Chromatin Biology

The chromatin biology group focuses on epigenetic regulation in stem cells and cancer.

Andrea Schwartz, Nazli C. Ozalp, Xuan Thang Ngyuen, Ragnhild Eskeland, Marit Ledsaak, Elizabeth Otti Surgucheva.

Photo: Åsne Rambøl Hillestad

The main interest in the Eskeland lab is to understand how gene activity is regulated by local composition (histone modifications and variants), chromatin structure and nuclear organisation. We uniquely combine in vitro and in vivo approaches to study these epigenetic mechanisms during in embryonic stem cell differentiation, in cancer cells and after exposure to drugs.

Eskeland is an Associate Professor at Department of Molecular Medicine, in the leader team of PharmaTox strategic research initiative and a partner PI in the Centre for Cancer Cell Reprogramming.

Learn more about Cancer Epigenetics and our research in our YouTube channel.

Our research is funded by:

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Published Jan. 18, 2019 7:17 AM - Last modified Apr. 14, 2024 7:31 PM

Participants

Ragnhild Eskeland University of Oslo
Marit Ledsaak University of Oslo
Xuan Thang Nguyen University of Oslo
Nazli Ozalp
Elizabeth Otti Surgucheva
Andrea Schwartz

Detailed list of participants

Groups

Positions Available

Please contact Ragnhild Eskeland if you are interested in working in our group. We take in master students on exiting projects related to cancer, CRISPR-Cas9 and stem cell differentiation. A computational biologist position will be available in 2024.

Github and web tools

Media

@EskelandLab
@ragnhildes.bsky.social
EskelandLab youtube channel

Blogs and Public Articles

Genomet som eit flokete garnnøste (Kristin Straumsheim Grønli)
Epigenetiske endringar med metyleringsmøster kan bidra til å nullstille alderen til ein organisme Tidsskriftet den norske legeforeningen (Ruth Halsen)
Kan vi behandle sykdommer ved å reparere gener? (Medisinerbloggen, Martine Isom Mesel og Ragnhild Eskeland)
Et steg nærmere tryggere genredigering (Aftenposten, Martine Isom Mesel og Ragnhild Eskeland)
Ny strategi i kreftbehandling: Omprogrammering av kreftceller (Medisinerbloggen, Harald Stenmark, Anne Simonsen, Jørgen Wesche, Jorrit Enserink, Tor Erik Rusten og Ragnhild Eskeland
Svangerskapet påvirker barnets DNA metylering (NRK.no, Kaja Kristin Ness)
Er livet vårt bestemt av våre besteforeldres levesett? (Medisinerbloggen, R. Eskeland)
Slik påvirkes genene våre (UiO, Elin Lunde)
Kald hyrdestund kan beskytte avkom mot overvekt (NRK.no, Frida J. Kruger)
Kulde gir epigenetiske endringer i spermier (Tidsskriftet Den Norske Legeforeningen, Haakon B. Benestad)
Oversolgt epigenetikk (Psykologitidskriftet, Per Olav Solberg)
Dette er CRISPR: Dei nyttar ny genteknologi forå endre DNA i stamceller (Titan, Åsmund H. Eikenes)
Farmakoepigenetikk: Samspillet mellom legemidler og epigenetikk (Publisert i Farmatid.no)
Gratulerer med SFF-partnerskap til Ragnhild Eskeland! (Elina Melteig IBV/Titan UiO)
Revolusjonær mikrobiolog sprengte lokalene i Vitenskapsakademiet (Bjarne Røsjø/Titan UiO)
Det skjer ein revolusjon på labben – genredigering for alle! (Åsmund H. Eikenes; Framtida.no)
Ingen vits i å klone en pen katt (Bjarne Røsjø/Titan UiO)
Stamcelle-forskning skal gi gravide trygg medisinbruk (Bjarne Røsjø/ Titan UiO)
Medisiner i svangerskapet (Camilla Smaadal; Apollon)
Tarmceller i spiserøret kan gi kreft (Kristine Gjul Harstad; Kreftforeningen) published at forskning.no
Fremtidens medisin bygger på epigenetikk (Yngve Vogt; Apollon)

Books

Presentations, Movies, Art and Debates

På oppdagingsferd i nye cellelandskap, BIO-Torsdag March 2023 (Norwegian)
Rebellion of the cell, Butoh dance and debate, Grusomhetens teater Nov 2021
Cancer Epigenetics Animation about our work in Chromatin Biology group (English)
Human Nature at Vega Scene a collaboration between UiO, BIFF, Bioteknologirådet
Cellenes Hemmeligheter, Forskningsdagene at Litteraturhuset 2019 and invitation.
Epigenetikk og Arv; BIO-torsdag (Norwegian)
CRISPR/Cas9-genredigering; BIO-torsdag (Norwegian)
Utstillingsåpning: DAMER! 100 år med kvinner i realfagene ved UiO; Realfagsbiblioteket, UiO (Norwegian)
Identically different: Questions toTim Spector and panel debate, Oslo Epigenetics Symposium 2012 (English)

Alumnis

Hallvard Wæhler (PhD student)
Synne Lindahl Neeb (Master student)
Naima Azouzi (Post doc)
Moritz Knickel (Erasmus exchange student)
Marie Rogne (Researcher)
Jørgen Dybevik Rønneberg (Master student)
Nils Anders Labba (PhD student)
Beata Nadratowska-Wesolowska (Researcher)
Emily Martinsen (Master student)
Mari Bergstøl Gornitzka (Master student)
Aruna Abraham (Master student)
Martin Falck (PhD student)
Cecile Palao (Erasmus student)
Ankush Sharma (Post doc)
Martine Mesel (Master student)
Tasmia Jinnurine (Master student)
Mohamed Ibrahim Abdelhalim (Master student)
Melanie Engelfriet (Master student)
Guro C. Mustorp (Master student)
Ignacio Cuervo (PhD student)
Gema Escribano Serrano (Erasmus student)
Madeleine L. Fosslie (PhD student)
Antonio Mora (Post doc)