osorio, Glentino Rodrigues Pinto & Brand-Arzamendi, Koroboshka [Vis alle 32 forfattere av denne artikkelen] (2018). Integrating glycomics and genomics uncovers SLC10A7 as essential factor for bone mineralization by regulating post-Golgi protein transport and glycosylation. Human Molecular Genetics. ISSN 0964-6906. 27(17), s. 3029–3045. doi: 10.1093/hmg/ddy213.
• Kvaslerud, Anette Borger; Hussain, Amjad Iqbal; Auensen, Andreas; Ueland, Thor; Michelsen, Annika & Pettersen, Kjell [Vis alle 10 forfattere av denne artikkelen] (2018). Prevalence and prognostic implication of iron deficiency and anaemia in patients with severe aortic stenosis. Open heart. ISSN 2053-3624. 5:e000901(2), s. 1–10. doi: 10.1136/openhrt-2018-000901. Fulltekst i vitenarkiv
• Johansen, Nora; Liavaag, Astrid Helene; Mørkrid, Lars & Michelsen, Trond Melbye (2018). Hormone Levels and Sexual Functioning After Risk-Reducing Salpingo-Oophorectomy. Sexual Medicine - Open Access. ISSN 2050-1161. 6(2), s. 143–153. doi: 10.1016/j.esxm.2018.02.002.
• Abu Bakar, Nurulamin; Voermans, Nicol C.; Marquardt, Thorsten; Thiel, Christian; Janssen, Mirian C.H. & Hansikova, Hana [Vis alle 14 forfattere av denne artikkelen] (2018). Intact transferrin and total plasma glycoprofiling for diagnosis and therapy monitoring in phosphoglucomutase-I deficiency. Translational Research: The Journal of Laboratory and Clinical Medicine. ISSN 1931-5244. 199, s. 62–76. doi: 10.1016/j.trsl.2018.04.008.
• Salvador, Cathrin Lytomt; Tøndel, Camilla; Rowe, Alexander D.; Bjerre, Anna Kristina; Brun, Atle & Brackman, Damien [Vis alle 7 forfattere av denne artikkelen] (2018). Estimating glomerular filtration rate in children: evaluation of creatinine- and cystatin C-based equations. Pediatric nephrology (Berlin, West). ISSN 0931-041X. s. 1–11. doi: 10.1007/s00467-018-4067-3.
• Dahlberg, Daniel; Struys, Eduard A.; Janssen, EE; Mørkrid, Lars; Midttun, Øivind & Hassel, Bjørnar (2017). Cyst Fluid From Cystic, Malignant Brain Tumors: A Reservoir of Nutrients, Including Growth Factor-Like Nutrients, for Tumor Cells. Neurosurgery. ISSN 0148-396X. 80(6), s. 917–924. doi: 10.1093/neuros/nyw101. Vis sammendrag

  BACKGROUND: Brain tumors may have cysts, whose content of nutrients could influence tumor cell microenvironment and growth. OBJECTIVE: To measure nutrients in cyst fluid from glioblastoma multiforme (GBM) and metastatic brain tumors. METHODS: Quantification of nutrients in cyst fluid from 12 to 18 GBMs and 4 to 10 metastatic brain tumors. RESULTS: GBM cysts contained glucose at 2.2 mmol/L (median value; range <0.8-3.5) and glutamine at 1.04 mmol/L (0.17-4.2). Lactate was 7.1 mmol/L (2.4-12.5) and correlated inversely with glucose level (r = -0.77; P < .001). Amino acids, including glutamate, varied greatly, but median values were similar to previously published serum values. Ammonia was 75 μmol/L (11-241). B vitamins were present at previously published serum values, and riboflavin, nicotinamide, pyridoxal 5΄-phosphate, and cobalamin were higher in cyst fluid than in cerebrospinal fluid. Inorganic phosphate was 1.25 mmol/L (0.34-3.44), which was >3 times higher than in ventricular cerebrospinal fluid: 0.35 mmol/L (0.22-0.66; P < .001). Tricarboxylic acid cycle intermediates were in the low micromolar range, except for citrate, which was 240 μmol/L (140-590). In cystic metastatic malignant melanomas and lung tumors values were similar to those in GBMs. CONCLUSION: Tumor cysts may be a nutrient reservoir for brain tumors, securing tumor energy metabolism and synthesis of cell constituents. Serum is one likely source of cyst fluid nutrients. Nutrient levels in tumor cyst fluid are highly variable, which could differentially stimulate tumor growth. Cyst fluid glutamate, lactate, and phosphate may act as tumor growth factors; these compounds have previously been shown to stimulate tumor growth at concentrations found in tumor cyst fluid.

• Salvador, Cathrin Lytomt; Hartmann, Anders; Åsberg, Anders; Bergan, Stein; Rowe, Alexander D. & Mørkrid, Lars (2017). Estimating Glomerular Filtration Rate in Kidney Transplant Recipients: Comparing a Novel Equation With Commonly Used Equations in this Population. Transplantation direct. ISSN 2373-8731. 3(12). doi: 10.1097/TXD.0000000000000742. Fulltekst i vitenarkiv
• Sarna, Vikas Kumar; Lundin, Knut Erik Aslaksen; Mørkrid, Lars; Qiao, Shuo Wang; Sollid, Ludvig Magne & Christophersen, Asbjørn (2017). HLA-DQ-gluten tetramer blood test accurately identifies patients with and without celiac disease in absence of gluten consumption. Gastroenterology. ISSN 0016-5085. 154(4), s. 886–896.e6. doi: 10.1053/j.gastro.2017.11.006. Fulltekst i vitenarkiv
• Kvisvik, Brede Alexander; Mørkrid, Lars; Røsjø, Helge; Småstuen, Milada C; Rowe, Alexander D. & Eek, Christian [Vis alle 9 forfattere av denne artikkelen] (2017). Troponinas de alta sensibilidad T vs I en Sindrome Coronario Agudo: Prediccion de lesiones coronarias significativas y pronostico a largo plazo. Acta Bioquimica Clinica Latinoamericana. ISSN 0325-2957. 51(3), s. 395–407.
• Salvador, Cathrin Lytomt; Tøndel, Camilla; Rowe, Alexander D.; Bjerre, Anna Kristina; Brun, Atle & Brackman, Damien [Vis alle 8 forfattere av denne artikkelen] (2017). Renal Function Influences Diagnostic Markers in Serum and Urine: A Study of Guanidinoacetate, Creatine, Human Epididymis Protein 4, and Neutrophil Gelatinase–Associated Lipocalin in Children. The Journal of Applied Laboratory Medicine. ISSN 2374-9679. 2(3), s. 297–308. doi: 10.1373/jalm.2016.022145.
• Holm, Maia Blomhoff; Bastani, Nasser Ezzatkhah; Holme, Ane Moe; Zucknick, Manuela; Jansson, Thomas & Refsum, Helga [Vis alle 10 forfattere av denne artikkelen] (2017). Uptake and release of amino acids in the fetal-placental unit in human pregnancies. PLOS ONE. ISSN 1932-6203. 12(10). doi: 10.1371/journal.pone.0185760. Fulltekst i vitenarkiv
• Gislefoss, Randi Elin; Lauritzen, Marianne; Langseth, Hilde & Mørkrid, Lars (2017). Effect of multiple freeze-thaw cycles on selected biochemical serum components. Clinical Chemistry and Laboratory Medicine. ISSN 1434-6621. 55(7), s. 967–973. doi: 10.1515/cclm-2016-0892.
• Kvisvik, Brede Alexander; Mørkrid, Lars; Røsjø, Helge; Småstuen, Milada Cvancarova; Rowe, Alexander D. & Eek, Christian [Vis alle 9 forfattere av denne artikkelen] (2017). High-Sensitivity Troponin T vs I in Acute Coronary Syndrome: Prediction of Significant Coronary Lesions and Long-term Prognosis. Clinical Chemistry. ISSN 0009-9147. 63(2), s. 552–562. doi: 10.1373/clinchem.2016.261107.
• Distante, Sonia; Eikeland, Joakim; Pawar, Tina; Skinnes, Ragnhild; Høie, Kari & You, Panpan [Vis alle 8 forfattere av denne artikkelen] (2016). Blood removal therapy in hereditary hemochromatosis induces a stress response resulting in improved genome integrity. Transfusion. ISSN 0041-1132. 56(6), s. 1435–1441. doi: 10.1111/trf.13588.
• Lundin, Karin E.; Hamasy, Abdulrahman; Backe, Paul Hoff; Moens, Lotte N.; Falk-Sörqvist, Elin & Elgstøen, Katja B. Prestø [Vis alle 14 forfattere av denne artikkelen] (2015). Susceptibility to infections, without concomitant hyper-IgE, reported in 1976, is caused by hypomorphic mutation in the phosphoglucomutase 3 (PGM3) gene. Clinical Immunology. ISSN 1521-6616. 161(2), s. 366–372. doi: 10.1016/j.clim.2015.10.002.
• Gislefoss, Randi Elin; Langseth, Hilde; Bolstad, Nils; Nustad, Kjell Johannes & Mørkrid, Lars (2015). HE4 as an Early Detection Biomarker of Epithelial Ovarian Cancer: Investigations in Prediagnostic Specimens from the Janus Serumbank. International Journal of Gynecological Cancer. ISSN 1048-891X. 25(9), s. 1608–1615. doi: 10.1097/IGC.0000000000000532.
• Salvador, Cathrin Lytomt; Tøndel, Camilla; Mørkrid, Lars; Bjerre, Anna Kristina; Brun, Atle & Bolann, Bjørn Johan [Vis alle 8 forfattere av denne artikkelen] (2015). Glomerular filtration rate measured by iohexol clearance: A comparison of venous samples and capillary blood spots. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 75(8), s. 710–716. doi: 10.3109/00365513.2015.1091091.
• Smedsrud, Marit Kristine; Gravning, Jørgen A.; Omland, Torbjørn; Eek, Christian; Mørkrid, Lars & Skulstad, Helge [Vis alle 10 forfattere av denne artikkelen] (2015). Sensitive cardiac troponins and N-terminal pro-B-type natriuretic peptide in stable coronary artery disease: correlation with left ventricular function as assessed by myocardial strain. The International Journal of Cardiovascular Imaging. ISSN 1569-5794. 31(5), s. 967–973. doi: 10.1007/s10554-015-0646-6.
• Mørkrid, Lars; Rowe, Alexander D.; Elgstøen, Katja B. Prestø; Olesen, Jess H.; Ruijter, George & Hall, Patricia L. [Vis alle 13 forfattere av denne artikkelen] (2015). Continuous age- and sex-adjusted reference intervals of urinary markers for cerebral creatine deficiency syndromes: A novel approach to the definition of reference intervals. Clinical Chemistry. ISSN 0009-9147. 61(5), s. 760–768. doi: 10.1373/clinchem.2014.235564.
• Turgeon, Coleman T.; Moser, Ann B.; Mørkrid, Lars; Magera, Mark J.; Gavrilov, Dimitar K. & Oglesbee, Devin [Vis alle 10 forfattere av denne artikkelen] (2015). Streamlined determination of lysophosphatidylcholines in dried blood spots for newborn screening of X-linked adrenoleukodystrophy. Molecular Genetics and Metabolism. ISSN 1096-7192. 114(1), s. 46–50. doi: 10.1016/j.ymgme.2014.11.013.
• Gislefoss, Randi Elin; Grimsrud, Tom Kristian & Mørkrid, Lars (2015). Stability of selected serum hormones and lipids after long-term storage in the Janus Serum Bank. Clinical Biochemistry. ISSN 0009-9120. 48(6), s. 364–369. doi: 10.1016/j.clinbiochem.2014.12.006.
• Bolann, Bjørn Johan; Distante, Sonia; Mørkrid, Lars & Ulvik, Rune Johan (2015). Bloodletting therapy in hemochromatosis: Does it affect trace element homeostasis? Journal of Trace Elements in Medicine and Biology. ISSN 0946-672X. 31, s. 225–229. doi: 10.1016/j.jtemb.2014.07.021.
• Stray-Pedersen, Asbjørg; Backe, Paul Hoff; Sorte, Hanne Sørmo; Mørkrid, Lars; Chokshi, N.Y. & Erichsen, Hans Christian [Vis alle 39 forfattere av denne artikkelen] (2014). PGM3 mutations cause a congenital disorder of glycosylation with severe immunodeficiency and skeletal dysplasia. American Journal of Human Genetics. ISSN 0002-9297. 95(1), s. 96–107. doi: 10.1016/j.ajhg.2014.05.007.
• Gravning, Jørgen A.; Smedsrud, Marit Kristine; Omland, Torbjørn; Eek, Christian; Skulstad, Helge & Aaberge, Lars [Vis alle 10 forfattere av denne artikkelen] (2013). Sensitive troponin assays and N-terminal pro-B-type natriuretic peptide in acute coronary syndrome: Prediction of significant coronary lesions and long-term prognosis. American Heart Journal. ISSN 0002-8703. 165(5), s. 716–724. doi: 10.1016/j.ahj.2013.02.008.
• Backe, Paul Hoff; Ytre-Arne, Mari; Røhr, Åsmund Kjendseth; Brodtkorb, Else; Fowler, Brian & Rootwelt, Helge [Vis alle 8 forfattere av denne artikkelen] (2013). Novel Deletion Mutation Identified in a Patient with Late-Onset Combined Methylmalonic Acidemia and Homocystinuria, cblC Type. JIMD Reports. ISSN 2192-8304. 11, s. 79–85. doi: 10.1007/8904_2013_225.
• Gislefoss, Randi Elin; Grimsrud, Tom Kristian; Høie, Kari & Mørkrid, Lars (2012). Stability of testosterone measured in male archival serum samples by two different methods. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 72(7), s. 555–562. doi: 10.3109/00365513.2012.705888.
• Odden, Nancy; Henriksen, Tore & Mørkrid, Lars (2012). Serum soluble urokinase plasminogen activator receptor (suPAR) in early pregnancy prior to clinical onset of preeclampsia. Acta Obstetricia et Gynecologica Scandinavica. ISSN 0001-6349. 91(10), s. 1226–1232. doi: 10.1111/j.1600-0412.2012.01504.x.
• Sorte, Hanne Sørmo; Mørkrid, Lars; Rødningen, Olaug Kristin; Kulseth, Mari Ann; Stray-Pedersen, Asbjørg & Matthijs, Gert [Vis alle 12 forfattere av denne artikkelen] (2012). Severe ALG8-CDG (CDG-Ih) associated with homozygosity for two novel missense mutations detected by exome sequencing of candidate genes. European Journal of Medical Genetics. ISSN 1769-7212. 55(3), s. 196–202. doi: 10.1016/j.ejmg.2012.01.003.
• Eskild, Anne; Fedorcsak, Peter; Mørkrid, Lars & Tanbo, Tom Gunnar (2012). Maternal body mass index and serum concentrations of human chorionic gonadotropin in very early pregnancy. Fertility and Sterility. ISSN 0015-0282. 98(4), s. 905–910. doi: 10.1016/j.fertnstert.2012.06.011.
• Holmboe, Laila Kampen Dajani; Andersen, Anders Mikal; Mørkrid, Lars; Slørdal, Lars & Hall, Kirsten Sundby (2012). High dose methotrexate chemotherapy: pharmacokinetics, folate and toxicity in osteosarcoma patients. British Journal of Clinical Pharmacology. ISSN 0306-5251. 73(1), s. 106–114. doi: 10.1111/j.1365-2125.2011.04054.x.
• Hustad, Simon Steinar; Eussen, Simone; Midttun, Øivind; Ulvik, Arve; van de Kant, Puck M & Mørkrid, Lars [Vis alle 8 forfattere av denne artikkelen] (2012). Kinetic modeling of storage ffects on biomarkers related to B vitamin status and one-carbon metabolism. Clinical Chemistry. ISSN 0009-9147. 58(2), s. 402–410. doi: 10.1373/clinchem.2011.174490.
• Bremer, Sara; Ohlsson, Annika; Brodtkorb, Else; Rootwelt, Helge; Rootwelt, Terje & Woldseth, Berit [Vis alle 7 forfattere av denne artikkelen] (2011). A novel mucopolysaccharidosis type I associated splice site mutation and IDUA splice variants. Molecular Genetics and Metabolism. ISSN 1096-7192. 104(3), s. 289–294. doi: 10.1016/j.ymgme.2011.07.012.
• Rehman, Yasser; Stensrud, Kjetil Juul; Mørkrid, Lars; Bjørnland, Kristin & Emblem, Ragnhild (2011). Endosonographic evaluation of anal sphincters in healthy children. Journal of Pediatric Surgery. ISSN 0022-3468. 46(8), s. 1587–1592. doi: 10.1016/j.jpedsurg.2011.03.067.
• Tangeraas, Trine; Midtvedt, Karsten; Fredriksen, Per-Morten; Småstuen, Milada Cvancarova; Mørkrid, Lars & Bjerre, Anna Kristina (2010). Cardiorespiratory fitness is a marker of cardiovascular health in renal transplanted children. Pediatric nephrology (Berlin, West). ISSN 0931-041X. 25(11), s. 2343–2350. doi: 10.1007/s00467-010-1596-9.
• Paulsen, Gøran; Crameri, R; Benestad, Haakon Breien; Fjeld, Jan Gunnar; Mørkrid, Lars & Hallén, Jostein [Vis alle 7 forfattere av denne artikkelen] (2010). Time Course of Leukocyte Accumulation in Human Muscle after Eccentric Exercise. Medicine & Science in Sports & Exercise. ISSN 0195-9131. 42(1), s. 75–85. doi: 10.1249/MSS.0b013e3181ac7adb. Vis sammendrag

  PAULSEN. G., R. CRAMERI, H. B. BENESTAD, J. G. HELD. L. MORKRID, J. HALLEN, and T. RAASTAD. Time course of Leukocyte Accumulation in Human Muscle after Eccentric Exercise. Med. Sci. Sports Exerc., Vol. 42, No. 1, pp. 75-85, 2010. Put-pose: To investigate the little course of leukocyte accumulation in eccentric exercised human muscles and its relation to recovery of muscle function and soreness. Methods: Eleven young males performed 300 unilateral. maximal voluntary, eccentric actions with the musculus quadriceps femoris (30 degrees.s(-1)). Before and at regular intervals for 7 d after exercise, force-generating capacity was measured with maximal concentric knee extensions (60 degrees.s(-1)). Accumulation of radiolabeled (autologous) leukocytes was measured with scintigraphy. Biopsies from musculus vastus lateralis were obtained 0.5, 4, 8, 24, 96, and 168 It after exercise from both the exercised leg and the control leg. Muscle cross-sections were stained with antibodies against leukocytes (CD16 and CD68). Muscle soreness was rated oil a visual analog scale. Results: Immediately after exercise, the Subjects' ability to generate force was reduced by 47 +/- 5%. Muscle function recovered slowly and was not fully restored after 1 wk. Radiolabeled leukocytes accumulated ill file Muscles during the first hour (3-24 h) after exercise, and leukocytes were at the same time observed histologically. primarily in the endomysium and perimysium. A pail of the accumulated radiolabeled leukocytes appeared to be located within local blood vessels. The highest numbers of CD16(+) and CD68(+) cells were found 4 and 7 (1 after exercise. There was a positive correlation between accumulation of radiolabeled leukocytes and muscle weakness measured 1-3 d after exercise (r = 0.8. P < 0.05) and, surprisingly. a negative correlation between radiolabeled leukocyte accumulation and Muscle soreness (r = -0.96, P < 0.01). Conclusion: Exercise-induced Muscle damage initiated a rapid local inflammatory response that gradually increased over the next days, Halted recovery Of muscle function Was associated with local accumulation of leukocytes, whereas muscle soreness could not be explained by the presence of leukocytes.

• Elgstøen, Katja B. Prestø; Woldseth, Berit; Høie, Kari & Mørkrid, Lars (2010). Liquid chromatography-tandem mass spectrometry determination of oxalate in spot urine. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 70(3), s. 145–150. doi: 10.3109/00365510903578765.
• Elgstøen, Katja B. Prestø; Johnsen, Linda Flaa; Woldseth, Berit; Mørkrid, Lars & Hartmann, Anders (2010). Plasma oxalate following kidney transplantation in patients without primary hyperoxaluria. Nephrology, Dialysis and Transplantation. ISSN 0931-0509. 25(7), s. 2341–2345. doi: 10.1093/ndt/gfq065.
• Hannisdal, Rita; Gislefoss, Randi Elin; Grimsrud, Tom K.; Hustad, Simon Steinar; Mørkrid, Lars & Ueland, Per Magne (2010). Analytical Recovery of Folate and Its Degradation Products in Human Serum Stored at-25 degrees C for up to 29 Years. Journal of Nutrition. ISSN 0022-3166. 140(3), s. 522–526. doi: 10.3945/jn.109.116418.
• Svalheim, Sigrid; Luef, G; Rauchenzauner, M; Mørkrid, Lars; Gjerstad, Leif & Taubøll, Erik (2010). Cardiovascular risk factors in epilepsy patients taking levetiracetam, carbamazepine or lamotrigine. Acta Neurologica Scandinavica. ISSN 0001-6314. 122, s. 30–33.
• Løvik, Astrid; Gjøen, Anne; Mørkrid, Lars; Guttormsen, Vigdis; Ueland, Thor & Lundin, Knut E A (2009). Oats in a strictly gluten-free diet is associated with decreased gluten intake and increased serum bilirubin. e - SPEN: the European e-journal of clinical nutrition and metabolism. ISSN 1751-4991. 4(6), s. 315–320. Vis sammendrag

  Summary Background and aims To investigate clinical, nutritional, and laboratory parameters during oats challenge and to cross-sectionally examine the levels of plasma bilirubin in a cohort of coeliac disease patients. Methods Intestinal biopsies, gastrointestinal symptom registration, standard blood tests, anthropometry, weighed food records, and calculations of nutrients and gluten were performed in 19 patients before and after oats challenge (50g/day). To further investigate bilirubin levels, blood samples were analysed in 136 patients (82 oats consumers) and 141 healthy controls. Results Three of 19 patients developed gastrointestinal symptoms during oats challenge. Compliance with gluten-free diet was good. Dietary fibre intake increased after oats inclusion (p<0.024) and met recommended levels. With three exceptions, calculated gluten intake remained within the proposed safe level and decreased after oats intake. Total P-bilirubin increased after oats challenge (p<0.003). In the cohort study a tendency of higher bilirubin levels was seen among oats consumers (17g/day). Conclusions Gluten-free oats were associated with recommended levels of dietary fibre, and calculated gluten intake was reduced by more than 50%. Gluten-free oats induced higher levels of the anti-oxidant bilirubin in treated coeliac disease patients. This may have positive health implications.

• Nenseter, Marit Sofie; Ueland, Thor; Retterstøl, Kjetil; Strøm, Ellen C.; Mørkrid, Lars & Landaas, Sverre [Vis alle 9 forfattere av denne artikkelen] (2009). Dysregulated RANK Ligand/RANK Axis in Hyperhomocysteinemic SubjectsEffect of Treatment with B-Vitamins. Stroke. ISSN 0039-2499. 40(1), s. 241–247. doi: 10.1161/STROKEAHA.108.522995.
• Almendingen, Kari; Fausa, Olav; Høstmark, Arne Torbjørn; Bratlie, Jorun; Mørkrid, Lars & Aabakken, Lars [Vis alle 7 forfattere av denne artikkelen] (2009). Serum nutrients and habitual dietary intake in colectomized FAP patients in Norway. European Journal of Nutrition. ISSN 1436-6207. 48(3), s. 129–136. doi: 10.1007/s00394-008-0772-1.
• Andresen, Jannicke Hanne; Carlsen, Birgitte; Solberg, Rønnaug; Mørkrid, Lars; Goverud, Ingeborg Løstegaard & Løberg, Else Marit [Vis alle 7 forfattere av denne artikkelen] (2009). Newborn piglets exposed to hypoxia after nicotine or saline pretreatment: Long-term effects on brain and heart. Journal of Maternal-Fetal & Neonatal Medicine. ISSN 1476-7058. 22(2), s. 161–168. doi: 10.1080/14767050802663186.
• Vistad, Ingvild; Kristensen, Gunnar S Balle; Fosså, Sophie Dorothea; Dahl, Alv A & Mørkrid, Lars (2009). Intestinal malabsorption in long-term survivors of cervical cancer treated with radiotherapy. International Journal of Radiation Oncology, Biology, Physics. ISSN 0360-3016. 73(4), s. 1141–1147. doi: 10.1016/j.ijrobp.2008.05.064.
• Åsberg, Anders; Midtvedt, Karsten; Voytovich, Monica Hagen; Line, Pål Dag; Narverud, Janicke & Reisæter, Anna Varberg [Vis alle 9 forfattere av denne artikkelen] (2009). Calcineurin inhibitor effects on glucose metabolism and endothelial function following renal transplantation. Clinical Transplantation. ISSN 0902-0063. 23(4), s. 511–518. doi: 10.1111/j.1399-0012.2009.00962.x.
• Gislefoss, Randi Elin; Grimsrud, Tom K & Mørkrid, Lars (2009). Stability of selected serum proteins after long-term storage in the Janus Serum Bank. Clinical Chemistry and Laboratory Medicine. ISSN 1434-6621. 47(5), s. 596–603. doi: 10.1515/CCLM.2009.121.
• Svalheim, Sigrid; Taubøll, Erik; Luef, G; Lossius, Andreass; Rauchenzauner, M & Sandvand, Fiona [Vis alle 9 forfattere av denne artikkelen] (2009). Differential effects of levetiracetam, carbamazepine, and lamotrigine on reproductive endocrine function in adults. Epilepsy & Behavior. ISSN 1525-5050. 16(2), s. 281–287. doi: 10.1016/j.yebeh.2009.07.033.
• Guttormsen, Vigdis; Løvik, Astrid; Bratlie, Jorunn; Mørkrid, Lars; Bye, Asta & Lundin, Knut E.A. (2008). No induction of anti-avenin IgA by oats in adult, diet-treated coeliac disease. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 43(2), s. 161–165. Vis sammendrag

  Objective. Coeliac disease is effectively treated with a gluten-free diet devoid of wheat, rye, barley and related cereals. Oats has until recently also been considered harmful but is now allowed in several countries. We have, however, identified three adult coeliac disease patients who developed a flare of active coeliac disease after ingestion of oats, which suggests that oats might not be entirely innocent in coeliac disease. It is known that patients with untreated coeliac disease have elevated IgA antibodies to oat prolamins. The objective of this study was to investigate whether levels of IgA against oats were increased in treated, adult coeliac disease patients. Material and methods. Serum was collected from 136 adult patients with treated coeliac disease and 139 controls. Eighty-two of the coeliac disease patients had been taking oats as part of their gluten-free diet for 6 months or more. IgA against oats avenin, wheat gliadin and tissue transglutaminase was tested with ELISA. Results. No significant differences were found in IgA against oats in oats-eating and non-oats-eating coeliac disease patients. Both groups had increased levels of IgA against wheat, oats and tissue transglutaminase compared to healthy controls. A significant positive correlation was found between anti-avenin and antigliadin IgA (p<0.0001), and between anti-avenin and anti-tissue transglutaminase IgA (p=0.0012). Conclusions. Ingestion of oats does not cause increased levels of IgA against oats in adult coeliac disease patients on a gluten-free diet. The findings support the notion that most adult coeliac disease patients can tolerate oats.

• Gravning, J; Ueland, T; Mørkrid, Lars; Endresen, Knut; Aaberge, Lars & Kjekshus, John (2008). Different prognostic importance of elevated troponin I after percutaneous coronary intervention in acute coronary syndrome and stable angina pectoris. Scandinavian Cardiovascular Journal. ISSN 1401-7431. 42, s. 214–221. doi: 10.1080/14017430801932824.
• Gislefoss, Randi Elin; Grimsrud, TK & Mørkrid, Lars (2008). Long-term stability of serum components in the Janus Serum Bank. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 68, s. 402–409. doi: 10.1080/00365510701809235.
• Vistad, Ingvild; Kristensen, Gunnar S Balle; Fosså, Sophie Dorothea; Dahl, Alv A & Mørkrid, Lars (2008). Intestinal malabsorption in long-term survivors of cervical cancer treated with radiotherapy. International Journal of Radiation Oncology, Biology, Physics. ISSN 0360-3016. s. 1–7. doi: 10.1016/j.ijrobp.2008.05.064.
• Wyller, Vegard Bruun; Godang, K; Mørkrid, Lars; Saul, J. Philip; Thaulow, Erik & Walløe, Lars (2007). Abnormal Thermoregulatory Responses in Adolescents With Chronic Fatigue Syndrome: Relation to Clinical Symptoms. Pediatrics. ISSN 0031-4005. 120(1), s. 129–137. doi: 10.1542/peds.2006-2759. Vis sammendrag

  OBJECTIVES. Chronic fatigue syndrome is a common and disabling disease of unknown etiology. Accumulating evidence indicates dysfunction of the autonomic nervous system. To further explore the pathophysiology of chronic fatigue syndrome, we investigated thermoregulatory responses dependent on catecholaminergic effector systems in adolescent patients with chronic fatigue syndrome. PATIENTS AND METHODS. A consecutive sample of 15 patients with chronic fatigue syndrome aged 12 to 18 years and a volunteer sample of 57 healthy control subjects of equal gender and age distribution were included. Plasma catecholamines and metanephrines were measured before and after strong cooling of 1 hand. Acral skin blood flow, tympanic temperature, heart rate, and mean blood pressure were measured during moderate cooling of 1 hand. In addition, clinical symptoms indicative of thermoregulatory disturbances were recorded. RESULTS. Patients with chronic fatigue syndrome reported significantly more shivering, sweating, sudden change of skin color, and feeling unusually warm. At baseline, patients with chronic fatigue syndrome had higher levels of norepinephrine, heart rate, epinephrine, and tympanic temperature than control subjects. During cooling of 1 hand, acral skin blood flow was less reduced, vasoconstrictor events occurred at lower temperatures, and tympanic temperature decreased more in patients with chronic fatigue syndrome compared with control subjects. Catecholamines increased and metanephrines decreased similarly in the 2 groups. CONCLUSIONS. Adolescent patients with chronic fatigue syndrome have abnormal catecholaminergic-dependent thermoregulatory responses both at rest and during local skin cooling, supporting a hypothesis of sympathetic dysfunction and possibly explaining important clinical symptoms.

• Hjelmesæth, Jøran; Hagen Liv Trine, Universitetet i Oslo; Hagen, Liv Trine; Åsberg, Anders; Midtvedt, Karsten & Størset, Øyvind [Vis alle 10 forfattere av denne artikkelen] (2007). The impact of short-term ciclosporin A treatment on insulin secretion and insulin sensitivity in man. Nephrology, Dialysis and Transplantation. ISSN 0931-0509. 22(6), s. 1743–1749. doi: 10.1093/ndt/gfl820.
• Emblem, Ragnhild; Mørkrid, Lars & Bjørnland, Kristin (2007). Anal endosonography is useful for postoperative assessment of anorectal malformations. Journal of Pediatric Surgery. ISSN 0022-3468. 42, s. 1549–1554. doi: 10.1016/j.jpedsurg.2007.04.017.

Se alle arbeider i Cristin

• Salvador, Cathrin Lytomt; Flemmen, Per Tryggve Kjelland; Woldseth, Berit; Storbraaten, Marielle; Tøndel, Camilla & Bjerre, Anna Kristina [Vis alle 8 forfattere av denne artikkelen] (2023). Reduced renal function and other factors influence the measured level of glycosaminoglycans (GAGs) and could lead to diagnostic misinterpretation.
• Klcovansky, Jakob; Mørkrid, Lars & Möller, Thomas (2016). Heart transplantation in a child with congenital disorder of glycosylation. The Journal of Heart and Lung Transplantation. ISSN 1053-2498. 35(8), s. 1048–1049. doi: 10.1016/j.healun.2016.05.007.
• Salvador, Cathrin Lytomt; Stray-Pedersen, Asbjørg; Woldseth, Berit; Backe, Paul Hoff; Helle, Høyer & Svendsen, Marit [Vis alle 8 forfattere av denne artikkelen] (2016). A novel homozygous LIAS mutation that causes glycine encephalopathy.
• Salvador, Cathrin Lytomt; Rowe, Alexander D.; Bjerre, Anna Kristina; Tøndel, Camilla; Brun, Atle & Brackman, Damien [Vis alle 7 forfattere av denne artikkelen] (2016). Glomerular filtration rate (GFR) strongly influences guanidinoacetic acid (GAA) in plasma and urine.
• Backe, Paul Hoff; Kittelsen, Lene Svendsen; Elgstøen, Katja B. Prestø; Mørkrid, Lars & Bjørås, Magnar (2015). Functional and structural characterization of the human phosphohexomutases PGM1 and PGM3.
• Stray-Pedersen, Asbjørg; Backe, Paul Hoff; Sorte, Hanne Sørmo; Mørkrid, Lars; Chokshi, N.Y. & Erichsen, Hans Christian [Vis alle 39 forfattere av denne artikkelen] (2014). A congenital disorder of glycosylation, with lymphopenia, neutropenia, and skeletal dysplasia, caused by mutations in the gene encoding phosphoglucomutase 3 (PGM3).
• Østeby, Anja; Gustavsen, Marita; Tune, Michelle; Bliksrud, Yngve Thomas; Rootwelt, Helge & Woldseth, Berit [Vis alle 13 forfattere av denne artikkelen] (2014). The use of LC-MS QTOF based metabolomics to reveal the identity of metabolites contributing to false positive results in the acylcarnitine profile.
• Backe, Paul Hoff; Elgstøen, Katja B. Prestø; Bjørås, Magnar & Mørkrid, Lars (2014). Measuring catalytic activity for wild type and mutant PGM3 by monitoring consumption or production of GlcNAc-6-P using mass spectrometry.
• Salvador, Cathrin Lytomt; Tøndel, Camilla; Mørkrid, Lars; Bjerre, Anna Kristina; Bolann, Bjørn Johan & Brun, Atle [Vis alle 8 forfattere av denne artikkelen] (2013). GLOMERULAR FILTRATION RATE (GFR) MEASURED BY IOHEXOL CLEARANCE IN CHILDREN; A COMPARISON BETWEEN VENOUS SAMPLES AND DRIED BLOOD SPOTS. Pediatric nephrology (Berlin, West). ISSN 0931-041X. 28(8), s. 1653–1654.
• Salvador, Cathrin Lytomt; Tøndel, Camilla; Mørkrid, Lars; Bjerre, Anna Kristina; Bolann, Bjørn Johan & Brun, Atle [Vis alle 8 forfattere av denne artikkelen] (2013). Glomerular Filtration Rate (GFR) measured by Iohexol Clearance in Children; a comparison between venous samples and dried spots.
• Bolann, Bjørn Johan; Ulvik, Rune Johan; Mørkrid, Lars & Distante, Sonia (2013). Bloodletting therapy in hemochromatosis: Does it effect trace elements homeostasis? American Journal of Hematology. ISSN 0361-8609. 88(5), s. E207–E207. doi: 10.1002/ajh.23453.
• Distante, Sonia; Høie, Kari; Mørkrid, Lars & Eide, Lars (2013). ASSESSING THE MITOCHONDRIAL IRON METABOLISM IN HEREDITARY HEMOCHROMATOSIS. American Journal of Hematology. ISSN 0361-8609. 88(5), s. E207–E207.
• Hausken, Jon; Klingenberg, Olav; Mørkrid, Lars; Rollag, Halvor; Foss, Aksel & Midtvedt, Karsten (2012). Elevated Troponin I and NT-proBNP at the Time of Transplantation May Predict a Major Adverse Cardiac Event in the Early Postoperative Period After Renal Transplantation. Transplantation. ISSN 0041-1337. 94(2), s. E15–E16. doi: 10.1097/TP.0b013e31825b7633.
• Johnsen, Linda Flaa; Elgstoen, Katja Benedikte Prestø; Woldseth, Berit; Mørkrid, Lars & Hartmann, Anders (2009). DETERMINANTS OF PLASMA OXALATE IN NON-HYPEROXALURIA KIDNEY TRANSPLANT PATIENTS. Transplant International. ISSN 0934-0874. 22, s. 187–187.
• Mørkrid, Lars (2008). Reference limits for components with strong age dependence from laboratory production data exemplified by urinary glycosamino-glycans (U-GAG). The Journal of Inherited Metabolic Disease (JIMD). ISSN 0141-8955. 31, s. 99–99.
• Odden, Nancy & Mørkrid, Lars (2008). High molecular weight adiponectin is raised in cord blood of newborns, but is unaffected by pre-eclamptic pregnancies. International Journal of Obesity. ISSN 0307-0565. 32, s. S132–S132.
• Åsberg, Anders; Midtvedt, Karsten; Voytovich, Monica Hagen; Line, Pål-Dag; Narverud, Janicke & Reisæter, Anna Varberg [Vis alle 9 forfattere av denne artikkelen] (2008). Calcineurin inhibitor effects on glucose metabolism and endothelial function following renal transplantation.
• Åsberg, Anders; Midtvedt, Karsten; Voytovich, Monica Hagen; Line, Pål-Dag; Narverud, Janicke & Reisæter, Anna Varberg [Vis alle 9 forfattere av denne artikkelen] (2008). CALCINEURIN INHIBITORS ALTER GLUCOSE METABOLISM AND ENDOTHELIAL FUNCTION IN RENAL TRANSPLANT RECIPIENTS.
• Åsberg, Anders; Midtvedt, Karsten; Voytovich, Monica Hagen; Line, Pål-Dag; Narverud, Janicke & Reisæter, Anna Varberg [Vis alle 9 forfattere av denne artikkelen] (2008). CALCINEURIN INHIBITOR INDUCED INSULIN RESITANCE FOLLOWING RENAL TRANSPLANTATION.
• Holven, Kirsten Bjørklund; Halvorsen, Bente ; Bjerkeli, Vigdis; Damås, Jan Kristian; Retterstøl, Kjetil & Mørkrid, Lars [Vis alle 9 forfattere av denne artikkelen] (2007). Impaired inhibitory effect of interleukin-10 on the balance between matrix metalloproteinas-9 and its inhibitor in mononuclear cells from hyperhomocysteinemic subjects. Clinical Chemistry and Laboratory Medicine. ISSN 1434-6621.
• Salvador, Cathrin Lytomt; Mørkrid, Lars; Bergan, Stein & Tøndel, Camilla (2020). Estimation and measurement of glomerular filtration rate in children. Universitetet i Oslo.
• Gislefoss, Randi Elin & Mørkrid, Lars (2010). Quality aspects of long-term stored samples. Studies in the Janus Serum Bank of Norway. Unipub forlag. ISSN 978-82-8072-502-8.

Se alle arbeider i Cristin