Dag Kvale

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Phone +47-22119153
Fax +47-22119181
Username
Visiting address Kirkeveien 166 Bygg 3 0450 OSLO
Postal address Postboks 4956 Nydalen 0424 OSLO
Other affiliations Division of Medicine

Publications

  • Brekke, Kristin; Sommerfelt, Maja; Ökvist, Mats Erik; Dyrhol-Riise, Anne Ma & Kvale, Dag (2017). The therapeutic HIV Env C5/gp41 vaccine candidate Vacc-C5 induces specific T cell regulation in a phase I/II clinical study. BMC Infectious Diseases.  ISSN 1471-2334.  17:228, s 1- 12 . doi: 10.1186/s12879-017-2316-x
  • Feruglio, Siri; Kvale, Dag & Dyrhol-Riise, Anne Ma (2017). T Cell Responses and Regulation and the Impact of In Vitro IL-10 and TGF-beta Modulation During Treatment of Active Tuberculosis . Scandinavian Journal of Immunology.  ISSN 0300-9475.  85(2), s 138- 146 . doi: 10.1111/sji.12511 Full text in Research Archive
  • Prebensen, Christian; Trøseid, Marius; Ueland, Thor; Dahm, Anders Erik A; Sandset, Per Morten; Aaberge, Ingeborg Sundsvalen; Waalen, Kristian; Dyrhol-Riise, Anne Ma; Tasken, Kjetil & Kvale, Dag (2017). Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial . PLoS ONE.  ISSN 1932-6203.  12:e0176527(5), s 1- 20 . doi: 10.1371/journal.pone.0176527 Full text in Research Archive
  • Prebensen, Christian; Lind, Andreas; Dyrhol-Riise, Anne Ma & Kvale, Dag (2016). Regulation of Gag- and Env-specific CD+ T cell responses in ART-naïve HIV-infected patients: Potential implications for individualized immunotherapy. PLoS ONE.  ISSN 1932-6203.  11(4) . doi: 10.1371/journal.pone.0153849 Full text in Research Archive
  • Stiksrud, Birgitte; Lorvik, Kristina Berg; Kvale, Dag; Mollnes, Tom Eirik; Ueland, Per Magne; Trøseid, Marius; Tasken, Kjetil & Dyrhol-Riise, Anne Ma (2016). Plasma IP-10 is increased in immunological nonresponders and associated with activated regulatory T cells and persisting low CD4 counts. Journal of Acquired Immune Deficiency Syndromes.  ISSN 1525-4135.  73(2), s 138- 148 . doi: 10.1097/QAI.0000000000001080
  • Tonby, Kristian; Wergeland, Ida; Lieske, Nora Valeska; Kvale, Dag; Tasken, Kjetil & Dyrhol-Riise, Anne Ma (2016). The COX- inhibitor indomethacin reduces Th1 effector and T regulatory cells in vitro in Mycobacterium tuberculosis infection. BMC Infectious Diseases.  ISSN 1471-2334.  16:599, s 1- 12 . doi: 10.1186/s12879-016-1938-8 Full text in Research Archive
  • Feruglio, Siri; Tonby, Kristian; Kvale, Dag & Dyrhol-Riise, Anne Ma (2015). Early dynamics of T helper cell cytokines and T regulatory cells in response to treatment of active Mycobacterium tuberculosis infection . Clinical and Experimental Immunology.  ISSN 0009-9104.  179(3), s 454- 465 . doi: 10.1111/cei.12468
  • Lieske, Nora Valeska; Tonby, Kristian; Kvale, Dag; Dyrhol-Riise, Anne Ma & Tasken, Kjetil (2015). Targeting tuberculosis and HIV infection-specific regulatory T cells with MEK/ERK signaling pathway inhibitors. PLoS ONE.  ISSN 1932-6203.  10:e0141903(11) . doi: 10.1371/journal.pone.0141903 Full text in Research Archive
  • Prebensen, Christian; Ueland, Thor; Michelsen, Annika; Lind, Andreas; Pettersen, Frank Olav; Mollnes, Tom Eirik; Aukrust, Pål; Dyrhol-Riise, Anne Ma & Kvale, Dag (2015). High MIP-1β levels in plasma predict long-term immunological nonresponse to suppressive antiretroviral therapy in HIV infection. Journal of Acquired Immune Deficiency Syndromes.  ISSN 1525-4135.  69(4), s 395- 402 . doi: 10.1097/QAI.0000000000000617
  • Stiksrud, Birgitte; Nowak, Piotr; Nwosu, Felix Chinweije; Kvale, Dag; Thalme, Anders; Sönnerborg, Anders; Ueland, Per Magne; Holm, Kristian; Birkeland, Stein-Erik; Dahm, Anders Erik A; Sandset, Per Morten; Rudi, Knut; Hov, Johannes Espolin Roksund; Dyrhol-Riise, Anne Ma & Trøseid, Marius (2015). Reduced levels of D-dimer and changes in gut microbiota composition after probiotic intervention in HIV-infected individuals on stable ART. Journal of Acquired Immune Deficiency Syndromes.  ISSN 1525-4135.  70(4), s 329- 337 . doi: 10.1097/QAI.0000000000000784
  • Tonby, Kristian; Ruhwald, Morten; Kvale, Dag & Dyrhol-Riise, Anne Ma (2015). IP-10 measured by Dry Plasma Spots as biomarker for therapy responses in Mycobacterium Tuberculosis infection. Scientific Reports.  ISSN 2045-2322.  5 . doi: 10.1038/srep09223 Full text in Research Archive
  • Ushakova, Anastasia; Pettersen, Frank Olav; Mæland, Arild; Lindqvist, Bo Henry & Kvale, Dag (2015). Bayesian estimation of HIV-1 dynamics in vivo. Mathematical Medicine and Biology.  ISSN 1477-8599.  32(1), s 38- 55 . doi: 10.1093/imammb/dqt018
  • Wergeland, Ida; Pullar, Nadine Durema; Assmus, Jörg; Ueland, Thor; Tonby, Kristian; Feruglio, Siri; Kvale, Dag; Damås, Jan Kristian; Aukrust, Pål; Mollnes, Tom Eirik & Dyrhol-Riise, Anne Ma (2015). IP-10 differentiates between active and latent tuberculosis irrespective of HIV status and declines during therapy. Journal of Infection.  ISSN 0163-4453.  70(4), s 381- 391 . doi: 10.1016/j.jinf.2014.12.019 Full text in Research Archive
  • Brekke, Kristin; Lind, Andreas; Holm-Hansen, Carol J C; Haugen, Inger Lise; Sørensen, Birger; Sommerfelt, Maja & Kvale, Dag (2014). Intranasal administration of a therapeutic HIV vaccine (Vacc-4x) induces dose-dependent systemic and mucosal immune responses in a randomized controlled trial . PLoS ONE.  ISSN 1932-6203.  9(11) . doi: 10.1371/journal.pone.0112556 Full text in Research Archive
  • Drozd, Filip; Skeie, Linda Gail; Kraft, Pål & Kvale, Dag (2014). A web-based intervention trial for depressive symptoms and subjective well-being in patients with chronic HIV infection. AIDS Care.  ISSN 0954-0121.  26(9), s 1080- 1089 . doi: 10.1080/09540121.2013.869541
  • Kran, Anne-Marte Bakken; Lind, Andreas; Sommerfelt, Maja A; Baksaas, I; Sørensen, Birger & Kvale, Dag (2014). Comparable cellular immune responses in patients with and without antiretroviral treatment after immunization with HIV-1 P24, P17 and Tat consensus peptides (Vacc-5q). Journal of AIDS and Clinical Research.  ISSN 2155-6113.  5(4), s 296- 304 . doi: 10.4172/2155-6113.1000296
  • Lind, Andreas; Brekke, Kristin; Pettersen, Frank Olav; Mollnes, Tom Eirik; Trøseid, Marius & Kvale, Dag (2014). A parameter for IL-10 and TGF-β mediated regulation of HIV-1 specific T cell activation provides novel information and relates to progression markers. PLoS ONE.  ISSN 1932-6203.  9(1) . doi: 10.1371/journal.pone.0085604 Full text in Research Archive
  • Pedersen, KK; MANNER, INGJERD W; Seljeflot, Ingebjørg; Kvale, Dag; Os, Ingrid; Gerstoft, J; Nielsen, SD & Trøseid, Marius (2014). Monocyte activation, but not micribial translocation, is independently associated with markers of endovascular dysfunction in HIV-infected patients receiving cART. Journal of Acquired Immune Deficiency Syndromes.  ISSN 1525-4135.  67(4), s 370- 374 . doi: 10.1097/QAI.0000000000000339
  • Trøseid, Marius; Manner, Ingjerd Wangensteen; Pedersen, Karin K.; Haissman, Judith M.; Kvale, Dag & Nielsen, Susanne D. (2014). Microbial translocation and cardiometabolic risk factors in HIV infection. AIDS Research and Human Retroviruses.  ISSN 0889-2229.  30(6), s 514- 522 . doi: 10.1089/aid.2013.0280
  • Feruglio, Siri; Trøseid, Marius; Damås, Jan Kristian; Kvale, Dag & Dyrhol-Riise, Anne Ma (2013). Soluble Markers of the Toll-Like Receptor 4 Pathway Differentiate between Active and Latent Tuberculosis and Are Associated with Treatment Responses. PLoS ONE.  ISSN 1932-6203.  8(7) . doi: 10.1371/journal.pone.0069896 Full text in Research Archive
  • Lind, Andreas; Brekke, Kristin; Sommerfelt, Maja; Holmberg, Jens O.; Aass, Hans Christian; Baksaas, Ingebjørg; Sørensen, Birger; Dyrhol-Riise, Anne Ma & Kvale, Dag (2013). Boosters of a therapeutic HIV-1 vaccine induce divergent T cell responses related to regulatory mechanisms. Vaccine.  ISSN 0264-410X.  31(41), s 4611- 4618 . doi: 10.1016/j.vaccine.2013.07.037
  • MANNER, INGJERD W; Bækken, Morten; Kvale, Dag; Øktedalen, Olav; Pedersen, M.; Nielsen, SD; Nowak, P.; Os, Ingrid & Trøseid, Marius (2013). Markers of microbial translocation predict hypertension in HIV-infected individuals. HIV Medicine.  ISSN 1464-2662.  14(6), s 354- 361 . doi: 10.1111/hiv.12015
  • Pedersen, K. K.; Trøseid, Marius; Gaardbo, J. C.; Lund, T. T.; Thomsen, C.; Gerstoft, J; Kvale, Dag & Nielsen, S. D. (2013). Translocation in HIV Infection is Associated with Dyslipidemia, Insulin Resistance, and Risk of Myocardial Infarction. JAIDS.  ISSN 1077-9450.  64(5), s 425- 433
  • Pedersen, Karin K.; Pedersen, Maria; Trøseid, Marius; Gaardbo, Julie C.; Lund, Tamara T.; Thomsen, Carsten; Gerstoft, Jan; Kvale, Dag & Nielsen, Susanne D. (2013). Microbial Translocation in HIV Infection Is Associated With Dyslipidemia, Insulin Resistance, and Risk of Myocardial Infarction. Journal of Acquired Immune Deficiency Syndromes.  ISSN 1525-4135.  64(5), s 425- 433
  • Trøseid, Marius; Lind, Andreas; Nowak, Piotr; Barqasho, Babilonia; Heger, Bernt; Lygren, Idar; Pedersen, Karin K.; Kanda, Tatsuo; Funaoka, Hiroyuki; Damås, Jan Kristian & Kvale, Dag (2013). Circulating levels of HMGB1 are correlated strongly with MD2 in HIV-infection: Possible implication for TLR4-signalling and chronic immune activation. Innate Immunity.  ISSN 1753-4259.  19(3), s 290- 297 . doi: 10.1177/1753425912461042
  • Brantsæter, Arne; Johannessen, Asgeir; Holberg-Petersen, Mona; Sandvik, Leiv; Naman, Ezra; Kivuyo, Sokoine; Rollag, Halvor; Bruun, Johan N & Kvale, Dag (2012). Cytomegalovirus viremia in dried blood spots is associated with an increased risk of death in HIV-infected patients: a cohort study from rural Tanzania. International Journal of Infectious Diseases.  ISSN 1201-9712.  16(12), s E879- E885 . doi: 10.1016/j.ijid.2012.08.003
  • Kran, Anne-Marte Bakken; Sommerfelt, Maja A; Baksaas, Ingebjørg; Sørensen, Birger & Kvale, Dag (2012). Delayed-type hypersensitivity responses to HIV Gag p24 relate to clinical outcome after peptide-based therapeutic immunization for chronic HIV infection. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS).  ISSN 0903-4641.  120(3), s 204- 209 . doi: 10.1111/j.1600-0463.2011.02843.x
  • Lind, Andreas; Sommerfelt, Maja; Holmberg, Jens Olof; Baksaas, Ingebjørg; Sørensen, Birger & Kvale, Dag (2012). Intradermal vaccination of HIV-infected patients with short HIV Gag p24-like peptides induces CD4+ and CD8+ T cell responses lasting more than seven years. Scandinavian Journal of Infectious Diseases.  ISSN 0036-5548.  44(8), s 566- 572 . doi: 10.3109/00365548.2011.653581
  • Pettersen, Frank Olav; Torheim, Eirik A.; Dahm, Anders Erik A; Aaberge, Ingeborg Sundsvalen; Lind, Andreas; Holm, Malin; Aandahl, Einar Martin; Sandset, Per Morten; Tasken, Kjetil & Kvale, Dag (2011). An exploratory trial of cyclooxygenase type 2 inhibitor in HIV-1 infection: Downregulated immune activation and improved T Cell-dependent vaccine responses. Journal of Virology.  ISSN 0022-538X.  85(13), s 6557- 6566 . doi: 10.1128/JVI.00073-11
  • Kran, Anne-Marte Bakken; Jonassen, Tom Øystein; Sommerfelt, Maja A.; Løvgården, G.; Sørensen, Birger & Kvale, Dag (2010). Low frequency of amino acid alterations following therapeutic immunization with HIV-1 Gag p24-like peptides. AIDS (London).  ISSN 0269-9370.  24(17), s 2609- 2618 . doi: 10.1097/QAD.0b013e32833e502b
  • Pettersen, Frank Olav; Tasken, Kjetil & Kvale, Dag (2010). Combined Env- and Gag-specific T cell responses in relation to programmed death-1 receptor and CD4+T cell loss rates in human immunodeficiency virus-1 infection. Clinical and Experimental Immunology.  ISSN 0009-9104.  161(2), s 315- 323 . doi: 10.1111/j.1365-2249.2010.04179.x
  • Bengtsson, P; Baksaas, Ingebjørg; Sommerfelt, MA; Sørensen, B. & Kvale, Dag (2009). Vacc-4x HIV p24-like peptide vaccine-associated increase of CD4 T-cells in chronically infected HIV-1 patients on antiretroviral therapy. Retrovirology.  ISSN 1742-4690.  6, s 413
  • Maagaard, Anne & Kvale, Dag (2009). Long term adverse effects related to nucleoside reverse transcriptase inhibitors: Clinical impact of mitochondrial toxicity. Scandinavian Journal of Infectious Diseases.  ISSN 0036-5548.  41(11-12), s 808- 817 . doi: 10.3109/00365540903186181
  • Maagaard, Anne & Kvale, Dag (2009). Mitochondrial toxicity in HIV-infected patients both off and on antiretroviral treatment: a continuum or distinct underlying mechanisms?. Journal of Antimicrobial Chemotherapy.  ISSN 0305-7453.  64(5), s 901- 909 . doi: 10.1093/jac/dkp316
  • Torheim, Eirik A.; Ndhlovu, Lishomwa C.; Pettersen, F.O.; Torgersen, Knut Martin; Jha, Aashish; Kvale, Dag; Nixon, Douglas F.; Tasken, Kjetil; Aandahl, Einar Martin & Aandahl, EM (2009). Interleukin-10-secreting T cells define a suppressive subset within the HIV-1-specific T-cell population. European Journal of Immunology.  ISSN 0014-2980.  39(5), s 1280- 1287 . doi: 10.1002/eji.200839002
  • Holm, Malin; Pettersen, Frank Olav & Kvale, Dag (2008). PD-1 predicts CD4 loss rate in chronic HIV-1 infection better than HIV RNA and CD38 but not in cryopreserved samples. Current HIV Research.  ISSN 1570-162X.  6, s 49- 58
  • Maagaard, Anne; Holberg-Petersen, Mona; Loevgaarden, G; Holm, Malin; Pettersen, Frank Olav & Kvale, Dag (2008). Distinct Mechanisms for Mitochondrial DNA Loss in T and B Lymphocytes from HIV-Infected Patients Exposed to Nucleoside Reverse-Transcriptase Inhibitors and Those Naive to Antiretroviral Treatment. Journal of Infectious Diseases.  ISSN 0022-1899.  198(19), s 345- 353 . doi: 10.1086/592713
  • Maagaard, Anne; Holberg-Petersen, M; Torjesen, PA; Bruun, Johan N & Kvale, Dag (2007). Insulin resistance is affected by increased levels of plasma lactate but not mitochondrial alterations in skeletal muscle in NRTIE-xposed HIV-Infected patients. HIV Clinical Trials.  ISSN 1528-4336.  8, s 345- 353 . doi: 10.1310/hct0805-345
  • Bakken, Anne-Marte; Sorensen, B; Sommerfelt, MA; Nyhus, J; Baksaas, I & Kvale, Dag (2006). Long-term HIV-specific responses and delayed resumption of antiretroviral therapy after peptide immunization targeting dendritic cells. AIDS (London).  ISSN 0269-9370.  20
  • Kvale, Dag; Ormaasen, V; Kran, AMB; Johansson, Carl Christian; Aukrust, Pål; Aandahl, Einar Martin; Frøland, Stig Sophus & Tasken, Kjetil (2006). Immune modulatory effects of cyclooxygenase type 2 inhibitors in HIV patients on combination antiretroviral treatment. AIDS (London).  ISSN 0269-9370.  20
  • Kvale, Dag; Kran, Anne-Marthe Bakken; Sommerfelt, Maja; Nyhus, J; Baksaas, I; Bruun, Johan N & Sørensen, B. (2005). Divergent in vitro and in vivo correlates of HIV-specific T-cell responses during onset of HIV viraemia. AIDS (London).  ISSN 0269-9370.  19, s 563- 567
  • Abrahamsen, IW; Somme, Stig; Heldal, Dag; Egeland, Torstein; Kvale, Dag & Tjønnfjord, Geir E (2005). Immune reconstitution after allogeneic stem cell transplantation: the impact of stem cell source and graft-versus-host disease. Haematologica.  ISSN 0390-6078.  90
  • Kran, AMB; Sommerfelt, MA; Sorensen, B; Nyhus, J; Baksaas, I; Bruun, Johan N & Kvale, Dag (2005). Reduced viral burden amongst high responder patients following HIV-1 p24 peptide-based therapeutic immunization. Vaccine.  ISSN 0264-410X.  23
  • Kran, Anne-Marte Bakken; Sommerfelt, Maja A; Sørensen, Birger; Nyhus, Jørgen; Baksaas, Ingebjørg; Bruun, Johan N & Kvale, Dag (2005). Reduced viral burden amongst high responder patients following HIV-1 p24 peptide-based therapeutic immunization. Vaccine.  ISSN 0264-410X.  23(31), s 4011- 4015
  • Kran, Anne-Marte Bakken; Sørensen, Birger; Nyhus, Jørgen; Sommerfelt, Maja A; Baksaas, Ingebjørg; Bruun, Johan N. & Kvale, Dag (2004). HLA- and Dose-Dependent Immunogenicity of a Peptide-Based HIV-1 Immunotherapy Candidate (Vacc-4x). AIDS (London).  ISSN 0269-9370.  18, s 1875- 1883

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  • Kvale, Dag; Ørn, Stein & Bach-Gansmo, Edvin (2016). Sykdom og behandling. Gyldendal Akademisk.  ISBN 978-82-05-48233-3.  602 s.

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  • Stiksrud, Birgitte; Lorvik, Kristina Berg; Kvale, Dag; Mollnes, Tom Eirik; Ueland, Per Magne; Berge, Rolf Kristian; Trøseid, Marius; Tasken, Kjetil & Dyrhol-Riise, Anne Ma (2015). Plasma Interferon-inducible Protein 10 Levels, T-cell Activation and Regulation are Increased in HIV Immunological Non-Responders.
  • MANNER, INGJERD W; Bækken, Morten; Øktedalen, Olav; Kvale, Dag; Nowak, Piotr; Nielsen, Susanne D.; Os, Ingrid & Trøseid, Marius (2014). Plasma Lipopolysaccharide and Triglycerides are Independently Associated and Both Markers Correlate With the Development of Metabolic Syndrome in HIV Infection . Journal of Acquired Immune Deficiency Syndromes.  ISSN 1525-4135.  65(4), s 158- 161 . doi: 10.1097/QAI.0000000000000055
  • Stiksrud, Birgitte; Nowak, Piotr; Kvale, Dag; Thalme, Anders; Birkeland, Stein-Erik; Dahm, Anders Erik A; Dyrhol-Riise, Anne Ma & Trøseid, Marius (2014). Reduced D-dimer levels and inflammation markers after probiotic supplement in HIV-infected on ART.
  • Drozd, Filip; Skeie, Linda Gail; Kraft, P & Kvale, Dag (2012). A web-based intervention for HIV patients in adjunct to medical treatment: A randomized clinical trial. Psychology and Health.  ISSN 0887-0446.  27, s 39- 39
  • Skeie, Linda Gail; Drozd, Filip; Kraft, Pål & Kvale, Dag (2012). A randomized controlled trial of a web-based psychological intervention for patients under treatment for chronic HIV infection. Journal of the International AIDS Society.  ISSN 1758-2652.  15, s 64- 65 . doi: 10.7448/IAS.15.6.18365
  • Skeie, Linda Gail; Drozd, Filip; Kraft, Pål & Kvale, Dag (2012). A randomized controlled trial of aweb-based psychological intervention for patients under treatment for chronic HIV infection.
  • Fløisand, Yngvar & Kvale, Dag (2010). Studies on dendritic cell ontogeny, differentiation and function.
  • Torheim, Eirik A.; Ndhlovu, Lishomwa C.; Jha, Aashish; Pettersen, Frank O.; Kvale, Dag; Nixon, Duglas F.; Tasken, Kjetil & Aandahl, Einar Martin (2007). IFN-y- and IL-10-producing HIV-specific T cells have suppressive properties.
  • Torheim, Eirik A.; Ndhlovu, Lishomwa C.; Jha, Aashish; Pettersen, Frank Olav; Kvale, Dag; Nixon, Douglas F.; Tasken, Kjetil & Aandahl, Einar Martin (2007). Isolation and characterization of suppressive HIV-specific T cells.
  • Tjelle, Torunn Elisabeth; Kjeken, R; Salte, Ragnar; Kvale, Dag & Mathiesen, Iacob (2004). Electroporation device for use in skeletal muscle; Clinical evaluation of pain and muscle damage.
  • Tjelle, Torunn Elisabeth; Kjeken, R; Salte, Ragnar; Kvale, Dag & Mathiesen, Iacob (2004). Electroporation device for use in skeletal muscle; Clinical evaluation of pain and muscle damage.

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Published Apr. 13, 2011 2:53 PM - Last modified May 27, 2011 4:02 PM